Neonatal Care Taps into Light Therapy

When a baby is born, all parents hope for a healthy child—all ten fingers and toes, a strong heart, and an able body. However, between 10 and 15 percent of babies born within the U.S. require special care within the NICU (Neonatal Intensive Care Unit), which is where preterm or diseased babies are cared for. 

This time is crucial for babies; it's the stage in which we, as humans, are most sensitive. After the first hour of life, newborns should receive eye care, vitamin K, and recommended immunizations (birth dose of OPV and Hepatitis B vaccine). They should be assessed for birth weight, fetal age, congenital disabilities, and newborn illness signs. Special care is provided for sick newborns, preterm and/or low birth weight, and babies exposed or infected by HIV or have congenital syphilis.

One of the more common diseases for premature babies is jaundice, which refers to the yellowish discoloration of the skin, sclerae, and mucous membranes caused by an increase in bilirubin in the blood. This substance derives from the metabolism of hemoglobin contained in red blood cells. For the newborn, it is (in most cases) destined to disappear within a few days.

Jaundice becomes evident when the amount of bilirubin exceeds 3 mg per deciliter. The yellowish color occurs first in the face and sclerae (the white part of the eye) and then extends to the trunk and upper and lower limbs. Jaundice can be physiological or indicate a pathology.

However, jaundice can become severe. This happens when it goes untreated for too long, it can cause a condition called kernicterus. Kernicterus is a type of brain damage resulting from high levels of bilirubin in a baby's blood. It can cause cerebral palsy and hearing loss.

Babies are naturally sensitive, and premature newborns are even more at risk. Their immune systems are still developing due to being born prematurely, which increases their risk of getting sick. Skin conditions of many kinds are common; in addition to jaundice, many experience feeding issues, and fever (always the first sign of an infection). 

Due to the nature of premature babies, it's essential to consider a non-invasive, non-medical treatment. They're still growing, just fully coming into their own and catching up on time missed developing in mom’s belly. 

Light therapy is an incredible tool for these little humans, working inward and targeting the cellular level. It helps with both external and internal problems, which means that at the cellular level, light therapy alters and enhances the cell constitution. This, as a result, leads to faster and better reproduction, creating a healthier and stronger organism and body to function with. 

Light therapy is a non-invasive, non-pharmaceutical form of therapy. The way it can help with neonatal care is unique. During treatments, the babies are completely safe and protected, with their eyes covered. The skin gets exposed to the light therapy lamp to absorb its benefits. The lamp is positioned specifically for the baby, no closer than 30.5cm. 

Light therapy has successfully treated newborn jaundice by lowering the bilirubin levels in the baby's blood through a process called photo-oxidation. Photo-oxidation adds oxygen to the bilirubin, making it dissolve in water easily. 

Since light therapy also helps to regulate circadian rhythm and melatonin, the treatments can also help babies sleep, which is essential in their healing and development. 


You can customize and completely control light therapy consumption for babies, thanks to Kaiyan Medical’s state-of-the-art light therapy device manufacturing services. We have been working for 15 years to produce the best light therapy products on the market which are MDA-certified and FDA-approved light therapy devices, many of which are cleared for at-home treatments. Of course, before using a light therapy device, always consult your doctor.

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Light Therapy & Sleep Quality: The Secret of the Chinese Female Basketball Players

Good sleep is a prerequisite for optimal performance. Given that people spend about one-third of their lives asleep, sleep has substantial development, daily functioning, and health. Perhaps no daytime behavior has been associated more closely with improved sleep than exercise. Researchers have shown that exercise serves as a positive function for sleep. Regular exercise consistently has been associated with better sleep. Moreover, the American Academy of Sleep Medicine considers physical exercise a modality of nonpharmacologic treatment for sleep disorders. When studying the influence of exercise on sleep, most investigators have compared acute and sedentary control treatments. In the study of regular moderate-intensity endurance exercise, researchers also provided compelling evidence that exercise promotes sleep.

However, exercise can negatively affect sleep quality. Exercising immediately before going to sleep is detrimental to sleep quality. Athletes train very hard to improve their on-field performances, but excessive training may decrease performance, known as overtraining syndrome. Researchers have shown that symptoms of overtraining indicate poor-quality sleep. Good sleep is an important recovery method for the prevention and treatment of overtraining in sports practice.

In a recent study in which red-light therapy (wavelength = 670 nm, light dose = 4 J/cm2) was used, researchers indicated that red light could restore glutathione redox balance upon toxicologic insult enhance both cytochrome c oxidase and energy production, all of which may be affected by melatonin. Melatonin is a neurohormone that is produced by the pineal gland and regulates sleep and circadian functions. No one knows whether sleep is regulated by melatonin after red-light irradiation in athletes. Researchers have demonstrated that phototherapy improves muscle regeneration after exercise. A red light could protect human erythrocytes in preserved diluted whole blood from the damage caused by experimental artificial heart-lung machines.

Participants

Twenty female athletes of the Chinese People’s Liberation Army team (age = 18.60 ± 3.60 years) participated in the study. All participants were healthy and were not using medications regularly or temporarily during the measurements. Athletes were excluded if they had participated in less than 80% of the scheduled team physical training and basketball sessions for the last 3 months or used any nutritional supplements or pharmacologic agents. All participants provided written informed consent, and the Ethical Committee approved the China Institute of Sport Science study.

Design

Participants were assigned randomly to either a red-light therapy intervention group (n = 10) or non–red-light therapy intervention group (placebo group, n = 10). Measurements were collected at preintervention (baseline) and postintervention (14 days). The exercise training schedule of the 2 groups was unchanged during the 14 days; the red-light treatment group used a red-light therapy instrument every night for total body irradiation for 30 minutes. The training routine of the athletes during the 14 intervention days included 12 exercise sessions with the following specifications: 2 hours of morning training, 2 hours of afternoon training, and no training on Sunday.

The red-light treatment participants lay in the supine position. Continuous illumination was performed using noncoherent red light from a whole-body red-light treatment machine-like Kaiyan’s red light therapy bed, with an average wavelength of 658 nm and a light dose of 30 J/cm2. The whole body received the phototherapy treatment. The placebo participants also lay in the supine position under the red-light device but did not receive any light illumination. All participants wore swimsuits to enhance irradiation from the device and were blind to the treatment.


Measurement

Sleep Quality

The Chinese version of the PSQI measured sleep quality. The 19-item measure assesses sleep quality and disturbances over a half-month time interval. The total PSQI score ranges from 0 to 21, and higher scores reflect poorer-quality sleep. The 7 items of this instrument measure several aspects of insomnia: difficulties with onset and maintenance of sleep, satisfaction with the current sleep pattern, interference with daily functioning, noticeable impairment attributed to sleep problems, degree of distress, and concern caused by any sleeping problems.

Cooper 12-Minute Run

Participants were instructed to complete as many laps as possible on a 400-m outdoor track during the 12-minute test period. Emphasis was placed on pacing oneself throughout the test. The test administrators counted the laps completed during the 12-minute test period while calling out the time elapsed at 3, 6, and 9 minutes and orally encouraging the participants. At the end of the 12-minute period, the test administrator instructed the participants to stop and used a measuring wheel to determine the fraction of the last lap completed by each participant. This distance was added to the distance determined by the number of laps completed to give the total distance covered during the test.

Serum Melatonin

In humans, the serum level of melatonin, derived mainly from the pineal gland, demonstrates a clear increase at night and a decrease during the day. Given that the masking effects of activities (e.g., exercise, sleep, and food intake) have little effect on the circulating melatonin level's daily pattern, melatonin secretion appears to directly reflect the function of the biological clock as a specific marker of the circadian rhythm.

Conclusions

The study has demonstrated that red-light illumination positively affected sleep quality and endurance performance variables in Chinese female basketball players. Based on previous studies, we can infer that red-light treatment contributes to increased melatonin secretion in the pineal gland and muscle regeneration. Although more studies involving phototherapy, sleep, and exercise performance need to be performed, red-light treatment is a possible nonpharmacologic and noninvasive therapy to prevent sleep disorders after training.

Acknowledgments

This research project was supported by the National Key Technologies R&D Program Fund of China (2006BAK37B06).

Originally from:


Red Light and the Sleep Quality and Endurance Performance of Chinese Female Basketball Players

Jiexiu Zhao, Ye Tian, Jinlei Nie, Jincheng Xu, Dongsen Liu

J Athl Train. 2012 Nov-Dec; 47(6): 673–678. doi: 10.4085/1062-6050-47.6.08

PMCID: PMC3499892

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Neonatal Care Taps into Light Therapy

When a baby is born, all parents hope for a healthy child—all ten fingers and toes, a strong heart, and an able body. However, between 10 and 15 percent of babies born within the U.S. require special care within the NICU (Neonatal Intensive Care Unit), which is where preterm or diseased babies are cared for. 

This time is crucial for babies; it's the stage in which we, as humans, are most sensitive. After the first hour of life, newborns should receive eye care, vitamin K, and recommended immunizations (birth dose of OPV and Hepatitis B vaccine). They should be assessed for birth weight, fetal age, congenital disabilities, and newborn illness signs. Special care is provided for sick newborns, preterm and/or low birth weight, and babies exposed or infected by HIV or have congenital syphilis.

One of the more common diseases for premature babies is jaundice, which refers to the yellowish discoloration of the skin, sclerae, and mucous membranes caused by an increase in bilirubin in the blood. This substance derives from the metabolism of hemoglobin contained in red blood cells. For the newborn, it is (in most cases) destined to disappear within a few days.

Jaundice becomes evident when the amount of bilirubin exceeds 3 mg per deciliter. The yellowish color occurs first in the face and sclerae (the white part of the eye) and then extends to the trunk and upper and lower limbs. Jaundice can be physiological or indicate a pathology.

However, jaundice can become severe. This happens when it goes untreated for too long, it can cause a condition called kernicterus. Kernicterus is a type of brain damage resulting from high levels of bilirubin in a baby's blood. It can cause cerebral palsy and hearing loss.

Babies are naturally sensitive, and premature newborns are even more at risk. Their immune systems are still developing due to being born prematurely, which increases their risk of getting sick. Skin conditions of many kinds are common; in addition to jaundice, many experience feeding issues, and fever (always the first sign of an infection). 

Due to the nature of premature babies, it's essential to consider a non-invasive, non-medical treatment. They're still growing, just fully coming into their own and catching up on time missed developing in mom’s belly. 

Light therapy is an incredible tool for these little humans, working inward and targeting the cellular level. It helps with both external and internal problems, which means that at the cellular level, light therapy alters and enhances the cell constitution. This, as a result, leads to faster and better reproduction, creating a healthier and stronger organism and body to function with. 

Light therapy is a non-invasive, non-pharmaceutical form of therapy. The way it can help with neonatal care is unique. During treatments, the babies are completely safe and protected, with their eyes covered. The skin gets exposed to the light therapy lamp to absorb its benefits. The lamp is positioned specifically for the baby, no closer than 30.5cm. 

Light therapy has successfully treated newborn jaundice by lowering the bilirubin levels in the baby's blood through a process called photo-oxidation. Photo-oxidation adds oxygen to the bilirubin, making it dissolve in water easily. 

Since light therapy also helps to regulate circadian rhythm and melatonin, the treatments can also help babies sleep, which is essential in their healing and development. 


You can customize and completely control light therapy consumption for babies, thanks to Kaiyan Medical’s state-of-the-art light therapy device manufacturing services. We have been working for 15 years to produce the best light therapy products on the market which are MDA-certified and FDA-approved light therapy devices, many of which are cleared for at-home treatments. Of course, before using a light therapy device, always consult your doctor.

Light Therapy Used for Ulcerative Colitis & IBD Treatment

Living with any pain is miserable, and inflammatory digestive issues can be one of the most frustrating conditions out there — and it’s widespread, particularly as autoimmunity on the rise.

Inflammatory Bowel Disease (IBD) is a life-long chronic condition of the gastrointestinal tract. Among these conditions, various digestive system parts, including the bowels (intestines), become swollen, inflamed, and ulcerated. This inflammation leads to disruption of the natural processes of digesting food, absorbing nutrition, and healthily eliminating waste.

There are three forms of IBD: Crohn’s disease, Ulcerative colitis, and indeterminate colitis. The main differences between the three are in the areas affected and the depth of inflammation.

Friendly bacteria may cause it, but that doesn’t make it friendly one bit — ulcerative colitis is rather uncomfortable even if the symptoms are often mild. This condition happens when the immune system mistakes our bacteria, which aids in digestion as friendly, leading to the colon and rectum's inflammation.

The main symptoms of IBD are recurring diarrhea, which may contain blood, mucus, stomach, and abdominal pain, and needing to empty your bowels frequently. It is also possible to experience extreme tiredness (fatigue) and loss of appetite, leading to weight loss.

The severity of the symptoms varies, depending on how much of the rectum and colon is inflamed and how severe the inflammation is.

In 2015, an estimated 1.3% of US adults (3 million) reported being diagnosed with IBD (either Crohn’s disease or ulcerative colitis). This was a large increase from 1999 (0.9% or 2 million adults). In the latest years, autoimmune diseases have risen, including stress, diet, lack of exercise, insufficient sleep, and smoking. In general, people haven’t been leading healthy lifestyles, which results in a higher chance of developing an autoimmune disease. While there are ways to treat autoimmune diseases, they typically are conditions that stick with you as long as they can.

The number of ulcerative colitis cases was 40% higher, and Crohn’s disease was 80% higher in northern Europe than southern Europe. This gives more evidence to the theory of vitamin D deficiency coming from lack of light. In France, a study described a transparent north-south gradient for the incidence of Crohn’s disease, but not colitis.

Light therapy can help with a wide range of problems, autoimmune diseases being one of them. For different autoimmune conditions, incidences increase at ranges between 3% and 9% year on year. This includes a 7.0% increase per year of rheumatic diseases such as rheumatoid arthritis. 6.3% increase of endocrinological conditions such as type 1 diabetes.

This is where light therapy comes in as a form of non-invasive therapy. Aside from being non-invasive, it’s an excellent option for those seeking non-pharmaceutical treatment.

The Health benefits of led light therapy are many, and that’s because of how it works. In its essence, light therapy works directly on our cells. Light deposits into our skin cells, penetrating each cell in the targeted area. Then by activation of ATP, reproduction is accelerated, and cellular rejuvenation occurs throughout the whole body.

Use of light therapy at home is available simply by purchasing your own device, using it in the comfort of your own home. How does light therapy help with IBD and ulcerative colitis? Well, light therapy first and foremost helps with tissue repair. Again, through the process of cell rejuvenation and reproduction, our tissue gets the opportunity of healing as well.

By default, UV light is highly anti-microbial, which means it prevents the spread of microorganisms, which infiltrates and causes infection and inflammation. Making an adequate UV light means having the perfect wavelength, which isn’t corrupting to the genetic material and will penetrate and effectively work on the colon.

To alleviate autoimmune symptoms, red light therapy is the perfect non-invasive solution. By healing the body from the inside out, those suffering from autoimmune diseases can finally progress in the right direction. Kaiyan’s light therapy devices are MDA-certified and FDA-approved and perfect at-home treatments for people suffering from these conditions.

Beard Growth & Light Therapy

Beard Growth & Light Therapy

“The benefit of having a beard is protection, as well as aesthetics,” says Dave Harvey, M.D. “It's good protection against wind, chafing, and traumatic injury. It’s also a trend, so we see a lot of men with some form of facial hair.”

The Health Benefits of Beards

Beards can:

  • Protect skin from sun damage. Beards can help protect the skin from harmful UV rays, though the degree of protection may depend on hair density and thickness. “You’re going to have some protection because hair is a reflective medium,” says Dr. Harvey. “Even though some UV rays get through, there is some scattering of the light, and that’s how it helps protect against sun damage.”
  • Keep you warm. Beards can add a layer of protection to your chin and neck, thus keeping you warm in colder weather. The longer and fuller the beard, the better it will insulate your face.
  • Make you feel more attractive. A study conducted by the Official Journal of the Human Behavior and Evolution Society found that men with a moderately full beard are most attractive. Men with full beards may be perceived as better fathers who could protect and invest in their children. “Men with beards have a powerful look,” says Dr. Harvey. “And that’s an attractive thing.”

Common Problems for Beard Growers

Growing a beard is not always easy. And if your beard is not properly cared for, it can become a harbinger for bacteria.

“If you don’t clean your beard well, and you let it just do its own thing, sometimes you can accumulate yeast and get dandruff within the beard,” says Dr. Harvey. “With that, you’ll get a reactive scaling on the face and flaking like you would with dandruff. So those patients need to be put on antifungal shampoo.”

Beard growers also face the challenge of ingrown follicles that result in bumps known as acne keloidalis.

“Some men will get a raised scarring type of bump called an acne keloidalis of the neck,” he says. “So we offer them topical antibiotics or Retin A for those particular reasons.”

Low-Level Laser Therapy for Beards

Low-level laser therapy (LLLT) is an FDA-approved treatment using laser light energy to circulate blood flow to hair follicles. Laser therapy for hair growth can be used to stop hair loss in men and women. The non-invasive lasers stimulate hair follicles to induce regrowth, resulting in a thicker beard in several weeks of treatments.

Laser hair therapy is also called red light therapy. The process irradiates photons in skin tissue, resulting in photons being absorbed into weaker hair follicles and promoting hair growth.

How Successful Is Laser Hair Restoration?

Laser treatment for hair loss works because photons amp up circulation and stimulation, which brings back hair follicles that may have died off.

Clinical Study

Laser hair restoration therapy is continuing to develop. Still, the National Institutes of Health has conducted multiple studies on laser hair growth therapy to see if it works for those with alopecia and male pattern baldness.

The NIH study used a controlled clinical trial that found laser hair therapy works for men and women, and it’s safe.

Another study from 2013 included male participants aged 18 to 48. The result of laser hair therapy treatment included a 39 percent increase in hair growth for participants over four months.

However, laser therapy is just one piece of the puzzle. Many factors contribute to repeated hair loss, including:

  • Age.
  • Genetics.
  • Medical conditions like diabetes and lupus.
  • Hormones.
  • Poor diet.
  • Side effects of medications, such as chemotherapy.
  • Stress.

How Long Does Laser Hair Therapy Take To Work?

From your first treatment, it can take several weeks to see a noticeable difference. This is because red light therapy for hair loss must be administered multiple times over 4 to 6 weeks to begin working.

If you don’t see any growth after 90 days, it’s probably unlikely you’ll regrow hair with this method. You should consult your doctor about the growth cycle and see how long it will take.

Wellness Gurus: Who's Turning to Light Therapy for Full-Body Treatment

Light therapy has many benefits, working from the inside, out. It not only helps with our appearance but also internal wellness — because who said beauty's just skin deep? 

Many people find themselves turning to this new form of treatment since it's non-invasive and comes with long-term positive effects — something most people aren't used to hearing. 

While outwardly, the skin smooths out, pores are reduced, wrinkles diminished, and collagen restored. Inwardly, light therapy works directly with our cells, generating an increase of ATP, the energy that fuels us. 

LED Light Therapy uses color wavelengths of visible light, each with specific skin benefits. Due to sun damage, aging, skin disorders, healthy skin cells are compromised and have a more difficult time renewing themselves normally.

But why are wellness gurus going crazy for light therapy? 

Light therapy is not that new; however, it's been gaining popularity due to its benefits, especially in the wellness industry. While everyone is eager to look younger, going under the knife is very invasive. Light therapy is not only effective and easy to use; it's non-invasive. The device needed for light therapy is usually a lamp or light therapy box. 

Is light therapy good for skin? Absolutely. And one of the best things next to the long-term effects is that light therapy can be used as laser light therapy at home. This is the most comfortable way of having the benefits of light therapy. Many celebrities themselves are opting for this route as opposed to invasive treatments.

Light is used as a source of energy, and our skin soaks it up, turning it into ATP (our life fuel). Cells reproducing faster and more efficiently brings the repair and rejuvenation of damaged cells, or, in the case of treating acne, kill bacteria. This stimulates the production of collagen and elastin, boosts circulation, and accelerates tissue repair. You simply lie underneath a light screen during the treatment while the LED light device.

What can light therapy be used for you may be wondering? It isn't only beneficial for your skin; it works directly within our cells, accelerating ATP production. This makes it helpful with overall health, physical and mental. Light exposure has also been linked to being a trigger of serotonin, the way natural light does as well. Not only does it trigger serotonin, but also melatonin, which helps regulate your sleep cycle. 

Luckily, instead of having to go to a doctor for your treatments, you have your own LED light therapy mask or device in the comfort of your home. Allowing wellness gurus and everyday people to enjoy the benefits of red light therapy. 

Light therapy devices work not only the face but as a full body treatment that can help with muscle tension and fascia. Fascia is the connecting tissue that holds every organ, blood vessel, bone, nerve fiber, and muscle in place.

Gwyneth Paltrow even explores on goop.com the many different appealing sides to it. “Light acts as a mild stressor on the body in a dose-dependent manner. We always consider stress to be a bad thing, but at low levels, stress can be good for us. It conditions our tissues and stimulates endogenous protective responses that prime us for either existing or future insult.”

Kourtney Kardashian has taken her LED light therapy mask to the public as well, promoting the device and its benefits. She enjoys both red and blue light treatments, often posting her with her at-home mask. She’s mentioned retinol use alongside the regular treatments, and other skin rejuvenating products. 

But more and more celebrities and wellness gurus are turning to light therapy for a full body treatment. Jessica Alba, alongside celebrities including Emma Stone, Chrissy Teigen, Lena Dunham, Kelly Rowland, and Real Housewives of New York City’s Carole Radziwill, have openly discussed red light therapy treatment. 

Many top skincare and wellness brands are turning to Kaiyan for their red light therapy device production. And though we produce devices that are incredibly effective, our devices are also MDA-certified and FDA-approved, giving you security in knowing your devices not only are effective but are safe. 

Conducting a Well-Controlled Clinical Trial for the FDA

In a scientific experiment, the tighter the controls on the experiment’s variables are, the more accurate and insightful the research’s findings will be. It’s the same case for clinical trials in the life sciences industry. A well-controlled clinical trial rooted in the scientific method's foundation will produce more reliable data and conclusions.

But how do you define a “well-controlled” clinical trial? Much to the relief of the life sciences manufacturers and their research teams, the U.S. Food and Drug Administration (FDA) provides explicit guidance on what it means to conduct an adequate and well-controlled clinical trial in 21 CFR 314.126.

What Is a Clinical Trial?

According to clinicaltrials.gov, in a clinical trial (also called an interventional study), participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or medical devices, procedures, or changes to participants’ behavior — for example, diet.

What’s the Difference Between Medical Device Clinical Trials and Drug Trials?

Many of the same factors that make a well-controlled clinical trial for medical devices are similar to what makes a well-controlled drug trial. Still, there are some fundamental differences researchers need to know.

Key differences between medical device trials versus drug trials include:

  • Differences in the Subjects who Participate. In most drug trials, the drug is tested on a small group of healthy individuals first, then administered to incrementally larger populations. Medical device trials typically only involve subjects with the condition for which the trial is designed.
  • Differences in who Administers Drugs versus Devices. In a drug trial, the patient or patient’s caregiver is typically the person who administers the drug. In a medical device trial, the person administering the device is typically the principal investigator.
  • Differences in who has Greater Responsibility. In a drug trial, the patient typically has a higher responsibility for taking the drug as required. In a device trial, the physician shares a greater part of ensuring the device is operated correctly.
  • Differences in Training Requirements. Because the physician has a greater responsibility to administer medical devices correctly, a medical device trial typically requires more practical experience — such as training in cadaver labs or proctoring during live cases.
  • Differences in the FDA Approval Process. The approval process for new drugs is typically longer than the approval process for medical devices. While it takes 12 years on average to bring a new drug to market, the average length of time it takes to bring a medical device to market is three to seven years. However, this does not always mean it’s easier to obtain approval for a new medical device. The extent of the approval process and whether a medical device requires premarket approval depends on its classification. Medical devices determined to carry significant risks to human subjects generally require premarket approval.

Which FDA Regulations Are Required in a Clinical Trial?

Both drug and device trials follow the same requirements for protecting human subjects, maintaining records, and disclosing financial relationships. Those requirements include:

  • 21 CFR 11 — Electronic medical records.
  • 21 CFR 50 — Human subject protection.
  • 21 CFR 54 — Financial disclosure.
  • 21 CFR 56 — Institutional Review Board (IRB) requirements.

While drug trials are required to follow 21 CFR 312, medical device trials are governed by 21 CFR 812.

What Makes A Well-Controlled Clinical Trial?

Whether it’s a drug trial or a medical device trial, the FDA makes it clear that all trials should have the following:

  • A clear statement of the investigation's objectives and a summary of the proposed methods of analysis in the protocol.
  • A design that permits a valid comparison with control to provide a quantitative assessment of the effect.
  • The subject selection provides adequate assurance that the subject has the disease or condition that the treatment is directed at.
  • A method of assigning patients to treatment and control groups minimizes bias and assures the groups' comparability.
  • Adequate measures to minimize bias by the subjects, observers, and data analysts.
  • Well-defined and reliable assessment of subjects’ responses.
  • Analysis of the results is adequate to assess the effect of the drug or device.

The experiment variables are designed to prove or disprove a causal relationship between the independent and dependent variables. This would be the drug or device versus the condition of the patient.

Control is a vital element of a well-designed experiment of the main variables. There needs to be a way to rule out the effects of extraneous variables other than the dependent and independent ones.

A good experiment, like a good clinical trial, often has blind controls or double-blind randomization to compare the results. The goal for a well-controlled experiment is for it to be repeated many times with the same or statistically similar results. Clinical trials are typically not repeated as much as they are designed with large numbers of subjects to remove the bias in a study with small subject sampling. This helps to rule out random samples or outliers in the “experiment.”

Many would argue other things go into the makeup of a well-controlled clinical trial, especially once sites and patients get involved. Having a research team with adequate facilities, knowledge of the federal regulations, and the time and staff to work on the project are also imperative. Additionally, having timely, well-documented data is vital to the trial’s continued success, which helps ensure the trial is being conducted in a way that will produce relevant results.

What Can We Do To Conduct Well-Controlled Clinical Trials?

A well-controlled clinical trial starts with a strong understanding of the risks involved and proper planning to mitigate those risks. Today, it increasingly requires deep knowledge of FDA regulations and global requirements like the European Union’s Medical Device Regulation (MDR) and In Vitro Device Regulation (IVDR) requirements.

Managing the many risks of any trial and keeping it moving forward requires diligent monitoring, record-keeping, and seamless coordination between all parties involved.

Finally, as clinical trials wind down, researchers need to ensure they have all the correct documentation in order in their trial master file.

A full-service contract research organization (CRO) with expertise in conducting global clinical trials is invaluable when conducting a well-controlled clinical trial. They can assist with clinical planning and consulting before a trial begins. They can help with monitoring, auditing, project management, and safety management during the trial. And they can ensure all your documents are in order as you wrap up a trial so you can obtain approval.

FDA Premarket Requirements

Bringing a device to the market in the United States may appear complex. Following these four steps may assist you in navigating the process:

1) Classify Your Device and Understand Applicable Controls

The first step in preparing a marketing device in the United States is to determine how the FDA has classified your device. A medical device is defined by law in section 201(h) of the Federal Food, Drug and Cosmetic (FD&C) Act.

Medical devices are categorized into three classes (I, II, or III) based on the degree of risk they present. As device class increases from class I to class II to class III, the regulatory controls also increase, with class I devices subject to the least regulatory control and class III devices subject to the most stringent regulatory control.

2) Select and Prepare the Correct Premarket Submission

You should select and prepare the appropriate premarket submission if required for your specific product’s classification. For most medical devices, the appropriate submission type is identified within the product classification, which may be obtained from the public Product Classification database. Note some device types do not require a premarket submission. The most common types of premarket submissions include:

  • 510(k) (Premarket Notification)
  • PMA (Premarket Approval)
  • De Novo Classification Request
  • HDE (Humanitarian Device Exemption)

510(k)

Some class I and most Class II devices require a 510(k). In a 510(k), the sponsor must demonstrate that the new device is “substantially equivalent” to a predicate device in terms of intended use, technological characteristics, and performance testing, as needed.

Some class I and class II devices are exempt from the 510(k) notification requirement if they do not exceed the exemption limitations stated in 21 CFR xxx.9, where xxx refers to 21CFR 862–892.

PMA

Class III devices require a PMA. A PMA is the most stringent type of premarket submission. Before the FDA approves a PMA, the sponsor must provide valid scientific evidence demonstrating reasonable assurances of safety and effectiveness for the device’s intended use.

De Novo Classification Request

The De Novo process provides a pathway to classify novel medical devices for which general controls alone, general and special controls, provide reasonable assurance of safety and effectiveness for the intended use. Still, there is no legally marketed predicate device.

HDE

HDE provides a regulatory pathway for class III devices intended to benefit patients with rare diseases or conditions. For a device to be eligible for an HDE, a sponsor must first obtain designation as a Humanitarian Use Device (HUD).

3) Prepare the Appropriate Information for the Premarket Submission

Once you have prepared the appropriate premarket submission for your device, you need to send your submission to the FDA and interact with FDA staff during its review. Before sending your submission to the FDA, you should be aware of the following:

  • Medical Device User Fees: There is a user fee associated with the submission of certain marketing applications.
  • Small Business Determination (SBD) Program: A qualified and certified business as a “small business” is eligible for substantially reducing most of these user fees.
  • eCopy: Premarket submissions must include an electronic copy (eCopy) on a compact disc (CD), digital video disc (DVD), or a flash drive.

Once the FDA has received your submission, you should be aware of the following:

  • Administrative Review: After a premarket submission is received, the FDA conducts an administrative review to assess whether the submission is sufficiently complete to be accepted for substantive review.
  • Interactive Review: While submission is under review, the FDA staff communicates with applicants to increase the review process's efficiency. Step Four: Comply with Applicable Regulatory Controls, Including Establishment Registration and Device Listing

Regulatory controls are risk-based requirements that apply to medical devices and give the FDA the oversight to ensure medical devices' reasonable safety and effectiveness.

SAD - Seasonal Affective Disorder 101

The first formal description of Seasonal Affective Disorder (SAD), the most well-known psychiatric condition associated with seasonality in humans, was introduced in the mid-1980s by Rosenthal, who described a group of 29 patients living in a temperate climate who experienced depressive episodes characterized by hypersomnia, hyperphagia, and weight gain in the fall or winter, and whose symptoms remitted by the next spring or summer.

SAD was incorporated into the Diagnostic and Statistical Manual (DSM) of Mental Disorders III-R when “seasonal pattern” was introduced as a specifier for Major Depression and Bipolar Disorders. Subsequent revision in DSM-IV described SAD as “a regular temporal relationship between the onset of Major Depressive Episodes in Bipolar I (BPI) or Bipolar II (BPII) Disorder or Major Depressive Disorder (MDD), recurrent, and a particular time of the year.”

Today, SAD, or MDD with seasonal pattern, is defined as recurrent episodes of major depression that meet the following criteria: at least two consecutive years where the onset and offset of depressive symptoms occur at characteristic times with no non-seasonal episodes, a temporal relationship between onset of symptoms and time of year, a temporal relationship between remission of symptoms and time of year, and an outnumbering of seasonal compared to non-seasonal episodes throughout the lifetime of the patient.

Pathophysiology of SAD

To date, the pathophysiology of SAD is unclear. Early research into the mechanism of SAD focused on day length or photoperiod. This hypothesis posited that shorter days in winter, possibly mediated by a longer duration of nocturnal melatonin secretion, leads to depressed mood in susceptible individuals. To date, there is little data to support this hypothesis. Furthermore, given that bright light in the evening has not been as effective as that given in the morning, it now seems unlikely that the photoperiod is the underlying pathological mechanism of SAD.

Although some animal studies have implicated a direct effect of light on the midbrain (Miller, Miller, Obermeyer, Behan, & Benca, 1999; Miller, Obermeyer, Behan, & Benca, 1998), the most prominent hypothesis driving human studies involves disruption of circadian rhythms. Research on the role of serotonin is also active.

Circadian Rhythm

A circadian rhythm refers to the approximately 24-hour cycle of physiological processes present in humans and other animals. This cycle is governed via clock gene expression by the suprachiasmatic nucleus (SCN), the master pacemaker located within the anterior hypothalamus. Though the SCN endogenously generates circadian oscillations, SCN endogenously generates circadian oscillations, and they need to be entrained to the 24-hour day by external cues. Light exposure is the most important synchronizing agent of endogenous circadian rhythms.

Downstream of the SCN, a collection of systemically active neurohumoral networks transduce circadian information to the rest of the body. For instance, via projections to the hypothalamus's paraventricular nucleus, the activation of the SCN leads to autonomic changes, including cardiovascular modulation, and together the central, peripheral, and autonomic nervous systems collaborate to affect systemic changes. Thus, the SCN receives information about the external day-night cycle directly through retinofugal pathways and indirectly through neuromodulatory signaling. Circadian information is then relayed systemically through neurohumoral networks.

The current primary hypothesis for the pathophysiology of SAD, known as the “phase-shift hypothesis,” posits that there is an optimal relationship in the alignment of the sleep-wake cycle and the endogenous circadian rhythm. During the fall and winter, as day length shortens, the circadian rhythm begins to drift later concerning clock time and the sleep-wake cycle. This phase delay is hypothesized to bring about mood symptoms. A pulse of morning bright light generates a circadian phase advance, which is thought to correct the discordance between sleep and circadian phase, thereby ameliorating depressive symptoms. However, the phase-shift hypothesis would predict that the amount of phase correction required for each patient would depend on an individual’s PAD, which has not yet been proven.

Serotonin

Several studies have also proposed that serotonin is implicated in the pathophysiology of SAD, as selective serotonin reuptake inhibitors (SSRIs) appear to be effective in the treatment of SAD. Supporting this hypothesis, one study used Positron Emission Tomography (PET) imaging to look at binding probability at synaptic serotonin transporters in 88 normal individuals living in the temperate climate of Toronto, Canada (Praschak-Rieder, Willeit, Wilson, Houle, & Meyer, 2008). The binding probability was increased during fall and winter compared to warmer months, thus eliciting an inverse correlation between binding potential and sunlight durationsunlight duration. Of note, the largest difference in transporter binding was found in the mesencephalon, a finding consistent with animal studies demonstrating the importance of direct effects of light to the midbrain on behavior. If increased transporter activity indicated greater reuptake of serotonin during the fall/winter, and if this resulted in a lower density of cleft serotonin, then the seasonal variation in transporter activity (i.e., higher transporter efficiency in the winter) would seem to leave susceptible individuals particularly prone to mood symptoms during the darker seasons. Moreover, following BLT and during periods of remission in the summer months, the synaptic transporter activity was shown to be reduced to control levels in these patients.

Eating Disorders

BLT has also been investigated to a lesser extent in eating disorders. Because binge eating episodes have been observed to increase in fall and winter in some patients, BLT has been examined as a treatment modality for anorexia nervosa (AN) and bulimia nervosa (BN). Thus, BLT's effects on patients with eating disorders remain enigmatic. Additional studies, including larger, randomized, blinded, and controlled trials, are needed to elucidate further the role of BLT in treating this patient population. Further research might also determine whether BLT would be a useful treatment in Binge-Eating Disorder, a diagnosis new to DSM-5.

Adult ADHD

Additionally, BLT has been studied in the context of adult Attention-Deficit/Hyperactivity Disorder (ADHD), where, in addition to normal ADHD symptoms, patients often have depressed mood and difficulties falling asleep, awakening on time, and maintaining arousal (Brown & McMullen, 2001). These symptoms are indicative of a possible delay in the circadian rhythm. A case report of symptom improvement following BLT in a child with ADHD who displayed signs of delayed sleep phase also supports the idea that BLT may be useful in treating symptoms of ADHD (Gruber, Grizenko, & Joober, 2007). Whether the pathways that subserve the improvement of mood symptoms in response to BLT are the same pathways that underlie the seemingly beneficial effects of BLT in ADHD remains to be studied. While these results are promising, further studies, preferably in randomized, blinded, and controlled studies will need to be performed.

Finally

A significant immediate reduction of depression scores with light treatment can be identified after 20 minutes and reaches the maximum at 40 minutes, with no additional benefit at 60 minutes. The rate of change is steepest during the first 20 minutes of light as compared with longer intervals. Comparing the clinical impact of these durations of administration may yield different results when measured after several daily sessions. The overnight effect on circadian rhythms and sleep was not assessed in our study and is thought to impact mood regulation in SAD. Larger, prospective, controlled, and hypothesis-driven studies in more naturalistic conditions would be desirable to replicate our study results and our study results and analyze the temporal dynamic of the persistence of the immediate mood-improvement effects. Besides, in larger samples, one could define early responders and nonresponders, analyze genetic (e.g., melanopsin related genes), demographic (children, adolescents, adults, elderly, gender), physiological (e.g., pupillary responses), and clinical (e.g., abundant atypical symptoms) predictors for early response. If proven effective and efficacious, shorter exposures to bright light could become a feasible and broadly employed intervention for immediate mood improvement as an early step on the road toward full antidepressant response and remission.


REFERENCES
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Dreaming of Light Therapy

Light therapy is beneficial for more than just one problem. Rather, it’s an all-in-one health and wellness treatment. It helps with skincare issues ranging from acne to wrinkles to eczema by supporting the mitochondria, which in return provokes better cell production within the body and targeted areas. 

But another thing light therapy is proving to be powerful with is sleep. Sleeping disorders are more frequent than ever, with many people experiencing sleep disorders and, if not full disorder, struggle with achieving restful sleep. 

Stress and anxiety build up through the day, and our addiction to our devices greatly disturbs our sleeping habits. However, a good night’s sleep is actually one of the most important things to maintain if you want optimal health.

While there are many types of sleep disorders—insomnia, sleep apnea, restless legs syndrome (RLS), and narcolepsy—bright light therapy has proven to help reduce many of these conditions. In addition, its effects are also being studied on how they can help with Parkinson’s disease. 

Sleep onset insomnia is one of the things light therapy can effectively treat. Insomnia is the inability to fall asleep at a normal time. Though there are various reasons for insomnia, one problem stems from the advanced or delayed circadian rhythms.

There’s also advanced sleep phase disorder when you tend to feel sleepy in the late afternoon or early evening. Bedtime typically happens between 6 p.m. and 9 p.m. Early bedtime means you often wake up between 2 a.m. and 5 a.m. Light therapy here can help reset your internal clock in the early evening hours.

With delayed sleep phase disorder, you tend to stay up all night or at least a few hours, often past midnight. As a result, you also tend to wake up later in the morning, having lost a good chunk of your day. In this instance, light therapy in the morning, right after you’ve woken up, helps to advance your internal clock and makes you feel sleepy earlier in the evening, helping to adjust to a normal sleeping pattern.

And yet, light therapy treatment is proving to be the perfect solution.

In 2012, Light therapy was studied and found to be an effective nonpharmacological and non-invasive way of treating sleep disorders and improving sleep quality among elite female basketball players. Each participant within the research received14-30 minute light therapy sessions once every night for 14 nights in a row.

Research also showed improved melatonin levels among basketball players, and melatonin is a hormone that promotes sleep. Players in return experienced improved endurance performance. 

In later studies as well, light therapy has proved itself to be very effective. In 2013, a Taiwanese study looked at participants and their electroencephalography (EEG), which means they examined their electrical brain activity. They checked before, during, and after the light therapy simulation. The research suggested that light therapy is beneficial in helping people with sleep disorders. But these are the only studies that show the effectiveness of light therapy.

A study on the cognitive function of people with traumatic brain injury discovered that light therapy helped those people with their cognitive function. Light therapy helped decrease episodes of post-traumatic stress disorder (PTSD). Participants also reported better sleep during the study. 

New research from the University of Arizona Health Sciences discovered that with light therapy, people with migraines have a better chance of improving their sleep, plus act as a preventative measure for future migraines. Patients who were submitted to the research experienced better sleep and fewer headaches with light therapy.

Our minds have been occupied with a lot, with the pandemic, with people experiencing more hardships than before. Even if they’ve gotten used to it, the way of living has drastically changed. It’s no surprise that our sleep has also been affected by this. It’s reported that having bad dreams due to the ongoing pandemic isn’t anything too surprising nor impossible. 

Growing evidence suggests that light therapy can help us improve the ability to fall asleep, remain asleep and get a good night’s all in one. In times when our dreams and sleep are invaded by negative feelings related to any upsetting and unsettling occurrence in our life, light therapy can help us ease our daily stressors and might help us avoid sleep-disturbing dreams.

That said, you want the right light therapy device to help you improve your sleep. Kayian medical produces MDA-certified and FDA-approved light therapy devices to ensure you get the most out of light therapy. 

Light Therapy & C-sections

The experience of transformation from womanhood into motherhood is a privilege reserved exclusively for women. Pregnancy and childbirth are wonderful and remarkable moments of life. Giving birth to a child can be one of the most joyful experiences too. Naturally, expectant mothers spend a lot of time thinking about how they will give birth. Although most people believe that vaginal birth is the best way to deliver, sometimes a Caesarean section cannot be avoided. As well, labor pain is one of the most intense pains experienced by women, which leads to an increase in the number of women opting to undergo a cesarean delivery. Pharmacological and nonpharmacological analgesia methods are used to control labor pain. Epidural analgesia is the most commonly used pharmacological analgesia method. However, it may have side effects on the fetus and the mother. Light-emitting diode (LED) photobiomodulation is an effective and noninvasive alternative to pharmacological methods.

Caesarean section was introduced in clinical practice as a lifesaving procedure both for the mother and the baby. It is a surgical procedure in which the incision is made on the products of conception. Caesarean birth is often used as a prophylactic measure to alleviate the problems of birth, such as cephalo pelvic disproportion, failure to progress in labor or fetal distress. A major concern in maternal and child health nursing is the increasing number of caesarean birth being performed annually. In India, primary caesarean birth is about 30.2% of births. The majority of the states are within the WHO specified range of Caesarean section (5 to 15%). Among that, five states are above the range and 12 states below the specified range. Reports also say that the prevalence of Caesarean section is generally more in the southern states. After the baby is born via C-section, the result is a wound that must heal, and pain is common during this healing process.

Wound healing acceleration and pain management in women who underwent the cesarean surgery could help them to return to their normal functioning, especially to begin breastfeeding their newborns as one of the most important aspects of newborn care. Failure incomplete healing of the wound is one of the probable complications of caesarean section. Post caesarean wound infection due to delayed wound healing and pain are not only a leading cause of prolonged hospital stay but a major cause of the widespread aversion to caesarean delivery in developing countries. Management of those problems is essential to decrease infection, length of the hospital stay, pain, and help to return for normal function.

Mothers who undergo caesarean section should achieve immediate recovery than other surgical patients because of maternal and neonatal wellbeing. Several studies have investigated many approaches and protocols of wound healing and pain management in women undergoing caesarean section. Though different approaches have been introduced, these approaches are still inadequate and unsatisfactory in many patients. Thus it seems that postoperative management in this group of people is more challenging than other surgical patients. Infrared Rays have a therapeutic effect of increasing the blood supply and relieving the pain. This will increase the supply of oxygen and nutrient available to the tissues, accelerate the removal of the waste products, and bring about the resolution of inflammation. When the heat is mild, pain relief is probably due to the sedative effect on the superficial sensory nerve endings. It also helps to achieve muscular relaxation. Infrared rays also have a physiological effect on cutaneous vasodilation due to the liberation of chemical vasodilators, histamine, and similar substance, and a possible direct effects on the blood vessels. Stronger heating of infrared stimulates the superficial nerve endings. It has been noticed that pain is due to the accumulation of waste products, and because of stronger heating, the blood flow increases and removes that waste product, and the pain is relieved. In some cases, the relief of pain is probably associated with muscle relaxation. The muscle relaxes most readily when the tissue is warm. The relief of pain itself facilitates muscle relaxation. So the infrared radiation is considered a choice of Electro Therapy Modality for wound healing and pain among mothers who underwent caesarean.

References

Hopkins K (2000) Are Brazilian women really choosing to deliver by cesarean? Soc Sci Med 51:725–740

https://doi.org/10.1590%2F1806-9282.64.11.1045

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16192541

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10594500

Light therapy and Obstetrics

Being a new mother isn't a walk in the park. While a woman is pregnant, her body is carrying a fetus, and she’s experiencing hormonal changes in the body. This can take a toll on a woman's mental health. 

After pregnancy, aside from bringing a new life into the world, women are experiencing changes in their body after childbirth and starting a new lifestyle. While some women transition smoothly into motherhood, others experience mental health issues such as post-partum depression. 

What types of treatments are offered for women experiencing depression during and after pregnancy? Of course, there are various forms of medications and psychotherapy available; however, many women are skeptical about taking medications, and none seem to work effectively. 

Women experiencing depression during and after pregnancy can have their symptoms last between days, months, or even years. Depression during pregnancy include symptoms such as changes in energy level, mood, appetite, and libido. Post-partum depression symptoms can include mood swings, crying spells, difficulty sleeping, and anxiety. 

While there are various treatments and psychotherapy for post-partum disorders, there's one non-invasive, non-pharmacological, and high-effective treatment: red light therapy. 

What is Red Light Therapy?

Red light therapy uses red and near-infrared wavelengths to penetrate through the skin and increase mitochondrial function, stimulating blood flow, tissue oxygenation, and overall healing. Aside from the physical healing properties, it also aids in treating depression. 

A recent study published by Wirz-Justice in the Journal of Clinical Psychiatry shows that light therapy is a useful non-pharmacological treatment for women who suffer depression during pregnancy. The authors showed how light therapy treats seasonal affective disorder. They also reviewed two pilot studies of light therapy of antepartum depression and found that:

  • In an open trial with 3-5 weeks of light therapy for 60 minutes per day, depression ratings improved by 50%.
  • In a 5-week randomized, controlled trial for 60 minutes per day, depression ratings improved by 60% and 40%. 

The women included in this study were between 18-45 years of age, between 4 and 32 weeks of gestation, and were medically healthy. The results showed that light therapy reduced depression in comparison to placebos after 5 weeks. Through this study, it proved the benefits of light therapy for pregnant women with depression.

Light therapy could play a significant role in treating women with depression during and after pregnancy. 

Light therapy and Newborns

Aside from pregnancy depression, it's also believed that light therapy can improve conditions such as Jaundice, for babies. Bilirubin is a yellow substance that is a normal part of the red blood cells. The liver removes bilirubin and passes it through the bowels to leave the body. However, a baby's liver doesn't function as optimally as an adult, meaning they can struggle to pass bilirubin out of their bodies. This is when Jaundice occurs. 

While most cases of Jaundice naturally go away, some cases become serious. Jaundice can be caused by physiological issues, such as a premature liver, breastfeeding, and blood group incompatibility with the mother.

Light therapy has been shown to be highly effective in treating Jaundice. But why? Light therapy uses light to eliminate bilirubin in the blood. The baby's skin and blood absorb the light waves, transforming bilirubin into water-soluble isomers that can be eliminated without the liver.

For years, light therapy has been used in hospitals as a treatment for Jaundice; however, light therapy can be easily and more safely administered with today's technological advancement. 
Light therapy isn't something new, but mothers want to make sure what they're using will be safe for themselves and their babies. Today, we now have MDA-certified and FDA-approved light therapy devices, ensuring they're given a safe amount of light for mothers and their newborn children.

Source: Epperson CN, Terman M, Terman JS. Et al. Randomized clinical trial of bright light therapy for antepartum depression, preliminary findings. J Clin Psychiatry. 2004; 65(3):421-425.


Creating Your Custom LED Mask

When we talk about skincare, we usually don’t think about customizing skincare products. The options available on the market are produced for the masses rather than for the individual. Many people with multiple skin issues struggle to find skincare products that truly speaks to their needs. However, light therapy masks can be customized to fit the individual customer’s needs.

If you’re working in the skincare industry, light therapy devices are a revolutionary step forward, as you’ll be able to provide your customers with a unique light therapy mask.

But what’s the process of creating a custom light therapy mask? Here are the six steps you need to consider when developing a customized light therapy mask.

The Six Steps to Create Your Custom Led Mask

While going through these six steps, keep your vision of your mask in mind. This will help you answer some of the questions that are going to be asked below.

What’s your Goal?

It would help if you determined your product’s goals. Who are your clients? What are their unique skincare challenges? By understanding the basics, you’ll help your company determine the right strategy when creating your customized product. Light therapy masks can be made using different LED colors for a full range of beauty treatments, including acne reduction, anti-aging treatment, and collagen production.

What Material will you Use?

You need to select the right material. Facial masks can be made from a variety of materials, each with its own advantages and versatility. There are three types of light therapy masks to consider: flexible, semi-hard, and hard.

Flexible allows users to wear it while doing their daily activities. The patented air cushions and emitting SMD LEDs are ideal for indoor and daily skincare. Semi-hard masks are for professional use and have a hard shell, while soft inside. Hard masks are powerful facial masks for professional use and come with selectable light area options. They offer a deeper light therapy experience for clients.

What Kind of Shape will your Mask be in?

Light therapy masks don’t have to come in a traditional one-size-fits-all design. Depending on your target market, you’ll be able to choose where the placement for the cheeks, forehead, and eyes will be on the mask. This gives you more control over how the mask will fit on your client’s face.

What Areas Will your Mask Treat?

A traditional mask will cover the full face. However, you may not necessarily want your mask to provide full coverage. Consider the areas of the face you’d like to treat, as you may only want to create a mask for a specific target area.

Apply for a Prototype

You’ve answered all the questions above and have a vision of how you want your mask to look. From here, we help you take your vision and use our creativity and 14 years of experience in the industry to create a mask that fits your goals.

Launch & Listen

Now that the product is created, it’s time to launch it. Before the launch, we produce pre-pilot quantities that allow us to fine-tune our devices and ensure high-quality from start to finish.

Creating a light therapy facial mask is one thing, but you want to make sure it’s achieving your goals and making your customers happy. Once your product is launched, it’s crucial to monitor product performance and listen to customer feedback.

Naturally, you don’t want your light therapy mask to be like all the others on the market. Our masks are MDA-certified and FDA-approved light therapy devices, ensuring you medical-grade quality devices for your business.


Private Label Your Dream Light Therapy Product with Kaiyan

Whether you’re a dermatologist, physical therapist, fitness enthusiast or just someone considering integrating light therapy into their practice, you’ve likely heard about the multitude of benefits that these non-invasive yet powerful devices offer. As light therapy continues to gain popularity, more professionals are looking for light therapy devices to level up. 

Naturally, you can purchase professional devices from light therapy companies, but you can also develop a light therapy device that can be customized to fit your individual client’s needs. This is where we, Kaiyan Medical, come in to help guide you through the process of producing your very own private label light therapy products at our state-of-the-art manufacturing facility. 

If you’re interested in creating your own light therapy products, it’s crucial you understand the development process.

The Steps of Private Label Product Development

We want our clients to comprehend the creative and manufacturing process of developing private label light therapy devices. As this is your idea we’re bringing to life, you need to be included every step of the way. Here’s our step-by-step process:

Step 1: Feasibility Study

It’s easy to lose money by investing in a product without understanding user needs. If you don’t know your target audience, you’ll struggle to create a viable product. During the feasibility step, we determine the practicality of your project and examine its strengths and weaknesses. This helps to ensure the idea you want to bring to life is viable and effective in achieving its goal. 

Step 2: Industrial Design

With our advanced conceptual design team, we determine how we can best engage with your target audience. While we focus on design, we also make sure your device fits under the required safety and health regulations. Our in-house design process creates visually appealing, high-quality, and functional concepts for manufacturing and product planning. 

Step 3: Electrical Engineering

Our in-house team has vast experience in lasers, sourcing, prototyping, and LEDs to incorporate these components and masterfully develop your product. Our electrical engineers, who are in charge of this step, take your idea and bring it to life while ensuring high-quality performance. 

Step 4: Rapid Prototyping

Rapid prototyping is essential for our projects and allows the client to see and feel their idea in the palm of their hands. In addition, it also helps clients test products with their users and receive constructive feedback. Our rapid prototyping is completed in-house as we have the capacity to create a range of samples varying from simple to complex, multi-piece models. 

Step 5: Mass Production

After your idea is turned into a tangible product and has been tested, we then plan production with in-house, pre-pilot quantities. By doing so, we’re able to identify production areas that need to be fine-tuned while ensuring high-quality and performance standards. Once these steps are completed, your product will be ready for shipment. Through our vast experience and stellar team, we can ensure a smooth manufacturing process and will guide you each step along the way, from start to finish. 

So, Who do we Work with?

We’ve been creating MDA-certified and FDA-approved light therapy devices for years. That said, we’ve successfully worked with various brands in different industries, taking their ideas and bringing them to life. Here are some of the brands and products we’ve developed.

DemarkQ

DenmarkQ offers skin care devices that use red and blue light LED to target acne and scarring. The LED light uses the body's natural healing process to improve its overall wellbeing. 

Aduro Mask
Established in 2006, Aduro Skincare specializes in LED beauty-related products under a medical license. The product is internationally renowned and clinically proven as an effective, non-invasive therapeutic skin care treatment.

Perfect Countour

Perfect Contour is our line of permanent make-up machines. Our permanent make-up machines were designed for clinical use; however, we feel permanent make-up is more of an art form than a medical procedure through our experience.

Golden Eagles

Teeth whitening has been around for ages, and we've mastered the art of developing effective teeth whitening devices. We currently have over 20 different OEM models for professional whitening and devices for at-home whitening. 

Akstra

Akstra's brand focuses on hair regrowth and hair rejuvenation and offers products ranging from home-use to professional-use models. Since Asktra's first line of hair lasers was made for clinical environments, we opted for a sleek and clean design. 

Lumiceuticals

Lumiceuticals is a brand focusing on using LED technology for pain relief. We combined LED technology with neoprene material for practical treatment pads. The pads are secured by Velcro straps, making them easy-to-use for customers. 

If you’re considering developing private label light therapy devices, at Kaiyan Medical, we create MDA-certified and FDA-approved light therapy devices, ensuring you medical-grade, high-quality devices for your business. We are eager to work with like-minded partners in developing truly effective, safe, and valuable products that tap into the power of light therapy. 

We look forward to working with you!


Red Light Therapy and Fertility

There is hardly a day in my various professional roles as a scientist, science watcher, or clinician without encountering new information or a new scenario that highlights the complexity of biology and biological systems. Such occurrences warrant careful evaluation and oftentimes lead to new management strategies or form the basis for further scientific investigation. This is inevitable as the knowledge base expands and our understanding of the variables potentially impacting our strategies and outcomes increases. We continually learn, re-learn and refine what we do and how we do it. The survival and performance of human spermatozoa in vitro is one evolving story that has far-reaching implications in numerous fields in addition to human reproduction.

Infertility is a problem that affects 15% of couples. Male reproductive issues account for one-third of infertility cases, with another third caused by combined male and female reproductive issues or unknown etiologies. Several strategies, including in vitro fertilization (IVF) techniques, are employed clinically to assist infertile couples in their quest for a successful pregnancy. Viable, strong, and normally motile sperm are critical to the success of IVF. It is well-known that spermatozoa in standard culture weaken and lose viability and motility at 12 hours and that by 42 hours, only about 52% remain viable. Fewer strong and motile sperm reduce the probability of a successful IVF cycle. Protocols that could improve viability and performance of sperm in vitro would be of great interest to clinicians and patients alike.

At low concentrations, reactive oxygen species (ROS) act as second messengers that regulate increases in cyclic adenosine monophosphate (cAMP), the activation of protein kinase A (PKA), the phosphorylation of PKA substrates of the arginine-X-X-(serine/threonine) motif, the phosphorylation of extracellular signal-regulated kinase (ERK) and mitogen-activated protein kinase (MEK) proteins and the threonine-glutamate tyrosine motif, as well as fibrous sheath protein tyrosine phosphorylation. These functions are involved in sperm capacitation, acrosome reaction, and oocyte fertilization.

Sperm plasma membranes contain large quantities of polyunsaturated fatty acids (PUFA), whereas their cytoplasm contains low concentrations of enzymes that scavenge ROS. High concentrations of ROS overwhelm the endogenous antioxidant defenses of gametes, causing multiple derangements. High concentrations of ROS cause peroxidative damage to plasma membrane PUFA, DNA damage, the depletion of mitochondrial adenosine triphosphate (ATP), apoptosis, and the loss of sperm motility.

ROS are generally short-lived in vivo due to several antioxidant pathways and compounds at play. However, they are known to accumulate in both oocytes, and spermatozoa cultures, both of which can generate ROS in small quantities as required for the fertilization process.

Sommer et al. posited that polystyrene softens in the presence of aqueous solutions. This creates conditions that would cause a nanoscopic layer of ROS to become established in plastic Petri dishes in common laboratory use. This hypothesis was confirmed by evaluating the cell performance of ROS-sensitive cell lines cultured in both polystyrene and ultrasmooth nanodiamond coated Petri dishes. The cell lines tested included mouse P19 embryonal carcinoma cells, murine-derived L929 cells, and HeLa cells derived from human cervical cancer. The nanomechanical softening was demonstrated in subsequent work by this group and others.

The use of nanodiamond surface coating of culture dishes was based on the knowledge that this material is both chemically and biologically inert, with a capacity to bind a nanoscopic layer of water to its surface. Sommer demonstrated that the material and this nanolayer were, for practical purposes, ROS-free. They subsequently reported that culturing human sperm cells in diamond-coated Petri dishes rather than the polystyrene dishes typically used for IVF resulted in approximately 20% greater cell survival at 42 hours in the nanodiamond coated cultures. This confirmed that the culture dishes themselves play a role in sperm survival in vitro. That accumulation of ROS on the polystyrene surface is a causative factor in decreasing viability over time.

Sommer et al. went further exposed the cultured spermatozoa to red light at 670 nm. Light at this wavelength is known to be absorbed by cytochrome C oxidase and other molecules, stimulating ATP synthesis and affecting ROS production, among numerous other activities at the cellular, tissue, and whole organism level. However, the caveat is that the light dose and dose rate are important and that all cells and tissues are not equally responsive to photoirradiation.

They found that the number of sperm cells demonstrating grade A motility was enhanced by nearly 300% after 1-hour contact with the nanodiamond coated quartz Petri dishes compared to the counts obtained for spermatozoa in the polystyrene Petri dishes. They also observed that sperm motility was significantly different after contact with polystyrene and nanodiamond when longer periods of photoirradiation were applied. A 3× higher light dose was detrimental to the motility of sperm in polystyrene plate cultures, resulting in a reduction of counts to those of the control group at 45 and 60 minutes post-exposure. The same light dose delivered to spermatozoa cultured in nanodiamond dishes produced a dramatic increase in progressive motility.

This series of experiments demonstrates that diamond Petri dishes and NIR light delivered at specific parameters energize sperm cells in a complementary fashion, whereas polystyrene Petri dishes exhaust them. The red light counteracts internal oxidative stress due to ROS production in mitochondria by suppressing ROS accumulation and enhancing ATP synthesis. Simultaneously, the diamond substrate prevents the build-up of a layer of interfacial ROS between the sperm cell and surface of the culture plate.

Photobiomodulation (PBM) describes the ability to stimulate or inhibit cellular functions by using light at specific wavelengths, intensities, and dosing regimens. The classically described PBM treatment window is between 600 and 1,200 nm. Light in this portion of the spectrum readily penetrates skin and tissues via the so-called optical window. Light is absorbed by various structures and molecules, primarily molecules that are instrumental in energy production and oxygen delivery.

PBM effects depend upon timing, site of treatment, and treatment parameters (dose). PBM has shown efficacy clinically in accelerating wound healing, reducing pain and inflammation, and benefiting other applications, including the treatment of neurologic disorders and injuries.

The mechanistic basis for the outcomes observed after using photobiomodulation therapy (PBMT) results from the upregulation of intracellular metabolism by increasing ATP production, augmenting other metabolic pathways, and reducing ROS and other free radicals production.

The interaction of photons with cells and cellular structures is a necessary condition for PBM. We have learned that all cells and tissues don’t respond to PBM and that one size does not fit all when determining the dose or treatment course. Different photobiomodulation effects have been described depending upon the specific cell lines and species being investigated. Our laboratory demonstrated that cell proliferation and metabolism in vitro could be influenced by varying the dose frequency or treatment interval of the PBMT (17). We have also demonstrated this same phenomenon regarding wound healing in a murine pressure ulcer model. These investigations underscore the concept that a unique dose frequency combination exists for tissues and cell lines. This specific treatment paradigm must be determined to optimize outcomes and maximally stimulate cellular metabolism and proliferation. Our work also demonstrated that using other treatment strategies will paradoxically cause big inhibition, despite delivering the same total energy.

It is becoming increasingly apparent that biological systems are quite complex. They contain numerous pathways poised to work in concert with, or in opposition to, depending upon the organism's current needs. We are beginning to understand that these systems utilize several common denominator substances and reactions and that these can be manipulated using several forces, including light.

As scientists and clinicians, we apply what we have gleaned from the laboratory to solve clinical problems and to form the basis for further investigations. We often base these decisions on results obtained using various cell, tissue, and whole animal models, presuming that these models are translatable to our specific applications. Careful in vitro studies can be powerful tools that guide the design of whole animal and human trials. They facilitate the efficient and reproducible screening of a matrix of treatment parameters. We presume that the animal models we develop accurately reflect the actual biology and physiology found in nature.

Abolins et al. recently demonstrated that laboratory and wild mice's serological, cellular, and functional immune responses differ. Wild-type mice have a population of highly activated myeloid cells that are not found in their laboratory counterparts. The point here is that laboratory models and laboratory conditions, in all likelihood, do not entirely replicate nature.

Sommers’ work demonstrates that PBM with a red light at 670 nm improves spermatic function and viability in vitro. This effect augments the beneficial effects of using nanodiamond coated culture dishes. It also demonstrates that various cell lines respond differently to similar manipulations. This body of work also highlights the fact that the ubiquitous polystyrene culture dish can have a deleterious effect on outcomes. We would do well to recognize that the seemingly innocuous may not be and that we should remain cautious as we interpret experimental results and attempt to apply them. Every detail matters, even the seemingly mundane.

References

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FDA Pre-Submission (Q-Sub) and Medical Device Companies

There is always uncertainty baked into any government submission process, and it’s helpful to companies if there is a way to tackle issues before submitting a 510(k).

The FDA Pre-Submission is a way for companies to request feedback from the agency on potential and planned medical device, biologics, and drug submissions. It’s a great service to take advantage of, only we’ve found that it tends to get underutilized.

What is the Pre-submission?

The Pre-Submission allows you to request formal feedback on your medical device before you make a move to submit your 510(k). This is known as a Q-Submission, which under the guidance published by FDA, allows you to request the following:

  • Pre-Submission (what we’re focusing on here)
  • An informal meeting
  • An agreement meeting
  • Other (such as submission issues or study risk determinations)

The Pre-Submission process was born out of a need to provide expanded access to the FDA and allow companies to get valuable feedback ahead of time. This can help keep your company on track for getting your device to market as soon as possible — it helps to be aware of possible issues ahead of time and deal with them before final submission.

The guidance for Pre-Submission is clearly laid out in the FDA document Requests for Feedback on Medical Device Submissions. If you happen to have a combination product (such as a stent that administers a drug or an inhaler), there may be other, similar processes you need to go through. The document to check out, in that case, is Guidance for Industry.

In any case, the basic definition of what a Pre-Submission is remains the same. It is a formal written request from an applicant/sponsor for feedback from the FDA to be provided in a formal written response, meeting, or teleconference. The feedback is documented in meeting minutes.

It’s a great way to meet with the FDA, ask them some questions, then document that information for future use. It boils down to identifying key issues that keep you up at night and making your overall submission process easier.

The FDA continues to expand its Pre-Submission program to include several different medical device submissions that a manufacturer may choose to bring a device to market. The comprehensive list of submission types is known collectively as Q-Submissions(Q-Subs), which include:

E, De Novo request, 510(k), Dual, BLA, IND), Accessory Classification Request, or CW.

  • Investigational device exemptions (IDE)
  • Premarket approvals (PMA)
  • Premarket notifications (510(k))
  • Dual
  • HDE — Humanitarian Device Exemption
  • De novo requests
  • Clinical Laboratory Improvement Amendments (CLIA)
  • Certain Investigational New Drug Applications (IND) and Biologic License Applications (BLAs)
Benefits of the Pre-submissions

Should I really use a Pre-Submission? This is a key question that companies often ask, so it’s important to understand the relative pros and cons. Here are some of the pros:

  • You develop a “human” relationship with the FDA. They are, after all, humans themselves and want to know who you are.
  • You can remove some of the risk elements from your submission. You get asked about things you don’t know and confirm things that you think you do know.
  • You can get “free advice” to help drive your development and regulatory strategy.
  • Sometimes the FDA will request a review of Pre-Submission materials, giving you a “bonus round” ahead of your 510(k) submission. This is a great opportunity to gain valuable feedback.

One thing to note is that you’re not getting a final acceptance at this stage; the FDA will never give you this until the actual submission. However, it’s well worth getting the early heads-up.

Cons of the Pre-submission

There’s always a money and time aspect. You’re looking at $5,000 to $25,000 to have a consultant help you with a Pre-Submission. If all timelines are met, the typical process takes 60–75 days.

A con that is frequently raised is, “What if they tell us no and say we have to do X, Y, and Z instead of what we’re already doing?”

Our answer to this will always be the same: Isn’t it better to know about this now rather than go ahead with your 510(k) submission and find out then? The FDA will pick out that same issue regardless, so it’s a much better use of your time to find out about it during a Pre-Submission.

Perhaps these cons are a big part of the reason that the Pre-Submission is underutilized, but I would strongly suggest that you don’t let them put you off using it. The FDA actively encourages medical device manufacturers to use the Pre-Submission because doing so helps the final submission's overall quality.

Conclusions

A Pre-Submission program is a valuable tool that tends to be underutilized. Perhaps companies are put off by the idea that the process will take too much time and money, or they’re worried that the FDA will tell them they need to do something they hadn’t already planned on doing. In Kaiyan Medical, we make sure our devices are FDA cleared and we constantly communicate with the FDA. Like many other medical device companies, you may find it’s well worth the time and money.

What Are the Different Types of Clinical Research?

Different types of clinical research are used depending on what the researchers are studying. Below are descriptions of some different kinds of clinical research.

Treatment Research generally involves an intervention such as medication, psychotherapy, new devices, or new approaches to surgery or radiation therapy.

Prevention Research looks for better ways to prevent disorders from developing or returning. Different kinds of prevention research may study medicines, vitamins, vaccines, minerals, or lifestyle changes.

Diagnostic Research refers to the practice of looking for better ways to identify a particular disorder or condition.

Screening Research aims to find the best ways to detect certain disorders or health conditions.

Quality of Life Research explores ways to improve comfort and the quality of life for individuals with a chronic illness.

Genetic studies aim to improve disorders' prediction by identifying and understanding how genes and illnesses may be related. Research in this area may explore how a person’s genes make him or her more or less likely to develop a disorder. This may lead to the development of tailor-made treatments based on a patient’s genetic make-up.

Epidemiological Studies seek to identify the patterns, causes, and control of disorders in groups of people.

An important note: some clinical research is “outpatient,” meaning that participants do not stay overnight at the hospital. Some are “impatient,” meaning that participants will need to stay for at least one night in the hospital or research center. Be sure to ask the researchers what their study requires.

Phases of Clinical Trials: When Clinical Research is Used to Evaluate Medications and Devices
Clinical trials are a kind of clinical research designed to evaluate and test new interventions such as psychotherapy or medications. Clinical trials are often conducted in four phases. The trials at each phase have a different purpose and help scientists answer different questions.

  • Phase I trials
    Researchers test an experimental drug or treatment in a small group of people for the first time. The researchers evaluate the treatment’s safety, determine a safe dosage range, and identify side effects.
  • Phase II trials
    The experimental drug or treatment is given to a larger group of people to see if it is effective and further evaluate its safety.
  • Phase III trials
    The experimental study drug or treatment is given to large groups of people. Researchers confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information to allow the experimental drug or treatment to be used safely.
  • Phase IV trials
    Post-marketing studies, which are conducted after a treatment is approved for use by the FDA, provide additional information, including the treatment or drug’s risks, benefits, and best use.

Examples of Other Kinds of Clinical Research
Many people believe that all clinical research involves testing new medications or devices. This is not true, however. Some studies do not involve testing medications, and a person’s regular medications may not need to be changed. Healthy volunteers are also needed so that researchers can compare their results to the results of people with the illness being studied. Some examples of other kinds of research include the following:

  • A long-term study that involves psychological tests or brain scans
  • A genetic study that involves blood tests but no changes in medication
  • A family history study involves talking to family members to learn about people’s medical needs and history.

Advantages of Medical Device Manufacturing in China Post Covid-19

China’s overall economic recovery in part has been attributed to the strong rebound in the manufacturing sector. The medical device manufacturing sector specifically recorded an astounding 46.4% growth.

High-Quality Human Resources

Despite living in the age of automation, labor remains one of the higher costs of manufacturing. Manufacturing companies in the west have to deal with worker’s unions, paying high wages, and inflexible staffing that cannot readily scale and resize as fluctuating production output needs may require. On the other hand, achieving this flexibility level is easier for Chinese manufacturers due to China’s readily available, efficient workforce. This used to be the primary reason for companies to outsource their manufacturing activities in China.

Manufacturing in China can significantly bring down overall production costs, and a large part of those savings is due to Chinese labor efficiency. Chinese facilities have been optimizing manufacturing costs for decades and have largely achieved very efficient workforce operations. Depending on the labor intensity of product manufacturing activities, a Chinese facility can offer an excellent number of parts produced per work hour spent.

Low Raw Materials Cost

Another most important manufacturing cost is raw materials cost, for which China also provides a cost-effective option, for two main reasons. Firstly, the same labor efficiency condition exists throughout the entire raw materials production value chain. So Chinese manufacturing companies can themselves access cost-efficient raw materials than most companies based in other countries. Secondly, the transfer of materials is cheap since it only happens from close sources and within China. This results in avoiding long shipping routes, additional customs tariffs, and long delivery waiting times. When manufacturers in all industries are trying to cut expenses and maximize profits to remain competitive, access to affordable raw materials can help bring down manufacturing costs to a considerable extent.

Most Chinese manufacturing facilities will typically have low cost local (or close) material suppliers. This way, they gain a significant cost advantage that further contributes to their cost-effectiveness.

Strategic Location

Companies worldwide are nowadays targeting the growing Asian markets, so much so that the phrase “expand to Asia” has become somewhat of a cliché business term. China is the largest of those markets, with its consumer market surpassing $6 trillion in value. Moreover, it also benefits from its proximity to several large and growing markets, such as India and South Korea. In terms of regulatory compliance, medical devices of Chinese manufacturing have no issues in being accepted in both the country’s domestic and other Asian markets. So outsourcing medical device production to China gives manufacturers access to its rapidly growing domestic market, as well as immediate access to its developing neighboring markets.

Evolving Supply Chain Network

In times of market, instability is when a supply chain is a huge determining factor for a manufacturer’s chance for survival. Chinese materials suppliers have been rapidly evolving, following the country's growing trend of becoming an international manufacturing hub. This has made it easier for medical device contract manufacturers to identify and establish a trustworthy network of reliable local suppliers.
This gives the more top tier Chinese manufacturers such as Kaiyan, the opportunity to create resilience in the face of the coronavirus outbreak. Additionally, a robust supply chain allows for a manufacturer’s flexibility to offer simple, efficient, and flexible options for increasing or scaling production as market needs change. What’s also important is that this supply chain evolution has also increased quality standards, which is a decisive factor in medical device manufacturing.

Access to Cutting-edge Technology

Realizing the potential of its market in the era of globalization, China has spent the last decades developing its technology. Heavy investments in research and development, importing talent and technology, and the emergence of specialized tech hubs have helped China gain an innovation edge over other emerging countries. The mentality of rapid research and development is of notable importance and surpasses the speed of many tech hubs in the west. Part of the reason this happens is that such a large portion of the world’s product manufacturing has been outsourced to China. And the low costs achieved by Chinese companies are not the result of just cheap labor, but also, to an extent, involve practical applications of innovative technologies.

Flexible Scale of Manufacturing

Another benefit of manufacturing in China is the ability to scale up or down as needs change. Top tier Chinese factories such as Kaiyan’s facilities are manufacturing products for many companies at the same facility, so they have the means to produce large quantities and adapt according to the market’s and customer’s needs. And being able to scale up easily is an obvious advantage. A critical characteristic of every trade is offering product availability. As you market your medical device to new markets, customers, importers, and distributors, you will be required to increase quantities and ensure timely delivery. Manufacturing your medical device in a Chinese facility that can support scaling up production becomes an obvious advantage.

Insomnia & the Dark Side of the Blue Light

Although it is environmentally friendly, blue light can affect your sleep and potentially cause disease. Until the advent of artificial lighting, the sun was the major lighting source, and people spent their evenings in (relative) darkness. Now, in much of the world, evenings are illuminated, and we take our easy access to all those lumens pretty much for granted.

But we may be paying the price for basking in all that light. At night, light throws the body’s biological clock — the circadian rhythm — out of whack. Sleep suffers. Worse, research shows that it may contribute to the causation of cancer, diabetes, heart disease, and obesity.

What is Blue Light?

Not all colors of light have the same effect. Blue wavelengths — which are beneficial during daylight hours because they boost attention, reaction times, and mood — seem to be the most disruptive at night. And the proliferation of electronics with screens and energy-efficient lighting increases our exposure to blue wavelengths, especially after sundown.

Light and Sleep

Everyone has slightly different circadian rhythms, but the average length is 24 and one-quarter hours. The circadian rhythm of people who stay up late is slightly longer, while earlier birds' rhythms fall short of 24 hours. Dr. Charles Czeisler of Harvard Medical School showed, in 1981, that daylight keeps a person’s internal clock aligned with the environment.

Is Nighttime Light Exposure Bad?

Some studies suggest a link between exposure to light at night, such as working the night shift, diabetes, heart disease, and obesity. That’s not proof that nighttime light exposure causes these conditions, nor is it clear why it could be bad for us.

A Harvard study shed a little bit of light on the possible connection to diabetes and possibly obesity. The researchers put 10 people on a schedule that gradually shifted the timing of their circadian rhythms. Their blood sugar levels increased, throwing them into a prediabetic state, and leptin levels, a hormone that leaves people feeling full after a meal, went down.

Exposure to light suppresses the secretion of melatonin, a hormone that influences circadian rhythms. Even dim light can interfere with a person’s circadian rhythm and melatonin secretion. A mere eight lux — a level of brightness exceeded by most table lamps and about twice that of a night light — effects, notes Stephen Lockley, a Harvard sleep researcher. Light at night is part of the reason so many people don’t get enough sleep, says Lockley, and researchers have linked short sleep to increased risk for depression, as well as diabetes and cardiovascular problems.

Effects of Blue Light and Sleep

While light of any kind can suppress melatonin's secretion, blue light at night does so more powerfully. Harvard researchers and their colleagues experimented comparing the effects of 6.5 hours of exposure to blue light to exposure to green light of comparable brightness. The blue light suppressed melatonin for about twice as long as the green light and shifted circadian rhythms by twice as much (3 hours vs. 1.5 hours).

In another blue light study, researchers at the University of Toronto compared the melatonin levels of people exposed to bright indoor light wearing blue-light-blocking goggles to people exposed to regular dim light without wearing goggles. The fact that the hormone levels were about the same in the two groups strengthens the hypothesis that blue light is a potent suppressor of melatonin. It also suggests that shift workers and night owls could protect themselves if they wore eyewear that blocks blue light. Inexpensive sunglasses with orange-tinted lenses block blue light, but they also block other colors, so they’re not suitable for use indoors at night. Glasses that block out only blue light can cost up to $80.

LED Blue Light Exposure

If blue light does have adverse health effects, then environmental concerns, and the quest for energy-efficient lighting, could be at odds with personal health. Those curlicue compact fluorescent lightbulbs and LED lights are much more energy-efficient than the old-fashioned incandescent lightbulbs we grew up with. But they also tend to produce more blue light.

The physics of fluorescent lights can’t be changed, but coatings inside the bulbs can produce a warmer, less blue light. LED lights are more efficient than fluorescent lights, but they also produce a fair amount of light in the blue spectrum. Richard Hansler, a light researcher at John Carroll University in Cleveland, notes that ordinary incandescent lights also produce some blue light, although less than most fluorescent lightbulbs.

Protect Yourself from Blue Light at Night
  • Use any of our red light devices for night lights. Red light is less likely to shift circadian rhythm and suppress melatonin.
  • Avoid looking at bright screens beginning two to three hours before bed.
  • If you work a night shift or use many electronic devices at night, consider wearing blue-blocking glasses or installing an app that filters the blue/green wavelength at night.
  • Expose yourself to lots of bright light during the day, which will boost your ability to sleep at night, as well as your mood and alertness during daylight.

Preparing your Skin for Light Therapy

Can I Use Serum With LED Mask?

It is a question that many people have asked — Can I use the serum with LED light therapy?

Our skin is exposed to harsh environmental factors such as sun, wind, cold, and dust daily. These factors tend to attack our immune system causing it to weaken over time.

When this happens, it allows harmful viruses and bacteria to attack our body, leading to acne breakouts and other skin issues such as dark spots and wrinkles. Acne creams are one way of reducing the symptoms associated with this skin condition. However, these can be irritating to your skin, resulting in unwanted side effects such as redness, irritation, and dryness.

The same can also be said for light therapy, which can have its own side effects. Side effects of LED light therapy include itching, burning, and pain. In fact, most users had reported experiencing these side effects when they first started using LED technology. If you were to use any acne medication type, whether prescribed by your doctor or over the counter, the results would depend largely on the person using the medication.

For example, it could take anything from a few days to a few weeks for acne to clear up. Another point to remember is that while certain medications do show better results for some people, they may not work for you at all.

This is because everyone has different skin types, responds differently to treatments, and requires different times to clear away acne completely.

Some people have found success in using LED therapy with a variety of skin creams. However, there is a downside to using this method. LED light therapy does not help remove excess dead skin cells, as some acne medications do. This means that the acne cream will just be left in place and continue to produce side effects for all patients. Besides, side effects can be more severe than a single acne medication dose when used over a long time when used over a long time.

Before you try to use a serum with an LED mask, you should consult with a dermatologist who can advise you on whether or not LED light therapy is right for you. LED light therapy is safe when administered by a certified medical professional. It can be used safely, even if you have sensitive skin, as long as you choose your doctors wisely. Before any treatment is begun, the medical professional will test your skin to determine what type of acne you have. Testing will determine whether your skin is allergic to any light-emitting diodes in the device used.

The last question to answer is, “How effective is Acne treatment with LED Light?” To answer this question, you will need to look at the results you get from the treatment. If you see immediate results after the treatment, it will likely react to the device's light and not the treatment itself.

However, if you don’t see good results after a month of continuous treatment, it is important to determine why the treatment is not working. It may be that you are allergic to any of the ingredients in the product, or it may be that your skin is not receptive to the treatment.

Hydrated Face For LED Mask Results

The serum is good for hydrated face for LED Mask. It can hydrate the skin by absorbing moisture, providing a slight lift to the skin, and removing any oil or makeup that you are using. The serum also contains vitamins and antioxidants that will help fight against free radicals in your body. Free radicals are harmful agents that have been linked with causing cancer.

By fighting against these harmful agents, Serum is good for hydrated face for LED Mask. People who have used Serum have claimed that the hydrated face and LED Mask work very well together. I have also used Serum on my skin, and I must say that the results were really amazing. In fact, I would go on to say that Serum is so good for hydrated face for LED Mask that I will be using it every single night before bed.

If you don’t have much experience making skin look hydrated, this is the forum for you. Let us first examine the ingredient list of Serum.

This product's main ingredients are Hyaluronic Acid, Vitamin C, Retinol A, Alpha Hydroxy Acids, Vitamin E, DMAE, Peptides, and Glycerin, Ferulic Acid, Aloe Vera.

  • AHA kills the bacteria causing acne and helps to get rid of blackheads.
  • Sodium Laureth Sulfate helps in cleaning the skin by getting rid of dead skin cells and excess oil.
  • Salicylic Acid gets rid of pimples and acne scars, and Glycolic Acid is good in treating acne scars.

All of these ingredients are perfectly good for your hydrated face for LED Mask.

  • Now let us move on to how does Serum works to get rid of the facial puffiness.
  • When you are applying Serum on your hydrated face for LED Mask, you are putting on a layer of serum to the surface of your face.
  • As the serum gets applied, it works its way down into your skin and starts working as a moisturizer.
  • This is why this particular product is top-rated as it works as a good moisturizer without over-drying the skin.
How to Prepare Your Skin For a Red Light Therapy Session?

There are different methods used to prepare your skin, but essentially they all work in the same way: removing all the oil and dirt from the skin and then cleaning it. When I talk about cleansing, I’m talking about daily skincare maintenance products. If you want to know how to prepare your skin for a red light therapy session, this is the part that you need to read.

Most people have no idea how their skin looks like, so when they go into the doctor’s office and they've asked if they’ve had a photodynamic therapy or a laser treatment, they’re not aware of what treatment they might have received.

  • The skin absorbs red light from the sun, and in return, it produces negative ions.
  • These are similar to the particles produced by an activated oxygen generator (you know those things at the gym).
  • During photodynamic therapy, the skin cells absorb the energy from the lasers' red light, which causes the release of more negative ions, which then penetrate deeper into the skin.
  • They’re working like the “batteries” on your car — they give the batteries extra power and allow the car to run much longer.
  • If you want to learn how to prepare your skin for a red light therapy session, you must remove all the grime from your face and neck before the session.
  • Cleansing is one of the most important steps to remember in preparation.
How to Prepare Your Skin for Red Light Therapy Session by Using Non-Dry Cleanser

You might need more than just a good cleanser when trying to prepare your skin for red light therapy. Your cleanser is your friend when you are trying to remove all the dirt and excess oil from your face, but what if your cleanser is too harsh on your skin? If you have dry skin, using a cleanser containing too harsh ingredients may cause dryness, making it harder for you to remove those excess oils from your face.

When you prepare your skin for red light therapy session using the non-drying cleanser, make sure that you would be using a toner with antioxidants and anti-inflammatory ingredients to increase the collagen level the skin.

This will help keep your skin healthy and younger-looking.

Caution: Lotion and Moisturizers For LED Masks Are Not Recommended

The use of moisturizers and lotions is not recommended for LED masks because it will damage your skin. There are also cases wherein people who used such products ended up suffering from adverse effects.

The ingredients in these products may be too strong for the skin to be able to absorb.

You can prevent this by using only non-comedogenic lotions and moisturizers for LED masks.

  • This way, the product is less likely to irritate your skin. In addition to that, you can also use other types of products designed for sensitive or dry skins to use on your face during the event's preparation.
  • However, there are cases wherein people who have been using such moisturizers and lotions as part of their LED facial make-up mask ended up suffering from adverse effects.
  • In these cases, the products were not properly applied to the skin, and the amount that was applied was also insufficient.
  • Because the skin did not get sufficient moisture, the cells underneath the skin's surface could not repair themselves properly.
  • This will result in damaged skin, which will cause more breakouts than before.

Aside from lotion and moisturizers, it would help if you also stayed away from mineral oil, alcohol, and preservatives. These ingredients are not good for your skin, as they can cause dryness and irritation. It would help if you also stayed away from using creams and lotions with fragrance, which can only irritate your skin even more. Instead, look for serums.

If you want to have a glowing complexion without enduring any adverse effects, use a good quality face serum.

Prepare Your Skin For Red Light Therapy by Removing Sunscreen

You probably have heard that it is unsafe to use the sun’s UV rays at home, especially if you use a tanning lotion or a self-tanning lotion. But did you know that it is also not safe to use self-tanning products like tan accelerators and sunless tanning pills to prepare your skin for red light therapy sessions?

This defeats the purpose of using red light therapy, and you must remove sunscreen so that your face and skin are completely ready to receive the red light therapy. This is because self-tanning products contain ingredients that can affect the skin in adverse ways and block the beneficial deep penetrating infrared wavelength from 650nm to 850nm.

How to Prepare Your Skin For Red Light Therapy by Removing Makeup

If you have chosen to have laser acne treatment and you are wondering how to prepare your skin for the red light therapy, you will want to take a moment to learn how red light therapy works before getting started.

Before your session begins, you will be given a short amount of time to get ready for the procedure. This is because your skin needs to be very clean and free of any makeup. Your skin needs to be completely dry before the procedure can begin.

If there is any moisturizer on your skin when you arrive for your appointment, you will have to remove it before your treatment.

Your doctor will ask you several questions about your skin during your appointment, including what type of skin you have and whether or not you have any allergies. During this time, they will also determine if you are a good candidate for the procedure. If you are cleared for the procedure, your skin will be exposed to an intense red light level. This is one of the most effective ways to get rid of acne, and it can also help prevent scars and aging from occurring on your face.

The amount of time that it takes to get your skin prepared for red light therapy varies. In most cases, it is normal to have it take from fifteen to thirty minutes to prepare your skin for the procedure. You may have to remove any makeup at this time as well.

How to Prepare Your Skin For Red Light Therapy by Exfoliating?

When a patient is getting a therapy session done, they will be required to go to the spa or beauty clinic to be given a facial.

A therapist will then start by cleaning the face thoroughly. After the initial cleaning process, the therapist will apply a chemical that will help exfoliate the skin.

This process can irritate the skin, so it is important to prepare your skin before undergoing this procedure. Some common preparations that people use include salicylic acid, alpha hydroxy acid, retinoids, glycolic acid, and other peel-type products.

The exfoliating procedure aims to help the skin cells shed off dead skin cells and replace them with new cells.

This is why it is important to remove all traces of dead skin cells from your face before undergoing the procedure.

It may seem odd at first, but if you want to get the best results from the procedure, you need to gently exfoliate your skin.

Prepare Your Skin For Red Light Therapy With Moisturizers

When you prepare your skin for red light therapy, you are basically preparing to expose the blue spectrum laser's high intensity and the eventual dry out of the epidermis. The skin must be prepared using a good cream containing Reductase or Salicylic Acid, or by exfoliating the skin using a scrub.

After the procedure, you will need to have topical products applied to your skin to prevent the skin from cracking and peeling. This will also help improve your appearance and prevent future scarring. Removing moisturizers before the therapy can be helpful. This is because the skin’s cells will still be in a dormant state when you receive the treatment; therefore, your skin is not at risk for the dryness associated with moisturizers.

This will also improve your skin's look, especially for those who have undergone this procedure many times. However, you must be youthful if e to remove moisturizers in preparation for the session, as some creams may cause excessive dryness and irritation. Once you are prepared for the session, you can expect the doctor to start the red light therapy by generating a small amount of blue light on your skin's top layer.

The light then travels through the skin, reaching the deepest layers where most of the damage occurs. When the blue light is emitted, it is believed that the cells below the surface of the skin begin to absorb the red light, helping to repair the skin. The increased circulation and nutrient absorption help to rejuvenate your skin, leaving it looking younger and healthier than ever before.


Celebs are Loving Red Light Therapy

When it comes to anti-aging remedies, celebrities are at the forefront of all the latest treatments. For years, Hollywood’s elite have opted for chemically-induced anti-aging treatments, like botox and chemical facial peels. But it looks like Hollywood is stepping away from harsh treatments, particularly with the prominence of clean and holistic beauty trends in recent years. Now, many celebrities have decided to avoid the needles and knives, opting for natural alternatives, instead. 

To prepare for red carpet events, celebrities are flocking to red light therapy for natural, non-invasive anti-aging treatments. Kourtney Kardashian, true to Kardashian form, was relatively early to the red light therapy scene in 2016, when she posted a photo of herself in wearing a red-light mask, touting the many anti-aging benefits of the treatment. Since then, other celebrities such as Kelly Rowland, Emma Stone, and Chrissy Teigen have openly shared their positive experiences using red and blue light facial therapy treatment. 

Some actresses love red light therapy so much, they have their own equipment set-up in their homes. Back in 2018, Olivia Munn told US, "I have my own facial set up, I've got the professional-grade products and machines...But one of the best things is the red and blue light mask."

Red light therapy works by increasing blood flow and oxygen, feeding the cells the necessary energy they need to speed up the cellular process. This process helps decrease inflammation and enhance collagen production, which reduces the appearance of fine lines and wrinkles for tighter and supple skin. 

Jewelry designer and reality T.V. star Kristin Cavallari told US that she keeps away from Botox, but shared that

"I use red light therapy twice a week to prevent lines and wrinkles."

But red light therapy isn’t only for wrinkles and fine lines. Celebrities are expanding the use of red light therapy and using it for their entire bodies. Why? Well, house-friendly red light devices help treat inflammation, joint pain, and muscle soreness. 

Ara Suppiah, M.D., an assistant professor at the University of Central Florida Medical School and an emergency and sports medicine physician, told Us Weekly that “increased energy within a muscle cell allows it to contract harder and repair itself after training.” Since red light increases cell energy, it subsequently helps organs, joints, and muscles to repair themselves and function optimally. 

The list of celebrities who swear by red light therapy continues to grow by the day. Joan Smalls and Bella Hadid visit celeb aesthetician Joanna Czech, who is well-known for using her light treatments on her clients. Riverdale’s Lili Reinhart and Camila Mendes also posted photos from Joanna Vargas’ red light bed.

So, it’s clear that the verdict is in: celebrities are loving red light therapy and the multiple external and internal benefits that come along with it. But do you need to undergo expensive treatments to get a taste of the benefits? Nope! You don’t need to be a celebrity status to enjoy the benefits of red light therapy - even in the comfort of your home. 

Luckily, red light therapy is now available for in-home treatment with Lunas’ FDA and MDA-approved red light therapy devices. By having a red light therapy device in your home, we can all attain our own red-carpet glow without the celebrity price tag.

Photo Credit: By Tinseltown - Shutterstock

How to Integrate Light Therapy into your Lifestyle

Our lives are busier than ever, and even though red light therapy sounds like something that could significantly benefit you, we know you might be thinking: “when will I have time for red light therapy?” 

Part of the beauty of red light therapy is that you don't need to change your current routine or lifestyle to enjoy its benefits: if you're someone whose day is busy in front of a desk, you can turn the device on while you work; or if you have easy-going mornings but hectic afternoons, you can enjoy your morning coffee while using our red light therapy device. Or, you can turn on the panel while you’re unwinding with a movie in the evenings –– the options are endless.  

Red light therapy treatment isn’t supposed to take over your day and cause an inconvenience. With an at-home red light therapy device, you make the rules. 

That said, you may be wondering what’s the best time of day to use our red light therapy devices. Well, there are a couple of ways you can integrate red light therapy into your lifestyle. 

There are three main parts of the day: morning, midday, and evening. Though you’re able to use red light therapy any time of the day, some parts of the day can be more effective than others, particularly given your personal health and wellness needs. 

If you’re someone who’s suffering from a sleep disorder, then you may want to focus on using red light therapy during the mornings and evenings. For sleep conditions, using red light therapy around sunrise or sunset are the best times of the day. Why is that? 

It has to do with our biological circadian rhythm, which is the natural internal process that helps regulate your sleep cycle within a 24-hour day. To optimize your circadian rhythm and improve your sleep cycle, you need to sync with your natural sleep rhythm. By doing so, you reduce sleep inertia, insomnia, and other sleep disorders. 

When regulating your circadian cycle, your body releases a hormone called melatonin. This particular hormone is the highest in the blood at night and optimal for helping you fall asleep. When using red light therapy at night, it can help you enhance your natural melatonin production

When using red light therapy in the morning, exposure to light helps stop melatonin production, giving your body a natural energy boost. So, either time of the day––morning or night––can be an incredible time to help your body reset its circadian rhythm. 

You don’t need to schedule off your morning for red light therapy treatment. While you’re eating your breakfast or going through your emails, you simply turn on your red light therapy device and enjoy 10 to 15 minutes of treatment. 

Or, in the evenings when you’re cozied up on the course, washing the dishes, or sitting in bed with a book, turn on your red light therapy panel to help regulate your sleep cycle, mood, and overall health. 

If you can’t manage to use red light therapy in the morning or evening, you can always have a treatment in the afternoon, as well. If you’re dealing with a sleep disorder or seasonal depression, we recommend morning or evening treatment. However, midday treatment will also provide you with a load of benefits, including collagen production, decreasing symptoms of depression, improving sleep disorders, and non-seasonal Bipolar depressive episodes. 

Whatever the condition may be, whether it's a sleeping disorder, skin condition, or depression, Lunas red light therapy devices promote cellular healing from the inside out. What’s important is you find the time of the day that best suits your body’s needs. Everyone is different, so it’s important to find out what works for you and your unique routine and lifestyle.

Red and Blue LED Light on Milk Yield in Dairy Cows

Ruminant nutritionists formulate rations balanced according to the nutritional needs for the ruminant at a specific production level. The assumption being that the cows will eat everything they offered. However, cattle can select their feed, as they put together feed using their tongue and lips. Sorting has been studied most in cows al mixed ration (TMR) since it is often is oftenibitum, allowing cows to pick the feed particles they prefer and still reach the total dry matter (DM) they want. The TMR reports show that the most likely sorting is in favor of the short particles (mostly concentrate) and against the long particles (forages). Therefore, the feeding behavior of the cow modulates the amount of feed she eats, the nutrients she gets, rumen health, and ultimately her milk production.

Several methods have been used to try and reduce feed sorting in dairy cows. Recently, a long day photoperiod has been reported that could lower feed sorting against long particles. Today, Kaiyan provides advanced LED light equipment that is available for commercial use. The LED wavelength can be adjusted to the desired output.

Blue and red wavelength light has attracted interest in dairy barns. The cow eye is not sensitive to a red light, and therefore red light has been suggested as an option for illumination when people need to work with the animals during a time of the day when the cows have night. In humans, blue light is known to cause a carryover effect with increased activity after the light is turned off. If cows respond similarly to blue light, it may be interesting to include blue light in the dairy barns in the late afternoon or evening to stimulate activity during the night. This is of particular interest for automatic milking systems since they require cow activity around the clock. Solutions for dairy barns that include periods of the day with more red or blue LED light are already available on the market, as we now have fixtures of white LED light.

Eating Behavior of Dairy Cows

Encouraging DMI to promote milk production is one of the primary objectives for dairy farmers. The daily eating time, selection, number of meals per day, duration, and number of eating occasions per day are important aspects of feeding behavior.

Factors that Influence Eating Behavior

The environment, age of cattle, teeth condition, feed composition, and processing influence eating behavior. Just like grazing cattle, group-housed cows synchronize their behavior, including eating when kept indoors. The eating behavior of cows is controlled by social interactions, management practices, the environment, and health. Long ago, dairy cows were thought to be crepuscular eaters, motivated by sunrise and sunset timing to go for grazing. However, studies reported that fresh feed delivery timing had more influence on the feeding behavior of dairy cows kept indoors than the time of day. Also, studies found that daily eating time distribution changed following an increase in feed delivery frequency in group-housed dairy cows. The first hour and a half after fresh feed delivery is the period of peak eating activity. Little effect on cow behavior was observed when feed push-ups were done while still some feed in the trough. The feed trough design also affects feeding behavior as cows prefer eating from a feed trough that allows their head to be in a natural grazing position than having their head in an elevated position.

Types of Lights Used in Dairy and the Newly Available Light Sources

Common light sources used in dairy facilities are fluorescent and metal halide lights. During the last few years, LED lights have also become available for animal housing. This is not a new technology; LED light has been used in plant growth research since the mid-1980s but has been costly; hence limited to research only. However, 19 the Haitz’ Law as projected by Steigerwald et al., has come to action, that every decade their cost will decrease by 10 whereas their performance advances by a factor of 20. Now they have become affordable and advanced white LED lights thereby increasing their potential use in animal houses commercially

Advantages of LED Lights

It is possible to adjust the light intensity and spectral composition of LED lights mimicking that of natural day sunrise and sunset, making it possible to control color combinations, e.g., green, blue, and red. A LED light's lifespan is longer than that of fluorescent lights, around 100 000h compared to 8000 h. Furthermore, LEDs thermal output is low, saving energy, containing no mercury, efficient photoelectric conversion, and easy-to-contact to digital control systems making photoperiod management easy, for example, in dairy barns. Due to their long life span, they can decrease production costs as they do not need regular replacement and cuts off labor costs and the often-high risk work task of replacing lights since most barns have very high ceilings. The white LEDs produce light in the wavelength that cows can detect better, with peaks of emission around 460nm and 550.

In one study, ten multiparous pregnant Swedish Red cows in post-peak lactation were used. Cows were housed in a tie-stall barn. They were subjected to a 33-day red or blue LED light treatment during a long day photoperiod with 16 hours day and 8 hours night. Cows were fed silage and concentrate separately. Silage was fed three times a day, ensuring ad libitum intake with 5–10% orts. The concentrate was fed four times per day. Samples of silage were collected thrice a day, and individual orts were collected at the end of the day and the night. Data for eating behavior and milk yield were collected five days before and five days after the treatment period. Eating behavior was determined using the difference in the distribution of fractions of different straw lengths in the silage fed and orts during daytime and night time. A 2-screen Penn State Particle Separator (PSPS) (19mm and 8mm) with a solid bottom pan was used to determine the distribution of large, medium, and short silage fractions. Treatments did not affect total DMI. Overall, cows sorted for the large fractions against the medium and short fractions. During the LED period, there was a difference (P<0.001) in sorting between Red and Blue cows during the daytime. Cows on the Red LED light are sorted for the short fractions during the daytime. Blue cows showed different sorting (P<0.05) during day and night. Their sorting for the large fractions was more pronounced during daytime than night. Milk yield did not change during the trial and did not differ between the Red and Blue groups. In conclusion, sorting activity was greater during the daytime in the LED period, which could have been influenced by the LED light. Interestingly cows seem to have better vision in red than blue LED light. Furthermore, it also possible that the LED light maintains milk yield since no change was observed during the four-week trial in post-peak lactation.

Bear, Wolf, Lion or Dolphin: How Understanding your Sleep Type Will Change your Life

Sleep is big business these days — one in three people are believed to experience sleep deprivation — and everyone is keen to rely on the latest fashionable theory.

For years, sleep cycles were divided into two categories. People who enjoy mornings were known as “early birds.” And those of us who prefer staying up late were labeled “night owls.”

Well, step-aside birds. Mammals are the new name of the game. That’s right; scientists now believe there are four ways to classify sleep/wake cycles. In the science world, these classifications are known as chronotypes.

Chronotypes describe the periods when your body wants to sleep and when it wants to be awake. And to make it easier, the chronotype categories are named after animals. Our natural sleep tendencies are now categorized as bear, wolf, lion, and dolphin.

It is crucial to understand your animal chronotype. Once you do, you can start to schedule your life around your body’s natural cycles. Kaiyan Medical suggests that this may help you sleep better and feel more productive at work.

Two Animals are not Enough

People have different circadian rhythms. That’s just a fact of life.

Science shows that:

“The human circadian system actively synchronizes to the 24-h day via environmental signals of light and darkness.”

Circadian? A 24-hour cycle. It’s your body clock. Sleep psychologists reckon they can determine our natural sleeping patterns. By understanding our own, we can have a happier, more productive life.

Now, Chronotype is a term that describes a person’s natural rhythm. And it doesn’t only relate to sleep. Chronotypes influence all primal instincts.

Author Michael Breus, Ph.D., recently suggested that there are 4 natural chronotypes. And he named these after 4 animals that follow similar sleep/wake patterns. So, say goodbye to night owls and early birds. Wolves, lions, bears, and dolphins are the new circadian rhythm mascots.


The Chronotypes

Check out the chronotypes below and let us know in the comment section which one sounds like you!

Wolves

Alright, night owls, this is your group. Just like these nocturnal creatures, you are most alert at night. Wolves tend to stay up later and struggle with waking up early.

Only about 15% of the population falls into this group. Wolves are more productive in the later afternoon and evening.

Sleep experts recommend that wolves set their alarm for 7 a.m. (snooze for 30 minutes) and go to sleep by midnight.

Lions

Lions are the new early birds. Like these wild cats, you are most alert in the morning. You have no trouble waking up and getting to work. But, lions tend to feel the afternoon slump. And by the evening, they feel drained.

About 15% of the population identifies as a lion. Sleep experts recommend that lions wake up around 5:30 a.m. and go to sleep by 10:30 p.m.

Bears

No, you don’t need to hibernate. But, like these diurnal (awake during the day, asleep at night) creatures, you follow the solar cycle. Bears generally feel awake during the day and need 8-hours of solid sleep at night.

About 50% of the population falls into this category. This group is productive in the morning and struggles with the mid-afternoon slump. Sleep experts recommend that bears wake up around 7 a.m. and go to sleep by 11 p.m.

Dolphins

Dolphins “only sleep with half of their brain at a time?” Sound familiar? Well, this is the insomniac (often self-diagnosed) group. You might be anxious and have trouble turning your brain off at night. Dolphins usually don’t get a complete night’s sleep.

About 10% of the population falls in this category. And even though they wake-up tired, dolphins are most productive by mid-morning.

Sleep experts recommend that dolphins get up around 6 a.m. and try to sleep around midnight.

Sleep Like an Animal

Who doesn’t want a better night’s sleep and a more productive day? Start scheduling your days based on your chronotypes! Once you know more about your chronotype, you can form sleep patterns that work with (not against!) your body’s natural rhythms.

So what are you waiting for? Here in Kaiyan, we are embracing our inner animals and start following our optimal sleep schedule.



Sources:

Fischer, Dorothee et al. "Chronotypes in the US – Influence of age and sex." PubMed, 21 Jun. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5479630/

Bellis, Rich. "How To Design Your Ideal Workday Based On Your Sleep Habits." Fast Company, 26 Nov. 2017, www.fastcompany.com/40491564/how-to-design-your-ideal-workday-based-on-your-sleep-habits

Levi, Anthea. "This Is the Best Time of Day to Do Everything, According to Your Chronotype." Health.com, 31 Oct. 2016, www.health.com/mind-body/how-to-get-more-energy-chronotype

Stretch Marks & Light Therapy

Why Do We Get Stretch Marks?

A stretch mark is a type of scar called striae, meaning “thin, narrow scar”. In people who develop stretch marks, the skin has stretched faster than it can grow, such as during pregnancy, growth spurts, or rapid fat or muscle gain. The abrupt stretching causes the collagen and elastin proteins responsible for the skin’s structure and elasticity to rupture. This, in turn, causes the dermis to tear.

As the dermis tears, the body’s healing mechanisms spring into action to close the wound as quickly as possible to prevent infection and further damage.

Normally, as the skin regenerates and grows, it’s an elegantly organized latticework of collagen and elastin proteins. But when the skin tears, the body doesn’t have time to build an elegant structure to fill in the gap. Time is of the essence in any wound repair, including torn skin.

The collagen clumps together hurriedly, aiming for efficient closure of the wound before infection can set in. “Scarring is the result of a system that has learned to respond extremely quickly to a wound,” says Dr. John Newman, a cosmetic surgeon and researcher at the Laser Center of Virginia in Virginia Beach.

This haphazard process results in tough and functional but unattractive tissue — what we know as a scar. “It is kind of like nailing down a crisscross of two-by-fours over a hole in a deck,” says Newman. “It seals the hole, but it doesn’t look very nice.”

Newly formed stretch marks are darker than the surrounding skin and can be slightly raised, itchy, or painful. If they’re left untreated, they become permanent scars. Their color will lighten, and their appearance will fade below the top layer of the surrounding skin.

The bigger mystery is why stretch marks don’t disappear over time as the skin regenerates. The key lies in the information that emerging cells receive from adult cells in the area. Skin cells, whether they’re normal cells or scar cells, regenerate about once every 30 days. Growth of new skin cells begins at the bottom-most layer of the scar, and older (dying) cells are pushed to the surface where they naturally slough off.

However, Neuman explains that that that that emerging cells “learn” from their immediate neighbors and predecessors and develop the same characteristics as ir replacement their replacement cells. As a result, any emerging cell in contact with scar cells will become new scar tissue rather than normal skin tissue.

Red Light Therapy For Stretch Marks

If you have tried to get rid of stretch marks, perhaps you’ve used specialized creams that contain retinoids. These work to some extent, but only if you catch your stretch marks early and treat them while they’re still forming. Retinoids work by stimulating collagen production. However, they can irritate sensitive individuals, and doctors often recommend that pregnant women avoid anything containing retinoids.

Another common treatment, known as microdermabrasion, essentially involves “sandblasting” the skin with tiny crystals. This sloughs off dead skin

cells and stimulates the production of collagen. Microdermabrasion is a fairly harsh treatment that can lead to irritation and damage, especially to sensitive skin.

The most extreme treatment for stretch marks is plastic surgery, such as a mini tummy tuck. This may be effective, but there are risks associated with any invasive procedure and the high cost.

Is there a better option for restoring the appearance of the skin? The answer is yes, absolutely. Also known as photobiomodulation and low-level light therapy (LLLT), red light therapy improves skin appearance, reduces signs of aging, treats chronic skin conditions, reduces scarring, and promotes skin wound healing.

When red light therapy is used, visible red light and invisible near-infrared (NIR) light are applied to the skin with LED bulbs' devices. Wavelengths of light are measured in nanometers (nm), with red light ranging from 630nm to 660nm and NIR light ranging from 810nm to 850nm. Human cells respond favorably to these wavelengths, similar to how natural sunlight affects plant cells by stimulating more energy and optimization of cell function.

When the red light is shone on bare skin, it soaks into the mitochondria, colloquially referred to as the powerhouses of cells' energy factories. The mitochondria are, in turn, stimulated to produce more adenosine triphosphate (ATP), which is the primary cellular fuel. This energizes cells to perform their normal functions, from fighting off pathogens to performing repair and regeneration.

Improved Blood Flow

Proper healing relies on good circulation to the skin. Red light promotes the proliferation of endothelial cells, which make up the inner layer of capillaries (the tiny blood vessels that deliver oxygen and nutrients throughout the body). This was the focus of a 2017 study by a team of researchers from Austria, who found that red light consistently increased migration and proliferation of endothelial cells.

Without proper blood circulation, there would be no healing since endothelial cells also deliver white blood cells to the sites they need. In skin wound healing, white blood cells are necessary to protect the vulnerable area from infection while the wound closes up.

Reduced Inflammation

Acute inflammation results in the redness that’s noticeable in fresh stretch marks. This is a normal and necessary part of the tissue regeneration scar's process. Acute inflammation, which is a function of the immune system, actually sets the stage for normal tissue repair and regeneration. Inflammation is quickly followed by the production of new skin structures — which, as previously described, are hastily assembled to ensure that the torn skin doesn’t become infected.

But sometimes, the inflammatory process continues after the wound has healed, leading to chronic inflammation. It can lead to a variety of widespread problems throughout the body, including disease. “Some inflammation is good,” says Dr. Robert H. Shmerling, an associate professor of medicine at Harvard Medical School. “Too much is often bad. The goal is to recognize when inflammation is simply doing its job, and when it can potentially cause problems.”

Hundreds of studies have shown how red light therapy can significantly reduce inflammation. Many of these were conducted by Dr. Michael A. Hamblin, an associate professor of dermatology at Harvard Medical School and a noted expert on red light therapy. In the final report of a 2017 study, Hamblin refers to red light therapy’s “pronounced anti-inflammatory effects.”

Mobilize Stem Cells

During the skin-rebuilding phase, stem cells, which are unspecialized “master” cells, mobilize to the site and develop into most any type of specialized cells that are needed by the body. Ideally, they develop into normal skin cells, rather than scar tissue, to replenish damaged or destroyed cells due to skin tearing.

Red light has been shown to activate stem cells. As Barbara Gefvert, editor-in-chief of BioOptics World, explains: “Recent research shows … that noninvasive application of light can boost the natural growth of an individual’s own stem cells to enable exciting new treatments.” Stem cells can assist with the tissue regeneration process and stimulate normal and healthy behavior in existing cells. This can prevent the formation of new stretch marks and gradually reduce the appearance of existing stretch marks.



Fetuses May be Able to See More Light than you Think

By the second trimester, long before a baby's eyes can see images, they can detect light.

But the light-sensitive cells in the developing retina -- the thin sheet of brain-like tissue at the back of the eye -- were thought to be simple on-off switches, presumably there to set up the 24-hour, day-night rhythms parents hope their baby will follow. University of California, Berkeley, scientists have now found evidence that these simple cells actually talk to one another as part of an interconnected network that gives the retina more light sensitivity than once thought, and that may enhance the influence of light on behavior and brain development in unsuspected ways.

In the developing eye, perhaps 3% of ganglion cells -- the retina cells that send messages through the optic nerve into the brain -- are sensitive to light. To date, researchers have found about six different subtypes that communicate with various places in the brain. Some talk to the suprachiasmatic nucleus to tune our internal clock to the day-night cycle. Others send signals to the area that makes our pupils constrict in bright light.

But others connect to surprising areas: the perihabenula, which regulates mood, and the amygdala, which deals with emotions.

Recent evidence suggests that in mice and monkeys, these ganglion cells also talk with one another through electrical connections called gap junctions, implying much more complexity in immature rodent and primate eyes than imagined.

"Given the variety of these ganglion cells and that they project to many different parts of the brain, it makes me wonder whether they play a role in how the retina connects up to the brain," said Marla Feller, a UC Berkeley professor of molecular and cell biology and senior author of a paper that appeared this month in the journal Current Biology. "Maybe not for visual circuits, but non-vision behaviors. Not only the pupillary light reflex and circadian rhythms, but possibly explaining problems like light-induced migraines, or why light therapy works for depression."

Parallel systems in developing retina

The cells, called intrinsically photosensitive retinal ganglion cells (ipRGCs), were discovered only 10 years ago, surprising those like Feller, who studied the developing retina for nearly 20 years. She played a major role, along with her mentor, Carla Shatz of Stanford University, in showing that spontaneous electrical activity in the eye during development -- so-called retinal waves -- is critical for setting up the correct brain networks to process images later on.

Hence her interest in the ipRGCs seemed to function in parallel with spontaneous retinal waves in the developing retina.

We thought they (mouse pups and the human fetus) were blind at this point in development. We thought that the ganglion cells were there in the developing eye, that they are connected to the brain, but that they were not really connected to much of the rest of the retina, at that point. Now, it turns out they are connected to each other, which was a surprising thing."

Marla Feller, the Paul Licht Distinguished Professor in Biological Sciences and a member of UC Berkeley's Helen Wills Neuroscience Institute.

UC Berkeley graduate student Franklin Caval-Holme combined two-photon calcium imaging, whole-cell electrical recording, pharmacology, and anatomical techniques to show that the six types of ipRGCs in the newborn mouse retina link up electrically, via gap junctions, to form a retinal network that the researchers found not only detect light but respond to the intensity of the light, which can vary nearly a billionfold.

Gap junction circuits were critical for light sensitivity in some ipRGC subtypes. Still, not others, providing a potential avenue to determine which ipRGC subtypes provide the signal for specific non-visual behaviors that light evokes.

"Aversion to light, which pups develop very early, is intensity-dependent," suggesting that these neural circuits could be involved in light-aversion behavior, Caval-Holme said. "We don't know which of these ipRGC subtypes in the neonatal retina actually contributes to the behavior, so it will be fascinating to see what role all these different subtypes have."

The researchers also found evidence that the circuit tunes itself in a way that could adapt to the intensity of light, which probably has an important role in development, Feller said.

"In the past, people demonstrated that these light-sensitive cells are important for things like the development of the blood vessels in the retina and light entrainment of circadian rhythms, but those were kind of a light on/light of the response, where you need some light or no light," she said. "This seems to argue that they are actually trying to code for many different intensities of light, encoding much more information than people had previously thought."
Source:

University of California, Berkeley

Journal reference:

Caval-Holme, F., et al. (2019) Gap Junction Coupling Shapes the Encoding of Light in the Developing Retina. Current Biology. doi.org/10.1016/j.cub.2019.10.025.


Keep Your Skin Healthy with Red Light Therapy

Skincare doesn’t just affect the way you look. It also plays a huge role in your overall health — from body temperature to hormone regulation to your immune system. If you’re into skincare as much as we are, one of the many ways that can help you keep your skin healthy is red light therapy. In this article, we’ll take a deep dive into why you should take care of your skin, and we’ll also discuss how red light therapy devices can help you achieve your skin goals.

Are you ready? Let’s go straight into it.

Why Do You Need to Take Care of Your Skin?

As the largest organ in our body, your skin is your body’s first defense line to bacteria, germs, viruses, etc. It’s a vital part of the immune system and some processes in your body, such as temperature control, blood circulation, and hormone production.

Main Functions of the Skin

Let’s take a look at the skin's main functions to help you understand how essential it is for you to take care of this vital organ.

1. Defense and Immunity

The skin is an active immune organ, and it serves as our physical barrier from the dangers of the environment. It helps protect our bodies from diseases, germs, viruses, dirt, UV radiation, and potential thermal and physical injuries. It also helps detect and fight off infection, toxins, allergens, hazardous substances, and carcinogens.

2. Temperature Regulation

Aside from protecting us from extreme cold or heat, the skin also helps prevent moisture loss, keeping us from being dehydrated.

3. Sense of touch

The skin has a somatosensory system that is composed of touch receptors and nerve endings. This system is responsible for the sensations we feel, including pain, pressure, vibrations, smoothness, roughness, heat, cold, tickle, itch, and more.

4. Storage and Production of Vitamin D

Your body also uses your skin's deeper layers to store metabolic products, fat, and water. The skin is also responsible for producing vitamin D, supplied in the body when the skin gets enough sunlight exposure.

5. Beauty

Need we say more? Your skin plays a huge part in your appearance. Of course, when your skin is healthy, you also look glowing, radiant, and definitely more attractive.

Red Light Therapy and Keeping Your Skin Healthy

Before we proceed with the “how,” let’s first define what red light therapy is. Red light therapy is a non-invasive treatment option for different kinds of medical conditions. It is also used for health improvement and various aesthetic procedures.

Decades ago, red light therapy machines were only available in clinics, high-end salons, and spas. Nowadays, red light therapy devices can be bought and used by anyone. In fact, you can do red light therapy at the comfort of your home and incorporate it into your skincare routine.

How Does Red Light Therapy Work?

Red light therapy works by delivering wavelengths of red and near-infrared (NIR) light to our cells and skin. Besides helping enhance cellular function, red light therapy also helps stimulate the mitochondria and produce ATP (adenosine triphosphate) energy. This treatment option usually takes only about 10 minutes per session.

How Does Red Light Therapy Help Keep Your Skin Healthy?

Our skin relies on millions of cells to be able to perform its functions. When our cells experience homeostasis or a state of balance, our skin and body perform (and look) better. And as mentioned above, red and NIR light enhances cellular function while also preventing inflammation and oxidative stress. Red light therapy helps make your skin look and feel softer, smoother, and healthier.

Besides, red light therapy also helps damaged tissues heal and regenerate faster. It also has anti-inflammatory benefits, potentially increasing blood flow to damaged and inflamed tissues and reducing oxidative stress.

Final Thoughts

Skincare is self-care, as keeping your skin healthy also produces multiple benefits to your health. Thankfully, aside from proper hygiene, regular exercise, a balanced diet, and an established skincare routine, red light therapy can also improve your overall skin health.

For more information about red light therapy or to view our catalog of red therapy devices, click here.

Sources:

https://www.hse.gov.uk/skin/professional/causes/structure.htm

The Light for your Wounds

I remember how I used to come home with a bruise or cut every day after playing basketball in my childhood. Cuts and bruises were a part of the game, but my mother never took them lightly.

They may not seem like a tiny problem, but sometimes even a small wound can affect critical ways. It can lead to an infection as the cut exposes your body to external bacteria. This is why it important not to neglect the wounds.

What Happens When we Get a Cut?

Do you know what exactly happens when we get a cut?

In a small cut, the skin gets punctured, and the regular blood vessels get damaged. The effect is on the dermis layer. Whereas in the case of a deep cut, the impact is majorly on the tissues and the blood vessels break down completely results bleeding.

How our Body Reacts to Wounds?

When you get a cut, the body gets help from cells like neutrophils and immune cells. The section starts clotting the blood and reduces the blood flow. Antibodies, proteins clean up the site and eat the dead skin cells and other wastes.

Once the cut is free from germs, the skin growth gets started, and your body starts to rebuild the lost tissues and fix the broken blood vessels with the new ones. This repair work is done by cells called fibroblasts. In the last stage of wound healing, a lot of remodeling done to make the vessels and tissue functional again.

(Image source: https://askabiologist.asu.edu/)

The Light on the Wounds

No wonder science and technology have covered a long way to make human life easier. Now wounds can be treated with light therapy.

Yes, light therapy!!

That sounds out of the ordinary. But light therapy can heal your wounds by 200%!!

Wounds that Can be Treated by Light Therapy

Since wounds are of different types, wounds can be open or closed wounds. According to reports, LED light therapy can treat non-healing wounds, i.e., that doesn’t heal after 4 weeks. People with the following types of wounds can be healed from LED light therapy:

• Diabetic ulcers

• Venous ulcers

• Pressure ulcers

• Non-healing surgical wounds

• Serious burns

• Oral sores from chemotherapy/radiation

• Metabolic-disease-related wounds

• Wounds that repeatedly break down

How Red and Near-Infrared light Works for Wound

Light therapy a broad range of light having different wavelengths. Red light (620 nm — 680 nm) is visible red light, whereas Near-Infrared light (700nm — 1100nm) is invisible. Many studies reported that biologists have found that treating the cells with near-infrared light can grow 150% to 200% faster than cells not stimulated by light.

Biologically the Near-Infrared light boosts microcirculation and formation of new capillaries at the wound section.

Infrared light rays increase cellular energy that speeds up any healing process and penetrates deeper into the skin. As a result, the wound section receives more oxygen and nutrients to naturally help with the wound's healing process.

The light nurtures the lymph system activity. This assists with the detoxification process of the wound without overtaxing the lymph system and prevents lymphedema. The near-infrared rays also clean up the dead or damaged cells, making a clear blood circulation path.

Another benefit of Infrared therapy is that it helps release ATP (raw cellular energy), which gives energy to the damaged cells in the wound to heal better and faster (study).

Not only this, the studies have shown that the wound size also decreased by up to 36%.

Source: www.slideshare.net/amintalebi1/light-and-wound-healing

So, next time you encounter a wound, put a light on it!!

Let your cut heal through LIGHT THERAPY!

References:

http://www.jofamericanscience.org/journals/am-sci/am0706/36_5769am0706_203_208.pdf

https://www.infrared-light-therapy.com/red-light-therapy-wound-healing/

https://pubmed.ncbi.nlm.nih.gov/25363448/

https://pubmed.ncbi.nlm.nih.gov/25654197/

https://iopscience.iop.org/article/10.1088/1054-660X/24/8/083001

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/

https://pubmed.ncbi.nlm.nih.gov/24155549/

How to Prevent Jet Lag with Light Therapy

How to Prevent Jetlag with Light Therapy Treatment

Globetrotters know flying across time zones can be all fun and games until headaches start to kick in, sleep cycles get disturbed, and frequent moments of inappetence prevents them from enjoying even the most sumptuous local cuisine. If you’ve had any of these unfortunate events disturb your travel plans and work productivity, you’ve most likely experienced a jet lag.

What is Jet Lag?

Jet lag, also known as jet lag disorder is our body’s reaction to abrupt changes in new environments that are two or more time zones ahead/delayed. This can affect even the most seasoned flyers like pilots and business travelers.

What causes Jet lag disorder?

Your body has a clock system called circadian rhythm that schedules your body for its sleep and wake up time. Your circadian clock is synced depending on your original time zone.

Jet lag is caused by a temporary discoordination with your circadian clock and your new time zone or sleep-wake schedule. This is why when you expose your body to abrupt schedule changes, its normal functions related to sleep, coordination, and gastrointestinal processes are disrupted. While your mind may be ready to fly west, your body may still be stuck home and is still hours ahead.

Treating Jet Lag with Light Therapy

Jet lag can take days, weeks, or longer to improve, which may affect daily activities. In addition, although jet lag may be a temporary disorder, frequent exposure also poses significant long-term risks such as disturbances in menstrual cycle, cognitive defects, and temporal lobe atrophy.

One popular and effective treatment for jet lag disorder is Light therapy. Light therapy has been considered as a popular and effective treatment for jet lag disorder and has been backed by research since 1980.

Your body clock is largely influenced, among other factors by light, which is indicative of the rising and setting of the sun. This means that adjusting to a new time zone also means adjusting to a new daylight-night time and awake-sleep schedule.

Essentially, light therapy assists your brain and body in adjusting to a new time zone by conditioning yourself to light at an appropriate time. This allows your normal body functions to be in sync with your new schedule. By regulating light exposure, you can adjust faster with new conditions.

Studies show that exposure to light therapy helps people adjust their circadian clocks to new time zones more efficiently and effectively. Treatment of jet lag by Light therapy involves an exposure to natural or artificial light such as red light therapy.


How does Red light therapy work?

Red light therapy is a non-invasive, quick and easy treatment for jet lag that brings concentrated natural light to your body cells in order to condition it for a new day-light schedule. Red light therapy emits natural light that can boost cell energy without the putting your body at risk of the damaging UV rays from the sun.

If you travel westwards, you can use Red Light in the evening to help you adjust to a later time. On the other hand, if you travel eastwards, you can expose yourself to red light in the morning in order to acclimate your body to an earlier time zone.

Kaiyan produces high-quality Red light therapy home devices that utilize medical-grade LED (Light-emitting Diode) in order to produce a natural red light that is ideal for adjusting to new time schedules.

The great thing about this device is that, if you often work away from sunlight, this indoor light therapy device can be a convenient way to adopt your circadian clock to a new time zone. Check out our top picks for the best FDA-cleared light therapy masks.

Experiencing jet lag may be the ultimate bummer for travelling, but sufficient knowledge and proper treatment can keep you away from ruining your travel plans and goals.

References:

https://www.scientificamerican.com/article/how-to-prevent-jet-lag/
https://www.mayoclinic.org/diseases-conditions/jet-lag/diagnosis-treatment/drc-20374031
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829880/


Red Light Therapy - 101

We are not just made of biochemical matter. We are charged energy beings, constantly interacting with the environment. Light plays a crucial role in this natural process. Comprehensive new research has unearthed a full new understanding of how our cells function optimally. Food is not the only way we obtain energy; the light also charges us.

Science now shows your body operates like a battery. Certain wavelengths of sunlight power it, and your general health is determined by your ability to receive and maintain a charge. This is what light therapy is about.

What is Red Light Therapy

Light at certain wavelengths is scientifically proven to interact with the body in beneficial ways.

Red light, comprising both red and near-infrared wavelengths, is a unique healing part of the electromagnetic spectrum, and it is one of the most natural ways to charge the body. It is now used as a new form of therapy under the umbrella term Photobiomodulation(PBM)

Red light wavelengths ranging from 600–680nm. Red light boosts the formation of collagen and elastin and assists in cell communication. It penetrates superficially and can be used for skin conditions.

Near-Infrared wavelengths ranging from 750–850nm. NIR stimulates healing, increases mitochondrial function, and improves blood flow and tissue oxygenation. It penetrates deeper into the body.

A high-quality home device like those produced by Kaiyan uses medical-grade LEDs to shine natural red and near-infrared light on your body. Like the wavelengths of light your body needs from natural sunlight, without the heat or UV rays that cause sun damage and without the need for sunny weather. Check the list of best light therapy masks.

How to Recharge your Body

Electric charge is a fundamental property of the body. The surfaces in our bodies — such as membranes, proteins, and DNA — are all charged, negatively or positively, depending on whether they lose or gain electrons.

At the core of your body’s power to heal itself are sub-cellar organelles called mitochondria. The number of mitochondria in a cell varies widely by organism, tissue, and cell type and are concentrated in organs with high energy demands such as the brain, heart, liver, skin, and muscles.

This is because mitochondria generate most of the body's chemical energy supply via the ATP (adenosine triphosphate). They also regulate various other tasks, such as signaling, cellular differentiation, and maintaining control of the cell cycle and cell growth. This is why they are often referred to as the powerhouse of the cell.

Mitochondria
  1. LED light at a wavelength from 600–680nm(red) and between 810–850nm(infrared) is delivered to the tissue via the red light therapy device.
  2. The light enters the cell’s mitochondria and is absorbed by the chromophores, including the protein cytochrome c oxidase(CCO) and EZ water, increasing its activity.
  3. As a result of this highlighted activity, three molecules are affected. Adenosine Triphosphate(ATP), Reactive Oxygen Species (ROS), and Nitric Oxide (NO).
Water

Approximately 70% of our body weight and 99% of our bodies ’ molecules are made of water, and this water is in a charged state.

Recent research by Prof Gerald Pollock of the University of Washington has shown that water adjacent to a cell or mitochondrial membrane is so-called structured water. This is also called EZ (exclusion zone) water because it creates a separation of charge. Positive proton is excluded and pushed to the bulk water, and a lattice-like negatively charged water for near the membrane. This increases the voltage across the membrane—this charge separation of water in the body functions as the positive and negative poles of a battery.

What Does “Red Light Therapy” Mean?

As a term, “red light therapy” refers to treatments from LEDs or cold lasers that deliver wavelengths of natural red and near-infrared light.

The term does not include white light, blue light, or blue LED masks, and it is not the same as full-spectrum light. Some people may include infrared or far-infrared wavelengths along with red light therapy, but those are typically used in dry saunas because of their ability to produce heat. Red light therapy does not rely on heat, a major difference between natural light treatments and heat-based modalities like an infrared sauna, traditional sauna, or other heat therapy type.

Generally, “red light therapy” describes natural light treatments that deliver the same therapeutic red and near-infrared wavelengths as natural sunlight. This differs from artificial light treatments like tanning — or bright light therapy from light therapy lamps, lightboxes, or happy-light if you’re interested in natural light treatments for seasonal affective disorder.

The following terms may also call red light therapy: RLT, photobiomodulation (PBM), phototherapy, LED therapy, LED light therapy, infrared therapy, low-level laser therapy, or low-level light therapy (LLLT).

A Multilevel Treatment

Red light therapy works on multiple levels in the body.

Molecular

  • Chromophores, cytochrome c oxidase, water, opsins
  • Retrograde mitochondrial signaling
  • Light-sensitive ion channels
  • Adenosine triphosphate ATP
  • Reactive Oxygen Species ROS

Calcium

  • Heat-shock proteins
  • Melatonin
  • Brain-derived neurotrophic factor
  • Gene transcription factors
  • Akt/mTOR/CyclinD1 pathway

Cellular

  • Inflammation, Cytoprotection, Proliferation
  • Protein synthesis
  • Stem cell production and migration
  • Immune cell viability
  • Retrograde mitochondrial signaling
  • Transforming growth factor
  • Pro-and anti-inflammatory cytokines
  • Vascular endothelial
  • Mitochondrial membrane potential

Tissue

  • Muscles: Increase endurance, tone density
  • Brain: Improves cognition and immune
  • Nerves: Repair and pain relief
  • Healing: Bones, tendons, and wounds
  • Hair: Increases growth
  • Skin: Improvements of the collagen network, anti-aging, skin disorders
  • Fat: Fat re-absorption improved by enhanced micro-circulation
  • Lymph: Improved immunity
Systemic Effects

Red light therapy affects multiple bodily systems:

Fascia

The fascia is a complex web of sensitive and highly interconnected connective tissue beneath the skin that attaches, stabilizes, encloses, and separates muscles and other internal organs.

Fascia is primarily made from hydrated collagen-Protein chains in a triple helix formation surrounded by water, with a capacity to generate an electric charge in response to applied mechanical stress (piezoelectric).

The bio-electrical nature of the collagen-rich matrix is the key to understanding how pathological changes in one part of the body may cause a cascade of “remote effects” in seemingly unrelated areas and organ systems. The fascia is the long-overlooked but absolutely crucial interconnecting organ of the human body. The therapeutic effect of red light energy can be carried through the fascia network to other parts of the body where it is needed. This is turn, elevates the body’s capacity to communicate via this charged matrix in a positive feedback loop.

The well-known energy meridians of traditional Chinese medicine may actually be low resistance pathways operating through the fascia, conveying energy to the rest of the body.

Gut-Brain Axis

The gut-brain axis links the emotional and cognitive center of the brain with peripheral intestinal functions. Red light energy applied to the abdomen area can therefore influence mood and neuropsychological issues via several mechanisms:

  • Reduction in bowel inflammation and gut spasms.
  • Stimulation of neurotransmitters and hormones in the gut, including serotonin, leptin, and ghrelin.
  • Modulation of the micro-biome. The gut microbes are sensitive to light energy and respond to light energy with differences in growth, migration, and proliferation of the different species.
  • The increasing availability of neurotransmitters activates the brain’s immune system, increases blood flow, and removes toxins.
  • Increased blood circulation and reduced blood pressure leading to a reduction of anxiety and brain fog.
  • Modulation of the vagus nerve, one of the biggest nerves connecting the gut and brain. This plays an important role in stress and social communication, communicating motor and sensory impulses to every organ in the body.

Immune System

Beaming red light and near-infrared light onto cells creates a short, low-dose metabolic stress that builds up the cells' anti-inflammatory, anti-oxidant, and natural defense systems, making the body stronger and more resilient to infections.

This is the concept of hormesis; safe, low-level exposure to stressor results in increased resistance to illness. Red light has been shown to influence the immune response in several ways:

  • Activation of the mast cells leading to the movement of leukocytes and reduced inflammation.
  • Mast cell DE-granulation and the release of pro-inflammatory cytokines.
  • Increased infiltration of the tissues by leukocytes.
  • Enhanced proliferation, maturation, and motility of fibroblasts
  • Increased production of fibroblast growth factor.
  • Lymphocyte activation and proliferation.
  • Macro-phages activated to act as phagocytes.

Circulatory System

Red light therapy has been shown to aid the circulatory system's functioning and increase the micro-circulation of blood, one of the most recognized and well-documented effects of this therapy.

Red light stimulates the formation of new capillaries carrying more oxygen to the body.

A good oxygen supply is intricately involved in numerous biological processes, including cell proliferation, angiogenesis, and protein synthesis, required to restore tissue function and integrity.

Increased circulation allows for waste products to be carried away more effectively. It triggers and heightens the body’s own scavenging process for and ingesting degenerated cells for clean-up.

In fact, increased micro-circulation of blood is thought to be the most vital function for healing the body for almost every illness. For general well-being, Nutrient-rich blood and efficient waste removal is strongly linked to good health.

Nervous System

The nervous system is a complex electrical system, including the brain and spinal cord. It collects, processes, and responds to the input of energy-be it light, sound, heat, or pressure — and it relays these messages to the brain and around the body.

Red light energy affects the nervous system in several crucial ways:

  • Myelination of fibers and a better lamellar organization of the myelin sheath.
  • Improvement of electrophysiological function.
  • Facilitation of neural regeneration.
  • Release of growth factors.
  • Increase of vascular network and collagen.
  • Faster regeneration of nerve lesions and functional improvement of damaged nerves.

The peripheral nerves can be damaged by infection or high sugar levels in the case of diabetic neuropathy.

Red light therapy is being explored as a promising drug-free therapy for all kinds of nerve damage.

Stem Cells

At the frontier of science, red light therapy shows huge promise in current research to stimulate the growth of stem cells in the body and maximize the effect of stem cell implantation for a wide variety of medical purposes.

Therefore, red light may be useful after surgery to stimulate stem cells to aid the repair of tissues and possibly organs.

Light at certain wavelengths has also been shown to coax stem cells to repair teeth, so red light therapy could soon revolutionize dental treatments. Indeed, some progressive dental clinics now offer red light therapy as an alternative to conventional drug and drill treatments.

Red light therapy has been shown to stimulate mesenchymal stem cells in the bone marrow to enhance their capacity to infiltrate the brain.

This has implications for healing degenerative conditions such as dementia, Alzheimer’s, and Parkinson’s disease , currently lacking any orthodox treatment solution.

Where Did Red Light Therapy Come From?

Red light therapy has become a popular natural health intervention, both in professional settings and with home devices.

Light therapy technology has been used in medicine for decades, and NASA experimented with red light therapy use in space in the 1980s and 1990s. In the last 10–20 years, red light therapy has become more widely used thanks to breakthroughs in LED lighting technology that have made affordable home devices possible.

Major advances in clinical light therapy research, and increased public interest in natural health technologies, have also contributed to the growing use and popularity of red light therapy.

In 2016, Kaiyan Medical was the first red light therapy manufacturer to offer affordable, medical-grade devices to consumers for convenient, at-home use.

Relieve Pain And Discomfort

In humans, photobiomodulation is reportedly effective against various pain conditions, including mucositis, carpal tunnel syndrome, orthodontic pain, temporomandibular joint pain, neck pain, neuropathic pain from amputation, and menstrual cramps.

Red light therapy significantly reduces the severity of pain hypersensitivity while improving sensorimotor function.

These improvements are preceded by an anti-inflammatory microglia/macrophage cell population in the injury zone, thereby providing a lasting pain relief effect.

Red light therapy has been shown to yield effective pain relief via the modulation of multiple mechanisms:

  • Inhibitory cyclooxygenase and prostaglandins
  • Modulating nerve transmission
  • Increasing endorphins serotonin release
  • Stimulating metabolism
  • Activating peripheral opioid receptors
Repair Skin

Red light therapy is used for the rapid and safe healing of wounds from burns, surgery incisions, scars, diabetic neuropathy, ulcers, and bedsores.

Faster and better wound healing was one of NASA’s original findings and one of the key recognized uses for this technology. Red and near-infrared light promote beneficial effects during all four phases of the wound-healing process:

  • Coagulation
  • Inflammation
  • Migration
  • Remodeling

These processes are regulated by many growth factors connected with nitric oxide (NO) signaling release, which is modulated by light energy.

A major typical inhibiting factor for the body’s ability to recover from a wound is low oxygen flow. Therefore, the unique ability of red light to increase oxygen flow to the affected area has a massive effect on the healing process.

By reducing inflammation, oxygenation of the area, and formation of new blood vessels, a rapid healing process unfolds with less pain and scarring.

Red light energy may also reduce or prevent the need for pharmaceutical painkiller medication during the healing process.

Revive Immunity

If your body is energized on a cellular level and communication between the organ systems is efficient, your body will naturally develop disease resistance.

Your immune defense works to fend off bacteria and viruses all the time. Red light therapy boosts this system in several ways.

It releases nitric oxide and melatonin, which are involved in DNA repair and have a powerful antimicrobial effect.

It also works through a process known as hormesis. When red and near-infrared light is beamed into cells, it causes mild metabolic stress, which results in cells engaging their anti-inflammatory and antioxidant response.

In this way, the body is primed and ready to respond better to infections. Boosted immunity is also a natural consequence of other systemic effects of red light therapy.

Studies have shown a variety of benefits to the immune system:

  • Improved melatonin production
  • Improved antioxidant production
  • Increased micro-circulation enabling the transportation of immune cells.
  • Promotes activity in the lymph nodes
  • Increased NO levels
  • Better flow of neurotransmitters
  • Boosted collagen and elastin production
  • The more efficient function of cells and organelles
  • Boosts T cells pre-operatively
  • Improved thyroid function
Reduce Inflammation

Inflammation can be acute and topical ( short-lived, caused by accidents, sprains, and infections ), chronic and general ( long-term, caused by persistent conditions ).

While acute inflammation is a healthy physical healing response, chronic and general inflammation can be detrimental to health and often goes undetected.

Currently, the main treatment for inflammation in the body is NSAID or steroid drugs, both of which have side effects and disrupt the body's healing process. Red light therapy stimulates the body to activate its own healing mechanism, dramatically reducing the health risks associated with long term drug use.

Red light therapy works by decreasing the number of inflammatory cells, increasing fibroblast proliferation ( the cell that synthesizes the extra-cellular matrix and collagen ), stimulating angiogenesis ( the formation of new blood vessels ), and activating the body’s innate anti-inflammatory, antioxidant defenses.

The following conditions, associated with chronic and acute inflammation, are currently being investigated as highly promising targets for red light therapy.

  • Arthritis
  • Asthma
  • Sinusitis
  • Muscular sprains
  • Fibro-myalgia
  • Neuron inflammatory disorders such as Alzheimer’s
  • Irritable bowel syndrome and colitis
  • Rheumatic conditions
Regain Performance

Red light therapy has become a hot topic in sports and performance. Not only is it safe and non-toxic-it yields rapid and lasting results in many areas of application.

Besides the overwhelmingly beneficial effects on health overall, red light therapy supports muscle growth and repair by increasing the amount of ATP available, which allows for better performance and faster recovery.

Red light therapy used before training is known to prepare and strengthen the body and physical exertion to help with recovery.

Documented effects from red light therapy include:

  • Reducing DOMS ( Delayed Onset Muscle Soreness )
  • Greater endurance and performance
  • Improving sleep quality
  • Increasing sexual function and libido ( Including Testosterone )
  • Aiding weight loss
  • Boosting cognitive function
  • Reversing skin aging
  • Reducing cellulite
Red Light Therapy for Depression and Seasonal Affective Disorder

Seasonal affective disorder (SAD) is a type of depression that impacts at least 5% of Americans, especially in the winter months, when natural light exposure is lowest. SAD is also called seasonal depression, winter depression, or the winter blues.

Some people treat SAD symptoms with treatment options like bright white light therapies that mimic the sun’s light intensity at a bright time of day.

More researchers and physicians have used natural light treatments like red light therapy to help with natural light deficiency and the winter blues in recent years in conjunction with antidepressant medication and psychotherapy.

Who Uses Red Light Therapy?

In addition to the growing number of people using red light therapy devices in their home, red light therapy systems can be found in many professional and clinical settings:

Skincare Professionals: Red light therapy is a popular skin treatment among Hollywood celebrities for anti-aging, and it’s used by leading skincare professionals like estheticians and dermatologists to treat skin conditions and promote collagen production.

Health Practitioners: Red light therapy is an emerging subspecialty of medicine in a wide range of fields. From oncologists treating cancer side effects, to dentists reducing oral inflammation, to physicians treating mental health conditions, red light therapy is becoming more widespread in clinical practice.

Natural Health Experts: Leading voices in natural health and wellness like Dr. Sarah Ballantyne, Dave Asprey, and Ben Greenfield use red light therapy. So do Paleo and Keto health experts like Mark Sisson, Dr. Anthony Gustin, Luke Storey, and Robb Wolf.

Sports Medicine Pros: Light therapy companies work side by side with the National Association of Sports Medicine (NASM), and red light therapy is used to heal sports injuries by sports medicine professionals across the globe. Including the top trainers and doctors on the PGA Tour, like Dr. Troy Van Biezen and Dr. Ara Suppiah.

Elite Pro Athletes: Red light therapy is a popular training tool across pro sports, from NFL stars like Patrick Peterson, to UFC champs like Anthony Pettis, to gold medal gymnast Sanne Wevers.

Fitness & Training: World-class personal trainers like Lacey Stone and Jorge Cruise use red light therapy to both enhance performance and improve the muscle recovery process.

Supportive Cancer Care: The Multinational Association of Supportive Care in Cancer (MASCC) recommends red light therapy for the treatment of oral mucositis (OM), a common and debilitating symptom of cancer treatment.

Sources and References:

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LED Lights Used in Plant Growth Experiments for Deep Space Missions. NASA.

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Kim HK, Choi JH. Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheek. Journal of Physical Therapy Science. 2017 February.

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Barolet D, Roberge CJ, et al. Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a single-blinded study. Journal of Investigative Dermatology. 2009 December.

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Liu KH, Liu D, et al. “Comparative effectiveness of low-level laser therapy for adult androgenic alopecia: a system review and meta-analysis of randomized controlled trials.” Lasers in Medical Science. 2019 Aug.

Gupta AK, Mays RR, et al. “Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis.” JEADV. 2018 Dec.

Afifi L, Maranda EL, et al. “Low-level laser therapy as a treatment for androgenetic alopecia.” Lasers in Surgery and Medicine. 2017 Jan.

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Hofling DB, Chavantes MC, et al. Assessment of the effects of low-level laser therapy on the thyroid vascularization of patients with autoimmune hypothyroidism by color Doppler ultrasound. ISRN Endocrinology. 2012.

Hofling DB, Chavantes MC, et al. Low-level laser therapy in chronic autoimmune thyroiditis: a pilot study. Lasers in Surgery and Medicine. 2010 Aug.

Vladimirovich Moskvin S., Ivanovich Apolikhin O. Effectiveness of low level laser therapy for treating male infertility. Biomedicine (Taipei). 2018 June.

Ban Frangez H., Frangez I., Verdenik I., Jansa V., Virant Klun I. Photobiomodulation with light-emitting diodes improves sperm motility in men with asthenozoospermia. Laser in Medical Science, 2015 Jan.

Salman Yazdi, R., Bakhshi, S., Jannat Alipoor, F. et al. Effect of 830-nm diode laser irradiation on human sperm motility. Lasers Med Sci. 2014.

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Preece D., Chow KW, Gomez-Godinez V., Gustafson K., et al. Red light improves spermatozoa motility and does not induce oxidative DNA damage. Scientific Reports. 2017 Apr.

American Psychiatric Association

Cassano P, Petrie SR, et al. Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial. Photomedicine and Laser Surgery. 2018 October.

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Blanco NJ, Maddox WT, Gonzalez-Lima F. Improving executive function using transcranial infrared laser stimulation. Journal of Neuropsychology. 2017 Mar.

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Caruso-Davis MK, Guillot TS, Podichetty VK, Mashtalir N, Dhurandhar NV, Dubuisson O, Yu Y. Efficacy of low-level laser therapy for body contouring and spot fat reduction. Obes Surg. 2011. Jun;21(6):722-9.

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Breast Milk and Light Therapy, the Timekeepers

We live in a 24-hour environment, in which light and darkness follow a diurnal pattern. Our circadian pacemaker, the suprachiasmatic nuclei (SCN) in the hypothalamus, is entrained to the 24-hour solar day via a pathway from the retina and synchronizes our internal biological rhythms. Once we come to this world, one of the first things we need, is food. Naturally, as mammals(from Latin mamma “breast”), we feed ourselves from the breast. But, Human breast milk is more than a meal — it’s also a clock, providing time-of-day information to infants. The composition of breast milk changes across the day, giving energizing morning milk a different cocktail of ingredients than soothing evening milk. Researchers believe this “chrononutrition” may help program infants’ emerging circadian biology, the internal timekeeper that allows babies to distinguish day from night.

What happens, though, when babies drink milk that does not come directly from the breast but is pumped at different times of the day and stored in advance of feeding? Scientists have rarely considered the potential effects of “mistimed” milk on infants’ development, but the implications are potentially far-reaching.

In the same way, rhythmic variations in ambient illumination impact behaviors such as rest during sleep and activity during wakefulness as well as their underlying biological processes. The availability of artificial light has substantially changed the light environment, especially during the evening and night hours. Phones, laptops, ipads, and more around the babies. This may increase the risk of developing circadian rhythm sleep-wake disorders (CRSWD), which are often caused by a misalignment of endogenous circadian rhythms and external light-dark cycles. On the other hand, light can also be used as an effective and non-invasive therapeutic option with little to no side effects, to improve sleep, mood, and general well-being.

The architecture of the circadian system

The central master-clock in mammalian species is a paired structure in the hypothalamus with a volume of just about 0.25 mm3 per nucleus. Within the mammalian SCN, a molecular oscillator keeps the clock oscillating at its normal pace. The basis of this oscillator is two interconnected molecular feedback loops of clock gene expression, a detailed description of which is beyond the scope of this review though.

Successful interaction between body and environment however needs more than just a central clock; it also requires input pathways relaying information about the environment and the body to the SCN to achieve adequate entrainment as well as output pathways communicating timing information to the body to synchronize bodily processes with the circadian phase

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Sleep, eating, and energy levels all show circadian rhythms, which means they follow a daily cycle. As any parent who has sleepwalked through a 3 a.m. feeding knows, infants are not born with these rhythms fully set. Instead, their sense of day and night develops over the first weeks and months of life, thanks to cues like sunlight and darkness.

Babies vary: Some show predictable circadian fluctuations in hormones linked with alertness, sleep, and appetite, and can sleep for long stretches shortly after birth, whereas others seem to have their daily rhythms upside-down for months. Delays in the development of circadian biology can increase the risk of colic and lead to growth and feeding problems.

Breast milk may help program infant circadian rhythms, helping to explain why some parents of newborns enjoy long full nights of sleep, whereas others struggle to get their infants on a schedule.

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Dynamic Milk

Breast milk changes dramatically over the course of the day. For example, levels of cortisol — a hormone that promotes alertness — are three times higher in morning milk than in evening milk. Melatonin, which promotes sleep and digestion, can barely be detected in daytime milk, but rises in the evening and peaks around midnight.

Night milk also contains higher levels of certain DNA building blocks which help promote healthy sleep. Day milk, by contrast, has more activity-promoting amino acids than night milk. Iron in milk peaks at around noon; vitamin E peaks in the evening. Minerals like magnesium, zinc, potassium, and sodium are all highest in the morning.

Daytime milk may pack a special immune punch. Among mothers who provided researchers with milk samples across the first month postpartum, immune components — including key antibodies and white blood cells — looked higher in day milk compared to night milk. Another study found higher levels of a component important for immune system communication in day milk compared to night milk.

While it’s clear that milk changes over the course of the day, scientists know little about what this means for infant health. Researchers do know that the hormones and immune components in breast milk are passed along to infants and that infants are starting to develop and refine their own circadian rhythms during the first months of life. It’s plausible that the chronosignals in breast milk would help to shape infants’ own circadian biology. Differences in infant feeding patterns might help explain why there’s such variability in the development of these daily rhythms from one infant to another.

Fundamentals of light

To understand the effects of light on human physiology, it is important to understand light. Briefly, light is radiation in a specific range of the electromagnetic spectrum.

The spectrum of daylight, which is light from the sun filtered by the atmosphere is relatively broadband in its distribution. The availability of daylight depends on geographical location and season. In the timeframe of human evolution, it is a rather recent development that light can be available during all times of day through artificial light. Artificial light allows for illuminating indoor and outdoor spaces. It comes in many forms, e.g. incandescent, fluorescent, or light-emitting diode (LED) lighting.

While light generated by these technologies may all appear “white”, the underlying spectra are rather different.

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The reason why many different types of spectra might have the same appearance lies in the retina. Critically, different spectra, even if they create the same visual impression, may vary in their chronobiological effects on the circadian clock.

Recently, the Commission International de l’Eclairage (CIE), the international standard body for quantities related to light, issued a new standard containing a reference framework for quantifying the effects of light on non-visual functions.

Effects of LED light on the circadian clock

Two effects of light have been interrogated extensively in human circadian and sleep research: (1) the acute suppression of melatonin in response to light exposure and (2) the ability of light exposure to shift circadian phase.

The system mediating melatonin suppression has a spectral sensitivity that is broadly consistent with the spectral sensitivity of melanopsin. Similarly, the spectral sensitivity of circadian phase-shifting shows its maximal effect near the peak spectral sensitivity of melanopsin.

The effects of light on the phase of the circadian clock depend on the timing of light exposure. This is formally summarised in the phase response curve (PRC), which describes the amount of phase shift (in minutes and hours) achieved by exposure of light at a given circadian phase. Roughly speaking, the effect of morning light is that it advances the clock, while evening and night light delays the clock.

Both melatonin suppression and circadian phase shifts are modulated by the “photic history”, i.e. the amount of light seen during the day. The long-term adaptive influences of the “spectral diet” in the real world remain an important area of investigation.

Effects of light on sleep

The human sleep-wake cycle, which is periods of sleep during the night and wakefulness during the day, is one of the most prominent examples of a circadian behavioral pattern, especially for babies. It results from the interaction between two factors: the circadian drive for wakefulness and the homeostatic sleep pressure. The activity of the circadian pacemaker is aligned to counteract the increasing sleep pressure resulting from sustained wakefulness during the daytime. Likewise, the nocturnal increase in circadian sleep tendency counteracts the decrease in sleep propensity resulting from accumulated sleep thereby supporting a consolidated phase of nocturnal sleep.

Breast milk, artificial lighting, smartphones, and visual display units

In addition to natural daylight, babies are nowadays also exposed to a considerable amount of artificial light. This is particularly the case in the evening hours, i.e. when the circadian system is most sensitive to light-induced phase delays. Thereby, light therapy is more efficient to delay the timing of the circadian clock and thus sleep.

Even thou, mothers can label their milk with the time it was pumped and coordinate infant feedings to offer morning milk in the morning, afternoon milk in the afternoon, and night milk at night, they keep the constant use of visual units around the baby. The use for the babies is not different, entertainment as well

So, which one is better?

Is always about finding the balance. Rather than only use one of the methods, the responsible practice of light therapy and adequate alimentation of your newborn should be combined to get on track the circadian system

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