What You Need to Know About Red Light Therapy and Homeostasis

Our bodies are in constant need of replenishing our cells with oxygen, nutrients, and ATP energy to stay on top of our day to day activities. Also, the optimal function of our cells boils down to maintaining the balance that our body needs. This is also known as homeostasis.

Homeostasis Defined

The scientific definition of homeostasis is in a state of equilibrium, wherein the body’s chemical and physical processes are stable. The balance of the body is dependent on a plethora of factors, such as body temperature, calorie intake, level of blood sugar, the balance of fluid, and pH levels.

These factors are constantly changing and require regulation. They also adapt to changing environments like temperature, light, and activities. Reaching homeostasis requires balance for the body to reach its optimal state. This is present in humans' biology and animals' biology because it determines physical and mental performance, even stress response.

Homeostasis in Cellular Energy

The mitochondria break down food and oxygen to produce ATP energy for the body during the cellular respiration process. Healthy light intake is important in cellular energy to stimulate the mitochondria and efficiently produce ATP energy without inflammation and oxidative stress that may disrupt the cellular respiration process. Red and NIR light therapy enhances cellular and mitochondrial function to ensure that the cellular respiration process works efficiently.

Homeostasis in Body Temperature

Our bodies respond to changes in external temperature through sweating and shivering. These internal temperature processes regulate the body to maintain a temperature balance. The normal body temperature is about 98.6 degrees Fahrenheit. When the body is at a normal temperature, it’s easier to perform well. It can also indicate homeostasis and balance in the body, which we naturally try to achieve. On the other hand, experiencing a fever or being exposed to the cold can make it hard to function well for a long time.

Homeostasis and Calcium Levels

The body’s calcium is usually found in the bones and teeth, but the calcium in the blood requires constant maintenance at about 10 mg/dL. Calcium is essential for blood circulation, coagulation, and bone mineralization. When calcium is low, you may suffer from an irregular heartbeat and other health risks. Meanwhile, when calcium is high, the body may feel exhausted and sluggish because of the nervous system's inactivity. Skeletal, endocrine, and digestive systems in the bodywork hand in hand to maintain basic calcium homeostasis and balance.

Imbalance in the Body

The natural and continuous goal of the body in homeostasis, but many factors are at play. When we use our digestive, respiratory systems, and all the other organs, we need the necessary energy to process nutrients from food, oxygen, and light. The bodily systems are interdependent with one another and need each other to maintain balance.

When one system is lacking, the body naturally compensates by getting from another system to maintain balance. An example is a homeostasis in calcium levels in the bloodstream, which relies on food intake. If the diet lacks calcium, the body gets calcium from the bones, which technically regulates the calcium needed in the bloodstream, but eventually, it will make the bones weak and brittle.

The resourcefulness of the body to shift functions is a great deal. Still, in the long run, it may lead to serious health problems, possibly building up deficiencies and difficulties over time. It is imperative to be aware of the body’s balance and how diet, exercise, and light exposure are interconnected.

Healthy Light’s Effects on Biological Balance and Good Health

Light empowers the cells and enhances the cellular respiration process, creating ATP energy more efficiently. Aside from being essential for our life on earth, having enough light intake is an indication of biological balance. In fact, not getting your regular dose of sunlight may result in inflammation, sluggishness, off circadian rhythms, and poor sleeping habits. Most of the time, people don’t get enough light from their environment since they stay indoors and are surrounded by artificial light.

Being indoors is not how bodies are designed. We are programmed to thrive when our cells intake a good amount of healthy light. Not enough sunlight exposure can make the body imbalanced and lead to decreased energy production and Vitamin D.

Red Light Therapy and Homeostasis

You must be intentional in spending time outdoors to ensure that your body gets the amount of healthy light it requires. However, given the circumstances and limitations that we have, most people really do not get enough natural light, which red light therapy can solve.

Red light therapy is a non-invasive treatment that delivers red and NIR light wavelengths to the skin and cells and helps the mitochondria in cells produce enough ATP energy. Red light therapy helps keep the body and cells balanced, giving enough energy and power to the body even if there’s not enough light in the environment.

Final Thoughts

Our bodies function better when we reach biological balance or homeostasis. A balanced cellular environment indicates good health, and getting healthy light is an important variable to biological balance, on top of exercise, diet, and sleep. Red light therapy helps promote homeostasis and improve overall health by supporting a more efficient cellular environment. Red and NIR light wavelengths stimulate the mitochondria, producing more ATP energy that empowers the body.

If you want to read more about red light therapy and its benefits, you may go to our red light therapy blog. On the other hand, if you want to see our red light therapy devices breakdown, please don’t hesitate to browse through our catalog.

References

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OpenStax, Anatomy & Physiology. Rice University. OpenStax CNX. 2016 Feb.

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Transitioning Skincare Routines from Winter to Spring


The right skincare routine is something to be crafted meticulously. Not only is it individual––meaning that what’s best for one person might not work for another––but what’s best for a person in winter may not work for them during spring and summer. 

As we get older, naturally, so does our skin. As we age, our cells age, slowing down the cellular turnover process. With aging skin, there are certain needs to cater to that differ throughout the aging process. Ingredients that are good for mature skin could be too harsh for teenage skin, and vice-versa. 

Finding the right skincare for winter can be a challenge. The air is drier and harsher, making skin more prone to dryness and irritation. Of course, people can do things like sleeping with a humidifier in the room, eating clean, showering in warm water, and staying hydrated; and while these ideas do help to prevent flaky and dehydrated skin, they only work to a certain extent. 

While many stick to a strict winter skincare routine, following the same routine during spring and summer can actually be counterproductive in achieving the results desired. In the winter, most skincare enthusiasts use thicker and heavier products for hydration and protection; however, it’s important to just incorporate lighter products during spring time

Why can’t we use the same products all year round? Spring brings us different temperatures and climate. Humidity goes up, UV increases, and the temperature is warmer. The creams used during winter become too heavy during springtime, and the cleansers and moisturizers that helped skin in wintertime clog can sometimes pores during the spring and summer. However, there is a way to help transition skincare routines from winter to spring, and that’s with light therapy.

What is light therapy? Well, before we dive in, you may be wondering, ‘is light therapy treatment safe?’ Absolutely. It’s a non-invasive, and non-pharmaceutical treatment providing outstanding skincare results. It helps produce ATP, which provides the energy that runs our whole body. Through increased ATP, cellular turnover is improved with long-term light therapy treatments. 

Light therapy can help with the transition in the way that it prepares the skin for the change. It helps reprogram cell turnover, which provides fresher skin and balances out the natural nutrients our skin needs. This can help with getting ready for the transition of seasonal skincare products. 

Within one week, you or your client’s skin sees an improvement in ATP production, thus, reducing complexion, aging, and acne issues. By regenerating new cells, you’re likely witnessing a fresher face, and glowing skin. Naturally, the longer a person commits to light therapy, the better the results – all good things come with time. But light therapy presents a more powerful solution than simply relying on creams and serums, alone. With skincare products, the outer layer of the skin is repaired and the job gets halfway done. 

Getting used to a new skincare routine can take from 5-8 weeks, which is why it’s important to have the skin in the best possible condition in-between transitions. Light therapy helps reduce the chances of the negative effects that can easily occur in changing a skincare routine. Having the option to avoid irritation, acne, and redness comes simply by integrating light therapy into one’s facial routine.

However, irritation is sometimes inevitable, particularly in those with acne-prone or sensitive skin, and this can sometimes lead to hyperpigmentation and acne scars. But, luckily, this irritation and acne scarring can be treated at home with light therapy, as well. 

And, it’s ideal for dermatologists and aestheticians who want a non-invasive and non-pharmaceutical treatment for their clients in the treatment room. In addition, light therapy masks can be customized with multi or single light to suit your client’s needs. Kayian's light therapy devices are MDA-certified and FDA-approved, and created for clinical use. If you’re a dermatologist or aesthetician, you have the freedom of customizing your light therapy device to provide the best results for your clients. With a light therapy device in your office, you’ll give your clients the results they want, and have them coming back for more.

Light Therapy Proves Effective in COVID-19 Treatment Once Again

Even though we’ve been in the pandemic for over a year now, we are still collecting knowledge on the disease. No one could’ve prepared us for the impact of this virus, and COVID-19 has changed our lives forever. 

It is a disease caused by the coronavirus, and the symptoms are similar, but people react differently. It isn’t a virus that gives the same outcome, which is why we have to be so cautious with it. Most common symptoms include fever and dry cough, and extreme fatigue. Apart from those, the other major symptoms are a loss of smell and taste, joint pain, diarrhea, conjunctivitis, and headaches.

Scientists and doctors have learned that respiratory problems are the biggest issue while having the disease. The downfall of our immune system during COVID-19 is what gives a chance for pneumonia to develop. Apart from those symptoms and the dangers of getting pneumonia, there’s also potential long-term effects. 

So far, only one peer-reviewed study has reported results on the long-term symptoms of COVID-19 infection: a single group of 143 survivors from Rome. Most of them did not need hospitalization and were assessed at least 60 days after infection. They reported a worsened quality of life in 44.1% of cases, including symptoms of persistent fatigue (53.1%), breathlessness (43.4%), joint pain (27.3%), and chest pain (21.7%).

Treatment has evolved within this short period, and now with the vaccine in power, it poses a question: is it the only solution? It's still necessary to nourish our immune system no matter what; intake of vitamins and supplements is still highly advised. But naturally, aside from the vaccine, you would want a non-invasive alternative as well, which is where light therapy comes into play.

Red light therapy is a non-invasive and non-pharmaceutical method of treatment. It works with light that emits at a close, safe distance, penetrating into the cells. Once it reaches cell level, it helps reproduce ATP, which gives a higher and better cell turnout. 

Our cells rejuvenate and reproduce themselves; light therapy only aids in this natural process. With light therapy, we get a better and higher count of cells that are genetically improved over time with treatment. 

The ways in which light therapy can help with COVID-19 have been studied for a while now, and we shared some information on early clinical trials with you previously. 

Light therapy can help with COVID-19 in reducing severity and prominence of symptoms; it works so that light therapy generates the activation of mitochondrial antiviral signaling protein (MAVS), thus resulting in the reduced expression of viral spike protein and restores the proliferation of infected cells.

Your cells are healing your body by using light therapy––similar to how UV light therapy aids wound healing––and it is there to provide you with more vital cells for your system. A significant reduction of viral infection in the trachea was noticed, the spots where we notice symptoms first, such as our nose and our throats. This means that light therapy helps regulate and decrease the possibility of getting a respiratory disease like pneumonia. 

A significantly smaller level of C-reactive protein was observed within seven days of UVA therapy regarding biochemical parameters. It proves that light therapy helps with the deconstruction of damaging proteins in our cells. 

Photo-disinfection is used to get rid of harmful bacteria from surgical patients; this is only another form of that. There's also a method where a non-toxic dye is inserted into the nose. It is one that is triggered by light, and then it is measured whether or not the light therapy device has successfully inactivated the virus. This method is used in the early stages of COVID-19.

The one used in the beforehand mentioned study included a light therapy device equipped with a multi-LED UVA light catheter connected to the nasal tube to deliver UVA light to the patients. Our devices are created with multi-LED, so the type of light therapy is your choice, depending on your needs.

The UVA therapy was administered for 20 minutes to all patients once daily for 5 consecutive days. Before the treatment, all patients received oxygen supplementation for 30 minutes. The regimen varies however light therapy should be done consecutively and 10 to 15 minutes.

The coronavirus is still here, but you’re not defenseless. Kaiyan Medical works to develop the best high-quality light therapy devices, with FDA-approved and MDA-certified light therapy devices perfect for at-home treatments. Whether you’re looking to bolster your immune system or wish to provide non-invasive treatment to patients with COVID-19, light therapy is an incredibly powerful and effective tool in fighting the serious symptoms of this virus.

Product Spotlight: Aduro Mask


When trying out new forms of non-invasive treatments such as light therapy, it’s extremely important that you find something that satisfies your own needs. Finding a product that suits you isn’t always as easy, which is why many of us conduct our own due diligence before trying something new. 

Light therapy has been around for decades, but is making a serious comeback as its effectiveness and results become more widely known. The best part is it’s not only beneficial for gaining a youthful glow, but overall health as well. So if you’re interested in incorporating a mask into your practice, it’s time you checked out the Aduro Mask (and guess what – with Kaiyan, you can create a private-labeled, premium light therapy facial mask of your own, too)! 

“Although I have only used it a few times, I can state that as LED goes, this one is amazing. I am not new to LED, so I speak from experience when I say - WOW. It is comfortable and has a nice weight. But most importantly, it leaves your skin glowing and smooth. Cannot wait to see even more results the longer I use it.” - Mary F.

Our LED face mask is a light therapy device that uses different wavelengths to create 11 different treatments for many types of skin problems. It took inspiration from NASAs light therapy devices. It has 7 different LED light options, and when the selected light color penetrates the skin, photon energy is transferred to the cells. This is the basic principle of all light therapy devices. 

When the light penetrates the skin, cells convert this energy into ATP (our energy source) – stimulating cellular activity and reproduction. The boosted cells improve their rate and stimulate the body’s natural rejuvenation. This leads to an increase in collagen production and the body’s natural rejuvenation processes – resulting in youthful skin and an overall improvement in your skin’s complexion. The Aduro LED light therapy is mainly for skin rejuvenation and improving skin conditions, depending on the type of light used during treatment.

“I was excited first off that it shipped so quickly!! Packaged great, instructions were easy to read. I love the device. So many features. I can really tell a difference in my complexion after just a few days. The texture of my face and the fine lines. Definitely worth it. This was a birthday gift to myself… Thank you for a great product!!!” - Judy R.

For example, to treat the epidermis—the outer layer of the skin—red or infrared light is used. When applied to the epidermis, it absorbs light and stimulates collagen production. The skin, therefore, has more collagen, appears smoother and fuller, which can reduce the appearance of fine lines and wrinkles. 

Whereas blue LED light therapy focuses on the sebaceous glands. These are necessary to lubricate the skin and hair, but they can also become hyperactive and lead to oily skin and acne.

The blue light under the skin also destroys the bacteria that cause acne, which can help in the treatment of severe acne, including cysts and sebaceous nodules. Blue light is often used in combination with red LED light to heal acne, reduce scars and increase anti-inflammatory effects. 

And this is just an example of the power of light therapy. Our LED facial masks offer seven different forms of light that all have their own unique healing components. 

The treatments available with our LED face mask range from anti-aging to pain blockers. The mask can:

  • Increases hydration from the inside out
  • Help to even out skin pigmentation and redness
  • Even skin tone and clear complexion
  • Reduce acne
  • Revitalize and brighten the skin
  • Reduce eczema and rosacea for sensitive skin

The treatments are calming and purifying for all skin types. With our face mask, there are also options of treatments for skin above the age of 40 and a specific treatment for cell rejuvenation. Depending on your needs, you get to customize the light you want to include in your therapy treatment.  

I’m over 40 & just moved to the Caribbean. Hoping that this will help with my aging & help with the sun exposure. Just started the 20 minute session 3 days ago & it truly feels like it’s working some magic! The mask is very comfortable & overall I can tell it’s extremely well made. Very happy with my purchase & will update with my results in a few months!  - Sarah D.

In addition to cosmetic purposes, the LED mask cycles through all light wavelengths, known as the overall wellness setting, can help with Seasonal Affective Disorder ‘SAD’. 

Kaiyan Medical manufactures MDA-certified and FDA-approved laser light therapy devices that can be customized to exactly what your customer’s needs are. However, one thing’s for sure, customers are raving about the Aduro mask and can’t get enough of it.

“I’ve been using LED masks for several years. This is the third type of mask I’ve used. The results have been excellent. Better than any mask I’ve used in the past. My only problem was that my skin was sticking to the plastic during treatments which made it slightly uncomfortable. Using a hydrating mask during the treatment helped. I love the mobility it gives me. I’ve done five full treatments before recharging the battery. You may be able to get more I didn’t try. I’ve only had the mask a couple of weeks but at present I find it amazing.” -Rhoda K.


Retinol and Light Therapy: Skincare Dream Team

You’ve probably heard of retinol. It’s been in the skincare industry for years and it provides amazing results for non-invasive treatment. It helps with wrinkles, aging, hyperpigmentation, and in general can produce flawless-looking skin.

A derivative of vitamin A, Retinol helps cellular turnover, making it powerful enough to significantly improve skin texture, pigmentation, and tone. Through cellular turnover, it combats sun damage and skin loosening for its collagen properties. 

Not to mention, you only need a couple of drops. Studies have shown that the use of an over-the-counter product with 0.1% retinol (referred to as regular and prolonged use) brings significant improvement with wrinkles, collagen production, blood flow, and sunspots, with results visible after one month. 

Once applied, the retinol is absorbed, broken down, and transformed into retinoic acid. This compound affects cellular structure (stimulates cell renewal and collagen production). 

The conversion process, however, does not occur immediately upon use—it’s not magic. Several applications may be required before it’s transformed into retinoic acid. But for faster and more immediate results, you can incorporate light therapy into your skincare regime. 

Though light therapy on its own is powerful, when paired with retinol, the two are a perfect combination for flawless skin.

On its own, light therapy proves to be highly effective for treating texture, scars, acne, and overall skin rejuvenation. However, light therapy also deals with more severe skin issues such as eczema and vitiligo. So, why is it so effective?

The specific wavelengths of red light create a biochemical effect in our cells that serves to increase mitochondrial function. This improves the production of ATP (adenosine triphosphate) in the body.

We care about ATP because it's the source of energy for every cell in the body. Without it, we don't work at all. Without enough, we don't perform well.

The wavelengths vary between 630-880 nm and are used to treat the skin’s surface. The red therapy light penetrates the skin approximately 8-10 millimeters. Depending on which area of ​​the body the red light is used for, it can easily affect all layers of the skin, reaching the blood vessels, lymphatics, nerves, and hair follicles.

When red light therapy and retinol are paired together, they quicken cellular turnover and replacement. Initially, retinol and LED light therapy were considered inadvisable. But scientists have now discovered that retinol products paired with light therapy are advantageous—if done properly.

How to prepare for LED light therapy

When it comes to using retinol and LED light therapy, you want to make sure you do it properly. Naturally, aside from using light therapy and retinol, you should focus on eating clean, staying hydrated, getting adequate sleep, and reduce your exposure to sunlight. Now that we have that out of the way, here’s what you need to do.

  1. Cleanse your face thoroughly and pat it dry
  2. Use LED Light therapy mask for 10-15 minutes
  3. Apply your preferred retinol product
  4. Apply SPF

As mentioned before, it’s best to do this at night, not to let sunlight interfere with the efficiency of the process. 

Though there are many ways to treat our skin, ideally, you want a treatment that’s the least invasive and the most effective. Kaiyan's red light therapy devices are designed to treat a variety of skin conditions, helping you stay youthful. Our devices are MDA-certified and FDA-approved, ensuring that your treatment will be safe for your skin while providing you the best results.

Red light Therapy and Hyperpigmentation

Skin conditions can majorly affect a person’s self-esteem. One of the most common issues: hyperpigmentation. We've all heard the term before, but what is it, exactly? 

Hyperpigmentation causes dark spots on the face, hands, and other visible parts of the body that have been exposed to the sun's rays. Not only can it cause insecurities, but it can be very difficult to hide as these spots form in different shapes and sizes, with colors ranging from light brown to black.

There are many types of hyperpigmentation, but the following are the most common:

Pigmentation spots are age spots that occur as a result of exposure to sunlight. This is why they mostly appear in parts of the body that are usually exposed, such as the face, hands and arms. These are usually small, darkened areas of skin.

Melasma or chloasma is often called a "pregnancy mask" because it affects 90% of pregnant women. It occurs as a consequence of hormonal influences during pregnancy and contraception. It causes dark spots of irregular shapes on the face or hands, which can be large in size.

Gradual hyperpigmentation occurs when a flat area of ​​discoloration remains after the skin injury has healed. It is a common occurrence among people who suffer from acne, and it can also be caused by cosmetic treatments such as dermabrasion, laser treatment, and chemical peels.

There are other factors that can darken parts of the skin - such as moles, scars, scars, sun or actinic keratosis, and skin cancer - but they’re not considered forms of hyperpigmentation. 

So, how does hyperpigmentation occur? It develops due to excessive production of melanin—a pigment that gives natural color to our skin, hair, and eyes—on certain parts of the skin. Many factors cause this overproduction, but the main ones can be related to sun exposure, genetic factors, age, hormonal influences, and injuries or inflammation of the skin. It can also be a symptom of certain diseases as well. 

Naturally, limiting the time you spend in the sun, wearing protective clothing, and using sunscreen with a high protection factor, both UVA and UVB, can help reduce the risk of hyperpigmentation and prevent worsening of existing dark spots.

Battling hyperpigmentation is possible in many ways, but red light therapy has proven to be the most effective form of treatment. It’s no secret that most of us lack vitamin D, at least in the Northern Hemisphere, yet light therapy has done wonders in vitamin D production. But red light therapy has shown to be helpful in even more ways than you could imagine. 

Red light therapy works by stimulating cells through red light. Mitochondria in the skin cells can absorb the light particles which emit through the red light, and this can help them produce more adenosine triphosphate (ATP), which is the energy source for all cells. By improving cellular energy, cells repair themselves quickly, returning the skin back to normal pigmentation levels. 

In turn, collagen levels increase, working to reduce other skin conditions, including rosacea. Elastin levels also increase, which helps fight against aging, giving the skin a lift and youthful glow. 

Though there are many ways to treat hyperpigmentation, ideally, you want a treatment that’s the least invasive and the most effective. Luna’s red light therapy devices are designed to treat a variety of skin conditions, including hyperpigmentation. Our devices are MDA-certified and FDA-approved, ensuring that your treatment will be safe for your skin while providing you the best results. 

Light Therapy: Detection and Treatment of Bovine Mastitis

Mastitis

“Mastitis” is one of the major challenges for the dairy industry worldwide, as this is the most common and costliest disease of dairy animals and contributes a substantial economic loss to dairy farmers. The subclinical stage of mastitis, i.e., Sub-clinical mastitis (SCM) in the dairy cow, is a matter of great concern for farmers as its incidence is more than clinical. In most animal farms, monitoring of sub-clinical and clinical mastitis (CM) is usually performed through an indirect test such as pH, electrical conductivity, somatic cell count (SCC), California mastitis test (CMT), culture test, and biomarker tests.

Apart from these, there is a need for new rapid and sensitive technology to identify udder infections at early stages. Early detection of mastitis using non-invasive technology needs the hour to reduce the dairy industry's economic loss and farmers. Skin surface temperature is a critical indicator of an organism's bio-physiological health status due to infection-induced inflammatory reactions, local blood circulation, metabolism, and skin surface temperature increases. Thus, monitoring the emitted heat from the udder can help in the early detection of mastitis. Moreover, Infrared thermography (IRT) using the susceptible thermal camera can monitor subtle skin surface temperature changes. IRT with the mobile-based application can further play an important role in managing dairy farms on various aspects.

IRT Imaging

SirWilliamHerschel,aBritishastronomer, in the year 1800, discovered Infrared radiation (IR) in sunlight. IR is electromagnetic radiation whose wavelength ranges from 700 nm (frequency 430 THz) to 1mm (300GHz). IR thermography works on principle proportional to their temperature, all objects using conduction, convection, and radiation, following Stefan-Boltzmann law, emits infrared radiation. Thus, Infrared thermography (IRT) can detect body surface temperature changes due to subtle blood flow changes.

Udder Health Status

Good udder health is one of the important conditions for clean milk production. The adequate steps help in the reduction of udder infections to contribute to clean milk production. Therefore, researchers are trying to monitor the milking process using IRT. Moreover, the udder thermogram can assess the milking hygiene, as the udder surface's cleanliness influences the measurement results, mostly surface temperature. The major concern of udder health is related to the occurrence of subclinical and clinical mastitis. Mastitis is the inflammation of the mammary gland causing physiological, biochemical, and pathological changes in udder parenchyma, result in alteration of milk quality.

Subclinical and Clinical Mastitis

IRT technology can detect clinical and subclinical mastitis. Subclinical mastitis is the major concern as it leads to more economic losses to the dairy farmers. In many cases, the cow's milk productivity and milk quality may reduce permanently. Early detection of sub-clinical mastitis can help diagnose and causative agents and help implement economic loss. The sensitivity and specificity technique used to detect subclinical mastitis using IRT is similar to that of the California mastitis test. An increase in temperature of more than 1oC was an indicator of mastitis and recommended IRT as a complementary tool in the early diagnosis of subclinical mastitis in Holstein and Brown Swiss cows.

Fig 1: Infrared thermogram of udder quarters for the normal and healthy quarter from a lateral view. RFQ: Right front quarter, RHQ: Right hind quarter LFQ: Left front quarter, LHQ: Left hindquarter.

Change in udder surface temperature and its measurement using Infrared thermography (IRT) in sub-clinical and clinical mastitis vary from the healthy quarter. Various researchers documented a wide range of differences. Therefore IRT can be used as a promising tool for the assessment of udder health. But, contradictory results are available in sub-clinical mastitis detection using RT, whereas mastitis can be detected efficiently using IRT.

Use of Light Therapy in the Treatment of Bovine Subclinical Mastitis

Methods: Forty cows with subclinical mastitis (n = 40) were divided into 4 groups (control, photodynamic therapy — PDT, light irradiation — LED, and photosensitizer — PS). The control group received no treatment. The PDT group received an application of 1.0 mL of 2.5% toluidine blue photosensitizer followed by LED irradiation at λ = 635 nm. The LED group was treated with LED irradiation alone, and the PS group received only 2.5% toluidine blue dye. LED irradiation was applied to the mammary gland utilizing an acrylic light guide coupled to the LED equipment. The PDT and LED groups were irradiated with 200 J/cm2 at three different positions inside the mammary gland. Milk samples were collected at 0 h, 12 h, 24 h after treatment for microbial identification and total bacterial count.

Results: The treatment of the PDT group showed a significant difference p < 0.05, characterizing this technique's efficiency with the reduction of the microorganisms Streptococcus dysgalactiae and coagulase-negative Staphylococcus.

Conclusion: Photodynamic therapy was effective when applied in vivo for subclinical bovine mastitis. There was no need to separate the animal from production.

Final Thoughts

Mastitis is one of the major concerns of the dairy industry, which leads to huge economic loss. In addition to established laboratory methods available for its diagnosis, there is a need to address in the light of early mastitis detection by some susceptible non-invasive techniques as well. Infrared thermography(IRT)using the susceptible thermal camera can be used as a non-invasive technique. Due to udder physiological changes during subclinical and clinical mastitis, IRT can measure the subtle change in udder temperature. Thus, infrared thermography may be a suitable tool for detecting mastic animals' early detection and dairy cattle screening. As there are some limitations adhered with IRT such as sunlight, moisture, dirt, weather conditions, etc. may influence the IRT's accuracy level, there is a need to explore IRT for diagnostic purposes subclinical and clinical mastitis under Indian climatic conditions.

References

Sinha, Ranjana. (2018). Infrared thermography as noninvasive technique for early detection of mastitis in dairy animals. 37. 10.18805/ajdfr.R-1746.

Moreira LH, de Souza JCP, de Lima CJ, Salgado MAC, Fernandes AB, Andreani DIK, Villaverde AB, Zângaro RA. Use of photodynamic therapy in the treatment of bovine subclinical mastitis. Photodiagnosis Photodyn Ther. 2018 Mar;21:246-251. doi: 10.1016/j.pdpdt.2017.12.009. Epub 2017 Dec 16. PMID: 29258951.

Ahmad, T., Bilal, M.Q., Ullah, S. and Muhammad, G. (2005). Effect of severity of mastitis on pH and specific gravity of buffalo milk.Pak J Agri Sci., 42: 3-4.

Alejandro, M., Romero, G., Sabater, J.M. and Diaz, J.R. (2014). Infrared thermography as a tool to determine teat tissue changes causedby machine milking in Murciano Granadina goats. Livest. Sci., 160: 178-185.

Annual Report, 2016-17, Department of Animal Husbandry Dairying and Fisheries, Ministry of Agriculture and Farmers welfare,Government of India, pp 61.

Bangar, Y.C., Singh B, Dohare, A.K. and Verma, M.R. (2015). A systematic review and meta-analysis of prevalence of subclinicalmastitis in dairy cows in India. Trop Anim Health Prod., 47: 291–297.


The Perfect Pair: Light Therapy & PRP

Platelet-Rich Plasma (PRP) Injections

In recent years, doctors have learned that the body has the ability to heal itself. Platelet-rich plasma therapy is a form of regenerative medicine that can harness those abilities and amplify the natural growth factors your body uses to heal tissue.

What is Plasma, and what are Platelets?

Plasma is the liquid portion of whole blood. It is composed largely of water and proteins, and it provides a medium for red blood cells, white blood cells, and platelets to circulate through the body. Platelets, also called thrombocytes, are blood cells that cause blood clots and other necessary growth healing functions. Platelet activation plays a key role in the body’s natural healing process.

What is Platelet-Rich Plasma (PRP), and what are PRP injections?

Platelet-rich plasma (PRP) therapy uses injections of a concentration of a patient’s own platelets to accelerate the healing of injured tendons, ligaments, muscles, and joints. In this way, PRP injections use each patient’s own healing system to improve musculoskeletal problems.

PRP injections are prepared by taking anywhere from one to a few tubes of your own blood and running it through a centrifuge to concentrate the platelets. These activated platelets are then injected directly into your injured or diseased body tissue. This releases growth factors that stimulate and increase the number of reparative cells your body produces.

Ultrasound imaging is sometimes used to guide the injection. The photographs below illustrate a PRP injection into a patient’s torn tendon. The ultrasound guidance is shown at the left, and the injection is shown at the right.

PRP harnesses the body’s own rejuvenating powers to stimulate hair growth naturally. The treatment involves drawing a small amount of blood from the patient’s arm. This blood is then spun in a centrifuge until the plasma is separated and growth factors and stem cells are extracted. This plasma, complete with growth factors and stem cells, is then injected into the patient’s scalp, stimulating hair growth.

Light Therapy

Red Light/Blue Light therapy uses light energy to stimulate hair growth. Red light/Blue Light therapy works using light delivered at specific therapeutic wavelengths within infrared and red-light spectrums. The energy from these lights stimulates the hair follicles so that they are constantly in the growth, or anagen, stage. This results in thicker, longer, and healthier hair.

Red light (630 nm) therapy stimulates ATP (cellular energy) production to stimulate hair follicle cells. It also increases blood flow to the hair root, which delivers more nutrients to the hair follicle cells. The increased blood flow is also thought to help flush away the damaging waste products that may affect hair growth.

Near-Infrared light (880 nm) therapy, which is an invisible light energy, promotes collagen and elastin production. It penetrates deeper into the scalp to help reduce inflammation, which causes thinning of hair.

Blue light (420 nm) therapy is especially effective for acne, penetrating molecules within the skin that cause P. acnes bacteria to form. These molecules react

Private Label Your Dream Light Therapy Product with Kaiyan

Whether you’re a dermatologist, physical therapist, fitness enthusiast or just someone considering integrating light therapy into their practice, you’ve likely heard about the multitude of benefits that these non-invasive yet powerful devices offer. As light therapy continues to gain popularity, more professionals are looking for light therapy devices to level up. 

Naturally, you can purchase professional devices from light therapy companies, but you can also develop a light therapy device that can be customized to fit your individual client’s needs. This is where we, Kaiyan Medical, come in to help guide you through the process of producing your very own private label light therapy products at our state-of-the-art manufacturing facility. 

If you’re interested in creating your own light therapy products, it’s crucial you understand the development process.

The Steps of Private Label Product Development

We want our clients to comprehend the creative and manufacturing process of developing private label light therapy devices. As this is your idea we’re bringing to life, you need to be included every step of the way. Here’s our step-by-step process:

Step 1: Feasibility Study

It’s easy to lose money by investing in a product without understanding user needs. If you don’t know your target audience, you’ll struggle to create a viable product. During the feasibility step, we determine the practicality of your project and examine its strengths and weaknesses. This helps to ensure the idea you want to bring to life is viable and effective in achieving its goal. 

Step 2: Industrial Design

With our advanced conceptual design team, we determine how we can best engage with your target audience. While we focus on design, we also make sure your device fits under the required safety and health regulations. Our in-house design process creates visually appealing, high-quality, and functional concepts for manufacturing and product planning. 

Step 3: Electrical Engineering

Our in-house team has vast experience in lasers, sourcing, prototyping, and LEDs to incorporate these components and masterfully develop your product. Our electrical engineers, who are in charge of this step, take your idea and bring it to life while ensuring high-quality performance. 

Step 4: Rapid Prototyping

Rapid prototyping is essential for our projects and allows the client to see and feel their idea in the palm of their hands. In addition, it also helps clients test products with their users and receive constructive feedback. Our rapid prototyping is completed in-house as we have the capacity to create a range of samples varying from simple to complex, multi-piece models. 

Step 5: Mass Production

After your idea is turned into a tangible product and has been tested, we then plan production with in-house, pre-pilot quantities. By doing so, we’re able to identify production areas that need to be fine-tuned while ensuring high-quality and performance standards. Once these steps are completed, your product will be ready for shipment. Through our vast experience and stellar team, we can ensure a smooth manufacturing process and will guide you each step along the way, from start to finish. 

So, Who do we Work with?

We’ve been creating MDA-certified and FDA-approved light therapy devices for years. That said, we’ve successfully worked with various brands in different industries, taking their ideas and bringing them to life. Here are some of the brands and products we’ve developed.

DemarkQ

DenmarkQ offers skin care devices that use red and blue light LED to target acne and scarring. The LED light uses the body's natural healing process to improve its overall wellbeing. 

Aduro Mask
Established in 2006, Aduro Skincare specializes in LED beauty-related products under a medical license. The product is internationally renowned and clinically proven as an effective, non-invasive therapeutic skin care treatment.

Perfect Countour

Perfect Contour is our line of permanent make-up machines. Our permanent make-up machines were designed for clinical use; however, we feel permanent make-up is more of an art form than a medical procedure through our experience.

Golden Eagles

Teeth whitening has been around for ages, and we've mastered the art of developing effective teeth whitening devices. We currently have over 20 different OEM models for professional whitening and devices for at-home whitening. 

Akstra

Akstra's brand focuses on hair regrowth and hair rejuvenation and offers products ranging from home-use to professional-use models. Since Asktra's first line of hair lasers was made for clinical environments, we opted for a sleek and clean design. 

Lumiceuticals

Lumiceuticals is a brand focusing on using LED technology for pain relief. We combined LED technology with neoprene material for practical treatment pads. The pads are secured by Velcro straps, making them easy-to-use for customers. 

If you’re considering developing private label light therapy devices, at Kaiyan Medical, we create MDA-certified and FDA-approved light therapy devices, ensuring you medical-grade, high-quality devices for your business. We are eager to work with like-minded partners in developing truly effective, safe, and valuable products that tap into the power of light therapy. 

We look forward to working with you!


FDA Pre-Submission (Q-Sub) and Medical Device Companies

There is always uncertainty baked into any government submission process, and it’s helpful to companies if there is a way to tackle issues before submitting a 510(k).

The FDA Pre-Submission is a way for companies to request feedback from the agency on potential and planned medical device, biologics, and drug submissions. It’s a great service to take advantage of, only we’ve found that it tends to get underutilized.

What is the Pre-submission?

The Pre-Submission allows you to request formal feedback on your medical device before you make a move to submit your 510(k). This is known as a Q-Submission, which under the guidance published by FDA, allows you to request the following:

  • Pre-Submission (what we’re focusing on here)
  • An informal meeting
  • An agreement meeting
  • Other (such as submission issues or study risk determinations)

The Pre-Submission process was born out of a need to provide expanded access to the FDA and allow companies to get valuable feedback ahead of time. This can help keep your company on track for getting your device to market as soon as possible — it helps to be aware of possible issues ahead of time and deal with them before final submission.

The guidance for Pre-Submission is clearly laid out in the FDA document Requests for Feedback on Medical Device Submissions. If you happen to have a combination product (such as a stent that administers a drug or an inhaler), there may be other, similar processes you need to go through. The document to check out, in that case, is Guidance for Industry.

In any case, the basic definition of what a Pre-Submission is remains the same. It is a formal written request from an applicant/sponsor for feedback from the FDA to be provided in a formal written response, meeting, or teleconference. The feedback is documented in meeting minutes.

It’s a great way to meet with the FDA, ask them some questions, then document that information for future use. It boils down to identifying key issues that keep you up at night and making your overall submission process easier.

The FDA continues to expand its Pre-Submission program to include several different medical device submissions that a manufacturer may choose to bring a device to market. The comprehensive list of submission types is known collectively as Q-Submissions(Q-Subs), which include:

E, De Novo request, 510(k), Dual, BLA, IND), Accessory Classification Request, or CW.

  • Investigational device exemptions (IDE)
  • Premarket approvals (PMA)
  • Premarket notifications (510(k))
  • Dual
  • HDE — Humanitarian Device Exemption
  • De novo requests
  • Clinical Laboratory Improvement Amendments (CLIA)
  • Certain Investigational New Drug Applications (IND) and Biologic License Applications (BLAs)
Benefits of the Pre-submissions

Should I really use a Pre-Submission? This is a key question that companies often ask, so it’s important to understand the relative pros and cons. Here are some of the pros:

  • You develop a “human” relationship with the FDA. They are, after all, humans themselves and want to know who you are.
  • You can remove some of the risk elements from your submission. You get asked about things you don’t know and confirm things that you think you do know.
  • You can get “free advice” to help drive your development and regulatory strategy.
  • Sometimes the FDA will request a review of Pre-Submission materials, giving you a “bonus round” ahead of your 510(k) submission. This is a great opportunity to gain valuable feedback.

One thing to note is that you’re not getting a final acceptance at this stage; the FDA will never give you this until the actual submission. However, it’s well worth getting the early heads-up.

Cons of the Pre-submission

There’s always a money and time aspect. You’re looking at $5,000 to $25,000 to have a consultant help you with a Pre-Submission. If all timelines are met, the typical process takes 60–75 days.

A con that is frequently raised is, “What if they tell us no and say we have to do X, Y, and Z instead of what we’re already doing?”

Our answer to this will always be the same: Isn’t it better to know about this now rather than go ahead with your 510(k) submission and find out then? The FDA will pick out that same issue regardless, so it’s a much better use of your time to find out about it during a Pre-Submission.

Perhaps these cons are a big part of the reason that the Pre-Submission is underutilized, but I would strongly suggest that you don’t let them put you off using it. The FDA actively encourages medical device manufacturers to use the Pre-Submission because doing so helps the final submission's overall quality.

Conclusions

A Pre-Submission program is a valuable tool that tends to be underutilized. Perhaps companies are put off by the idea that the process will take too much time and money, or they’re worried that the FDA will tell them they need to do something they hadn’t already planned on doing. In Kaiyan Medical, we make sure our devices are FDA cleared and we constantly communicate with the FDA. Like many other medical device companies, you may find it’s well worth the time and money.

Removing the Double Chin with Light Therapy

Your face is the first thing people notice about you, and it stares back at you every time you see a mirror. If you aren’t friends with your image in the mirror because of a double chin, it can be an annoying reminder of the aging process at best and hurtful to your self-esteem at worst.

You don’t have to have plastic surgery to see results that rid you of a double chin. Advances in technology and some simple exercises can help you see the return of your younger jawline.

Youthful skin has an abundance of collagen and elastin to keep the skin smooth, firm, and plump. But, in your 20’s, collagen decreases, elastin breaks down, and cells don’t turn over. By age 30, your skin loses half its collagen. Once collagen breaks down, the skin loses firmness and elasticity, resulting in wrinkles, crow’s feet, loss of firmness, and dullness. At the same time, the layer of skin beneath the dermis begins to thin.

The body is always looking for new places to put fat cells, and one area it particularly likes is the top part of the front of your neck, right underneath your jaw. The technical name for this is ‘submental fat.’ If too much fat gets stored in this area and the skin isn’t taut enough to hold that canopy up in the battle with gravity, you can look in the mirror and find that it looks like you’ve grown a second chin. This can even continue developing into a triple or quadruple chin. The two factors you need to be aware of as you read on are fat levels and skin tautness.

What About the Creams?

In a word? No. Why don’t double-chin creams work? Because they’re not removing the bulk of the fat cells that are creating the double chin, nor are they tightening up the sagging skin, letting that double chin flop forward. Perhaps, if a double-chin cream is one that contains active ingredients such as high-strength vitamin C and retinol or another retinoid, it may be strengthening the skin. Still, this effect won’t be strong enough to rein in an existing double chin.

Then, What to Do?

Low levels of infrared light waves applied to the chin's skin can achieve excellent results and help you lose a double chin. Applying heat to the deeper layers of the skin while keeping the upper layers cool appears to trigger the skin’s ability to renew the collagen beneath the skin's surface layers.

Changes in skin thickness, elasticity, and tightness were visible changes that patients noticed when their double chin was treated with infrared light. These near-infrared devices are handheld systems that a dermatologist or physician can apply in an outpatient procedure with no pain.

The Jaw and Double Chin Kaiyan LED Therapy Slimming Device safely brighten, rejuvenates, shapes, and repairs your chin and jaw areas using red and blue LED light therapy, plus vibration. You just need 10min session, 2 times per day and you will see the results in weeks.

What Are the Different Types of Clinical Research?

Different types of clinical research are used depending on what the researchers are studying. Below are descriptions of some different kinds of clinical research.

Treatment Research generally involves an intervention such as medication, psychotherapy, new devices, or new approaches to surgery or radiation therapy.

Prevention Research looks for better ways to prevent disorders from developing or returning. Different kinds of prevention research may study medicines, vitamins, vaccines, minerals, or lifestyle changes.

Diagnostic Research refers to the practice of looking for better ways to identify a particular disorder or condition.

Screening Research aims to find the best ways to detect certain disorders or health conditions.

Quality of Life Research explores ways to improve comfort and the quality of life for individuals with a chronic illness.

Genetic studies aim to improve disorders' prediction by identifying and understanding how genes and illnesses may be related. Research in this area may explore how a person’s genes make him or her more or less likely to develop a disorder. This may lead to the development of tailor-made treatments based on a patient’s genetic make-up.

Epidemiological Studies seek to identify the patterns, causes, and control of disorders in groups of people.

An important note: some clinical research is “outpatient,” meaning that participants do not stay overnight at the hospital. Some are “impatient,” meaning that participants will need to stay for at least one night in the hospital or research center. Be sure to ask the researchers what their study requires.

Phases of Clinical Trials: When Clinical Research is Used to Evaluate Medications and Devices
Clinical trials are a kind of clinical research designed to evaluate and test new interventions such as psychotherapy or medications. Clinical trials are often conducted in four phases. The trials at each phase have a different purpose and help scientists answer different questions.

  • Phase I trials
    Researchers test an experimental drug or treatment in a small group of people for the first time. The researchers evaluate the treatment’s safety, determine a safe dosage range, and identify side effects.
  • Phase II trials
    The experimental drug or treatment is given to a larger group of people to see if it is effective and further evaluate its safety.
  • Phase III trials
    The experimental study drug or treatment is given to large groups of people. Researchers confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information to allow the experimental drug or treatment to be used safely.
  • Phase IV trials
    Post-marketing studies, which are conducted after a treatment is approved for use by the FDA, provide additional information, including the treatment or drug’s risks, benefits, and best use.

Examples of Other Kinds of Clinical Research
Many people believe that all clinical research involves testing new medications or devices. This is not true, however. Some studies do not involve testing medications, and a person’s regular medications may not need to be changed. Healthy volunteers are also needed so that researchers can compare their results to the results of people with the illness being studied. Some examples of other kinds of research include the following:

  • A long-term study that involves psychological tests or brain scans
  • A genetic study that involves blood tests but no changes in medication
  • A family history study involves talking to family members to learn about people’s medical needs and history.

Advantages of Medical Device Manufacturing in China Post Covid-19

China’s overall economic recovery in part has been attributed to the strong rebound in the manufacturing sector. The medical device manufacturing sector specifically recorded an astounding 46.4% growth.

High-Quality Human Resources

Despite living in the age of automation, labor remains one of the higher costs of manufacturing. Manufacturing companies in the west have to deal with worker’s unions, paying high wages, and inflexible staffing that cannot readily scale and resize as fluctuating production output needs may require. On the other hand, achieving this flexibility level is easier for Chinese manufacturers due to China’s readily available, efficient workforce. This used to be the primary reason for companies to outsource their manufacturing activities in China.

Manufacturing in China can significantly bring down overall production costs, and a large part of those savings is due to Chinese labor efficiency. Chinese facilities have been optimizing manufacturing costs for decades and have largely achieved very efficient workforce operations. Depending on the labor intensity of product manufacturing activities, a Chinese facility can offer an excellent number of parts produced per work hour spent.

Low Raw Materials Cost

Another most important manufacturing cost is raw materials cost, for which China also provides a cost-effective option, for two main reasons. Firstly, the same labor efficiency condition exists throughout the entire raw materials production value chain. So Chinese manufacturing companies can themselves access cost-efficient raw materials than most companies based in other countries. Secondly, the transfer of materials is cheap since it only happens from close sources and within China. This results in avoiding long shipping routes, additional customs tariffs, and long delivery waiting times. When manufacturers in all industries are trying to cut expenses and maximize profits to remain competitive, access to affordable raw materials can help bring down manufacturing costs to a considerable extent.

Most Chinese manufacturing facilities will typically have low cost local (or close) material suppliers. This way, they gain a significant cost advantage that further contributes to their cost-effectiveness.

Strategic Location

Companies worldwide are nowadays targeting the growing Asian markets, so much so that the phrase “expand to Asia” has become somewhat of a cliché business term. China is the largest of those markets, with its consumer market surpassing $6 trillion in value. Moreover, it also benefits from its proximity to several large and growing markets, such as India and South Korea. In terms of regulatory compliance, medical devices of Chinese manufacturing have no issues in being accepted in both the country’s domestic and other Asian markets. So outsourcing medical device production to China gives manufacturers access to its rapidly growing domestic market, as well as immediate access to its developing neighboring markets.

Evolving Supply Chain Network

In times of market, instability is when a supply chain is a huge determining factor for a manufacturer’s chance for survival. Chinese materials suppliers have been rapidly evolving, following the country's growing trend of becoming an international manufacturing hub. This has made it easier for medical device contract manufacturers to identify and establish a trustworthy network of reliable local suppliers.
This gives the more top tier Chinese manufacturers such as Kaiyan, the opportunity to create resilience in the face of the coronavirus outbreak. Additionally, a robust supply chain allows for a manufacturer’s flexibility to offer simple, efficient, and flexible options for increasing or scaling production as market needs change. What’s also important is that this supply chain evolution has also increased quality standards, which is a decisive factor in medical device manufacturing.

Access to Cutting-edge Technology

Realizing the potential of its market in the era of globalization, China has spent the last decades developing its technology. Heavy investments in research and development, importing talent and technology, and the emergence of specialized tech hubs have helped China gain an innovation edge over other emerging countries. The mentality of rapid research and development is of notable importance and surpasses the speed of many tech hubs in the west. Part of the reason this happens is that such a large portion of the world’s product manufacturing has been outsourced to China. And the low costs achieved by Chinese companies are not the result of just cheap labor, but also, to an extent, involve practical applications of innovative technologies.

Flexible Scale of Manufacturing

Another benefit of manufacturing in China is the ability to scale up or down as needs change. Top tier Chinese factories such as Kaiyan’s facilities are manufacturing products for many companies at the same facility, so they have the means to produce large quantities and adapt according to the market’s and customer’s needs. And being able to scale up easily is an obvious advantage. A critical characteristic of every trade is offering product availability. As you market your medical device to new markets, customers, importers, and distributors, you will be required to increase quantities and ensure timely delivery. Manufacturing your medical device in a Chinese facility that can support scaling up production becomes an obvious advantage.

Clinical Trials for Medical Devices: FDA and the IDE Process

What is a Medical Device?

Section 201(h) of the Food, Drugs, and Cosmetics Act defines a medical device as any healthcare product that does not achieve its principal intended purposes by chemical action or metabolized.

Medical Device Classes
  • Class I — General Controls — Most exempt from premarket submission.
  • Class II — Special Controls — Premarket Notification [510(k)].
  • Class III — Premarket Approval — Require Premarket Application [PMA].
510(k) Premarket Notification
  • Substantial equivalence.
  • 10–15% require clinical data.
  • Performance testing.
  • Usually confirmatory.
  • Type of study dictated by
  • The ability of bench and animal testing to answer questions.
  • Amount of difference between subject device and predicate.
PMA Premarket Approval Application
  • Establish reasonable assurance of safety and effectiveness.
  • Bench-Animal-Human.
  • Clinical Studies.
  • Feasibility and pivotal.
Stages of Review for PMA Device
  1. Pre-Sub: Discuss the device design, bench/animal testing, and the clinical trial
  2. IDE: Request approval for a clinical trial.
  3. PMA: Request market approval.
  4. PMA-S: Request approval for device change or upgrade.

What is an Investigational Device Exemption (IDE)?

The FDA approval of an IDE is required for US human study of a significant risk device that is not approved for the study's indication.

Device trials are unique.

  • Trials tend to be smaller than drug trials.
  • Some novel, many “me-too.”
  • Many difficult to blind, randomize, and control.
  • Many depend on physician technique.
  • Device modifications occur during the trial.
  • Endpoints are highly diverse.
  • Typically, a single pivotal trial follows the feasibility stage(s).
  • Designed to support a “reasonable assurance of safety and effectiveness” for the marketing application.

Types of IDEs

Feasibility Study
  • May provide support for a future pivotal study or may be used to answer basic research questions.
  • Not intended to be the primary support for a marketing application.
  • Endpoints and sample size are generally not statistically driven.
  • Often required by the FDA before the pivotal study to assess basic safety and potential for effectiveness.
  • Generally ~10–40 patients but may be larger.
  • The FDA review is primarily focused on safety and whether the data's potential benefit or value justifies the risk.
Pivotal Study
  • Designed to demonstrate a “reasonable assurance of safety and effectiveness. ness.”
  • Generally intended as the primary clinical support for a marketing application.
  • Endpoints and sample size are statistically driven.
  • Designed to assess both safety and effectiveness.
  • FDA review is much more complex.

Basic Submission Elements

Background of medical issue, the study goals, and why this study will further the science.

A Detailed Description of the Device Understudy
  • Previous studies (preclinical and clinical).
  • Summary of available data.
  • Why is a clinical study needed at this stage?
  • What evidence supports this study/device's safety and the study data's potential to be meaningful?
  • Are there outstanding safety questions that should be addressed with preclinical data?
Risk analysis

Should include:

  • What are the potential risks to the patient?
  • Does the study mitigate the risks where possible?
  • Are the risks outweighed by the potential for benefit and/or value of the study?
  • Patient monitoring and follow-up plan.
  • Inclusion and exclusion criteria.
  • Informed consent document.
  • Sample size and the number of investigational centers, with justification.

Submission Elements, Pivotal IDEs

Primary and Secondary Endpoints

Discussion of the appropriateness of endpoint parameters, hypotheses, and success criteria

Basic Trial Design
  • Controlled? If not, why not?
  •   Randomized? If not, why not?
  •   Blinded? If not, why not?
Trial Conduct and Study Monitoring
  • Sponsor blinding
  • Data handling and adjudication process
  • Independent committees
  • Case report forms
  • Is the right information being gathered to support the study endpoints, and are investigators adequately prompted to report adverse events?

Primary Endpoint Design

Should evaluate the safety and effectiveness of the device in the population expected to be indicated.

  • Generally divided into 1 or more “safety” endpoints and 1 or more “effectiveness” endpoints.
  • A study will be considered successful if both the safety and effectiveness endpoints are met.
  • The clinical protocol should clearly and prospectively detail: — Methods for obtaining endpoint data — Definitions for what will be counted as a primary event in the analysis — Situations in which patient data will be excluded — How missing data will be handled — How the impact of covariates will be assessed.

Sample Size & Follow-Up

Driven by either:

  • Primary safety endpoint
  • Primary effectiveness endpoint

The minimum number of patients and/or minimum duration of follow-up may be required depending on:

  • Understanding of the device's safety and effectiveness  
  • concerns regarding the durability of device safety or effectiveness.

Secondary Endpoints

Generally used to evaluate additional meaningful claims.

  • Generally only considered if primary endpoints are successful.
  • It should be used to provide further insight into the device's effects and mechanisms of action.
  • Definitions and analysis methods should be clearly detailed prospectively.
  • Not considered “statistically significant” unless a pre-specified alpha allocation plan is in the protocol, even if the p-value is < 0.05.

FDA’s IDE Review Decisions

  1. Approval — Approves the trial for a specified number of patients and investigational centers.
  2. Approval with Conditions — Allows sponsor to begin the trial if the sponsor agrees to address the conditions (deficiencies) from the conditional approval letter within 45 days.
  3. Disapproval — The trial may not start until the sponsor addresses the letter's deficiencies, submits this information to the FDA, and receives approval.

Conclusions

One size does not fit all for device trials. Pivotal studies should be designed to evaluate whether there is a “reasonable assurance of safety and effectiveness.” PMA approbation is based upon a Benefit-Risk assessment that strongly considers the outcome of primary safety and effectiveness endpoints. Secondary endpoints are generally used to support claims if the primary endpoints are successful. All endpoint analyses and definitions should be clearly pre-specified in the approved clinical protocol.

Clinical Trial Participation - Diversity

Medical products are safer and more effective for everyone when clinical research includes diverse populations.

Sec. 907 of the Food and Drug Administration Safety and Innovation Act (FDASIA) directed FDA to investigate how well demographic subgroups (sex, age, race, and ethnicity) in applications for medical products — drugs, biologics, and devices, submitted to the agency for marketing approval:

1) Are included in clinical trials; and
2) If subgroup-specific safety and effectiveness data are available.

It is important to test drugs and medical products in the people they are meant to help. The FDA works to ensure that people of different ages, races, ethnic groups, and genders are included in clinical trials. The links below provide information on different populations and their involvement in clinical trials for medical products.

The Office of Minority Health is leading groups made up of many FDA centers to develop actions to reduce health disparities.

  • FDASIA Section 907 required the FDA to provide Congress with an action plan detailing “recommendations for improving the completeness and quality of analyses of data on demographic subgroups in summaries of product safety and effectiveness data and labeling; on the inclusion of such data, or the lack of availability of such data, in labeling; and on improving the public availability of such data to patients, health care professionals, and researchers” and to indicate the center(s) tasked with each recommendation. Congress directed the Agency to issue the action plan one year following the Sec. 907 reports publication.
  • More information on CERSI (Centers of Excellence in Regulatory Science and Innovation)
  • Action Plan to Enhance the Collection and Availability of Demographic Subgroup Data
  • Questions and Answers about section 907
  • Drug Trials Snapshots: Drug Trials Snapshots provide consumers with information about who participated in clinical trials that supported new drugs' FDA approval. The Snapshots' information also highlights any differences in the benefits and side effects among sex, race, and age groups. Drug Trials Snapshots as part of an overall FDA effort to make demographic data more available and transparent.

More Information on Diversity in Clinical Trials

  • Men During Their Reproductive Years
    It gives men who were previously excluded because of potential reproductive harm access to clinical trials to treat life-threatening diseases.
  • Women
    See how the FDA and the Office of Women’s Health are working for diversity in clinical trials.
  • Minority Health Resources
    See how the FDA Office of Minority Health keeps you informed about; safe medication use, diabetes, food safety, product approvals, HIV/AIDS, and clinical trials.
  • Racial/Ethnic Groups
    Reviews the participation of racial or ethnic groups in clinical trials (data from 1995 to 1999).
  • NIH Office of Equity, Diversity, and Inclusion
    Sexual and Gender Minority
  • Older Adults
    Information on why older adults should participate in clinical trials.
  • Children
    A Consumer Update article from January 2010 on children and clinical trials.

Preparing your Skin for Light Therapy

Can I Use Serum With LED Mask?

It is a question that many people have asked — Can I use the serum with LED light therapy?

Our skin is exposed to harsh environmental factors such as sun, wind, cold, and dust daily. These factors tend to attack our immune system causing it to weaken over time.

When this happens, it allows harmful viruses and bacteria to attack our body, leading to acne breakouts and other skin issues such as dark spots and wrinkles. Acne creams are one way of reducing the symptoms associated with this skin condition. However, these can be irritating to your skin, resulting in unwanted side effects such as redness, irritation, and dryness.

The same can also be said for light therapy, which can have its own side effects. Side effects of LED light therapy include itching, burning, and pain. In fact, most users had reported experiencing these side effects when they first started using LED technology. If you were to use any acne medication type, whether prescribed by your doctor or over the counter, the results would depend largely on the person using the medication.

For example, it could take anything from a few days to a few weeks for acne to clear up. Another point to remember is that while certain medications do show better results for some people, they may not work for you at all.

This is because everyone has different skin types, responds differently to treatments, and requires different times to clear away acne completely.

Some people have found success in using LED therapy with a variety of skin creams. However, there is a downside to using this method. LED light therapy does not help remove excess dead skin cells, as some acne medications do. This means that the acne cream will just be left in place and continue to produce side effects for all patients. Besides, side effects can be more severe than a single acne medication dose when used over a long time when used over a long time.

Before you try to use a serum with an LED mask, you should consult with a dermatologist who can advise you on whether or not LED light therapy is right for you. LED light therapy is safe when administered by a certified medical professional. It can be used safely, even if you have sensitive skin, as long as you choose your doctors wisely. Before any treatment is begun, the medical professional will test your skin to determine what type of acne you have. Testing will determine whether your skin is allergic to any light-emitting diodes in the device used.

The last question to answer is, “How effective is Acne treatment with LED Light?” To answer this question, you will need to look at the results you get from the treatment. If you see immediate results after the treatment, it will likely react to the device's light and not the treatment itself.

However, if you don’t see good results after a month of continuous treatment, it is important to determine why the treatment is not working. It may be that you are allergic to any of the ingredients in the product, or it may be that your skin is not receptive to the treatment.

Hydrated Face For LED Mask Results

The serum is good for hydrated face for LED Mask. It can hydrate the skin by absorbing moisture, providing a slight lift to the skin, and removing any oil or makeup that you are using. The serum also contains vitamins and antioxidants that will help fight against free radicals in your body. Free radicals are harmful agents that have been linked with causing cancer.

By fighting against these harmful agents, Serum is good for hydrated face for LED Mask. People who have used Serum have claimed that the hydrated face and LED Mask work very well together. I have also used Serum on my skin, and I must say that the results were really amazing. In fact, I would go on to say that Serum is so good for hydrated face for LED Mask that I will be using it every single night before bed.

If you don’t have much experience making skin look hydrated, this is the forum for you. Let us first examine the ingredient list of Serum.

This product's main ingredients are Hyaluronic Acid, Vitamin C, Retinol A, Alpha Hydroxy Acids, Vitamin E, DMAE, Peptides, and Glycerin, Ferulic Acid, Aloe Vera.

  • AHA kills the bacteria causing acne and helps to get rid of blackheads.
  • Sodium Laureth Sulfate helps in cleaning the skin by getting rid of dead skin cells and excess oil.
  • Salicylic Acid gets rid of pimples and acne scars, and Glycolic Acid is good in treating acne scars.

All of these ingredients are perfectly good for your hydrated face for LED Mask.

  • Now let us move on to how does Serum works to get rid of the facial puffiness.
  • When you are applying Serum on your hydrated face for LED Mask, you are putting on a layer of serum to the surface of your face.
  • As the serum gets applied, it works its way down into your skin and starts working as a moisturizer.
  • This is why this particular product is top-rated as it works as a good moisturizer without over-drying the skin.
How to Prepare Your Skin For a Red Light Therapy Session?

There are different methods used to prepare your skin, but essentially they all work in the same way: removing all the oil and dirt from the skin and then cleaning it. When I talk about cleansing, I’m talking about daily skincare maintenance products. If you want to know how to prepare your skin for a red light therapy session, this is the part that you need to read.

Most people have no idea how their skin looks like, so when they go into the doctor’s office and they've asked if they’ve had a photodynamic therapy or a laser treatment, they’re not aware of what treatment they might have received.

  • The skin absorbs red light from the sun, and in return, it produces negative ions.
  • These are similar to the particles produced by an activated oxygen generator (you know those things at the gym).
  • During photodynamic therapy, the skin cells absorb the energy from the lasers' red light, which causes the release of more negative ions, which then penetrate deeper into the skin.
  • They’re working like the “batteries” on your car — they give the batteries extra power and allow the car to run much longer.
  • If you want to learn how to prepare your skin for a red light therapy session, you must remove all the grime from your face and neck before the session.
  • Cleansing is one of the most important steps to remember in preparation.
How to Prepare Your Skin for Red Light Therapy Session by Using Non-Dry Cleanser

You might need more than just a good cleanser when trying to prepare your skin for red light therapy. Your cleanser is your friend when you are trying to remove all the dirt and excess oil from your face, but what if your cleanser is too harsh on your skin? If you have dry skin, using a cleanser containing too harsh ingredients may cause dryness, making it harder for you to remove those excess oils from your face.

When you prepare your skin for red light therapy session using the non-drying cleanser, make sure that you would be using a toner with antioxidants and anti-inflammatory ingredients to increase the collagen level the skin.

This will help keep your skin healthy and younger-looking.

Caution: Lotion and Moisturizers For LED Masks Are Not Recommended

The use of moisturizers and lotions is not recommended for LED masks because it will damage your skin. There are also cases wherein people who used such products ended up suffering from adverse effects.

The ingredients in these products may be too strong for the skin to be able to absorb.

You can prevent this by using only non-comedogenic lotions and moisturizers for LED masks.

  • This way, the product is less likely to irritate your skin. In addition to that, you can also use other types of products designed for sensitive or dry skins to use on your face during the event's preparation.
  • However, there are cases wherein people who have been using such moisturizers and lotions as part of their LED facial make-up mask ended up suffering from adverse effects.
  • In these cases, the products were not properly applied to the skin, and the amount that was applied was also insufficient.
  • Because the skin did not get sufficient moisture, the cells underneath the skin's surface could not repair themselves properly.
  • This will result in damaged skin, which will cause more breakouts than before.

Aside from lotion and moisturizers, it would help if you also stayed away from mineral oil, alcohol, and preservatives. These ingredients are not good for your skin, as they can cause dryness and irritation. It would help if you also stayed away from using creams and lotions with fragrance, which can only irritate your skin even more. Instead, look for serums.

If you want to have a glowing complexion without enduring any adverse effects, use a good quality face serum.

Prepare Your Skin For Red Light Therapy by Removing Sunscreen

You probably have heard that it is unsafe to use the sun’s UV rays at home, especially if you use a tanning lotion or a self-tanning lotion. But did you know that it is also not safe to use self-tanning products like tan accelerators and sunless tanning pills to prepare your skin for red light therapy sessions?

This defeats the purpose of using red light therapy, and you must remove sunscreen so that your face and skin are completely ready to receive the red light therapy. This is because self-tanning products contain ingredients that can affect the skin in adverse ways and block the beneficial deep penetrating infrared wavelength from 650nm to 850nm.

How to Prepare Your Skin For Red Light Therapy by Removing Makeup

If you have chosen to have laser acne treatment and you are wondering how to prepare your skin for the red light therapy, you will want to take a moment to learn how red light therapy works before getting started.

Before your session begins, you will be given a short amount of time to get ready for the procedure. This is because your skin needs to be very clean and free of any makeup. Your skin needs to be completely dry before the procedure can begin.

If there is any moisturizer on your skin when you arrive for your appointment, you will have to remove it before your treatment.

Your doctor will ask you several questions about your skin during your appointment, including what type of skin you have and whether or not you have any allergies. During this time, they will also determine if you are a good candidate for the procedure. If you are cleared for the procedure, your skin will be exposed to an intense red light level. This is one of the most effective ways to get rid of acne, and it can also help prevent scars and aging from occurring on your face.

The amount of time that it takes to get your skin prepared for red light therapy varies. In most cases, it is normal to have it take from fifteen to thirty minutes to prepare your skin for the procedure. You may have to remove any makeup at this time as well.

How to Prepare Your Skin For Red Light Therapy by Exfoliating?

When a patient is getting a therapy session done, they will be required to go to the spa or beauty clinic to be given a facial.

A therapist will then start by cleaning the face thoroughly. After the initial cleaning process, the therapist will apply a chemical that will help exfoliate the skin.

This process can irritate the skin, so it is important to prepare your skin before undergoing this procedure. Some common preparations that people use include salicylic acid, alpha hydroxy acid, retinoids, glycolic acid, and other peel-type products.

The exfoliating procedure aims to help the skin cells shed off dead skin cells and replace them with new cells.

This is why it is important to remove all traces of dead skin cells from your face before undergoing the procedure.

It may seem odd at first, but if you want to get the best results from the procedure, you need to gently exfoliate your skin.

Prepare Your Skin For Red Light Therapy With Moisturizers

When you prepare your skin for red light therapy, you are basically preparing to expose the blue spectrum laser's high intensity and the eventual dry out of the epidermis. The skin must be prepared using a good cream containing Reductase or Salicylic Acid, or by exfoliating the skin using a scrub.

After the procedure, you will need to have topical products applied to your skin to prevent the skin from cracking and peeling. This will also help improve your appearance and prevent future scarring. Removing moisturizers before the therapy can be helpful. This is because the skin’s cells will still be in a dormant state when you receive the treatment; therefore, your skin is not at risk for the dryness associated with moisturizers.

This will also improve your skin's look, especially for those who have undergone this procedure many times. However, you must be youthful if e to remove moisturizers in preparation for the session, as some creams may cause excessive dryness and irritation. Once you are prepared for the session, you can expect the doctor to start the red light therapy by generating a small amount of blue light on your skin's top layer.

The light then travels through the skin, reaching the deepest layers where most of the damage occurs. When the blue light is emitted, it is believed that the cells below the surface of the skin begin to absorb the red light, helping to repair the skin. The increased circulation and nutrient absorption help to rejuvenate your skin, leaving it looking younger and healthier than ever before.


Sinus Infections & Low-level Laser Therapy

Sinus infections are inflammation based. Sinusitis is when inflammation is chronic, and the body is unable to overcome it. Sinusitis or sinus infections may be acute (coming on suddenly) or chronic (long-lasting & nothing seems to fix it.

There are sinus cavities above the eyebrows, behind the nose, and under the cheekbones. When the mucus membranes within the sinuses become inflamed, mucus is generated. Sometimes even air is trapped, which puts pressure on the walls of the sinus cavities, making our face hurt, causing difficulty in breathing thru the nose — this is called sinusitis.

Studies have shown that 37 million people per year in the US are affected with sinusitis at one time or another involving all age brackets.

Is There a Natural, Safer Treatment Option?

Some people immediately run to a doctor wanting antibiotics, which may not help since not all sinusitis is due to bacteria. Low-level laser therapy (LLLT) has been proven effective in enabling the body to overcome inflammation. Many of our patients find that when they use low light Laser Therapy to treat their sinus infections, they experience two things: First — patients notice a significant difference after 1 treatment (breathing easier and sinus drainage); Second — they are less likely to get recurring infections, as is often the case when taking antibiotics.

Irradiation of red light penetrates several millimeters into tissue; in the infrared part of the spectrum, the penetration goes up to several centimeters, usually 4–6 cm. This is a very advantageous fact for treating sinusitis, for laser irradiation can be applied externally. However, when applying a red laser, it is necessary to introduce a light guide in the sinus.

Laser therapy is a safe, painless, non-invasive, and effective therapy to reduce pain and swelling, allowing the body to restore damaged tissue. Laser therapy uses red and infrared light to relieve pain and accelerate healing and decrease inflammation. When the light source is placed against the skin, the photons penetrate several centimeters and get absorbed by the mitochondria, the cell’s energy-producing cells part. This energy fuels many positive physiological responses resulting in the restoration of normal cell function. Laser therapy offers our bodies the opportunity to heal with no side effects and no long term damage.

Long Term/Cumulative Effects of Laser Therapy:

  • Improved resistance to infections
  • The immune response is stimulated
  • Reduction in swelling
  • Lymphatic drainage is improved
  • The body’s natural healing process is enhanced

LLLT irradiation is a benefit for the treatment of acute sinusitis. External irradiation with a laser with 830 nm wavelength, enabling the beam to penetrate 4–6 cm deep, is recommended. Irradiation with red light-emitting lasers is also effective. Still, due to the need for application through a light guide inserted into the cavity, this method has been discarded from clinical practice.

Laser irradiation works through its analgesic, anti-inflammatory, and biostimulation effects on ease of pain or elimination. It also causes a quicker withdrawal of inflammation and edema of the mucosa. It thus brings restoration of drainage of sines as well as normalization of mucociliary function. Immunomodulatory effect — improvement of both specific and non-specific immunities by stimulation of T and B lymphocytes, lysozyme, and phagocytosis — is also significant. Stimulation of Langerhans cells of the mucose of sines is presumed, too.

Laser irradiation in treating sinusitis has no contraindications (except for general contraindications, i.e., malignant tumors in the irradiation area or epilepsy). As physiotherapy, it can suitably complement therapy with antibiotics, mucolytics, and antihistaminics. The use of a laser with 830 nm wavelength appears to be the most beneficiary on diagnosis sinusitis acute with liquid levels in paranasal sinuses, the treatment of which was cut down by 59 percent in average, and on a group of patients with plain catarrhal obscure and decreased transparency (the most frequent) where the duration of therapy was shortened by 39 percent.

By using red light therapy devices from Kaiyan Medical, you’re able to reduce sinus inflammation and improve your immune system by investing a few minutes using a red light device.

Celebs are Loving Red Light Therapy

When it comes to anti-aging remedies, celebrities are at the forefront of all the latest treatments. For years, Hollywood’s elite have opted for chemically-induced anti-aging treatments, like botox and chemical facial peels. But it looks like Hollywood is stepping away from harsh treatments, particularly with the prominence of clean and holistic beauty trends in recent years. Now, many celebrities have decided to avoid the needles and knives, opting for natural alternatives, instead. 

To prepare for red carpet events, celebrities are flocking to red light therapy for natural, non-invasive anti-aging treatments. Kourtney Kardashian, true to Kardashian form, was relatively early to the red light therapy scene in 2016, when she posted a photo of herself in wearing a red-light mask, touting the many anti-aging benefits of the treatment. Since then, other celebrities such as Kelly Rowland, Emma Stone, and Chrissy Teigen have openly shared their positive experiences using red and blue light facial therapy treatment. 

Some actresses love red light therapy so much, they have their own equipment set-up in their homes. Back in 2018, Olivia Munn told US, "I have my own facial set up, I've got the professional-grade products and machines...But one of the best things is the red and blue light mask."

Red light therapy works by increasing blood flow and oxygen, feeding the cells the necessary energy they need to speed up the cellular process. This process helps decrease inflammation and enhance collagen production, which reduces the appearance of fine lines and wrinkles for tighter and supple skin. 

Jewelry designer and reality T.V. star Kristin Cavallari told US that she keeps away from Botox, but shared that

"I use red light therapy twice a week to prevent lines and wrinkles."

But red light therapy isn’t only for wrinkles and fine lines. Celebrities are expanding the use of red light therapy and using it for their entire bodies. Why? Well, house-friendly red light devices help treat inflammation, joint pain, and muscle soreness. 

Ara Suppiah, M.D., an assistant professor at the University of Central Florida Medical School and an emergency and sports medicine physician, told Us Weekly that “increased energy within a muscle cell allows it to contract harder and repair itself after training.” Since red light increases cell energy, it subsequently helps organs, joints, and muscles to repair themselves and function optimally. 

The list of celebrities who swear by red light therapy continues to grow by the day. Joan Smalls and Bella Hadid visit celeb aesthetician Joanna Czech, who is well-known for using her light treatments on her clients. Riverdale’s Lili Reinhart and Camila Mendes also posted photos from Joanna Vargas’ red light bed.

So, it’s clear that the verdict is in: celebrities are loving red light therapy and the multiple external and internal benefits that come along with it. But do you need to undergo expensive treatments to get a taste of the benefits? Nope! You don’t need to be a celebrity status to enjoy the benefits of red light therapy - even in the comfort of your home. 

Luckily, red light therapy is now available for in-home treatment with Lunas’ FDA and MDA-approved red light therapy devices. By having a red light therapy device in your home, we can all attain our own red-carpet glow without the celebrity price tag.

Photo Credit: By Tinseltown - Shutterstock

How to Integrate Light Therapy into your Lifestyle

Our lives are busier than ever, and even though red light therapy sounds like something that could significantly benefit you, we know you might be thinking: “when will I have time for red light therapy?” 

Part of the beauty of red light therapy is that you don't need to change your current routine or lifestyle to enjoy its benefits: if you're someone whose day is busy in front of a desk, you can turn the device on while you work; or if you have easy-going mornings but hectic afternoons, you can enjoy your morning coffee while using our red light therapy device. Or, you can turn on the panel while you’re unwinding with a movie in the evenings –– the options are endless.  

Red light therapy treatment isn’t supposed to take over your day and cause an inconvenience. With an at-home red light therapy device, you make the rules. 

That said, you may be wondering what’s the best time of day to use our red light therapy devices. Well, there are a couple of ways you can integrate red light therapy into your lifestyle. 

There are three main parts of the day: morning, midday, and evening. Though you’re able to use red light therapy any time of the day, some parts of the day can be more effective than others, particularly given your personal health and wellness needs. 

If you’re someone who’s suffering from a sleep disorder, then you may want to focus on using red light therapy during the mornings and evenings. For sleep conditions, using red light therapy around sunrise or sunset are the best times of the day. Why is that? 

It has to do with our biological circadian rhythm, which is the natural internal process that helps regulate your sleep cycle within a 24-hour day. To optimize your circadian rhythm and improve your sleep cycle, you need to sync with your natural sleep rhythm. By doing so, you reduce sleep inertia, insomnia, and other sleep disorders. 

When regulating your circadian cycle, your body releases a hormone called melatonin. This particular hormone is the highest in the blood at night and optimal for helping you fall asleep. When using red light therapy at night, it can help you enhance your natural melatonin production

When using red light therapy in the morning, exposure to light helps stop melatonin production, giving your body a natural energy boost. So, either time of the day––morning or night––can be an incredible time to help your body reset its circadian rhythm. 

You don’t need to schedule off your morning for red light therapy treatment. While you’re eating your breakfast or going through your emails, you simply turn on your red light therapy device and enjoy 10 to 15 minutes of treatment. 

Or, in the evenings when you’re cozied up on the course, washing the dishes, or sitting in bed with a book, turn on your red light therapy panel to help regulate your sleep cycle, mood, and overall health. 

If you can’t manage to use red light therapy in the morning or evening, you can always have a treatment in the afternoon, as well. If you’re dealing with a sleep disorder or seasonal depression, we recommend morning or evening treatment. However, midday treatment will also provide you with a load of benefits, including collagen production, decreasing symptoms of depression, improving sleep disorders, and non-seasonal Bipolar depressive episodes. 

Whatever the condition may be, whether it's a sleeping disorder, skin condition, or depression, Lunas red light therapy devices promote cellular healing from the inside out. What’s important is you find the time of the day that best suits your body’s needs. Everyone is different, so it’s important to find out what works for you and your unique routine and lifestyle.

Light Therapy - An Alternative to Botox and Fillers?

It’s safe to say that most people would prefer to slow down the physical signs of aging, particularly on their faces – and the proof is in the numbers. In 2018, the global anti-aging market was estimated to be worth around $50.2 billion U.S. dollars. Now that's a lot of skin cream and Botox. And those numbers are only increasing: by 2027, the anti-aging product industry is projected to be worth $83.2 billion U.S. dollars. 

Of course, a large portion of sales are going to anti-aging creams and serums; however, there's been an increase in soft-tissues cosmetic procedures like Botox and filler treatments. A report from the American Society of Plastic Surgeons from 2018 reported around 7.4 million injections of botulinum toxin (Botox) and 2.6 million dermal filler injections we used that year. 

In America alone, Botox and fillers ranked the second most popular, minimally-invasive cosmetic procedures. But why are they so popular? Due to their invasiveness, they're more effective than anti-aging creams. However, that comes at a potentially risky and painful price. 

Botox's side effects include bruising and swelling at the injection site, fever, chills, and headaches. Some side effects are specific to the area of injection and include drooping eyelids, excessive tearing, and uneven eyebrows and other facial muscles. More importantly, research on the long-term side effects of Botox and fillers is limited. There are immediate results, yes; however, there's an unclear understanding of what Botox and fillers do to the body in the long-term.

Aside from health concerns, Botox and fillers can quickly add up financially, too. The most common Botox and filler treatments cost hundreds of dollars per session. Women and men around the world are risking their health and money to look youthful, but what they don't realize is there's non-invasive alternatives to these procedures, including light therapy. 

Aside from light therapy’s plethora of benefits for the human body, it is an amazing anti-aging alternative for those looking for non-invasive and natural anti-aging results. Light therapy reduces fine lines and wrinkles, but goes beyond just skin deep. 

While Botox and fillers work to cover the symptoms of aging skin, light therapy solves the problem at a cellular level. As we age, our body’s collagen production decreases, leaving our skin less plump and full. However, through light therapy, you’re actually stimulating collagen production beneath the skin to receive natural and similar results to Botox and fillers. 

Light therapy works by delivering wavelengths of red and near-infrared light to our skin and cells. Red light enhances our cellular function, stimulating the cell's mitochondria to produce ATP (adenosine triphosphate) energy. This boost of cell energy promotes collagen and elastin production, bringing the plumpness back into your skin. 

A 2014 study found that users of red light therapy experienced significantly improved skin complexion and increased collagen. Angela Lamb, M.D. and associate professor of the Department of Dermatology at the Icahn School of Medicine at Mount Sinai Hospital in New York City, stated that "Science shows that red light therapy protects existing collagen and boosts new production. Plus, it helps with texture, tone, pore size, and wrinkles."

However, there are more benefits to red light therapy than natural collagen production. Light therapy also aids in diminishing fine lines and wrinkles, reduces scarring, fights acne, treats inflammation, and aids in muscle recovery.

The proof is in the research, and study after study has shown the same results: red light therapy works for anti-aging. Rhonda Klein, M.D., a board-certified dermatologist in Connecticut, said that “Realistically, you can expect RLT to improve your skin’s tone and texture. We know that it soothes inflammation, improves mild acne, and proactively treats fine lines and wrinkles, in addition to other benefits.”

Lunas’ red light therapy devices are both MDA and FDA-approved, assuring you receive the highest quality of red light treatments available on the market, which is essential in receiving the best, most efficacious results.

Laser and Light-based Treatment of Keloids

Keloids are an overgrowth of fibrotic tissue outside the original boundaries of an injury and occur secondary to defective wound healing. Keloid scars commonly grow beyond the wound boundaries, while hypertrophic scars are confined to the wound’s original area. Both types of scars arise as a result of impaired fibroblastic proliferation and collagen deposition after skin injury. Keloids often have a functional, aesthetic, or psychosocial impact on patients, as highlighted by quality-of-life studies. They can greatly affect the patient’s quality of life and emotional wellbeing by causing intense pain, itching, unappealing red appearance, and inexorable spread. Interestingly, keloids and hypertrophic scars are exclusively found in humans and do not occur in animals naturally. The lack of suitable animal models that recapitulate the key processes in keloidal/hypertrophic scarring has greatly hampered our understanding and treatment of these scars.

Treatments for keloids include surgical excision, intralesional or topical corticosteroids, other intralesional therapies: 5-fluorouracil (5-FU), bleomycin, and interferon, topical imiquimod, compression, cryotherapy, radiation, silicone sheeting, and laser or light-based therapies. Recurrence is common, even with combination therapy. Laser and other light-based technology have introduced new ways to manage keloids that may improve aesthetic and symptomatic outcomes and decrease keloid recurrence. Laser and light-based therapies for keloids can be grouped into three categories: ablative lasers, non-ablative lasers, and non-coherent light sources.

Non-ablative lasers target hemoglobin or melanin. 585 or 595-nm pulsed-dye lasers (PDL) are non-ablative, and the major chromophore is oxyhemoglobin. PDL also targets melanin; therefore, care must be taken to avoid pigmentary alterations. PDL is hypothesized to treat keloids by selective damage of blood vessels that supply the scar. The 980-nm diode laser targets hemoglobin and melanin. The 1064-nm neodymium-doped: yttrium, aluminum, and garnet laser and the 532-nm neodymium-doped: vanadate laser is hypothesized to primarily treat keloids by damaging deep dermal blood vessels.

Non-laser light sources are also used to treat keloids. These techniques include intense pulsed light therapy (IPL), light-emitting diode (LED) phototherapy, also known as low-level light therapy, and photodynamic therapy (PDT). These modalities utilize light energy that may cause keloid fibroblast functional modification. IPL emits non-coherent, broadband wavelength, pulsed light, and targets pigmentation and vasculature. LED phototherapy is hypothesized to photomodulate mitochondrial cytochrome C oxidase altering intracellular signaling. PDT requires the application of a photosensitizer, commonly 5-aminolevulinic acid or methyl aminolevulinic acid, that is preferentially absorbed by highly vascularized or metabolically active tissue and converted to protoporphyrin IX. Upon exposure to light, PpIX causes reactive oxygen species free radicals that have a cytotoxic effect. PDT may also cause alterations in extracellular matrix synthesis and degradation and modulate cytokine and growth factor expression.

The mechanisms by which topical PDT improves abnormal scars are largely unknown. However, they probably involve downstream responses to the ROS produced by the photodynamic reactions: the ROS induces membrane and mitochondrial damage, which activates signaling molecules such as TNF-α and interleukins 1 6 and cell death. The cell death may be via apoptosis, necrosis, and/or autophagy. These changes may alter growth factor and cytokine expression in the lesion, thereby modulating collagen production and extracellular matrix organization.

Notably, the shallowness of PDT suggests that it may be useful as an adjunct treatment of the wound area after keloid resection. In this setting, PDT may help to prevent postoperative keloid recurrence.

Blue & Red Light for Rosacea

Rosacea is a common inflammatory skin condition affecting approximately 5% of the world population. Therapeutic approaches to rosacea are focused on symptom suppression employing anti-inflammatory agents. Photodynamic therapy, especially light-emitting diodes, has been introduced as a valid alternative to conventional therapy.

Because of rosacea's potential complexity, it has been classified into subtypes according to signs and symptoms that often occur together. Patients may have characteristics of more than one subtype at the same time. Although the cause of rosacea is unknown, several possibilities are currently being studied, including flushing, inflammatory pathways, and Demodex mites. Simultaneously, a growing range of therapies is available to address rosacea's signs and symptoms. While your doctor will tailor medical therapy to your individual case, treatment options may often be keyed to standard subtypes and level of severity.1

As with any medical therapy, outcomes of rosacea treatment may vary from case to case. Compliance with therapy — using your medication as your doctor prescribes — is an important key to success. Please consult a dermatologist or other physician to determine the appropriate therapy for your individual case.

Subtype 1: Facial Redness

Subtype 1 (erythematotelangiectatic) rosacea is characterized by flushing and persistent facial redness. Visible blood vessels may also be present, and facial discomfort is common.

Research into the physical processes involved in rosacea has recently led to new prescription therapy to relieve facial redness. It may also be important for you to identify and avoid lifestyle and environmental factors that trigger flushing or irritating your skin. The most common factors are covered in Rosacea Triggers, and a Rosacea Diary is available to help you identify and avoid those factors that affect your individual case.

The appearance of flushing, redness, and visible blood vessels may also be concealed with cosmetics, and facial discomfort may benefit from appropriate skincare, both discussed under Skin Care & Cosmetics.

Visible blood vessels and severe background redness may be reduced with lasers or intense pulsed light therapy. Several sessions are typically required for satisfactory results, and touch-up sessions may later be needed as the underlying disease process is still present.

In specific cases, extensive flushing may be moderated somewhat through the use of certain drugs.

Subtype 2: Bumps and Pimples

Subtype 2 (papulopustular) rosacea is characterized by persistent facial redness and acne-like bumps and pimples and is often seen after or at the same time as subtype 1. Fortunately, however, several medications have been extensively studied and approved for this common form of rosacea and may also be used on a long-term basis to prevent symptoms recurrence.

In mild to moderate cases, doctors often prescribe oral and topical rosacea therapy to bring the condition under immediate control, followed by long-term use of topical therapy alone to maintain remission. A version of oral therapy with less risk of microbial resistance has also been developed specifically for rosacea and is safe for long-term use.

Higher doses of oral antibiotics may be prescribed, and other drugs may be used for patients who are unresponsive to conventional treatments.

Subtype 3: Skin Thickening

Subtype 3 (phymatous) rosacea is characterized by skin thickening and enlargement, most frequently around the nose. This condition develops primarily in men. Although mild cases may be treated with medications, moderate to severe manifestations, typically require surgery.

A wide range of surgical options is available, including cryosurgery, radiofrequency ablation, electrosurgery tangential excision combined with scissor sculpturing, and skin grafting. A surgical laser may be used as a bloodless scalpel to remove excess tissue and recontour the nose, often followed by dermabrasion.

Subtype 4: Eye Irritation

Subtype 4 (ocular) rosacea is characterized by any one of many eye symptoms, including a watery or bloodshot appearance, foreign body sensation, burning or stinging, dryness, itching, light sensitivity, and blurred vision. A history of having styles is a strong indication and has “dry eye” or blepharitis.

Treatment for mild to moderate ocular rosacea may include artificial tears, oral antibiotics, and the eyelashes' daily cleansing with baby shampoo on a wet washcloth. More severe cases should be examined by an eye specialist, who may prescribe ophthalmic treatments, as potential corneal complications may involve visual acuity loss.

Treatment and Conditions


Currently, there are two traditional treating methods, such as medications and physical treatment. Doctors can prescribe medications. Usually, the medications are antibiotics. The thing is, however, there are side effects from the antibiotics. Additionally, there is no proof that Rosacea is a bacterial condition. So the effectiveness of treatment could remain uncertain. Plus, going to see a doctor can be time-consuming & money consuming.

Physical treatment can be soup or gel to help better improve the skin. However, people have different skin types. Usually, it is super expensive to diagnose the skin condition in great detail; people have different skin types. The wrong usage of beauty products could lead to worsen skin problems or increase sensitivity.

Several therapeutic approaches are currently available for treating rosacea, and they are mainly aimed at controlling disease symptoms. The therapeutic plan has to be adapted to the rosacea subtype and tailored according to the patient's dominant manifestations. In general, the reduction of oral therapy in favor of topical or physical therapy is desirable to reduce side effects for patients and increase the treatment's safety.

The therapeutic approach has blue (480 nm ± 15 nm) and red (650 ± 15 nm) LED light-based therapy in patients affected by rosacea. Previous research reported the efficacy of red and blue light coupled with mild to moderate acne lesions. Blue light (400–470 nm), due to its lower penetration, is useful in such skin conditions related to the skin's epidermis layer; therefore, it can also interfere with human sebocyte proliferation. On the other hand, red light (630 nm) is reported to affect sebum production significantly. The benefits deriving from PDT using LEDs are not limited to its efficacy but are also related to its safety and tolerance by patients; therefore, its advantages can be extended to a broad range of dermatological conditions.

References:

Two AM, Wu W, Gallo RL, Hata TR. Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors. J Am Acad Dermatol. 2015;72(5):749–58. quiz 759–60. PMID: 25890455

Plewig G, Kligman AM. History of Acne and Rosacea. In: ACNE and ROSACEA. Berlin: Springer; 2000.

Odom R, Dahl M, Dover J, Draelos Z, Drake L, Macsai M, Powell F, Thiboutot D, Webster GF, Wilkin J. Standard management options for rosacea, part 2: Options according to subtype. Cutis, 2009;84:97–104.

Kolontaja-Zauber, I., Ināra Ančupāne, Andra Dērveniece, Aija Žileviča, & Ilze Ķikuste. (, 2018). Impact of intense pulsed light therapy on the quality of life of rosacea patients. Proceedings of the Latvian Academy of ences Section B Natural Exact and Applied sciences, 72(1), 9–15.

Kim, B. Y., Moon, H. R., & Ryu, H. J. . (2018). Comparative efficacy of short-pulsed intense pulsed light and pulsed dye laser to treat rosacea. Journal of Cosmetic & Laser Therapy, 1–6.

Bo, Young, Kim, Hye-Rim, Moon, & Hwa, et al. (2018). Comparative efficacy of short-pulsed intense pulsed light and pulsed dye laser to treat rosacea. Journal of Cosmetic & Laser Therapy Official Publication of the European Society for Laser Dermatology.

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Melasma & Light Therapy

Light can be a powerful skincare tool, whether it’s an LED facial or light therapy for all skin. Light therapy can also seem a little mysterious if you’ve never done it before because light doesn’t interact with the skin in the same obvious way as, say, serum or moisturizer.

Here, we’re breaking down light therapy and melasma, explaining what they are, how they work, and experts’ advice for adding them to your skincare routine.

Melasma is sometimes referred to as the mask of pregnancy because it is sometimes triggered by an increase in pregnant women's hormones. But while the condition may be common among pregnant women, it isn’t limited to them.

“It’s not only associated with pregnancy but can affect women at all stages of life,”

Says Dr. Shadi Kourosh, director of the Pigmentary Disorder and Multi-Ethnic Skin Clinic at Harvard-affiliated Massachusetts General Hospital. And it may last for many years.

“Women who develop melasma in their teens or 20s or 30s may see it stay around for decades,”

Says Dr. Barbara Gilchrest, senior lecturer on dermatology at Harvard Medical School.

What is Melasma

Melasma is a common skin problem. The condition causes dark, discolored patches on your skin.

It’s also called chloasma, or the “mask of pregnancy,” when it occurs in pregnant women. The condition is much more common in women than men, though men can get it too. According to the American Academy of Dermatology, 90 percent of people who develop melasma are women.

Causes of Melasma

It isn’t obvious what causes melasma. Darker-skinned individuals are more at risk than those with fair skin. Estrogen and progesterone sensitivity are also associated with the condition. This means birth control pills, pregnancy, and hormone therapy can all trigger melasma. Stress and thyroid disease are also thought to be causes of melasma.

Additionally, sun exposure can cause melasma because ultraviolet rays affect the cells that control pigment (melanocytes).

How is Melasma Diagnosed?

A visual exam of the affected area is often enough to diagnose melasma. To rule out specific causes, your healthcare professional might also perform some tests.

One testing technique is a Wood’s lamp examination. This is a special kind of light that’s held up to your skin. It allows your healthcare professional to check for bacterial and fungal infections and determine how many skin layers the melasma affects. To check for any serious skin conditions, they might also perform a biopsy. This involves removing a small piece of the affected skin for testing.

Light Therapy Based Treatments

Light therapy for melasma treatment is best suited for patients with refractory melasma who failed with topical treatment or a series of chemical peels. Topical therapy takes at least three months or longer to see skin lightening, and those patients who are interested in a more rapid response could consider light therapy.

When a patient wishes for an accelerated pace of improvement, analogous to chemical peels, these modalities accelerate melanin pathways’ removal. Still, they do not target the melanin production itself.

One key point of patient counseling before laser- and light-based treatment is that these therapies can speed up removing melasma-related hyperpigmentation, but they are not cures for melasma.

References

Arora P, Sarkar R, Garg VK, Arya L. Lasers to treat melasma and post-inflammatory hyperpigmentation. J Cutan Aesthet Surg.

Barolet D. Light-emitting diodes (LEDs) in dermatology. Semin Cutan Med Surg. 2008;27(4):227–238.

Lee HM, Haw S, Kim JK, et al. Split-face study using a 1,927-nm thulium fiber fractional laser to treat photoaging and melasma in Asian skin. Dermatol Surg. 2013;39(6):879–888.

Kauvar AN. The evolution of melasma therapy: targeting melanosomes using low-fluence Q-switched neodymium-doped yttrium aluminum garnet lasers. Semin Cutan Med Surg.

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Light & Food Preservation

Consumers demand high-quality processed foods with minimal changes in nutritional and sensory properties. Nonthermal methods are considered to keep food quality attributes better than traditional thermal processing. Pulsed light (PL) is an emerging non-thermal technology for decontamination of food surfaces and food packages, consisting of short time high-peak pulses of broad-spectrum white light. It is considered an alternative to continuous ultraviolet light treatments for solid and liquid foods. This paper provides a general review of the principles, mechanisms of microbial inactivation, and PL treatments applications on foods. Critical process parameters that are needed to be optimized for better efficiency of PL treatments are also discussed. PL has considerable potential to be implemented in the food industry. However, technological problems need to be solved to avoid food overheating and achieve better penetration and treatment homogeneity. Besides, more extensive research is needed to understand how PL affects quality food attributes.

Nonthermal technologies

Nonthermal technologies are being applied in food processing as a viable alternative to thermal processing. Traditionally, most foods are thermally processed by subjecting them to temperatures between 60 °C for a few minutes and 100 °C for a few seconds. During this period, a large amount of energy is transferred to the food, which may trigger reactions that lead to undesirable changes or by-products formation. During nonthermal processing, food temperature is held below that achieved in thermal treatments. Thus, vitamins, essential nutrients, and flavors are expected to undergo minimal or no changes.

Pulsed light (PL) is used for the rapid inactivation of microorganisms on food surfaces, equipment, and food packaging materials. The terms high-intensity broad spectrum pulsed light and pulsed white light are synonymous with PL.

Inert-gas flash lamps generate intense and short pulses of ultraviolet (UV) light for microbial inactivation started during the late 1970s in Japan. In 1988, extensive experimentation carried out by PurePulse Technologies Inc. provided a pulsed light process called PureBright® to sterilize pharmaceuticals, medical devices, packaging, and water. The process's efficacy was tested against a broad range of microorganisms, including bacteria (vegetative cells and spores), fungi, viruses, and protozoa. However, the food industry adopted the technology only in 1996, when the Food and Drug Administration approved the use of PL technology for the production, processing, and handling of foods.

Description of PL

PL involves the use of intense pulses of short duration and a broad spectrum to ensure microbial inactivation on the surface of either foods or packaging materials. Electromagnetic energy is accumulated in a capacitor during fractions of a second and then released in the form of light within a short time (nanoseconds to milliseconds), resulting in an amplification of power a minimum of additional energy consumption (Dunn et al. 1995). Typically, the equipment used to produce PL comprises one or more adjustable xenon lamp units, a power unit, and a high-voltage connection that allows the transfer of a high current electrical pulse. As the current passes through the lamp unit's gas chamber, a short, intense burst of light is emitted. The light produced by the lamp includes broad-spectrum wavelengths from UV to near-infrared. The wavelength distribution ranges from 100 to 1,100 nm: UV (100–400 nm), visible light (400–700 nm), and infrared (700–1,100 nm). Pulses of light used for food processing applications typically emit 1 to 20 flashes per second at an energy density in the range of about 0.01 to 50 J cm−2 at the surface (Barbosa-Canovas et al. 1998).

Liquid Foods

Many fluids, such as water, have a high degree of transparency to a broad range of wavelengths, including visible and UV light. Other liquids, such as sugar solutions and wines, exhibit more limited transparency. Increasing the number of solids will diminish the intensity of UV radiation's penetration. In an aqueous solution, the lower the transparency, the less effective the PL treatment. Liquids with high UV absorbance must be treated as a thin layer to reduce the liquid's radiation absorption. In this manner, the liquid's UV absorption is low, and bacteria are more likely to be subjected to lethal doses. The absorbance of clarified fresh juices and juices containing pulp varies considerably. Clarified apple juice has a low absorbance, with absorption coefficients about 11 cm−1, whereas absorbance of orange juice can achieve values close to 50 cm−1. A positive correlation between vitamin C content and the absorption coefficient of clear apple juices was observed.

Conclusions

PL is a novel non-thermal technology to inactivate pathogenic and spoilage microorganisms on foods. The significant microbial reductions in short treatment times, the limited energy cost of PL, the lack of residual compounds, and its great flexibility are some of the technique's major benefits. This method is clearly efficient in inactivating microorganisms in vitro, but its potential for real foods is still under investigation. Further studies need to be conducted to assess PL treatments' effects on food properties beyond safety and spoilage. There is a need for optimizing the critical process factors to achieve the target inactivation level for specific food applications without affecting quality. PL equipment with good penetration and short treatment times need to be designed for commercial purposes. Also, the applicability of PL treatments on an industrial scale needs to be compared with other nonthermal or conventional thermal processes.

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Stretch Marks & Light Therapy

Why Do We Get Stretch Marks?

A stretch mark is a type of scar called striae, meaning “thin, narrow scar”. In people who develop stretch marks, the skin has stretched faster than it can grow, such as during pregnancy, growth spurts, or rapid fat or muscle gain. The abrupt stretching causes the collagen and elastin proteins responsible for the skin’s structure and elasticity to rupture. This, in turn, causes the dermis to tear.

As the dermis tears, the body’s healing mechanisms spring into action to close the wound as quickly as possible to prevent infection and further damage.

Normally, as the skin regenerates and grows, it’s an elegantly organized latticework of collagen and elastin proteins. But when the skin tears, the body doesn’t have time to build an elegant structure to fill in the gap. Time is of the essence in any wound repair, including torn skin.

The collagen clumps together hurriedly, aiming for efficient closure of the wound before infection can set in. “Scarring is the result of a system that has learned to respond extremely quickly to a wound,” says Dr. John Newman, a cosmetic surgeon and researcher at the Laser Center of Virginia in Virginia Beach.

This haphazard process results in tough and functional but unattractive tissue — what we know as a scar. “It is kind of like nailing down a crisscross of two-by-fours over a hole in a deck,” says Newman. “It seals the hole, but it doesn’t look very nice.”

Newly formed stretch marks are darker than the surrounding skin and can be slightly raised, itchy, or painful. If they’re left untreated, they become permanent scars. Their color will lighten, and their appearance will fade below the top layer of the surrounding skin.

The bigger mystery is why stretch marks don’t disappear over time as the skin regenerates. The key lies in the information that emerging cells receive from adult cells in the area. Skin cells, whether they’re normal cells or scar cells, regenerate about once every 30 days. Growth of new skin cells begins at the bottom-most layer of the scar, and older (dying) cells are pushed to the surface where they naturally slough off.

However, Neuman explains that that that that emerging cells “learn” from their immediate neighbors and predecessors and develop the same characteristics as ir replacement their replacement cells. As a result, any emerging cell in contact with scar cells will become new scar tissue rather than normal skin tissue.

Red Light Therapy For Stretch Marks

If you have tried to get rid of stretch marks, perhaps you’ve used specialized creams that contain retinoids. These work to some extent, but only if you catch your stretch marks early and treat them while they’re still forming. Retinoids work by stimulating collagen production. However, they can irritate sensitive individuals, and doctors often recommend that pregnant women avoid anything containing retinoids.

Another common treatment, known as microdermabrasion, essentially involves “sandblasting” the skin with tiny crystals. This sloughs off dead skin

cells and stimulates the production of collagen. Microdermabrasion is a fairly harsh treatment that can lead to irritation and damage, especially to sensitive skin.

The most extreme treatment for stretch marks is plastic surgery, such as a mini tummy tuck. This may be effective, but there are risks associated with any invasive procedure and the high cost.

Is there a better option for restoring the appearance of the skin? The answer is yes, absolutely. Also known as photobiomodulation and low-level light therapy (LLLT), red light therapy improves skin appearance, reduces signs of aging, treats chronic skin conditions, reduces scarring, and promotes skin wound healing.

When red light therapy is used, visible red light and invisible near-infrared (NIR) light are applied to the skin with LED bulbs' devices. Wavelengths of light are measured in nanometers (nm), with red light ranging from 630nm to 660nm and NIR light ranging from 810nm to 850nm. Human cells respond favorably to these wavelengths, similar to how natural sunlight affects plant cells by stimulating more energy and optimization of cell function.

When the red light is shone on bare skin, it soaks into the mitochondria, colloquially referred to as the powerhouses of cells' energy factories. The mitochondria are, in turn, stimulated to produce more adenosine triphosphate (ATP), which is the primary cellular fuel. This energizes cells to perform their normal functions, from fighting off pathogens to performing repair and regeneration.

Improved Blood Flow

Proper healing relies on good circulation to the skin. Red light promotes the proliferation of endothelial cells, which make up the inner layer of capillaries (the tiny blood vessels that deliver oxygen and nutrients throughout the body). This was the focus of a 2017 study by a team of researchers from Austria, who found that red light consistently increased migration and proliferation of endothelial cells.

Without proper blood circulation, there would be no healing since endothelial cells also deliver white blood cells to the sites they need. In skin wound healing, white blood cells are necessary to protect the vulnerable area from infection while the wound closes up.

Reduced Inflammation

Acute inflammation results in the redness that’s noticeable in fresh stretch marks. This is a normal and necessary part of the tissue regeneration scar's process. Acute inflammation, which is a function of the immune system, actually sets the stage for normal tissue repair and regeneration. Inflammation is quickly followed by the production of new skin structures — which, as previously described, are hastily assembled to ensure that the torn skin doesn’t become infected.

But sometimes, the inflammatory process continues after the wound has healed, leading to chronic inflammation. It can lead to a variety of widespread problems throughout the body, including disease. “Some inflammation is good,” says Dr. Robert H. Shmerling, an associate professor of medicine at Harvard Medical School. “Too much is often bad. The goal is to recognize when inflammation is simply doing its job, and when it can potentially cause problems.”

Hundreds of studies have shown how red light therapy can significantly reduce inflammation. Many of these were conducted by Dr. Michael A. Hamblin, an associate professor of dermatology at Harvard Medical School and a noted expert on red light therapy. In the final report of a 2017 study, Hamblin refers to red light therapy’s “pronounced anti-inflammatory effects.”

Mobilize Stem Cells

During the skin-rebuilding phase, stem cells, which are unspecialized “master” cells, mobilize to the site and develop into most any type of specialized cells that are needed by the body. Ideally, they develop into normal skin cells, rather than scar tissue, to replenish damaged or destroyed cells due to skin tearing.

Red light has been shown to activate stem cells. As Barbara Gefvert, editor-in-chief of BioOptics World, explains: “Recent research shows … that noninvasive application of light can boost the natural growth of an individual’s own stem cells to enable exciting new treatments.” Stem cells can assist with the tissue regeneration process and stimulate normal and healthy behavior in existing cells. This can prevent the formation of new stretch marks and gradually reduce the appearance of existing stretch marks.



Photodynamic Therapy for Cancer

Photodynamic therapy (PDT) is a treatment that uses a drug, called a photosensitizer or photosensitizing agent, and a particular type of light. When photosensitizers are exposed to a specific wavelength of light, they produce a form of oxygen that kills nearby cells

Each photosensitizer is activated by light of a specific wavelength. This wavelength determines how far the light can travel into the body. Thus, doctors use specific photosensitizers and wavelengths of light to treat different areas of the body with PDT.

How is PDT Used to Treat Cancer?

In the first step of PDT for cancer treatment, a photosensitizing agent is injected into the bloodstream. The agent is absorbed by cells worldwide but stays in cancer cells longer than it does in normal cells. Approximately 24 to 72 hours after injection, when most of the agent has left normal cells but remains in cancer cells, the tumor is exposed to light. The photosensitizer in the tumor absorbs the light and produces an active form of oxygen that destroys nearby cancer cells.

In addition to directly killing cancer cells, PDT appears to shrink or destroy tumors in two other ways. The photosensitizer can damage blood vessels in the tumor, thereby preventing cancer from receiving necessary nutrients. PDT also may activate the immune system to attack the tumor cells.

The light used for PDT can come from a laser or other sources. Laser light can be directed through fiber optic cables (thin fibers that transmit light) to deliver light to areas inside the body. For example, a fiber optic cable can be inserted through an endoscope (a thin, lighted tube used to look at tissues inside the body) into the lungs or esophagus to treat cancer in these organs. Other light sources include light-emitting diodes (LEDs), which may be used for surface tumors, such as skin cancer.

PDT is usually performed as an outpatient procedure. PDT may also be repeated and used with other therapies, such as surgery, radiation therapy, or chemotherapy.

Extracorporeal photopheresis (ECP) is a type of PDT in which a machine is used to collect the patient’s blood cells, treat them outside the body with a photosensitizing agent, expose them to light, and then return them to the patient. The U.S. Food and Drug Administration (FDA) has approved ECP to help lessen the severity of skin symptoms of cutaneous T-cell lymphoma that has not responded to other therapies. Studies are underway to determine if ECP may have some application for other blood cancers and help reduce rejection after transplants.

What Types of Cancer are Currently Treated with PDT?

To date, the FDA has approved the photosensitizing agent called porfimer sodium, or Photofrin®, for use in PDT to treat or relieve the symptoms of esophageal cancer and non-small cell lung cancer. Porfimer sodium is approved to relieve esophageal cancer symptoms when cancer obstructs the esophagus or when cancer cannot be satisfactorily treated with laser therapy alone. Porfimer sodium is used to treat non-small cell lung cancer in patients for whom the usual treatments are not appropriate and relieve symptoms in patients with non-small cell lung cancer that obstruct the airways. In 2003, the FDA approved porfimer sodium to treat precancerous lesions in patients with Barrett esophagus, a condition that can lead to esophageal cancer.

What are the Limitations of PDT?

The light needed to activate most photosensitizers cannot pass through more than about one-third of an inch of tissue. For this reason, PDT is usually used to treat tumors on or just under the skin or on the lining of internal organs or cavities. PDT is also less effective in treating large tumors because the light cannot pass far into these tumors. PDT is a local treatment and generally cannot treat cancer that has spread.

Does PDT have any Complications or Side Effects?

Porfimer sodium makes the skin and eyes sensitive to light for approximately 6 weeks after treatment. Thus, patients are advised to avoid direct sunlight and bright indoor light for at least 6 weeks.

Photosensitizers tend to build up in tumors, and the activating light is focused on the tumor. As a result, damage to healthy tissue is minimal. However, PDT can cause burns, swelling, pain, and scarring in nearby healthy tissue. Other side effects of PDT are related to the area that is treated. They can include coughing, trouble swallowing, stomach pain, painful breathing, or shortness of breath; these side effects are usually temporary.

What Does the Future Hold for PDT?

Researchers continue to study ways to improve the effectiveness of PDT and expand it to other cancers. Clinical trials (research studies) are underway to evaluate PDT's use for cancers of the brain, skin, prostate, cervix, and peritoneal cavity (the space in the abdomen that contains the intestines, stomach, and liver). Other research is focused on the development of more powerful photosensitizers, more specifically target cancer cells, and are activated by light that can penetrate tissue and treat deep or large tumors. Researchers are also investigating ways to improve equipment and the activating light's delivery.

Blue Light Reduces Photosynthetic Efficiency of Cyanobacteria

Almost 140 years ago, professor Theodor Engelmann showed that light color plays an important role in photosynthesis (Engelmann 1882). In his classic experiment, Engelmann placed a filamentous green alga from the genus Cladophora on a microscopic slide. He illuminated through a prism glass, thus dividing sunlight into separate wavelengths across the filament. By introducing aerotactic bacteria and observing how regions of visible light these bacteria aggregated, he established that photosynthetic oxygen (O2) production occurred in red and blue light, thereby creating the first “living” action spectrum of chlorophyll.

In the following years, Engelmann continued his studies with cyanobacteria from the genus Oscillatoria, demonstrating that in these cyanobacteria, red and blue light and orange light resulted in high O2 production rates (Engelmann 1883, 1884). Engelmann’s findings were criticized for many years, but 60 years later, his results were confirmed by Emerson and Lewis, who showed that the phycobiliproteins of cyanobacteria and red algae play a key role in light-harvesting for photosynthesis (Emerson and Lewis 1942). We now know that these phycobiliproteins make up specialized light-harvesting antennae, called phycobilisomes (PBSs), consisting of an allophycocyanin core and stacked rods of phycocyanin often in combination with phycoerythrin. These phycobiliproteins consist of an apo-protein and one or more chromophores, also known as bilins, including phycocyanobilin absorbing orange light (620 nm), phycoerythrobilin absorbing green light (545 nm), and phycourobilin absorbing blue-green light (495 nm) (Grossman et al. 1993; Tandeau de Marsac 2003; Six et al. 2007). Recent reviews on the structure and function of PBSs are provided by Tamary et al. (2012), Watanabe and Ikeuchi (2013), and Stadnichuk and Tropin (2017).

Light energy absorbed by PBSs is effectively transferred via allophycocyanin to the chlorophyll a (Chl a) pigments in the photosystems (Arnold and Oppenheimer 1950; Duysens 1951; Lemasson et al. 1973). It has long been assumed that most PBSs transfer their energy to photosystem II (PSII). However, it is now well established that cyanobacteria can re-balance excitation energy by moving PBSs between photosystem I (PSI) and PSII in a process called state transitions (van Thor et al. 1998; Mullineaux 2008). As a consequence of these state transitions, which occur at time scales of seconds to minutes, the PBSs associate with PSII (state 1) or PSI (state 2) and transfer the absorbed light energy to the reaction center of the photosystem they are associated with (Kirilovsky 2015). At longer time scales, cyanobacteria can also adjust their PSI: PSII ratio to optimize their photosynthetic activity under different environmental conditions (Fujita 1997). In cyanobacteria, the PSI: PSII ratio generally ranges between 5:1 and 2:1 depending on light quality and intensity, which is higher than the approximately 1:1 ratio often found in eukaryotic phototrophs (Shen et al. 1993; Murakami et al. 1997; Singh et al. 2009; Allahverdiyeva et al. 2014; Kirilovsky 2015).

Several studies have described that cyanobacteria use blue light less efficiently for photosynthesis than most eukaryotic phototrophs, but comprehensive studies of this phenomenon lack. Here, we study the effect of blue (450 nm), orange (625 nm), and red (660 nm) light on the growth of the model cyanobacterium Synechocystis sp. PCC 6803, the green alga Chlorella sorokiniana, and other cyanobacteria containing phycocyanin or phycoerythrin. Our results demonstrate that the cyanobacteria's specific growth rates were similar in orange and red light but much lower in blue light. Conversely, specific growth rates of the green alga C. sorokiniana were similar in blue and red light but lower in orange light. Oxygen production rates of Synechocystis sp. PCC 6803 was five-fold lower in blue than in orange and red light at low light intensities but approached the same saturation level in all three colors at high light intensities. Measurements of 77 K fluorescence emission demonstrated a lower ratio of photosystem I to photosystem II (PSI: PSII ratio) and relatively more phycobilisomes associated with PSII (state 1) blue light than in orange and red light. These results support the hypothesis that blue light, which is not absorbed by phycobilisomes, creates an imbalance between the two photosystems of cyanobacteria with an energy excess at PSI and a deficiency at the PSII-side of the photosynthetic electron transfer chain. Our results help to explain why phycobilisome-containing cyanobacteria use blue light less efficiently than species with chlorophyll-based light-harvesting antennae such as Prochlorococcus, green algae, and terrestrial plants.

Since blue and red light are both strongly absorbed by Chl a, and the intermediate wavelengths by the different phycobiliproteins, one would expect that these light colors are all used for photochemistry at approximately equal efficiency. However, several studies have described that blue light yields lower O2 production rates than red light in cyanobacteria (Lemasson et al. 1973; Pulich and van Baalen 1974; Jørgensen et al. 1987; Tyystjärvi et al. 2002), in cyanolichens (Solhaug et al. 2014), and also in PBS-containing red algae (Ley and Butler 1980; Figueroa et al. 1995). Furthermore, other studies noted that blue light resulted in lower growth rates in a variety of cyanobacteria (Wyman and Fay 1986), including Synechocystis sp. PCC 6803 (Wilde et al. 1997; Singh et al. 2009; Bland and Angenent 2016), Synechococcus sp. (Choi et al. 2013), and Spirulina platensis (Wang et al. 2007; Chen et al. 2010).

A possible explanation for their poor performance in blue light might be that most chlorophyll of cyanobacteria is located in PSI (Myers et al. 1980; Fujita 1997; Solhaug et al. 2014; Kirilovsky 2015), and hence, blue light induces high PSI but low PSII activity. This phenomenon is also known from fluorescence studies, where the use of blue measuring light complicates interpretation of the fluorescence signal of cyanobacteria (Campbell et al. 1998; Ogawa et al. 2017). However, although several of the above-cited studies measured growth rates and/or pigment composition in different light colors, they did not report on, e.g., O2 production, PSI:PSII ratios, or state transitions. Conversely, other studies measured O2 production rates or PSI:PSII ratios but did not measure growth rates or other relevant parameters. To our knowledge, more comprehensive studies of the photophysiological response of cyanobacteria to blue light are largely lacking, and no clear consensus has yet been reached on the question why their photosynthetic activity might be hampered by blue light.

The Frozen Healer - Cryotherapy

Cryotherapy is a trend with a cult following in the recovery, wellness, and beauty industries. It can be used in combination with light therapy for better results. You may have heard people talking about it or seen celebrities or athletes posting themselves coming out of icy cold chambers on social media, but what is Cryotherapy? Why is everyone talking about it?

In its most basic form, Cryotherapy is simply the use of cold temperatures to heal the body. Using the cold to help our bodies recover from injury, inflammation, soreness, or relaxation has been used since the beginning. Putting ice on a wound or bruise, jumping in a cold lake, or taking an ice bath are basic cryotherapy forms. These methods cause stagnant blood to start moving again, promoting new blood flow, which brings healing. It is a fundamental, well-understood principle that has been widely accepted and used as a means of after the fact recovery but can be quite uncomfortable, inconvenient, and extremely inefficient compared to modern-day cryotherapy through the use of cryotherapy chambers.

Day by day

Modern-day cryotherapy lends from past cold modalities to provide a much more comfortable, convenient, and effective recovery through cryotherapy chambers. Cryotherapy chambers provide a quick, 2–3 minute private session of whole-body exposure to shallow temperatures in a dry, contained, breathable air environment. Add in some music, light therapy, and awesome fog from the cold, and it becomes a fun experience that completely distracts from how cold you just got!

The goal of true whole body cryotherapy is to expose as much skin as possible to temperatures of -166F or below for a short period of time (2–3 minutes) to create a drop in the external skin temperature of 30–40 degrees. The best way to measure this is to use an infrared temperature device before and after the session on the upper arm's back, measuring the two temperature readings' delta.

Effects of Cryotherapy

Blood rushing to the core is our body’s natural way of protecting our core organs from extreme cold. When exposed to freezing temperatures, blood rushes from our extremities to our core, creating a systemic response throughout the body that produces many benefits. Cold promotes increased blood flow, bringing fresh, oxygenated blood full of white blood cells to the body's areas that need it. Cryotherapy amplifies these positive effects and adds many more incredible benefits by activating the vagus nerve and causing vasoconstriction and vasodilation. The vagus nerve is responsible for the regulation of internal organ functions [NCBI]. The vagus nerve is activated by cold on the back of the neck and touches every major organ in the body.

Whole Body Cryotherapy is not just for extreme athletes or those with present injuries, either. The best practice is for healthy, normal adults (minors with doctors) to regularly practice whole body cryotherapy 3–5 times per week. It is important to maintain a constant cryotherapy regimen and not just use it when you feel you need it or are injured. It is a continual recovery modality that helps the body stay healthy and even resist injuries and illness.

How Intense Light can Protect Against Heart Attacks

Researchers at the University of Colorado Anschutz Medical Campus have found that intense light amplifies a specific gene that bolsters blood vessels and offers protection against heart attacks.

"We already knew that intense light can protect against heart attacks, but now we have found the mechanism behind it.”

Study’s senior author Tobias Eckle, MD, PhD, professor of anesthesiology, University of Colorado School of Medicine

The study was published recently in the journal Cell Reports.

The scientists discovered that housing mice under intense light conditions for one week robustly enhances cardioprotection, which resulted in a dramatic reduction of cardiac tissue damage after a heart attack. They also found that humans could potentially benefit from a similar light exposure strategy.

To find out why they developed a strategy to protect the heart using intense light to target and manipulate the function of the PER2 gene, which is expressed in a circadian pattern in the part of the brain that controls circadian rhythms.

By amplifying this gene through light, they found that it protected cardiovascular tissues against low oxygen conditions like myocardial ischemia, caused by reduced oxygen flow to the heart.

They also discovered that the light increased cardiac adenosine, a chemical that plays a role in blood flow regulation.

Mice that were blind, however, enjoyed no cardioprotection indicating a need for visual light perception.

Next, they investigated whether intense light had similar effects on healthy human volunteers. The subjects were exposed to 30 minutes of intense light measured in lumens. In this case, volunteers were exposed to 10,000 LUX, or lumens, on five consecutive days. Researchers also did serial blood draws.

The light therapy increased PER2 levels as it did in mice. Plasma triglycerides, a surrogate for insulin sensitivity and carbohydrate metabolism, significantly decreased. Overall, the therapy improved metabolism.

Eckle has long known that light plays a critical role in cardiovascular health and regulating biological processes. He pointed out that past studies have shown an increase in myocardial infarctions during darker winter months in all U.S. states, including sunnier places like Arizona, Hawaii, and California. The duration of the light isn’t as important as the intensity, he said.

“The most dramatic event in the history of the earth was the arrival of sunlight,” Eckle said. “Sunlight caused a great oxygen event. With sunlight, trillions of algae could now make oxygen, transforming the entire planet.”

Eckle said the study shows, on a molecular level, that intensive light therapy offers a promising strategy in treating or preventing low oxygen conditions like myocardial ischemia.

He said if the therapy is given before high-risk cardiac and non-cardiac surgery, it could offer protection against injury to the heart muscle, which can be fatal.

“Giving patients light therapy for a week before surgery could increase cardioprotection,” he said. “Drugs could also be developed that offer similar protections based on these findings. However, future studies in humans will be necessary to understand the impact of intense light therapy and its potential for cardioprotection.”

Source:

University of Colorado Anschutz Medical Campus

Journal reference:

Oyama, Y. et al. (2019) Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Reports. doi.org/10.1016/j.celrep.2019.07.020.


Fetuses May be Able to See More Light than you Think

By the second trimester, long before a baby's eyes can see images, they can detect light.

But the light-sensitive cells in the developing retina -- the thin sheet of brain-like tissue at the back of the eye -- were thought to be simple on-off switches, presumably there to set up the 24-hour, day-night rhythms parents hope their baby will follow. University of California, Berkeley, scientists have now found evidence that these simple cells actually talk to one another as part of an interconnected network that gives the retina more light sensitivity than once thought, and that may enhance the influence of light on behavior and brain development in unsuspected ways.

In the developing eye, perhaps 3% of ganglion cells -- the retina cells that send messages through the optic nerve into the brain -- are sensitive to light. To date, researchers have found about six different subtypes that communicate with various places in the brain. Some talk to the suprachiasmatic nucleus to tune our internal clock to the day-night cycle. Others send signals to the area that makes our pupils constrict in bright light.

But others connect to surprising areas: the perihabenula, which regulates mood, and the amygdala, which deals with emotions.

Recent evidence suggests that in mice and monkeys, these ganglion cells also talk with one another through electrical connections called gap junctions, implying much more complexity in immature rodent and primate eyes than imagined.

"Given the variety of these ganglion cells and that they project to many different parts of the brain, it makes me wonder whether they play a role in how the retina connects up to the brain," said Marla Feller, a UC Berkeley professor of molecular and cell biology and senior author of a paper that appeared this month in the journal Current Biology. "Maybe not for visual circuits, but non-vision behaviors. Not only the pupillary light reflex and circadian rhythms, but possibly explaining problems like light-induced migraines, or why light therapy works for depression."

Parallel systems in developing retina

The cells, called intrinsically photosensitive retinal ganglion cells (ipRGCs), were discovered only 10 years ago, surprising those like Feller, who studied the developing retina for nearly 20 years. She played a major role, along with her mentor, Carla Shatz of Stanford University, in showing that spontaneous electrical activity in the eye during development -- so-called retinal waves -- is critical for setting up the correct brain networks to process images later on.

Hence her interest in the ipRGCs seemed to function in parallel with spontaneous retinal waves in the developing retina.

We thought they (mouse pups and the human fetus) were blind at this point in development. We thought that the ganglion cells were there in the developing eye, that they are connected to the brain, but that they were not really connected to much of the rest of the retina, at that point. Now, it turns out they are connected to each other, which was a surprising thing."

Marla Feller, the Paul Licht Distinguished Professor in Biological Sciences and a member of UC Berkeley's Helen Wills Neuroscience Institute.

UC Berkeley graduate student Franklin Caval-Holme combined two-photon calcium imaging, whole-cell electrical recording, pharmacology, and anatomical techniques to show that the six types of ipRGCs in the newborn mouse retina link up electrically, via gap junctions, to form a retinal network that the researchers found not only detect light but respond to the intensity of the light, which can vary nearly a billionfold.

Gap junction circuits were critical for light sensitivity in some ipRGC subtypes. Still, not others, providing a potential avenue to determine which ipRGC subtypes provide the signal for specific non-visual behaviors that light evokes.

"Aversion to light, which pups develop very early, is intensity-dependent," suggesting that these neural circuits could be involved in light-aversion behavior, Caval-Holme said. "We don't know which of these ipRGC subtypes in the neonatal retina actually contributes to the behavior, so it will be fascinating to see what role all these different subtypes have."

The researchers also found evidence that the circuit tunes itself in a way that could adapt to the intensity of light, which probably has an important role in development, Feller said.

"In the past, people demonstrated that these light-sensitive cells are important for things like the development of the blood vessels in the retina and light entrainment of circadian rhythms, but those were kind of a light on/light of the response, where you need some light or no light," she said. "This seems to argue that they are actually trying to code for many different intensities of light, encoding much more information than people had previously thought."
Source:

University of California, Berkeley

Journal reference:

Caval-Holme, F., et al. (2019) Gap Junction Coupling Shapes the Encoding of Light in the Developing Retina. Current Biology. doi.org/10.1016/j.cub.2019.10.025.


Light Therapy Clinical Trial Aims to Accelerate Recovery from COVID-19

Ontario is a known leader in conducting innovative clinical trials, and the clinical trials community in Ontario has proven this strength throughout the COVID-19 pandemic. One innovative trial underway in Ontario is Vielight Inc.’s COVIDlight trial, which tests whether the recovery of COVID-19 patients may be accelerated by the use of a specialized light therapy device. This trial was made possible in part by Clinical Trials Ontario’s Trial Site Network through a connection made between Vielight Inc. and Impact Clinical Trials. CTO spoke with representatives from Vielight and Impact Clinical Trials about their trial and their experience with the Trial Site Network.

Light Therapy Device for the Treatment of COVID-19

Vielight Inc. has developed a compact and portable device named the “Vielight RX Plus,” based on the science of photobiomodulation (PBM). PBM uses certain light energy to modify cellular functions and can play a role in the management of COVID-19. This clinical trial assesses the efficacy of the Vielight RX Plus to reduce symptom duration and severity in patients suffering from COVID-19.

The Vielight RX Plus device delivers light therapy to the sternum and the nasal canal.

“This device brings a holistic approach to the treatment of COVID-19 patients,”

said Nazanin Hosseinkhah, Research Scientist and Physicist at Vielight Inc.

“The device stimulates the thymus gland, creates nitric oxide, increases natural killer cells, acts as an anti-inflammatory therapy, and increases cellular energy.”

This unique, at-home study has the potential to modulate immune cell and cytokine activity in COVID-19 patients with an easy to use the device.

“We are very hopeful that this trial will prove to help patients recover from COVID-19 at home, and result in less burden to the healthcare system,”

said Hosseinkhah.

Clinical Ttrial

This randomized controlled trial, being managed by Impact Clinical Trials, is actively recruiting 280 participants who are confirmed to have contracted COVID-19. The trial was authorized by Health Canada in early September and is recruiting participants in Ontario and the United States. Participants are allocated into a treatment or a control group, with 140 participants randomized to receive the Vielight RX Plus device and the other 140 participants receiving the current standard of care. The trial is conducted remotely with non-hospitalized participants.

Participants in the treatment group receive the device by courier within 24 hours of registering for the trial. They are asked to place the device on their chest and onto their nostril for 20 mins each day. They then track their symptoms within a daily survey over a 30-day period.

“This is a simple, at-home study for participants to be involved in,”

said Andrea Berk from Impact Clinical Trials.

“Participants in both the treatment and the control groups are completely supported throughout the trial, with a 24-hour number they can call if they have any questions.”
Connections

This trial was made possible in part by a connection made directly through CTO’s Trial Site Network.  The Trial Site Network, part of CTO’s Industry Concierge program, comprises more than 230 sites. The Network allows CTO to provide warm introductions to Ontario’s hospitals, research institutions, private research networks, and CROs.

“We have been able to guide companies such as Vielight in getting their trials up and running in Ontario,”

said Andrew Haller.

“I was introduced to Andrew Haller from CTO a few months before the COVID-19 pandemic,”

said Berk.

“Pre-COVID I was working on half a dozen connections that had been made through the Trial Site Network. When COVID-19 hit, those projects were put on hold. I reached out to Andrew to let him know Impact Clinical Trials had the consulting capacity, and that is when he introduced us to Vielight.”

Haller knew that Vielight had been searching for someone to take on the management of their clinical trial. “When Andrew introduced us to Andrea Berk from Impact Clinical Trials, we immediately connected and knew they were the right fit,” said Hosseinkhah.

The Bright Hope for Allergic Rhinitis

As the name suggests, Allergic rhinitis (also known as hay fever) is an inflammatory disorder of the nasal mucosa, which occurs when the immune system overreacts to allergens in the air. This might sound small, but it affects 20% of the adult population and up to 40% of children.

Allergic rhinitis is biologically associated and equated with decreased learning, performance, productivity at work and school, and reduced life quality. It affects the quality of life, including fatigue, irritability, memory deficits, and depression. It is reflecting the social-economic costs and the negative impact on the quality of life.

Light Therapy for Rhinitis

If we talk about the current therapeutic options like allergen avoidance, medication, and immunotherapy, they are quite far from ideal. Light therapy has been treating immune-mediated dermatological conditions, e.g., psoriasis and atopic dermatitis.

Light Therapy has been There!

It is one of the oldest treatments that has been practiced in ancient times. Red light therapy has profound immunosuppressive effects on the human body.

As per ARIA guidelines, Red light therapy has been recommended for patients with allergic rhinitis who do not respond to standard medical treatment.

Now, the questions arise what the benefits of red light therapy are? Why should you opt for it?

Well, there are many benefits to using red light therapy:

  • Better and increased blood circulation in the nasal tissues
  • Enhanced local blood oxygen saturation
  • Reduced nasal obstruction (congestion) caused by nasal swelling
  • Improved nasal anti-virus ability
  • Repaired local blood capillaries
  • Strengthened detoxification ability of the nasal mucosa
The Mechanism

Light therapy treatment delivers light to pathological areas to promote tissue regeneration, reduce inflammation, and relieve pain. This treatment improves the nasal obstruction caused by Allergic rhinitis. The sessions involve illuminating the nasal cavity through specific wavelength log light ((660nm — 810nm) to the nose for a certain amount of time.

Most light therapy devices include one or two small LED light-emitting probes, which quickly stimulate the nasal cavity's blood capillaries.

Light therapy mechanisms reduce the number and function of dendritic cells and induce immunomodulatory cytokines like IL-10. Cytokines are a large group of proteins, peptides secreted by specific cells of our immune system. The Red Light therapy generates little heat, modulating mucosal blood supply and histamine release (organic nitrogenous compound involved in local immune responses). This heat alters mucosal blood supply.

The therapy shows improvement in the symptoms of nasal congestion and a decrease in nasal resistance. Studies showed that Phototherapy resulted in a significant improvement of clinical symptoms for nasal itching, rhinorrhea, sneezing, and total nasal score.

Red light therapy resulted in a remarkable improvement of clinical symptoms for nasal itching, rhinorrhea, sneezing, and total nasal score.

Adopt light therapy and give your life a better quality. Improve the shape of your life; let the negativity and obstructions be at bay!

References:

What You Need to Know About Red Light Therapy and Homeostasis

Our bodies are in constant need of replenishing our cells with oxygen, nutrients, and ATP energy to stay on top of our day to day activities. Also, the optimal function of our cells boils down to maintaining the balance that our body needs. This is also known as homeostasis.

Homeostasis Defined

The scientific definition of homeostasis is in a state of equilibrium, wherein the body’s chemical and physical processes are stable. The balance of the body is dependent on a plethora of factors, such as body temperature, calorie intake, level of blood sugar, the balance of fluid, and pH levels.

These factors are constantly changing and require regulation. They also adapt to changing environments like temperature, light, and activities. Reaching homeostasis requires balance for the body to reach its optimal state. This is present in humans' biology and animals' biology because it determines physical and mental performance, even stress response.

Homeostasis in Cellular Energy

The mitochondria break down food and oxygen to produce ATP energy for the body during the cellular respiration process. Healthy light intake is important in cellular energy to stimulate the mitochondria and efficiently produce ATP energy without inflammation and oxidative stress that may disrupt the cellular respiration process. Red and NIR light therapy enhances cellular and mitochondrial function to ensure that the cellular respiration process works efficiently.

Homeostasis in Body Temperature

Our bodies respond to changes in external temperature through sweating and shivering. These internal temperature processes regulate the body to maintain a temperature balance. The normal body temperature is about 98.6 degrees Fahrenheit. When the body is at a normal temperature, it’s easier to perform well. It can also indicate homeostasis and balance in the body, which we naturally try to achieve. On the other hand, experiencing a fever or being exposed to the cold can make it hard to function well for a long time.

Homeostasis and Calcium Levels

The body’s calcium is usually found in the bones and teeth, but the calcium in the blood requires constant maintenance at about 10 mg/dL. Calcium is essential for blood circulation, coagulation, and bone mineralization. When calcium is low, you may suffer from an irregular heartbeat and other health risks. Meanwhile, when calcium is high, the body may feel exhausted and sluggish because of the nervous system's inactivity. Skeletal, endocrine, and digestive systems in the bodywork hand in hand to maintain basic calcium homeostasis and balance.

Imbalance in the Body

The natural and continuous goal of the body in homeostasis, but many factors are at play. When we use our digestive, respiratory systems, and all the other organs, we need the necessary energy to process nutrients from food, oxygen, and light. The bodily systems are interdependent with one another and need each other to maintain balance.

When one system is lacking, the body naturally compensates by getting from another system to maintain balance. An example is a homeostasis in calcium levels in the bloodstream, which relies on food intake. If the diet lacks calcium, the body gets calcium from the bones, which technically regulates the calcium needed in the bloodstream, but eventually, it will make the bones weak and brittle.

The resourcefulness of the body to shift functions is a great deal. Still, in the long run, it may lead to serious health problems, possibly building up deficiencies and difficulties over time. It is imperative to be aware of the body’s balance and how diet, exercise, and light exposure are interconnected.

Healthy Light’s Effects on Biological Balance and Good Health

Light empowers the cells and enhances the cellular respiration process, creating ATP energy more efficiently. Aside from being essential for our life on earth, having enough light intake is an indication of biological balance. In fact, not getting your regular dose of sunlight may result in inflammation, sluggishness, off circadian rhythms, and poor sleeping habits. Most of the time, people don’t get enough light from their environment since they stay indoors and are surrounded by artificial light.

Being indoors is not how bodies are designed. We are programmed to thrive when our cells intake a good amount of healthy light. Not enough sunlight exposure can make the body imbalanced and lead to decreased energy production and Vitamin D.

Red Light Therapy and Homeostasis

You must be intentional in spending time outdoors to ensure that your body gets the amount of healthy light it requires. However, given the circumstances and limitations that we have, most people really do not get enough natural light, which red light therapy can solve.

Red light therapy is a non-invasive treatment that delivers red and NIR light wavelengths to the skin and cells and helps the mitochondria in cells produce enough ATP energy. Red light therapy helps keep the body and cells balanced, giving enough energy and power to the body even if there’s not enough light in the environment.

Final Thoughts

Our bodies function better when we reach biological balance or homeostasis. A balanced cellular environment indicates good health, and getting healthy light is an important variable to biological balance, on top of exercise, diet, and sleep. Red light therapy helps promote homeostasis and improve overall health by supporting a more efficient cellular environment. Red and NIR light wavelengths stimulate the mitochondria, producing more ATP energy that empowers the body.

If you want to read more about red light therapy and its benefits, you may go to our red light therapy blog. On the other hand, if you want to see our red light therapy devices breakdown, please don’t hesitate to browse through our catalog.

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OpenStax, Anatomy & Physiology. Rice University. OpenStax CNX. 2016 Feb.

Klepeis NE, Nelson WC, Ott WR, et al. The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants. Journal of Exposure Analysis and Environmental Epidemiology. 2001 May.

How Effective is Blue Light Therapy for Spider Veins?

Medical spas often recommend Blue light therapy for spider veins because they don’t have to be administered by trained doctors. And, yes, after several expensive sessions, you might start seeing a difference. The most effective method to treat spider veins is Sclerotherapy. We’ll also discuss the benefits of using Sclerotherapy is an effective alternative.

What are Spider Veins?

Before discussing how to treat spider veins with blue light therapy or sclerotherapy, we need to discuss what causes spider veins.

Spider Veins, scientifically called Telangiectasias, are a small network of blood vessels visible just under the skin's surface. They are called “spider veins” because they look like red spider webs.

Spider veins generally occur on the legs, feet, thighs, and face. They can also cause slight pain and discomfort.

Causes and Dangers of Spider Veins

While spider veins aren’t dangerous in and of themselves, they can indicate underlying vein disease.

Vein Disease, also known as Chronic Venous Insufficiency, is a disease in which the valves in the veins malfunction. The valves are usually supposed to act as one-way doors and facilitate blood flow to the heart. However, when they malfunction, blood flows back down and pools around the legs. This can put pressure on the veins and lead to spider veins or varicose veins.

While spider veins themselves aren’t dangerous, vein disease is hazardous and needs to be treated immediately. If left untreated, venous insufficiency can result in bleeding, skin infections, and ulcers.

In the worst-case scenario, vein disease can also lead to Deep Vein Thrombosis, a medical condition in which blood clots in the veins. If the clotted blood breaks, it can get carried to the lungs, leading to a potentially fatal condition called Pulmonary Embolism.

What is Blue Light Therapy for Spider Veins?

Blue Light Therapy for spider veins is a method in which blue light or laser is used to treat spider veins. The laser is non-UV in nature and emits photons that generate heat. The heat can destroy the damaged blood vessel over time. As such, the damaged vein shrinks and eventually dissolves.

Advantages of Blue Light Therapy for Spider Veins

The only time that blue light therapy for spider veins has an advantage over sclerotherapy is when it comes to the foot or face.

Both the face and the foot are dense with venous-arterial connections. When using Sclerotherapy, the Sclero has to be injected into the veins. Injecting it into the arteries can be dangerous. Most conservative physicians prefer not to use Sclerotherapy for spider veins in the face or foot.

As such, it’s better to go for blue light therapy for spider veins in the face or foot.

Sclerotherapy: An Alternative to Blue Light Therapy for Spider Veins

Sclerotherapy is the most effective and permanent method to treat spider veins. It is a minimally-invasive procedure in which a medicine called Sclerosant is injected into the damaged vein.

The Sclerosant inflicts some chemical damage to the veins, which leads to the vein walls sticking together and eventually closing up. The blood is then routed to healthier veins, and the damaged vein eventually gets reabsorbed.

Advantages of Sclerotherapy for Spider Veins

There are multiple advantages of using Sclerotherapy to treat spider veins:

  • The process is minimally-invasive and non-surgical in nature.
  • Sclerotherapy doesn’t hurt or cause much discomfort.
  • It works immediately, and you don’t need to come back for multiple treatment sessions.
  • It can get rid of spider veins permanently.
  • The entire process takes just about 30 minutes.
  • You can resume your daily activities immediately after.
  • It is cheaper than Blue Light Therapy.


Red Light Therapy Can Help Reduce Inflammation

We can usually identify inflammation when we see it. The inflamed part of the body looks red and swollen, and it feels hot and painful. But in this article, we’ll find out why we experience inflammation, as well as its causes, risk factors, and how red light therapy devices can help reduce it.

What Really is Inflammation?

Inflammation is our body’s natural response to pain, irritation, damaged cells, exposure to germs, and potential danger. There are two types of inflammation:

1. Acute inflammation

This type of inflammation happens as our body’s healthy response to injury or stress. We mean “healthy” because it helps the body recover faster. The inflammation happens only for a few hours and then starts to repair the damaged tissue.

2. Chronic inflammation

On the other hand, chronic inflammation can be excruciating and may cause discomfort or inconvenience. It causes an imbalance in the body, making it operate inefficiently over time. Chronic inflammation can be caused by viral infections, repetitive tissue damage, autoimmune reactions, and persistent and recurring acute inflammation. At its worse, this type of inflammation may lead to more serious diseases and/or conditions such as cancer, stroke, depression, and heart disorder.

Common Causes of Inflammation

Anything that causes stress on your body may lead to inflammation. These include:

  • Bruises
  • Bumps
  • Burns
  • Chemical irritants
  • Dehydration
  • Diseases
  • Excessive alcohol
  • Infection
  • Irritants
  • Poor nutrition
  • Poor sleep
  • Splinters
  • Toxin exposure
  • Wounds and injuries

Signs of Inflammation

There are five common signs of inflammation:

  • Heat on the inflamed area
  • Loss of function (i.e., you can’t move your arms or legs)
  • Pain
  • Redness
  • Swelling
Treatment Options for Inflammation

For acute inflammation, doctors normally recommend nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and paracetamol. Meanwhile, chronic inflammation may also be prescribed with NSAIDs, along with steroids and supplements.

However, these common treatment options help prevent inflammation symptoms but do not deal with the root cause, including improper cellular function, biological imbalance, and damaged tissues. This is also why lifestyle changes (improved diet, regular exercises, and high-quality sleep) and red light therapy could be of great help.

How Red Light Therapy Works Against Inflammation

Red light therapy, also referred to as low-level laser therapy (LLLT) or photobiomodulation (PBM), is a non-invasive treatment option. This kind of therapy delivers wavelengths of red and near-infrared (NIR) light to your skin and cells for multiple benefits. When it comes to inflammation, it can help cut down oxidative stress and activate protective cellular mechanisms to boost your immune system and protect you from diseases that may cause inflammation. It can also boost the generation of healing agents and antioxidants in the body to speed up damaged tissues' healing process.

Red light therapy can give your body the light exposure needed to function more efficiently, improve blood flow, and limit inflammation.

Conclusion

Inflammation is a natural part of our biological processes, but chronic cases may also lead to serious health risks that can affect the quality of your life. Therefore, if you’re experiencing signs of inflammation, regardless if it’s acute or chronic, please schedule an appointment with your doctor to get the care and treatment you need as early as possible.

In the meantime, to protect your body from the stress that may cause inflammation, you can do red light therapy either through a health provider or from the comfort of your home. If you need to purchase red light therapy devices, you can browse through our catalog to see the brands and products that we offer.


Keep Your Skin Healthy with Red Light Therapy

Skincare doesn’t just affect the way you look. It also plays a huge role in your overall health — from body temperature to hormone regulation to your immune system. If you’re into skincare as much as we are, one of the many ways that can help you keep your skin healthy is red light therapy. In this article, we’ll take a deep dive into why you should take care of your skin, and we’ll also discuss how red light therapy devices can help you achieve your skin goals.

Are you ready? Let’s go straight into it.

Why Do You Need to Take Care of Your Skin?

As the largest organ in our body, your skin is your body’s first defense line to bacteria, germs, viruses, etc. It’s a vital part of the immune system and some processes in your body, such as temperature control, blood circulation, and hormone production.

Main Functions of the Skin

Let’s take a look at the skin's main functions to help you understand how essential it is for you to take care of this vital organ.

1. Defense and Immunity

The skin is an active immune organ, and it serves as our physical barrier from the dangers of the environment. It helps protect our bodies from diseases, germs, viruses, dirt, UV radiation, and potential thermal and physical injuries. It also helps detect and fight off infection, toxins, allergens, hazardous substances, and carcinogens.

2. Temperature Regulation

Aside from protecting us from extreme cold or heat, the skin also helps prevent moisture loss, keeping us from being dehydrated.

3. Sense of touch

The skin has a somatosensory system that is composed of touch receptors and nerve endings. This system is responsible for the sensations we feel, including pain, pressure, vibrations, smoothness, roughness, heat, cold, tickle, itch, and more.

4. Storage and Production of Vitamin D

Your body also uses your skin's deeper layers to store metabolic products, fat, and water. The skin is also responsible for producing vitamin D, supplied in the body when the skin gets enough sunlight exposure.

5. Beauty

Need we say more? Your skin plays a huge part in your appearance. Of course, when your skin is healthy, you also look glowing, radiant, and definitely more attractive.

Red Light Therapy and Keeping Your Skin Healthy

Before we proceed with the “how,” let’s first define what red light therapy is. Red light therapy is a non-invasive treatment option for different kinds of medical conditions. It is also used for health improvement and various aesthetic procedures.

Decades ago, red light therapy machines were only available in clinics, high-end salons, and spas. Nowadays, red light therapy devices can be bought and used by anyone. In fact, you can do red light therapy at the comfort of your home and incorporate it into your skincare routine.

How Does Red Light Therapy Work?

Red light therapy works by delivering wavelengths of red and near-infrared (NIR) light to our cells and skin. Besides helping enhance cellular function, red light therapy also helps stimulate the mitochondria and produce ATP (adenosine triphosphate) energy. This treatment option usually takes only about 10 minutes per session.

How Does Red Light Therapy Help Keep Your Skin Healthy?

Our skin relies on millions of cells to be able to perform its functions. When our cells experience homeostasis or a state of balance, our skin and body perform (and look) better. And as mentioned above, red and NIR light enhances cellular function while also preventing inflammation and oxidative stress. Red light therapy helps make your skin look and feel softer, smoother, and healthier.

Besides, red light therapy also helps damaged tissues heal and regenerate faster. It also has anti-inflammatory benefits, potentially increasing blood flow to damaged and inflamed tissues and reducing oxidative stress.

Final Thoughts

Skincare is self-care, as keeping your skin healthy also produces multiple benefits to your health. Thankfully, aside from proper hygiene, regular exercise, a balanced diet, and an established skincare routine, red light therapy can also improve your overall skin health.

For more information about red light therapy or to view our catalog of red therapy devices, click here.

Sources:

https://www.hse.gov.uk/skin/professional/causes/structure.htm

Improving Mental Acuity with Light Therapy

It’s common knowledge that as we age, our normal brain function gets disrupted. We tend to find it harder to recall information, memorize names, and respond with reason. The decline of our mental acuity causes these commonplace mental problems. Contrary to popular belief, aging is not the sole culprit for mental deterioration. Many factors, such as aging, lifestyle changes, and environmental stress, contribute to the decline of mental acuity.

As cognitive decline progresses, significant mental changes can result in disorders such as dementia, Alzheimer’s disease, and Parkinson’s disease. While these can be common aspects of life, they aren’t inevitable. Many medical experts believe that there are many lifestyle changes that you can take to prevent the degradation of Mental Acuity.

What is Mental Acuity?

Mental acuity is known as the sharpness of the mind. It involves our cognitive ability to concentrate, process, understand, reason, and memorize. On the other hand, intelligence means the extent to which our brains absorb and process a specific amount of information at a given amount of time. Mental acuity is a natural and essential aspect of our brain health and is not a measure of how “smart” we are.

Mental acuity allows us to perform daily activities effectively and efficiently. When our cognitive ability functions well, we’re more capable of doing things without damage or conflict.

What are the symptoms of a Deteriorating Mental Acuity?

Some signs of a deteriorating cognitive ability may be subtle. However, when left untreated could progress over time to more serious mental disorders. According to the National Institute on Aging, 8 out of 10 people who experience amnestic mild cognitive impairment develop into having Alzheimer’s disease.

Here are some early symptoms of a deteriorating mental acuity:

  • Absent-mindedness and having trouble concentrating
  • Forgetfulness of specific details like names, dates, events, and facts
  • Inability to reason and make vital decisions
  • Difficulty in retrieving information
  • Memory loss
  • Difficulty in following simple instructions

How to Improve Mental Acuity

Prevention is better than cure when it comes to developing chronic brain disorders. Here’s how you can take your brain health into your own hands by observing these lifestyle habits:

  1. Ensure a well-balanced diet

Getting enough nutrition is the key to ensure mental sharpness. Making sure you eat a well-balanced diet can help your body supply enough nutrients to your brain. Omega 3 Fatty Acids are essential nutrients that help build and restore brain cells. The brain also needs antioxidants to prevent inflammation.

Excessive intake of toxins such as alcohol and drug can depreciate your mental ability. Experts agree that poor gut health also results in a weakened immune system. As a result, it weakens your body’s inflammatory response. A poor inflammatory response causes mental disorders such as schizophrenia and dementia.

  1. Have Enough Sleep

Irregular sleep patterns and sleep deprivation disrupt your body’s circadian rhythm that can lead to short-term mental problems as well as long-term chronic health problems.

Your body’s circadian rhythm is a natural body clock that controls your sleep-wake schedule as well as your digestive patterns. When you’re sleep-deprived, these rhythms get disturbed. As a result, you experience headaches, mood swings, and difficulty to focus and recall information. Aside from these unwanted effects, not having enough sleep also negatively impacts your overall brain health.

  1. Get Yourself Moving

Exercise isn’t just for physical and aesthetic purposes. It also affects brain function in multiple ways. When you exercise, your body pumps more oxygen into your brain through an increased heart rate. Exercise allows your body to release hormones that are vital in nourishing your brain cells. It also promotes growth factors in your brain to assist in the growth of neuronal connections.

A study at the University of Georgia shows that a 20-minute exercise daily can improve memory retention and information processing. Many experts agree that a sedentary lifestyle may accelerate your way into cognitive decline.

  1. Use Red Light Therapy

Red Light therapy is a more modern approach to non-invasive and low-risk medical treatments. It is a form of photobiomodulation that allows light to change human cells' physiology that causes a wide range of benefits such as biological balance and cellular energy.

Kaiyan Medical is one of the pioneers of Red light therapy that uses red wavelengths to deliver benefits to the skin and near-infrared lights to penetrate deeper within the skin’s surface. This dual technology allows for better absorption and effectiveness of the benefits of Red light therapy.

As near-infrared wavelengths penetrate the brain’s cellular system, it promotes energy production by stimulating the mitochondria. It also prevents stress by keeping away oxidative stress. Thus, it delivers multiple benefits such as better blood flow, faster cell regeneration, and improved healing.

A study shows that red light therapy has significantly improved brain function when given to patients with cognitive dysfunction. All these benefits are vital in promoting and maintaining a healthy mental acuity. Red light therapy delivers all these cellular benefits to promote better sleep quality and a more balanced circadian clock.

As you maintain these lifestyle changes, you can experience a more improved brain function and better brain health. Now you can defy all odds and allow your brain to perform at its peak by having a healthy lifestyle and a balanced body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043367/

https://www.medicalnewstoday.com/articles/324044#oily-fish

https://pubmed.ncbi.nlm.nih.gov/12595152/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403829/

https://www.healthline.com/health/mental-health/brain-exercises

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870908/


How Does Red Light Therapy Relate with Ketogenic Diet?

Red light therapy is an easily accessible and affordable clinical device that boosts metabolism and increases ATP energy production. It is a non-invasive modulator of metabolism that delivers proper frequency, power, and luminance by shifting the mitochondria's function organically.

Ketogenic Diet and Red Light Therapy

A ketogenic diet involves the consumption of low-carb, high-fat meals. When practiced together with red light therapy, it can amplify your metabolic flexibility. It also helps cells burn more sugar and fat efficiently. Good levels of ATP energy production (empowered by mitochondria by converting oxygen and nutrients to ATP) can help prevent high-blood or low-blood pressure conditions. The process of creating ATP energy works best when our body and cells are well-balanced, reaching a state called homeostasis.

One thing to consider in following a diet plan is over-nutrition, which may lead to metabolic inflexibility. When over-feeding happens, the production of ATP energy may result in metabolic congestion. Red light therapy can help alleviate this metabolic congestion by focusing amplification of ATP energy levels. Insulin can mediate metabolic congestion by the fluidity between glucose, fatty acids, and amino acids. An important step for ATP energy production is forming the COX enzyme, which can aid metabolism by pairing oxygen neutralized into the water with high-energy electrons.

If the COX enzyme goes out of sync with electrons' flow, the high-energy electrons won’t effectively be neutralized into water. Red light can help regulate the healthy formation of the COX enzyme, efficiently oxidizing fat. The ketogenic diet triggers cells to insulin by stimulating ATP energy production by increasing metabolic flexibility, reducing carbon combustion, and helping clear metabolic congestion.

Significance to Healing

The chemical DHEA (dehydroepiandrosterone) plays numerous vital roles in health. It helps with the metabolism of cholesterol that produces hormones such as progesterone, estrogen, and testosterone. As we age, our levels of DHEA decreases, as well as the synthesis of such hormones. Low levels of progesterone can affect women in their peri-menopausal and post-menopausal stages. This is a function of the decline in mitochondria, which then affects ATP energy levels.

Low levels of DHEA may contribute to the insufficiency of adrenaline and estrogen dominance, which is common to middle-aged women at the peri-menopausal or post-menopausal stage. Women rely on the production of adrenaline and DHEA to keep their progesterone levels and prevent estrogen dominance.

Lower production of DHEA and progesterone can be an effect of elevated secretion of cortisol that is caused by acute/chronic stress. When high levels of stress reduce the adrenal glands' proper functions due to the decrease of synthesis of the adrenal cortex steroid hormones in the mitochondria, it results in adrenal insufficiency.

Based on health professionals' studies, when cortisol levels drop, it inhibits the synthesis and secretion of DHEA/progesterone, resulting in pathophysiological changes caused by stress. Enzyme activation and regulatory signaling can affect the fluidity dynamics between cortisol, DHEA, and other hormones such as progesterone, estrogen, and testosterone.

Red light therapy and ketogenic diet can mediate inflammatory stress and regulate the healthy production of DHEA.

Estrogen Levels

Estrogen is a master regulator of female metabolism. A youthful and regulatory expression of estrogen is the production of 17B-estradiol (E2). It modulates the menstrual cycle to ensure the healthy release of the corpus luteum, which secretes progesterone.

On the other hand, progesterone helps maintain a healthy uterus lining. When the expression of E2 is sufficient, progesterone secretion also increases. Having high progesterone levels means having lower estrogen and a lesser risk of getting diseases like breast, ovary, and colon cancer. E2 also contributes to potential partition fuel, orchestrating metabolic flexibility, and increasing energy levels that lead to optimal cerebral glucose metabolism.

The decline in the peripheral steroidogenesis of E2, progesterone, and testosterone is common as time goes by.

Testosterone Levels

A 12-week ketogenic diet may increase testosterone levels in men due to an increase in cholesterol and DHEA. Red light therapy also improves the mitochondrial synthesis of testosterone from DHEA.

For males, testosterone naturally converts to E2, but healthy testosterone levels stipulate a hormonal challenge to the synthesis of E2. An enlarged prostate can be caused by estrogen dominance when there is no testosterone/estrogen ratio balance. Having healthy testosterone levels may lead to a decline of estrogen dominance, as it is for progesterone in women.

Other Healing Benefits

Healthcare professionals strongly believe that red light therapy can be a powerful healing agent that may help prevent diabetic ulcers and lower chances of extremity amputations when practiced together with a ketogenic diet.

Diabetic ulcers usually result to lower limb amputations in the long-run. Studies show that diabetic foot ulcers and lower extremity amputations are increasing in number. In fact, having unhealed wounds can be alarming as the post-amputation survival rate for people with diabetes averages to only five years. Statistics show the urgent need to prevent, detect, and prove that treatments for lower limb ulcers should be highly considered. Red light therapy has been proven to increase the circulation of blood flow and healthier skin.

Innovation

Red light therapy and ketogenic diets are considered to be disruptive innovators in the healthcare system. Apart from the fact that red light therapy is non-invasive, such treatment shows great potential in helping lengthen the lifespan and improve people's overall health. Red light therapy also promotes a more affordable and accessible treatment that can be done in the comfort of your home.

Here at Kaiyan Medical, we offer red light therapy devices to help you achieve your health and aesthetic goals. To learn more about the brands and products we offer, please click here.

More References

https://perfectketo.com/red-light-therapy/

https://perfectketo.com/keto-diet-plan-for-beginners/

https://www.rejuvcryo.com/the-science/2019/8/14/article-the-surprising-synergy-between-keto-and-red-light-therapy-rejuvcryo-north-county-san-diego

How Saunas and Red Light Therapy are Distinct but Complementing

Saunas and red light therapy devices are clinically-proven treatments that complement each other wonderfully, even if they depend on distinct biological mechanisms to yield various natural health and aesthetic benefits.

In this article, we’ll focus on how things work for red light therapy and the distinctions of traditional saunas, and what you can actually gain by availing of either of them.

What You Need to Know About Saunas

Saunas can make your body’s core temperature hotter by supplying sufficient heat throughout your body. It has been a part of traditional medicine for various centuries, as the old century folks realized the health benefits of sweating. Although there are multiple types of saunas, two of them are the most popular:

  1. Traditional Convection Saunas

When you think of saunas, this is the first scenario that comes to mind: hot and steamy. This type of sauna requires more energy as it delivers heat to the atmosphere, warming the air inside the sauna, and distributes heat in the body. Traditional convection saunas can maintain air temperatures between 170–200°F and are an ideal type of sauna for general use. It is important to comprehend the different temperatures required for specific health concerns since being exposed to heat more than what has required triggers a warning for unsubstantiated claims.

  1. Infrared Saunas

The latest trend in saunas is the infrared saunas. Inside, instead of warming the air, this kind of sauna heats actual objects. Such objects include those with emitting surfaces, charcoal, and carbon fiber. Infrared saunas' effectivity is directly attributed to the temperature, humidity, and length of time your body is exposed to heat, even though many saunas claim to provide “full-spectrum” infrared wavelengths.

The farther the wavelengths are in the infrared spectrum, the more they are considered efficient and effective in heat production. This will be thoroughly discussed later, but the general gist is that heat supplementation is the primary purpose of saunas, convection, and infrared.

On the other hand, near-infrared wavelengths in near-infrared saunas generate very little heat. Most of the high-quality standard saunas use more effective heats from the far-infrared spectrum or IR-C wavelengths.

What are the Health Benefits of Saunas?

Inducing thermal stress on the body is the primary function of every sauna, but what does it really mean?

One of many biological responses from sauna usage is increased heart rate as well as perspiration. The essential body processes protein metabolism and is also affected by enough heat. Heat shock proteins are a special kind of protein that responds specifically to cellular stress from heat. Heat stress induction leads to natural health benefits like those we gain doing physical activities.

One experiment had participants sat in a sauna treatment for 30 minutes at 194°F for 3 weeks, totaling 13 work sessions. The results showed that the participants improved 32% in performance tests versus those who underwent sauna treatments.

Besides improving your cardiovascular functions, using saunas can help reap benefits such as detoxication, decreased depression, and lesser chronic fatigue.

Red Light Therapy vs. Saunas

What differentiates saunas from red light therapy devices is their mechanism of action. While saunas utilize heat for biological effects, red light therapy devices supply healthy light wavelengths directly to the skin and cells. Even when producing almost no heat, red light therapy devices help with cellular function improvement and support bodily balance. Simply put, red light therapy helps energize the body with light, while saunas heat your body.

How does red light therapy work?

Mitochondria, the powerhouse of our cells, is wonderfully affected by certain wavelengths of natural light. This helps in producing energy within the cells of our body, feeding photons to our cells from natural light via red light therapy.

What about clinically-proven wavelengths?

We feel warm when exposed to sunlight and other heat sources such as fire and hot coals because most of the wavelengths, including ultraviolet (UV), are rapidly absorbed by the outer layers of the skin tissue as heat.

However, unknown to many, some wavelengths have the unique capability of boosting your cellular functions and energy. These are those few wavelengths that can penetrate human tissues more effectively, having photons power-up your “cellular batteries.”

What to Look for When Buying Red Light Therapy Devices and Saunas?

One of the first few things you need to look for in saunas is the temperature it produces. You need to consider some other factors, including the type of wood, the heating unit (Is it conventional or infrared? Is it near far or full-spectrum?), finishes and stains, price, and more.

On the other hand, some of the factors you need to consider when choosing a red light therapy device are the device’s light energy output, light color or frequency range in terms of nanometers, warranty, body or treatment coverage area, the price, and the credibility of the company provider.

Light Therapy and Saunas: Friends with Benefits

Saunas and red light therapy devices offer a wide range of natural health benefits, which surprisingly go well with each other. They both support balance and health to improve your fitness and function but do not overlap with each other’s effects because of energy supplementation in distinct forms and wavelengths. What a great combination of complementary natural therapies!

Here at Kaiyan Medical, we provide different types of red light therapy devices for various medical, wellness, and aesthetic uses. To see our list of products, click here.

References:

https://www.health.harvard.edu/staying-healthy/saunas-and-your-health

https://www.healthline.com/health/fitness-exercise/are-saunas-good-for-you

Scoon GS, Hopkins WG, Mayhew S, Cotter JD. Effect of post-exercise sauna bathing on the endurance performance of competitive male runners. Journal of Science and Medicine in Sport. 2007 Aug.

Crinnion WJ. Sauna as a valuable clinical tool for cardiovascular, autoimmune, toxicant- induced and other chronic health problems. Altern Med Rev. 2011 Sep.



Blue Light Therapy for Acne: Does it Work?

Having acne-prone skin can be incredibly frustrating, especially when your oral and topical treatments don’t seem to work well enough. Skincare ingredient junkies know actives that target acne problems such as salicylic acid and benzoyl peroxide can be a few of the most irritating ingredients that you can put on your skin- especially when used in hefty amounts.

If you’ve been wallowing into these-but to no avail, you might ease your frustrations by learning about what Blue Light Therapy can do to acne problems.

What is Blue Light Therapy?

Blue Light therapy is a form of phototherapy that uses a visible light device that has been used by dermatologists for decades as a clinically proven treatment for acne.

The treatment is considered a generally safe, non-invasive, and pain-free procedure with no downtime. Besides being a popular anti-acne treatment, Blue Light therapy has also been shown to remove stubborn acne marks and sunspots. It eliminates free radicals caused by exposure to harsh environments that may oxidize and age your skin.

One significant impact of Blue light therapy is that it has been used to treat skin cancer in patients with actinic keratoses at University of Iowa Hospitals & Clinics. The American Academy of Dermatology considers Blue light therapy a promising treatment for numerous skin issues like acne.

How effective is Blue Light Therapy Work for Acne?

Blue light has been shown to have an antimicrobial effect that penetrates deep into the skin’s pores to eliminate the acne-causing bacteria, otherwise known as Propionibacterium acnes, or P. acnes. Blue Light has been proven to have an antimicrobial effect, making it an ideal treatment to effectively kill several types of bacteria in your pores and oil glands responsible for causing breakouts.

A clinical study shows that 77% of people with acne-prone skin treated with blue light therapy for five weeks have seen significant changes in their skin. Another research suggests that at-home blue light therapy has reduced acne lesions on people who have used the therapy for 28 days.

Unlike other topical treatments that address inflammation, blue light therapy targets breakout-causing bacteria in your pores and by healing the skin from within. Blue Light Therapy is a form of defensive treatment to acne by eradicating bacteria that causes redness and inflammation and a proactive solution to preexisting acne.

Who is a good candidate for Blue Light Therapy?

Experts at the American Academy of Dermatologists agree that blue light therapy works best for people who have mild to moderate acne problems. It is also a great treatment to eliminate acne scars. Blue light therapy works by addressing the acne issue from its core. It works by removing preexisting mild to moderate acne while preventing sebum build-up that causes the inflammation. Severely too deep abdominal cystic acne may benefit from other prescriptive medications that target more serious skin problems. People who incorporate Retinols in their skincare routine may also want to avoid getting Blue Light treatments as such ingredients make the skin very sensitive.

What Blue Light Devices should I use?

Although many dermatologists use current clinical studies, there are available at-home blue light therapy devices that effectively treat acne problems.

The best Blue Light Devices should be FDA- cleared, just like our Blue Lights Therapy Beauty Skin Complexion Handheld Device and Aduro Mask, that is made with medical-grade quality. FDA-cleared at-home devices have innovated into using the same technology that delivers satisfactory results for acne-related problems.

Blue Light therapy works best as a treatment for acne when used consistently. A weekly maintenance appointment to your dermatologist’s clinic for a blue light treatment may cost you $100, which makes it a much more expensive endeavor than investing in at-home devices.

Portable blue light therapy devices can be more beneficial for you as they can be used more frequently as an addition to your skincare routine at a lower price point.

The best blue light therapy devices in the market provide a safer alternative to other harsh treatments for acne that may require risks such as scarring and irritation. If you want to know more about effective light therapy treatments, check this out.

Now you can add a cool, avant-garde addition to your skincare that can be a very convenient and effective treatment for your stubborn acne problems.

References

https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/radiation/photodynamic-therapy.html
https://www.medicalnewstoday.com/articles/319254
https://uihc.org/health-topics/blue-light-therapy-warding-skin-cancer
https://www.healthline.com/health/blue-light-therapy

Putting the Light on Psoriasis

Psoriasis is an autoimmune inflammatory skin disease where the skin cells build up and form scales and itchy, dry patches over the surface. It is a misunderstood skin condition. The misbelief is that it not treatable and affects a particular gender or at a certain age. However, it can affect both men and women equally, and more than 5 million adults deal with this skin disorder — which is about 2% of the U.S. population.

Another common misconception is that it is contagious and can spread from one person to another. Well, Psoriasis is an immune system problem in which your immune system does not work as it should normally do.

Light Therapy: The Advanced Way

With some options available for Psoriasis, light therapy is one of the oldest, safest, effective, convenient, and highly preferred treatment by dermatologists. It has been widely used to treat stable psoriatic lesions, including different parts like the trunk, scalp, arms, and legs, and partial nail psoriasis. The treatment of light therapy is available in a variety of light with different mechanisms of action. Based on the bandwidths, the varied versions includes ultraviolet B (UVB), psoralen ultraviolet A (PUVA), pulsed dye laser (PDL), photodynamic therapy (PDT), intense pulsed light (IPL), light-emitting diodes (LED), etc.

How it Works

Light therapy has a very long history of dermatological benefits. Psoriasis happens when the skin cells there is an abnormal production of skin cells. Light therapy works by slowing down the excessive production of skin cells on the epidermis layer. This reduces plaque formation. It also reduces inflammation and limits the growth of skin cells by affecting the functioning of the DNA.

Many clinical studies and researches have displayed positive and effective result in the treatment of various types of Psoriasis like –

  • Small areas of stubborn, thick plaque psoriasis
  • Palmoplantar psoriasis (on hands and feet)
  • Nail psoriasis
  • Scalp psoriasis

Why do Dermatologists Prescribe Light Therapy?

Light therapy treatment can:

  • Slow down the growth of abundant skin cells
  • Repress the functioning of an overly active immune system
  • Reduce inflammation and allow the skin to heal itself
  • Reduce or eliminate the dry and itchiness

Light Therapy Mechanism

Light therapy can be delivered on any affected skin areas such as the hands or scalp, or across their whole body. But proper care and protection are given to the skin areas, such as the eyes and genitals, before treatment.

The treatment doesn’t work in on-go. Several sessions are required as the effect is gradually seen in patients. The treatment requires multiple sessions where the amount of light is gradually increased per session. The light exposure is not instant and varies for a different duration depending on the skin condition severity.

The sessions give proper time to heal the skin. Usually, the sessions go from two to three months. We need to understand the fact that every person’s skin reacts to light therapy differently. Hence, how much improvement one sees in their psoriasis symptoms and how long those benefits last depends totally on their system.

Now the time has changed, and technology has brought more convenience in getting the treatment. Kaiyan Medical provides you numerous products that you can use at your home and enjoy your daily activities without getting disturbed. Break the old and mainstream treatments and adopt effective light therapy to let your skin and life heal completely!

References:

The Effect of Green & Red Light Therapy on Hearing

Low-level laser therapy

Low-level laser therapy (LLLT) has been practiced for over 20 years in Europe and has been introduced in the United States as a treatment for pain and postsurgical tissue repair. It has been proposed that laser energy in the red and near-infrared light spectrum may aid in the repair of tissue damage. A proposed mechanism for this therapeutic effect is the stimulation of mitochondria in the cells to produce more energy through the production of adenosine triphosphate.

Studies in humans have investigated the effects of LLLT on both hearing loss and tinnitus, with equivocal results. Some studies have found an improvement in hearing thresholds and tinnitus symptoms.

The Subjects

A total of 35 adult subjects were enrolled in the study. Two subjects withdrew from the study due to loss of interest and/or scheduling difficulty. The data from three additional subjects were not included in the analysis. One subject yielded unreliable audiometric and speech understanding data, speech scores could not be obtained from one subject with a profound hearing loss, and calibration problems compromised data from the third subject. Data from the remaining 30 subjects were included in the analyses. The experimental protocol was approved by the Institutional Review Board of The University of Iowa, and written informed consent was obtained from all participants.

The Device

An Erchonia EHL laser was used to provide the laser stimulation. The device was a portable unit that consisted of a hand-held probe and a main body. The probe contained two laser diodes. One diode produced light in the green part of the visible light spectrum (532 nm wavelength), and the other diode produced light in the red part of the visible light spectrum (635 nm wavelength). Both diodes produced energy levels of 7.5 mW (class IIIb). The laser beams from both diodes were dispersed through lenses to create parallel line-generated beams, rather than spots. A second Erchonia EHL device served as the placebo. It was identical to the treatment device, except that the laser diodes were replaced with nonfunctioning standard light-emitting diodes.

The Groups

The study used three groups: treatment, placebo, and control. Subjects were pseudorandomly assigned to one of the three groups.

Initial group assignment was random with occasional adjustment to ensure that the three groups were similar in terms of number of participants, female/male ratio, mean age of participants, and mean pure-tone audiometric thresholds. The treatment group received the laser treatment protocol using the functional laser device. The placebo group also received the laser treatment protocol, but using the nonfunctioning laser device. The control group made similarly timed visits to the laboratory but received no real or feigned “treatment.” The study used a repeated-measures design, with each subject taking a battery of pretests, followed by treatment followed by a battery of posttests.

Analysis

Data were obtained from both ears of each subject. Since no obvious differences were seen between left and right ears, data from both ears were combined in the following analyses. Strictly speaking, this likely violates the statistical assumption of independent sampling, since the test results from left and right ears of a single subject are likely to be highly correlated. None of the statistical tests used in the analyses are robust to the assumption of independent sampling, and the effect of including both ears is likely to be that of artificially increasing the sample size, making it more likely that a statistically significant result will be found. All statistical tests were conducted using a significance level of .

Conclusions

No statistically significant effect of LLLT on auditory function was found, as assessed by pure-tone audiometry, speech understanding, and TEOAEs in this test. Additionally, no individual subjects showed any clinically significant change. It remains possible that other methods of LLLT could have an effect on hearing. The type of device used was not the best one for this type of study. Further research elucidating the anatomic and physiologic bases for therapeutic effects of LLLT on hearing are needed before further clinical testing is warranted.

More References

Clinical Study | Open Access. Volume 2013 |Article ID 916370 | https://doi.org/10.1155/2013/916370

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How Music Healing Therapy Can Help Breast Cancer Patients

What is music therapy?

According to the World Federation of Music Therapy, this term refers to the use of music and / or its elements (sound, rhythm, melody, harmony) with a patient or group of patients, in a process created to facilitate, promote communication , relationships, learning, movement, expression, organization, and other relevant therapeutic goals to meet physical, emotional, mental, social, and cognitive needs.

Music therapy aims to develop potential and / or restore the functions of the individual in such a way that he can achieve a better intra and / or interpersonal integration and consequently a better quality of life through prevention, rehabilitation and treatment.

Learn also more about sound healing and light therapy.

How does this therapy help breast cancer patients?

It was the Taipei Medical University that has developed a study that has given the following conclusion: listening to music at home reduces the severity of symptoms, the intensity of pain and the fatigue experienced by patients with breast cancer .

For the study, published in the “European Journal of Cancer Care,” 60 participants listened to music in five 30-minute sessions per week. After 6, 12 and 24 weeks, music therapy reduced the severity of symptoms, as well as the intensity of pain and fatigue. Furthermore, it instantly reduced physical and mental fatigue.

“The use of music can help the physical and psychological well-being of patients,” explained the study’s lead author, Kuei-Ru Chou. He has also recommended that home music interventions be given to breast cancer patients to reduce their negative thoughts associated with the disease.

From Medina Reeds we send a message of support to all patients who suffer from this disease and we invite everyone, patients and non-patients to apply music therapy on a day-to-day basis for all the wonderful benefits that music brings us.

References

Ref.“Hamburg, 1996, Clinical Practice Committee of the World Federation of Music Therapy”. nineteen ninety six.

https://www.sespm.es/la-musicoterapia-ayuda-a-pacientes-con-cancer-de-mama/

No More Menstrual Pain with Light Therapy

Light exposure may affect menstrual cycles and symptoms through the influence of melatonin secretion. In Kaiyan Medical we have been studying portable devices to relieve menstrual pain using low-level light stimulation. Menstrual pain often afflicts women and girls, but the intensity and impact on quality of life vary widely. A cross-sectioned analytical study found that 84 percent reported menstrual pain which often required medication and even resulted in missing work.

Reduce the pain with light therapy

Many women rely on non-steroidal anti-inflammatory drugs, but of course, some prefer to avoid their undesirable side-effects. Other common menstrual pain management methods, according to the National Institutes of Health, include: applying heat with hot water bottles or heating pads, warm baths, or going to the sauna; special diets and dietary supplements; herbal products and herbal teas for medicinal use; homeopathic medicines; and procedures which target pain stimulus such as acupuncture, acupressure or TENS (transcutaneous electrical nerve stimulation). Light therapy devices add another alternative to targeting the pain source with low-level light stimulation applied at acupuncture points.

Light therapy devices improves blood flow and thereby reduces menstrual cramps with via photo-activated modulation of smooth muscle tissue. Usually, the light from the light therapy devices is emitted for a fixed amount of time (from 10 to 20 minutes). The light stimulation reaches the uterus and increases the secretion of nitrous oxide (NO). The NO spreads over the smooth muscle in the uterine cells and under continuous light stimulation produces a phosphate particle called cyclic guanosine monophosphate (cGMP). These particles continuously flow out and relax the smooth muscles so they receive oxygen and nutrition.

In the Archives of Gynecology and Obstetrics, subjects using the low-level light therapy showed statistically significant reduction in pain levels after a month and barely any pain after three months. This compares to a placebo group that showed slight pain reduction over time. The study concluded that

“skin adhesive low-level light therapy on acupuncture points might be an effective, simple, and safe non-pharmacological treatment for dysmenorrhoea.”

In this study, a total of 31 women with dysmenorrhoea were enrolled and randomly assigned to either the active or placebo low-level light therapy groups . Of 31 participants, 21 participants received real light therapy, while the remaining 10 participants received placebo one. All participants in the active low-level light therapy group reported either complete pain relief In the active low-level light therapy group, 16 women had successful results during their menstrual cycle, and 5 women had successful results at the second menstrual cycle.

The most interesting thing about this study, is that they conclude that the direct cause of dysmenorrhoea might not be changes in bioactive substances, such as hormone imbalance, a decrease in serotonin levels or excessive prostaglandin production, but the abnormal function of parts of smooth muscles in the uterus secondary to long-term deficient blood supply into smooth muscle tissue caused by disease or stress. This condition can be improved with light therapy.

Our light therapy products can help as well with back pain, skin, depression, sleep cycles, and pets.


References

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Why Hollywood Stars Love Light Therapy

Julia Roberts Uses LED Face Mask | PEOPLE.com
Julia Roberts using LED light therapy mask

From the red carpet to the spotlight stage, Hollywood’s stars are no strangers to the powerful power of light. Their skin is glowing thanks to the latest light-based skin treatment. Stars like Julia Roberts, Kate Hudson, and Jessica Alba have been sharing their experience with LED light therapy masks that are designed to boost collagen, reduce inflammation and banish acne-related bumps and scars.

In Kaiyan Medical we can develop your own beauty light therapy mask worth of the celebrities’ skin.

Kate Hudson using LED light mask
How it Works

These amazing light masks are recommended by dermatologists and estheticians who credit the masks’ multi-colored UV-free wavelengths with improving clients’ complexions.

“Tiny particles of light are called photons, which cells absorb and transform into ATP (adenosine triphosphate), the form of energy that cells use to carry out normal functions,”

says L.A.-based celebrity facialist Shani Darden.

“ATP is then used to power the metabolic process and repair and regenerate cells.”

In short, just like LEDs have been proven to encourage plant growth (what’s a greenhouse without a good grow light?), LEDs can have a similar stimulating effect on skin cells by jump-starting the rejuvenation process.

But not all lights are created equal. Different wavelengths of light have different benefits.

“Blue-light wavelengths destroy bacteria in the skin to improve acne,”

says Toronto-based cosmetic dermatologist Dr. Martie S. Gidon. It’s worth noting that LED therapy is not effective at treating hormonal acne and is only recommended for inflammatory acne — in other words, pimples caused by bacteria — and works best when paired with topical acne medication.

Anti-aging benefits

For anti-aging results, red light therapy is for you.

“Red-light wavelengths penetrate more deeply than blue light and stimulate fibroblasts to produce collagen, resulting in tighter skin and smooth fine lines,”

says Dr. Gidon, who also praises the red light’s anti-inflammatory effect for use post-facials and peels. Another light used in combination with the other two is infrared.

“It accelerates healing and encourages greater product absorption,”

says Shani who recommends clients use a combination of both blue/red light therapy and infrared.

Home LED masks have been growing in popularity, especially with the COVID restrictions. You can opt for flexible home masks for personal use or well, the spa line which packs more lights and cover a bigger zone. With so effective results, it’s no wonder stars like Michelle Williams and Rachel Weisz are opting to lay down inside LED beds in order to treat their entire bodies to the rejuvenating powers of the lights.

If you have question on how to create your own beauty mask, don’t hesitate in contacting us. We will guide you in the whole creative process.

More References


https://ca.hellomagazine.com/health-and-beauty/02017032134254/guiding-light

https://www.womansworld.com/posts/celebrities/julia-roberts-light-therapy-mask

Therapeutic and Aesthetic Uses of Blue & Red Light Therapy Together

Acne vulgaris remains one of the most common dermatologic disorders. Clinicians are always searching for new therapies to utilize in their therapeutic armamentarium for this common skin concern. We have many medical therapies at our disposal and these have proven useful in many cases in controlling the disease process. However, some patients need or want other therapies, and laser and light treatments for acne vulgaris have become popular over the past several years.

Regarding LED light therapy for the skin, “There is a science to support it” says Angela Lamb, director of the Westside Mount Sinai Dermatology Practice,

“but it’s important to know its limitations.”

Exposing your skin to different forms of low-level LED light does have anti-bacterial and anti-inflammatory benefits, which is why they’re commonly used for treating redness or acne. Blue light therapy in the right wavelength can be FDA-cleared.

Light Therapy with Aduro Mask

Other blue light trials have supported the efficacy of blue light. Papageorgiou described their experiences with phototherapy comparing a mixed blue and red light system (415 and 660nm) with blue light therapy alone and white light therapy. The results showed that the combination of blue and red light decreased inflammatory acne vulgaris lesions by 76 percent versus 58 percent in the blue light alone group, which were both better than white light (25%). Meffert reported experiences with a high-energy, broad-spectrum, blue light source that combined blue light and UVA with a wavelength of 410 to 420nm and noted marked improvement in patients with pustular acne vulgaris after 10 treatments.

There are a variety of at-home light treatments out there like the Aduro mask (which is patented with medical grade quality) who uses red, orange, purple, infrared, cyan, blue,green and yellow light — but typically what you’ll see on shelves are ones harnessing blue or red light . Blue light is a shorter wavelength that destroys acne-causing bacteria on the skin’s surface, while red light penetrates deeper to help with inflammation, but Hooman Khorasani, the chief of the division of Dermatologic and Cosmetic Surgery at the Icahn School of Medicine at Mount Sinai, says that both blue- and red-light therapy “may reduce the size of the sebaceous glands, so you don’t produce as much oil.”

Blue & Red Light Therapy

The good thing about light therapy is that experts say that there aren’t really downsides if you’re willing to give it a shot. Light treatments have been shown to be relatively safe, with minimal side effects. For acne, Khorasani notes that LED devices won’t take the place of acne fighters like retinoids; instead, they should be used in concert with a multipronged treatment plan — and never for severe acne. If you are combining them with retinoids, Lamb also suggests alternating the days you use either of them, to avoid photosensitivity.

When you combine the blue and red light using the aduro mask, you can get a pink/purple amazing color that will help remove the p-acne causing bacteria from the skin while purifying and cleansing it. Also, you will speed up the healing process and rejuvenate the skin cells increasing the cell regeneration.

More references

https://www.accessdata.fda.gov/cdrh_docs/pdf9/K093963.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013592

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Light Therapy & Vitiligo

Our life is full of patches!

Patches in job, career, personal life, and skin too! When we can handle the life patches and hardship with determination, then why not with skin. The skin patches disease is termed as Vitiligo. It is a medical condition where skin loses its color. Vitiligo affect not only physically but also cause a mentally & emotionally. According to VRF, this condition affects 2% of the world’s population. So, around 70 million people across the world have vitiligo. It can affect can affect people of any age, gender, or ethnicity.

How does it occur?

Well many of us are not aware of the biological reasoning behind the condition. It occurs when cells responsible for making skin pigment called melanocytes get destroyed. It can affect any part of your body like limbs, back, neck, face, etc. The body stops producing melanin — the pigment that gives your skin, hair and eyes color.

The symptoms of Vitiligo are like – Patchy, loss of skin color, which usually first appears on the hands, face, and areas around body openings. Other like premature whitening or greying of the hair on the scalp, eyelashes, eyebrows or beard. Vitiligo is an auto-immune disease, where the person’s immune system mistakenly attacks its own body (or host body). Other than that, the skin cells (melanocytes) of the affected person appears to unable to deal with the imbalance of antioxidants and harmful free radicals generated inside the body. This results in cell damage and death.

Light therapy - the hope

Today a number of treatments which are aimed for the restoring the discoloration of the skin. But the best and the convenient is Light Therapy. Especially the narrow-band ultraviolet B (NB-UVB) has come up as one of the safest and most effective therapy for this skin condition.

In this treatment, the depigmented or discolored skin is exposed under a specific wavelength of light for a specific amount of time and using a specified amount of light monitored or prescribed by the dermatologist. The duration of a session can gradually increase as one’s progress based on his/her skin’s response to the light.

Light therapy treatment often involves the usage if specific light which are used in combination with topical medications that are applied to the skin. The topical treatments can be topical steroids, topical calcineurin inhibitors or topical Vitamin D etc. Although the treatment can be used without the topical as well. Topical medications may also be used on their own, without light therapy, however, when the two treatments are used together, the results are typically seen well.

According to the studies, the light therapy session have a great response to treatment. The greatest response is shown majorly on the face and neck. Several retrospective and prospective studies have displayed superior repigmentation, color matching results.

Light therapy is a hope for people who perceive it as an incurable disease. The technology of light therapy helps people to overcome the physical as well as mental aspect of their body.

References:

https://nyulangone.org/conditions/vitiligo/treatments/phototherapy-laser-treatment-for-vitiligo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536079/

https://www.medscape.com/answers/1068962-87933/how-is-narrowband-uv-b-nb-uvb-used-to-treat-vitiligo

https://www.umassmed.edu/vitiligo/vitiligo-treatment/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607222/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817459/

Light Therapy - Color Meaning

Introduction to Color Light Therapy

Color Light therapy is based on the idea of restoring balance by applying color to the body. Its history is rooted as far back as the Mayan culture.

In India, Ayurveda, an ancient form of medicine practiced for thousands of years, is based on the idea that every individual contains five elements of the universe that are present in specific proportions unique to each individual, including their personality type and constitution. When these elements are out of balance, Ayurveda works with the energies inherent in the colors of the spectrum to restore this balance.

In ancient Egypt the art of healing with color was founded in the Hermetic tradition, the Ancient Egyptians and Greeks used colored minerals, stones, crystals, salves, and dyes as remedies, and painted treatment sanctuaries in various shades of color.

In China, traditional Chinese medicine incorporates color to be associated with each organ and elemental system. This healing method looks at the idea that every individual is a balance. The first color wheel was invented by Sir Isaac Newton. He split white sunlight into red, orange, yellow, green, cyan, and blue. He then joined the two ends of the color spectrum together to show the natural progression of colors.

Light Therapy has been valued throughout history as a remarkable source of healing. Today, the therapeutic applications of light and color are being investigated in major hospitals and research centers worldwide. Results indicate that full-spectrum, ultraviolet, colored, and laser light can have therapeutic value for a range of conditions from chronic pain and depression to immune disorders.

Wellness Benefits

Light Therapy has been reported, as part of a healthy lifestyle, to temporarily reduce swelling, relieve pain, decrease inflammation, accelerate open wound healing and greatly reduce overall recovery after medical/surgical procedures. Patients have demonstrated an increased range of motion, decreased muscle tension and spasm, and improved circulation.

Rejuvenating LED light therapy can be used for temporary pain management such as joint and back pain, sore or torn muscles, sprains, arthritis, post-surgical scars, burns, wounds, and more. When used with infrared technology, light therapy (phototherapy) is one of the most effective and non-invasive ways to improve overall wellness.

Light therapy is also used to temporarily relieve Seasonal Affective Disorder (SAD). SAD affects individuals when the lack of sunlight results in seasonal depression. Phototherapy helps with SAD by resetting the internal biological clock (Circadian rhythms), helping individuals sleep better, and regulate their mood. Even companies, such as GE and Philips, have created phototherapeutic products to improve and regulate mood.

Cosmetic Benefits

Light therapy is also a growing treatment for anti-aging. Many individuals have seen a temporary reduction in the appearance of fine lines, wrinkles, crow’s feet, and age spots.

Light therapy is “effective at improving the appearance of the face, neck, and chest by reducing the signs of aging, wrinkles and age spots”, says Web M.D. Combined with infrared therapy, LED phototherapy can be a great way to revitalize skin.

Healing With Color

Color is light split into different wavelengths vibrating at different speeds and at different frequencies. Objects that ABSORB all wavelengths and DO NOT reflect are black in nature. Objects that REFLECT all wavelengths and DO reflect are white in nature. Between black and white lies COLOR. Colors are wavelengths of energy that, to us, appear as color because of the potential and capabilities of the object to either absorb or reflect the energy.

Red Light

In the early 1990s, RLT was used by scientists to help grow plants in space. The scientists found that the intense light from red light-emitting diodes (LEDs) helped promote the growth and photosynthesis of plant cells.

The red light was then studied for its potential application in medicine, more specifically to find out if RLT could increase energy inside human cells. The researchers hoped that RLT could be an effective way to treat the muscle atrophy, slow wound healing, and bone density issues caused by weightlessness during space travel.

You may have heard of red light therapy (RLT) by its other names, which include:

  • photobiomodulation (PBM)
  • low-level light therapy (LLLT)
  • soft laser therapy
  • cold laser therapy
  • biostimulation
  • photonic stimulation
  • low-power laser therapy (LPLT)

Red is called “The Great Healer”. So far is the most popular light therapy. To wind down before bed, use red light. “The color signals that it’s night, which may encourage the body to produce melatonin,” says Michael Breus, Ph.D., an advisory board member for SleepScore Labs.

Red light can also improve your workout. Just one to five minutes of exposure to red and infrared light right before exercise boosted strength and prevented soreness, says Ernesto Leal-Junior, Ph.D., the head of the Laboratory of Phototherapy in Sports and Exercise at Nove de Julho University in Brazil. “Certain wavelengths of red and infrared light-660 to 905 nanometers-reach skeletal muscle tissue, stimulating the mitochondria to produce more ATP, a substance that cells use as fuel,” he says.

Green Light

Green is the universal healing color. Originally, the color of love. Green is midway in the color spectrum; therefore, it contains both a physical nature and a spiritual nature, in equal balance and in equal harmony.

Gazing at green light can reduce chronic pain (caused by fibromyalgia or migraines, for example) by up to 60 percent, according to a study in the journal Pain, and animal studies have shown that the beneficial effects can last up to nine days. “Looking at green light seems to lead to an increase in the body’s production of enkephalins, pain-killing opioid-like chemicals. And it reduces inflammation, which plays a role in many chronic pain conditions,” says researcher Mohab Ibrahim, M.D., Ph.D.

More studies are needed before doctors can make recommendations on how and how often to use green light to treat migraines and other pain, and Dr. Ibrahim says you should see a physician before trying to treat yourself at home. But at this point research indicates that exposing yourself to an hour or two every night-either by using a green light bulb in a lamp or by wearing glasses fitted with tinted optical filters-may decrease migraines and other types of chronic pain

Helps to treat and prevent hyper-pigmentation by inhibiting the production of excess melanin which then prevents it from traveling to the surface. It will help break up the melanin clusters that are already on the surface.

Yellow Light

Yellow helps awaken mental inspiration arousing a higher mentality. Thus, it is an excellent color for nervous or nerve-related conditions or ailments; fueling the solar plexus. Yellow has a very enriching effect upon the intellect. Yellow can be used for conditions of the stomach, liver, and intestines. It can help the pores of the skin by repairing scarred tissue. These rays have an alkalizing effect which strengthens the nerves. Awakening, inspiring, and vitally stimulating the higher mind promoting self-control. Typical diseases treated by yellow are constipation, gas, liver troubles, diabetes, eczema, and nervous exhaustion. Providing clarity of thought, increasing awareness, stimulating interest, and curiosity yellow energy is related to the ability to perceive or understand.

The yellow is used for treating redness, flushing, irritation, and Rosacea. It may also reduce the appearance of the tiny blood vessels on the nose and face.

Blue Light

Blue light therapy technology is an additional option for the treatment of acne. Research has shown in-office and at-home systems produce positive results.

“Blue light therapy effectively helps alleviate this common skin condition affecting 50 million Americans and 94 percent of all females, according to Judith Hellman, MD, a board-certified dermatologist, in practice in New York City. Dr. Hellman, who practices medical dermatology and specializes in dermatological surgery, laser surgery, and anti-aging skin treatments, explains how the blue light treatment system works for acne, its uses, and her clinical experience with the technology.

Cyan Light

It is used as a gentle acne treatment to control oil production in the skin as well as reduce inflammation. It also promotes the synthesis of protein and collagen.

Orange Light

Orange has a freeing action upon the mind, relieving repression. Because orange is a blend of red and yellow, it combines physical energy with mental wisdom, inducing a transformation between lower physical reaction and higher mental response. Thus, it is often referred to as “The Wisdom Ray.” Orange is warm, cheering, and non-constricting.

Through orange, we are able to heal the physical body (red) and, at the same time, induce within the mind (yellow) greater understanding. Orange helps assimilate new ideas. Orange is the best emotional stimulant, helping to remove inhibitions paving independent social behavior. Bring joy to your workday and strengthen your appetite for life. Orange aids in repairing inflammation of the kidneys, gallstones, menstrual cramps, epilepsy, wet cough, and all sinus conditions.

Purple Light

Violet is the last color we can see before light passes on to ultra-violet. Violet purifies our thoughts and feelings giving us inspiration in all undertakings. The violet energy connects us to our spiritual self bringing guidance, wisdom, and inner strength and enhances artistic talent and creativity. Leonardo da Vinci proclaimed that you can increase the power of meditation ten-fold by meditating under the gentle rays of Violet, as found in church windows.

Light therapy uses colors for their proposed wellness abilities in treating emotional and physical disturbances. Light therapy is based on the premise that different colors evoke different responses in people. For example, some colors are considered to be stimulating, whereas others may be soothing. Color therapy has been suggested for many uses, based on tradition or on scientific theories. Consult with a health care provider before using color therapy for any use.

Infrared Light

Infrared light penetrates to the inner layers of the skin at about 2 to 7 centimeters deep. Hence, it reaches the muscles, nerves, and even the bones. Many studies have shown that a frequency of infrared light, with wavelengths from 700 to 1,000 nanometers, is best used for healing inflammatory conditions.

The use of electricity for healing purposes began in 2,750 BC when people used electric eels to give electric shocks. Electricity and magnetism were used in people with just little success. However, in 1975, transcutaneous electrical stimulation (TENS) was developed to treat chronic pain. It was not until recently that infrared therapy was developed to improve wound healing, reduce the pain caused by arthritis, boost endorphin levels, and bioactivate neuromodulators.

Infrared therapy technology allows people to harness the benefits of the sun, without being exposed to harmful ultraviolet rays. Also, infrared therapy is safe and effective, without adverse side effects. As a matter of fact, infrared light is safe and is used even for infants in neonatal intensive care.

Infrared light is absorbed by the photoreceptors in cells. Once absorbed, the light energy kickstarts a series of metabolic events, triggering several natural processes of the body on a cellular level.

Kaiyan Medical

In Kaiyan, we are in love with light therapy. We believe in the natural balance in our bodies. We develop devices such as the Aduro mask which will provide you with the full range of color light therapies.

References

https://www.estyspot.com/blogs/esthetician-tips/an-estheticians-view-of-led-therapy-benefits-for-all-7-colors

https://www.the-dermatologist.com/content/acne-treatment-blue-light-therapy-benefits-0#:~:text=A%3A%20Blue%20light%20kills%20the,oil%20glands%20in%20the%20skin.

https://www.healthline.com/health/red-light-therapy#summary

https://www.estyspot.com/blogs/esthetician-tips/an-estheticians-view-of-led-therapy-benefits-for-all-7-colors

Deppe A. Ocular light therapy: a case study. Aust J Holist Nurs 2000;7(1):41.

Geldschlager S. Osteopathic versus orthopedic treatments for chronic epicondylopathia humeri radialis: a randomized controlled trial. Forsch Komplementarmed Klass Naturheilkd 2004;Apr, 11(2):93-97.

Maher CG. Effective physical treatment of chronic low back pain. Orthop Clin North Am 2004;Jan, 35(1):57-64.

Natural Standard Research Collaboration, Chief Editors: Ulbricht C, Basch E, Natural Standard Herb and Supplement Reference: Evidence-Based Clinical Reviews, USA. Elsevier/Mosby, 2005.

Ohara M, Kawashima Y, Kitajima s, et al. Inhibition Of lung metastasis of B16 melanoma cells exposed to blue light in mice. Int J Molecular Medicine 2002;10(6):701-705.

Wileman SM, Eagles JM, Andrew JE, et al. Light therapy for seasonal affective disorder in primary care: randomised controlled trial. Br J Psych 2001;178:311-316.

Wohlfarth H, Schultz A. The effect of colour psychodynamic environment modification on sound levels in elementary schools. Int J Biosocial Res 2002;(5):12-19.

Zifkin BG, Inoue Y. Visual reflex seizures induced by complex stimuli. Epilepsia 2004;45(Suppl 1):27-29.

Fighting Breast Cancer with Light Therapy

Researcher fighting breast cancer with light therapy
"Metastatic breast cancer can be a devastating diagnosis with high rates of relapse and death, and there are currently no effective therapies,"

Nalinikanth Kotagiri, MD, Ph.D. says.

"Despite newer treatments, many patients still succumb to the disease. Major limitations include acquired resistance to therapies and serious side effects from treatment. Due to the widespread location of breast cancer cells, particularly in the bone marrow, which harbors the tumor cells as well as vital stem cells, the risk of toxicity is even higher with conventional therapies. Therefore, new therapeutic strategies that selectively destroy tumor cells, increase treatment efficacy, prevent relapse and reduce side effects by sparing the healthy stem cells are necessary."


This is why Nalinikanth Kotagiri, MD, Ph.D., assistant professor in the James L. Winkle College of Pharmacy and a cluster hire for the Cincinnati Cancer Center, is hoping to study ways ultraviolet light can activate light-sensitive drugs to treat this invasive breast cancer and provide that light at the end of the tunnel patients yearn for.

Kotagiri has been awarded the Department of Defense Breast Cancer Breakthrough Award—over $600,000 for three years—to try to do just that. His project will focus on light-mediated therapies, which could activate light-sensitive drugs to target only the cancerous cells.

"Therapies such as photodynamic therapy (PDT), involving light and a photosensitizing chemical substance, which used in conjunction with molecular oxygen can cause cell death, offer a high degree of control that is effectively used to manage cancer in early to advanced stages," he says. "It operates on a simple principle where a light-sensitive drug, which is otherwise nontoxic, introduced into certain tissues can cause cell death when activated by light. Despite the promise of PDT, it can't penetrate tissue deeply so its use is limited. Also, current light-sensitive drugs require oxygen to be effective, but many tumors, including breast tumors, have pockets of low oxygen or grow in regions where oxygen is either low or absent, which could prevent effective application of PDT in cancer treatment."

However, Kotagiri says recent work in the lab has led his team to a "two-pronged approach" in addressing these issues.

"We've been using ultraviolet (UV) light from radionuclides (radioactive nuclide or atom), which are already used to image tumors and tissues, and tried to solve oxygen dependence by using metal-based light-sensitive drugs for depth- and oxygen-independent PDT," he says. "By replacing the external light source, such as lasers and lamps, with light from radionuclides as an 'internal' light source, we've been able to better control therapy in the body.
"This could mean more effective therapies with minimal toxicity to vital organs and tissues. Since radionuclides are used in imaging and locating tumors, we can now simultaneously image and treat breast cancer metastasis using the same radionuclide."

Using animal models, researchers in Kotagiri's lab will test whether radionuclide light activation of tumor targeting, light-sensitive drugs will destroy metastatic cancer cells—including those that are resistant to traditional therapies.

"Since how we're killing the cells is not dependent on a certain molecular pathway, the technology could be applicable to treat a wide variety of breast cancers," he adds. "This has the potential to be a common image-guided treatment strategy to treat patients in early as well as advanced stages of the disease, and because of the safety of this treatment strategy, it could be effectively used alongside other treatments, like chemotherapy and immunotherapy, without the risk of additional side effects.
"This could tremendously benefit patients, as it could potentially improve therapeutic outcomes in addition to setting a precedent to tailor other FDA-approved light-sensitive drugs as radionuclide activated therapies, expanding the scope and range of the diseases these drugs currently treat. If proven beneficial, this treatment could be ready for a patient population in 5 to 10 years, since all the materials involved have already been used in humans—this could be an exciting breakthrough."
Clinical Trial - The Effects of Light Therapy to Treat Cancer-related Side Effects

ClinicalTrials.gov Identifier: NCT04418856

Besides what Kotagiri said, severe fatigue, depression, sleep problems and cognitive impairment are the most commonly reported side effects of cancer treatment. These aversive side effects are hypothesized to be related to the disruption of circadian rhythms associated with cancer and its treatment. Exposure to Bright White Light (BWL) has been found to synchronize the circadian activity rhythms but research with cancer patients has been scarce. Therefore, the proposed randomized control trial (RCT) will test if systematic light exposure (sLE) will minimize overall levels of cancer-related fatigue (CRF), depression, sleep problems and cognitive impairment among breast cancer patients undergoing breast cancer treatment (i.e., surgery, chemotherapy). SLE incorporates the delivery of harmless UV-protected BWL or Dim White Light (DWL - standard comparison in light studies) delivered to patients by using special glasses for 30 minutes each morning, during their treatment.

Learn more about the how to improve your circadian rhythm and light therapy & breast feeding

References

https://medicalxpress.com/news/2018-10-breast-cancer-therapy.html

https://www.mayoclinic.org/tests-procedures/photodynamic-therapy/about/pac-20385027#:~:text=Photodynamic%20therapy%20(PDT)%20is%20a,energy%2C%20usually%20from%20a%20laser.

https://clinicaltrials.gov/ct2/show/NCT04418856

Red Light Therapy - 101

We are not just made of biochemical matter. We are charged energy beings, constantly interacting with the environment. Light plays a crucial role in this natural process. Comprehensive new research has unearthed a full new understanding of how our cells function optimally. Food is not the only way we obtain energy; the light also charges us.

Science now shows your body operates like a battery. Certain wavelengths of sunlight power it, and your general health is determined by your ability to receive and maintain a charge. This is what light therapy is about.

What is Red Light Therapy

Light at certain wavelengths is scientifically proven to interact with the body in beneficial ways.

Red light, comprising both red and near-infrared wavelengths, is a unique healing part of the electromagnetic spectrum, and it is one of the most natural ways to charge the body. It is now used as a new form of therapy under the umbrella term Photobiomodulation(PBM)

Red light wavelengths ranging from 600–680nm. Red light boosts the formation of collagen and elastin and assists in cell communication. It penetrates superficially and can be used for skin conditions.

Near-Infrared wavelengths ranging from 750–850nm. NIR stimulates healing, increases mitochondrial function, and improves blood flow and tissue oxygenation. It penetrates deeper into the body.

A high-quality home device like those produced by Kaiyan uses medical-grade LEDs to shine natural red and near-infrared light on your body. Like the wavelengths of light your body needs from natural sunlight, without the heat or UV rays that cause sun damage and without the need for sunny weather. Check the list of best light therapy masks.

How to Recharge your Body

Electric charge is a fundamental property of the body. The surfaces in our bodies — such as membranes, proteins, and DNA — are all charged, negatively or positively, depending on whether they lose or gain electrons.

At the core of your body’s power to heal itself are sub-cellar organelles called mitochondria. The number of mitochondria in a cell varies widely by organism, tissue, and cell type and are concentrated in organs with high energy demands such as the brain, heart, liver, skin, and muscles.

This is because mitochondria generate most of the body's chemical energy supply via the ATP (adenosine triphosphate). They also regulate various other tasks, such as signaling, cellular differentiation, and maintaining control of the cell cycle and cell growth. This is why they are often referred to as the powerhouse of the cell.

Mitochondria
  1. LED light at a wavelength from 600–680nm(red) and between 810–850nm(infrared) is delivered to the tissue via the red light therapy device.
  2. The light enters the cell’s mitochondria and is absorbed by the chromophores, including the protein cytochrome c oxidase(CCO) and EZ water, increasing its activity.
  3. As a result of this highlighted activity, three molecules are affected. Adenosine Triphosphate(ATP), Reactive Oxygen Species (ROS), and Nitric Oxide (NO).
Water

Approximately 70% of our body weight and 99% of our bodies ’ molecules are made of water, and this water is in a charged state.

Recent research by Prof Gerald Pollock of the University of Washington has shown that water adjacent to a cell or mitochondrial membrane is so-called structured water. This is also called EZ (exclusion zone) water because it creates a separation of charge. Positive proton is excluded and pushed to the bulk water, and a lattice-like negatively charged water for near the membrane. This increases the voltage across the membrane—this charge separation of water in the body functions as the positive and negative poles of a battery.

What Does “Red Light Therapy” Mean?

As a term, “red light therapy” refers to treatments from LEDs or cold lasers that deliver wavelengths of natural red and near-infrared light.

The term does not include white light, blue light, or blue LED masks, and it is not the same as full-spectrum light. Some people may include infrared or far-infrared wavelengths along with red light therapy, but those are typically used in dry saunas because of their ability to produce heat. Red light therapy does not rely on heat, a major difference between natural light treatments and heat-based modalities like an infrared sauna, traditional sauna, or other heat therapy type.

Generally, “red light therapy” describes natural light treatments that deliver the same therapeutic red and near-infrared wavelengths as natural sunlight. This differs from artificial light treatments like tanning — or bright light therapy from light therapy lamps, lightboxes, or happy-light if you’re interested in natural light treatments for seasonal affective disorder.

The following terms may also call red light therapy: RLT, photobiomodulation (PBM), phototherapy, LED therapy, LED light therapy, infrared therapy, low-level laser therapy, or low-level light therapy (LLLT).

A Multilevel Treatment

Red light therapy works on multiple levels in the body.

Molecular

  • Chromophores, cytochrome c oxidase, water, opsins
  • Retrograde mitochondrial signaling
  • Light-sensitive ion channels
  • Adenosine triphosphate ATP
  • Reactive Oxygen Species ROS

Calcium

  • Heat-shock proteins
  • Melatonin
  • Brain-derived neurotrophic factor
  • Gene transcription factors
  • Akt/mTOR/CyclinD1 pathway

Cellular

  • Inflammation, Cytoprotection, Proliferation
  • Protein synthesis
  • Stem cell production and migration
  • Immune cell viability
  • Retrograde mitochondrial signaling
  • Transforming growth factor
  • Pro-and anti-inflammatory cytokines
  • Vascular endothelial
  • Mitochondrial membrane potential

Tissue

  • Muscles: Increase endurance, tone density
  • Brain: Improves cognition and immune
  • Nerves: Repair and pain relief
  • Healing: Bones, tendons, and wounds
  • Hair: Increases growth
  • Skin: Improvements of the collagen network, anti-aging, skin disorders
  • Fat: Fat re-absorption improved by enhanced micro-circulation
  • Lymph: Improved immunity
Systemic Effects

Red light therapy affects multiple bodily systems:

Fascia

The fascia is a complex web of sensitive and highly interconnected connective tissue beneath the skin that attaches, stabilizes, encloses, and separates muscles and other internal organs.

Fascia is primarily made from hydrated collagen-Protein chains in a triple helix formation surrounded by water, with a capacity to generate an electric charge in response to applied mechanical stress (piezoelectric).

The bio-electrical nature of the collagen-rich matrix is the key to understanding how pathological changes in one part of the body may cause a cascade of “remote effects” in seemingly unrelated areas and organ systems. The fascia is the long-overlooked but absolutely crucial interconnecting organ of the human body. The therapeutic effect of red light energy can be carried through the fascia network to other parts of the body where it is needed. This is turn, elevates the body’s capacity to communicate via this charged matrix in a positive feedback loop.

The well-known energy meridians of traditional Chinese medicine may actually be low resistance pathways operating through the fascia, conveying energy to the rest of the body.

Gut-Brain Axis

The gut-brain axis links the emotional and cognitive center of the brain with peripheral intestinal functions. Red light energy applied to the abdomen area can therefore influence mood and neuropsychological issues via several mechanisms:

  • Reduction in bowel inflammation and gut spasms.
  • Stimulation of neurotransmitters and hormones in the gut, including serotonin, leptin, and ghrelin.
  • Modulation of the micro-biome. The gut microbes are sensitive to light energy and respond to light energy with differences in growth, migration, and proliferation of the different species.
  • The increasing availability of neurotransmitters activates the brain’s immune system, increases blood flow, and removes toxins.
  • Increased blood circulation and reduced blood pressure leading to a reduction of anxiety and brain fog.
  • Modulation of the vagus nerve, one of the biggest nerves connecting the gut and brain. This plays an important role in stress and social communication, communicating motor and sensory impulses to every organ in the body.

Immune System

Beaming red light and near-infrared light onto cells creates a short, low-dose metabolic stress that builds up the cells' anti-inflammatory, anti-oxidant, and natural defense systems, making the body stronger and more resilient to infections.

This is the concept of hormesis; safe, low-level exposure to stressor results in increased resistance to illness. Red light has been shown to influence the immune response in several ways:

  • Activation of the mast cells leading to the movement of leukocytes and reduced inflammation.
  • Mast cell DE-granulation and the release of pro-inflammatory cytokines.
  • Increased infiltration of the tissues by leukocytes.
  • Enhanced proliferation, maturation, and motility of fibroblasts
  • Increased production of fibroblast growth factor.
  • Lymphocyte activation and proliferation.
  • Macro-phages activated to act as phagocytes.

Circulatory System

Red light therapy has been shown to aid the circulatory system's functioning and increase the micro-circulation of blood, one of the most recognized and well-documented effects of this therapy.

Red light stimulates the formation of new capillaries carrying more oxygen to the body.

A good oxygen supply is intricately involved in numerous biological processes, including cell proliferation, angiogenesis, and protein synthesis, required to restore tissue function and integrity.

Increased circulation allows for waste products to be carried away more effectively. It triggers and heightens the body’s own scavenging process for and ingesting degenerated cells for clean-up.

In fact, increased micro-circulation of blood is thought to be the most vital function for healing the body for almost every illness. For general well-being, Nutrient-rich blood and efficient waste removal is strongly linked to good health.

Nervous System

The nervous system is a complex electrical system, including the brain and spinal cord. It collects, processes, and responds to the input of energy-be it light, sound, heat, or pressure — and it relays these messages to the brain and around the body.

Red light energy affects the nervous system in several crucial ways:

  • Myelination of fibers and a better lamellar organization of the myelin sheath.
  • Improvement of electrophysiological function.
  • Facilitation of neural regeneration.
  • Release of growth factors.
  • Increase of vascular network and collagen.
  • Faster regeneration of nerve lesions and functional improvement of damaged nerves.

The peripheral nerves can be damaged by infection or high sugar levels in the case of diabetic neuropathy.

Red light therapy is being explored as a promising drug-free therapy for all kinds of nerve damage.

Stem Cells

At the frontier of science, red light therapy shows huge promise in current research to stimulate the growth of stem cells in the body and maximize the effect of stem cell implantation for a wide variety of medical purposes.

Therefore, red light may be useful after surgery to stimulate stem cells to aid the repair of tissues and possibly organs.

Light at certain wavelengths has also been shown to coax stem cells to repair teeth, so red light therapy could soon revolutionize dental treatments. Indeed, some progressive dental clinics now offer red light therapy as an alternative to conventional drug and drill treatments.

Red light therapy has been shown to stimulate mesenchymal stem cells in the bone marrow to enhance their capacity to infiltrate the brain.

This has implications for healing degenerative conditions such as dementia, Alzheimer’s, and Parkinson’s disease , currently lacking any orthodox treatment solution.

Where Did Red Light Therapy Come From?

Red light therapy has become a popular natural health intervention, both in professional settings and with home devices.

Light therapy technology has been used in medicine for decades, and NASA experimented with red light therapy use in space in the 1980s and 1990s. In the last 10–20 years, red light therapy has become more widely used thanks to breakthroughs in LED lighting technology that have made affordable home devices possible.

Major advances in clinical light therapy research, and increased public interest in natural health technologies, have also contributed to the growing use and popularity of red light therapy.

In 2016, Kaiyan Medical was the first red light therapy manufacturer to offer affordable, medical-grade devices to consumers for convenient, at-home use.

Relieve Pain And Discomfort

In humans, photobiomodulation is reportedly effective against various pain conditions, including mucositis, carpal tunnel syndrome, orthodontic pain, temporomandibular joint pain, neck pain, neuropathic pain from amputation, and menstrual cramps.

Red light therapy significantly reduces the severity of pain hypersensitivity while improving sensorimotor function.

These improvements are preceded by an anti-inflammatory microglia/macrophage cell population in the injury zone, thereby providing a lasting pain relief effect.

Red light therapy has been shown to yield effective pain relief via the modulation of multiple mechanisms:

  • Inhibitory cyclooxygenase and prostaglandins
  • Modulating nerve transmission
  • Increasing endorphins serotonin release
  • Stimulating metabolism
  • Activating peripheral opioid receptors
Repair Skin

Red light therapy is used for the rapid and safe healing of wounds from burns, surgery incisions, scars, diabetic neuropathy, ulcers, and bedsores.

Faster and better wound healing was one of NASA’s original findings and one of the key recognized uses for this technology. Red and near-infrared light promote beneficial effects during all four phases of the wound-healing process:

  • Coagulation
  • Inflammation
  • Migration
  • Remodeling

These processes are regulated by many growth factors connected with nitric oxide (NO) signaling release, which is modulated by light energy.

A major typical inhibiting factor for the body’s ability to recover from a wound is low oxygen flow. Therefore, the unique ability of red light to increase oxygen flow to the affected area has a massive effect on the healing process.

By reducing inflammation, oxygenation of the area, and formation of new blood vessels, a rapid healing process unfolds with less pain and scarring.

Red light energy may also reduce or prevent the need for pharmaceutical painkiller medication during the healing process.

Revive Immunity

If your body is energized on a cellular level and communication between the organ systems is efficient, your body will naturally develop disease resistance.

Your immune defense works to fend off bacteria and viruses all the time. Red light therapy boosts this system in several ways.

It releases nitric oxide and melatonin, which are involved in DNA repair and have a powerful antimicrobial effect.

It also works through a process known as hormesis. When red and near-infrared light is beamed into cells, it causes mild metabolic stress, which results in cells engaging their anti-inflammatory and antioxidant response.

In this way, the body is primed and ready to respond better to infections. Boosted immunity is also a natural consequence of other systemic effects of red light therapy.

Studies have shown a variety of benefits to the immune system:

  • Improved melatonin production
  • Improved antioxidant production
  • Increased micro-circulation enabling the transportation of immune cells.
  • Promotes activity in the lymph nodes
  • Increased NO levels
  • Better flow of neurotransmitters
  • Boosted collagen and elastin production
  • The more efficient function of cells and organelles
  • Boosts T cells pre-operatively
  • Improved thyroid function
Reduce Inflammation

Inflammation can be acute and topical ( short-lived, caused by accidents, sprains, and infections ), chronic and general ( long-term, caused by persistent conditions ).

While acute inflammation is a healthy physical healing response, chronic and general inflammation can be detrimental to health and often goes undetected.

Currently, the main treatment for inflammation in the body is NSAID or steroid drugs, both of which have side effects and disrupt the body's healing process. Red light therapy stimulates the body to activate its own healing mechanism, dramatically reducing the health risks associated with long term drug use.

Red light therapy works by decreasing the number of inflammatory cells, increasing fibroblast proliferation ( the cell that synthesizes the extra-cellular matrix and collagen ), stimulating angiogenesis ( the formation of new blood vessels ), and activating the body’s innate anti-inflammatory, antioxidant defenses.

The following conditions, associated with chronic and acute inflammation, are currently being investigated as highly promising targets for red light therapy.

  • Arthritis
  • Asthma
  • Sinusitis
  • Muscular sprains
  • Fibro-myalgia
  • Neuron inflammatory disorders such as Alzheimer’s
  • Irritable bowel syndrome and colitis
  • Rheumatic conditions
Regain Performance

Red light therapy has become a hot topic in sports and performance. Not only is it safe and non-toxic-it yields rapid and lasting results in many areas of application.

Besides the overwhelmingly beneficial effects on health overall, red light therapy supports muscle growth and repair by increasing the amount of ATP available, which allows for better performance and faster recovery.

Red light therapy used before training is known to prepare and strengthen the body and physical exertion to help with recovery.

Documented effects from red light therapy include:

  • Reducing DOMS ( Delayed Onset Muscle Soreness )
  • Greater endurance and performance
  • Improving sleep quality
  • Increasing sexual function and libido ( Including Testosterone )
  • Aiding weight loss
  • Boosting cognitive function
  • Reversing skin aging
  • Reducing cellulite
Red Light Therapy for Depression and Seasonal Affective Disorder

Seasonal affective disorder (SAD) is a type of depression that impacts at least 5% of Americans, especially in the winter months, when natural light exposure is lowest. SAD is also called seasonal depression, winter depression, or the winter blues.

Some people treat SAD symptoms with treatment options like bright white light therapies that mimic the sun’s light intensity at a bright time of day.

More researchers and physicians have used natural light treatments like red light therapy to help with natural light deficiency and the winter blues in recent years in conjunction with antidepressant medication and psychotherapy.

Who Uses Red Light Therapy?

In addition to the growing number of people using red light therapy devices in their home, red light therapy systems can be found in many professional and clinical settings:

Skincare Professionals: Red light therapy is a popular skin treatment among Hollywood celebrities for anti-aging, and it’s used by leading skincare professionals like estheticians and dermatologists to treat skin conditions and promote collagen production.

Health Practitioners: Red light therapy is an emerging subspecialty of medicine in a wide range of fields. From oncologists treating cancer side effects, to dentists reducing oral inflammation, to physicians treating mental health conditions, red light therapy is becoming more widespread in clinical practice.

Natural Health Experts: Leading voices in natural health and wellness like Dr. Sarah Ballantyne, Dave Asprey, and Ben Greenfield use red light therapy. So do Paleo and Keto health experts like Mark Sisson, Dr. Anthony Gustin, Luke Storey, and Robb Wolf.

Sports Medicine Pros: Light therapy companies work side by side with the National Association of Sports Medicine (NASM), and red light therapy is used to heal sports injuries by sports medicine professionals across the globe. Including the top trainers and doctors on the PGA Tour, like Dr. Troy Van Biezen and Dr. Ara Suppiah.

Elite Pro Athletes: Red light therapy is a popular training tool across pro sports, from NFL stars like Patrick Peterson, to UFC champs like Anthony Pettis, to gold medal gymnast Sanne Wevers.

Fitness & Training: World-class personal trainers like Lacey Stone and Jorge Cruise use red light therapy to both enhance performance and improve the muscle recovery process.

Supportive Cancer Care: The Multinational Association of Supportive Care in Cancer (MASCC) recommends red light therapy for the treatment of oral mucositis (OM), a common and debilitating symptom of cancer treatment.

Sources and References:

Klepeis N., Nelson W., Ott W., Robinson J., Tsang A., Switzer P., Behar J., Hern S., Engelmann W. “The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants”. Journal of Exposure Analysis and Environmental Epidemiology 2001.

Hamblin M. “Mechanisms and applications of the anti-inflammatory effects of photobiomodulation.” AIMS Biophys. 2017.

LED Lights Used in Plant Growth Experiments for Deep Space Missions. NASA.

Gál P,  Stausholm MB, et al. Should open excisions and sutured incisions be treated differently? A review and meta-analysis of animal wound models following low-level laser therapy. Lasers in Medical Science. 2018 Aug.

John Foley, David B Vasily, et al. 830 nm light-emitting diode (led) phototherapy significantly reduced return-to-play in injured university athletes: a pilot study. Laser Therapy. 2016 Mar.

Kim HK, Choi JH. Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheek. Journal of Physical Therapy Science. 2017 February.

Wunsch A and Matuschka K. A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase. Photomedicine and Laser Surgery. Feb 2014.

Barolet D, Roberge CJ, et al. Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a single-blinded study. Journal of Investigative Dermatology. 2009 December.

Morita T., Tokura H. “ Effects of lights of different color temperature on the nocturnal changes in core temperature and melatonin in humans” Journal of Physiological Anthropology. 1996, Sept.

Naeser M., Zafonte R, Krengel MH, Martin PI,  Frazier J, Hamblin MR, Knight JA, Meehan WP, Baker EH. “Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study”  Journal of Neurotrauma. 2014, June.

Liu KH, Liu D, et al. “Comparative effectiveness of low-level laser therapy for adult androgenic alopecia: a system review and meta-analysis of randomized controlled trials.” Lasers in Medical Science. 2019 Aug.

Gupta AK, Mays RR, et al. “Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis.” JEADV. 2018 Dec.

Afifi L, Maranda EL, et al. “Low-level laser therapy as a treatment for androgenetic alopecia.” Lasers in Surgery and Medicine. 2017 Jan.

Hofling DB, Chavantes MC, et al. Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial. Lasers in Surgery and Medicine. May 2013.

Hofling DB, Chavantes MC, et al. Assessment of the effects of low-level laser therapy on the thyroid vascularization of patients with autoimmune hypothyroidism by color Doppler ultrasound. ISRN Endocrinology. 2012.

Hofling DB, Chavantes MC, et al. Low-level laser therapy in chronic autoimmune thyroiditis: a pilot study. Lasers in Surgery and Medicine. 2010 Aug.

Vladimirovich Moskvin S., Ivanovich Apolikhin O. Effectiveness of low level laser therapy for treating male infertility. Biomedicine (Taipei). 2018 June.

Ban Frangez H., Frangez I., Verdenik I., Jansa V., Virant Klun I. Photobiomodulation with light-emitting diodes improves sperm motility in men with asthenozoospermia. Laser in Medical Science, 2015 Jan.

Salman Yazdi, R., Bakhshi, S., Jannat Alipoor, F. et al. Effect of 830-nm diode laser irradiation on human sperm motility. Lasers Med Sci. 2014.

Chow KW, Preece D, Burns MW. Effect of red light on optically trapped spermatozoa. Biomedical Optics Express. 2017 Aug.

Preece D., Chow KW, Gomez-Godinez V., Gustafson K., et al. Red light improves spermatozoa motility and does not induce oxidative DNA damage. Scientific Reports. 2017 Apr.

American Psychiatric Association

Cassano P, Petrie SR, et al. Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial. Photomedicine and Laser Surgery. 2018 October.

Barrett DW, et al. Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans. 2013 Jan.

Blanco NJ, Maddox WT, Gonzalez-Lima F. Improving executive function using transcranial infrared laser stimulation. Journal of Neuropsychology. 2017 Mar.

Paolillo FR, Borghi-Silva A, et al. New treatment of cellulite with infrared-LED illumination applied during high-intensity treadmill training. J Cosmet Laser Ther. 2011 Aug;13(4):166-71.

Caruso-Davis MK, Guillot TS, Podichetty VK, Mashtalir N, Dhurandhar NV, Dubuisson O, Yu Y. Efficacy of low-level laser therapy for body contouring and spot fat reduction. Obes Surg. 2011. Jun;21(6):722-9.

Jackson RF, Dedo DD, Roche GC, et al. Low-level laser therapy as a non-invasive approach for body contouring: a randomized, controlled study. Lasers in Surgery and Medicine. Dec 2009;41(10):99-809.

McRae E and Boris J. Independent evaluation of low-level laser therapy at 635 nm for non-invasive body contouring of the waist, hips, and thighs. Lasers in Surgery and Medicine. Jan 2013.

Avci P, Gupta A, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Seminars in Cutaneous Medicine and Surgery. Mar 2013; 32(1): 41-52.

Does Your Cat Get Depression in Winter? Light Therapy Can Solve it

A typical morning for our cats may involve purring, stretching, or meowing at the family members. After some time, the cat might retire to its favorite spot looking normal. But, do we really understand our felines? What if they were depressed? Would we understand why? Can we help them overcome the winter blues?

Cats are sensitive to changes in light, more so than people. Less lighting in the fall may cause a decrease in brain chemicals like serotonin. Given the inevitability of rain, snow, and cold weather in the fall, cats are often faced with a change of schedule.

If your cat is indoor/outdoor, he may become depressed during the winter months and shorter days. Even if your feline is indoor-only, lack of sunlight, less exercise during the fall, and longer periods of alone-time all contribute to the telltale symptoms of restlessness and depression of seasonal affective disorder, or SAD.

What causes SAD?

SAD in felines, as in people, is influenced by the amount of sunlight that your cat is exposed to. You may notice your cat appearing slower and gloomier during the winter months, yet when April and May arrive, he is more energetic and has a healthier appetite.

Lack of sunlight reduces the production of melatonin, which in turn leads to depression, drowsiness, and sometimes anxiety. It also results in low levels of serotonin, a hormone that serves as a neurotransmitter; cats may display symptoms of depression, aggression, and mood changes.

Restoring the chemical balance is not done easily, since serotonin cannot be given as a shot or in pill form. Many veterinarians turn to drugs — the same ones prescribed for humans.

If the idea of giving your cat pills or a serotonin reuptake inhibitor (SRI) makes your heartache, then it’s a good idea to learn about light therapy, which manipulates your cat’s environment to simulate the brightness of sunlight.

Using light therapy to treat SAD

Veterinarians often recommend light therapy to treat SAD. These natural, non-invasive, and low-cost treatments can cost less than a yearly supply of cat's food, and they let you maintain control over your pet’s emotional highs and lows.

In Kaiyan Medical, we recommend using light therapy for 30 minutes a day.

Like us, cats and dogs suffer from conditions such as inflammation, infections, and arthritis. And no matter how closely we watch them, they’ll scrape their legs, cut their pads, jar their shoulders and sprain their ankles.

How it works

So, how does red light actually help animals? Very simply, it delivers an energy boost to the cells, which provides wide-ranging health benefits.

Using LEDs or LASER diodes, LLLT penetrates your animal’s skin, blood, muscle, and bone using specific wavelengths of photons. Photoreceptors in your animal’s cells absorb this light energy, which enhances the healing process by giving the cells a boost of energy. Various wavelengths reach different layers of tissue. Red light, for example, is more efficiently absorbed by tissue rich in hemoglobin and is beneficial for healing surface wounds and stimulating acupressure points. Near-infrared light is able to pass through to deeper tissues such as tendons, ligaments, bones, joints, and muscles. Ideally, a combination of both red, green and near-infrared light is used in a light therapy session.


What else light therapy can do for your cat?

Because of the way it energizes the cells, red light can help with a number of health conditions in animals, including the following:

  • Joint pain
  • Osteoarthritis
  • Muscle soreness
  • Wounds and injuries
  • Rashes and infections
  • Inflammation

And there’s clinical data to prove it! In one study, horses that suffered from chronic back pain for years responded so well to red light therapy that in less than 3 months, over 70% were back to training and competing! (3) In addition, studies have also shown that horses treated with red light experience significantly faster tissue healing times.


Getting started

If you’re thinking of trying light therapy for your dog or cat, the first step is to ask yourself — and your vet — if it’s the right option for your companion’s needs. Light therapy can help with a wide variety of minor conditions. If your pet is experiencing something more severe, light therapy may be able to complement a more extensive treatment plan. In Kaiyan Medical we love animals and we want health and wellness for them as well.

References:

Does Your Cat Get Depression in Winter? Light Therapy Can Help | Catster
A typical morning for your cat may involve stretching, purring, or meowing the family awake at the break of dawn. After…www.catster.com

https://animalwellnessmagazine.com/light-therapy-for-dogs-and-cats/

https://www.healthline.com/health/depression/light-therapy

https://www.psychiatry.org/patients-families/depression/what-is-depression

http://www.slideshare.net/JLS10/light-therapy

Low-Intensity Light Therapy: Exploring the Role of Redox Mechanisms. Joseph Tafur, M.D. and Paul J. Mills, Ph.D.

Effect of NASA light-emitting diode irradiation on wound healing. J Clin Laser Med Surg. 2001

Treatment of chronic back pain in horses. Stimulation of acupuncture points with a low-powered infrared laser. Martin BB Jr. 1987.

Equine wound healing: influence of low-level laser therapy on an equine metacarpal wound healing model. Jann. 2012.

Effect of light-emitting diode (LED) therapy on the development of osteoarthritis (OA) in a rabbit model. Biomed Pharmacother. 2011

Low-level laser therapy reduces time to ambulation in dogs after hemilaminectomy: a preliminary study. Draper WE. 2012

The Sleeping Beauty Secret: The Red Light Therapy

Lack of sleep is a villain in America and Europe. Light intake is a big part of the problem. Over 65% of adults say they don’t get enough good sleep every week. Most people also don’t get nearly enough natural light for optimal health: the average American spends over 90% of their time indoors.

In addition to not getting enough natural light, people today are surrounded by artificial blue light from screens and overhead lighting. An overload of artificial blue light can cause headaches and make it harder to get to sleep and stay asleep. When we take in all that bright blue light from laptops, TVs, and phones, especially before we go to bed, our bodies get the signal that it's time to be awake, even if we're tired.

Melatonin is the naturally-occurring hormone that regulates sleep and wakefulness. Emerging research is showing that red light therapy treatments can help people produce more of their own, natural melatonin than exposure to other light sources like blue light. Red light therapy is natural light. It’s much less bright than blue light, with a lower color temperature than daytime sun, as the image above shows. Research has shown that red light doesn’t upset your sleep cycle like bright blue light. Red light therapy is showing great clinical results for people with insomnia and sleep disorders.

The light therapy is a simple, non-invasive treatment that delivers concentrated natural light to your skin and cells. Clinical research is showing that red light therapy can improve sleep quality and duration, and help people produce more of their own melatonin.

Light plays a major role in your sleep cycle. The body’s circadian clock interprets light as a sign of when to sleep and when to be awake. Artificial blue light from phones, computers, and other screens is extremely bright and can knock your circadian rhythm out of whack. Red light has the opposite effect: it’s ideal for evenings because it has a low color temperature—far lower than blue light and much closer to the natural sunset.

Red light therapy treatments are quick and simple: you just sit or stand in natural light for 5 to 15 minutes, ideally every day. This stimulates your mitochondria and gives your cells the natural light they need to make energy.

How Does Red Light Therapy Help You Sleep?

Natural light is a key ingredient for a healthy circadian rhythm and restful sleep. If you struggle to sleep, your light intake could be a big factor. Red light therapy delivers natural light like you’d get from the sun, but without UV rays, excess heat, or the need for sunny weather.

Red light therapy treatments supercharge your cells with the natural light they need to make more core ATP (adenosine triphosphate) energy. This helps your body run more efficiently, heal faster, and has shown great results for producing more natural melatonin and improving sleep disorders like insomnia.

Red light therapy treatments have shown great sleep results in a range of peer-reviewed clinical studies. One study on the sleep of pro basketball players showed that a 2-week course of red light therapy in the evening improved players’ sleep quality in the short term. Based on the results, the researchers suggested red light therapy would be a good non-invasive, drug-free solution to sleep struggles.

Overcoming Sleep Disorders with Red Light Therapy

Kaiyan's light therapy products are registered with the FDA as class II medical devices for the treatment of pain, strain, and inflammation. While the existing clinical research has been very positive for red light therapy and sleep, keep in mind that Kaiyan's devices are not cleared with the FDA for the treatment of various sleep disorders or melatonin.

Recent research on sleep disorders among people with migraine headaches has shown that red light therapy both decreased headache frequency, and was the only treatment that improved patients’ sleep disorders.

A 2014 study on cognitive function and traumatic brain injury (TBI) recorded that participants had significantly decreased episodes of post-traumatic stress disorder (PTSD), and improved sleep.

Analyzing patients’ electrical brain activity, a 2013 sleep study concluded that red light therapy was especially effective at helping people with sleep disorders fall asleep.


When I’m indoors training under the buzz of artificial lights, my body doesn’t get the natural light it needs. Add computers, cell phones, televisions, etc. and it’s easy to overload yourself with blue light. I used to have trouble sleeping after long training days, but since adding more natural light to my routine with red light therapy, I’ve been falling asleep as soon as I lie down, and I’ve been staying asleep all night.*

Sanne Wevers

Gold-Medal Winning Dutch Gymnast

Red Light Therapy, Sleep, Depression, and Seasonal Affective Disorder (SAD)

Research is showing how closely mood and sleep disorders are interconnected. Parts of the brain that regulate sleep have also been found to closely affect mood. A 2013 review concluded that “nearly all people suffering from mood disorders have significant disruptions in circadian rhythms and the sleep/wake cycle.”

This Greatist post on natural light and serotonin gives good background on the connections between natural light intake, mental health, and sleep. It also mentions using Kaiyan's red light therapy devices to get more natural light, even when you can’t get more sunlight.

Trouble sleeping is one of the most common symptoms of seasonal affective disorder, a type of depression most common in the darker winter months. Some physicians treating patients with mental health disorders have said red light therapy both improves mood, and helps people with depression get better sleep.

Sources and References:

Morita T., Tokura H. “ Effects of lights of different color temperature on the nocturnal changes in core temperature and melatonin in humans” Journal of Physiological Anthropology. 1996, September

Lirong Z., Phyllis Z. “Circadian Rhythm Sleep Disorders” Neurologic Clinics. 2012, November.

Color Temperature

The State of Sleep Health in America.

Klepeis N., Nelson W., et al. “The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants”. Journal of Exposure Analysis and Environmental Epidemiology 2001.

Sheppard A and Wolffsohn J. “Digital eye strain: prevalence, measurement and amelioration.” BMJ Open Ophthalmology. 2018 April.

Gooley, J., Chamberlain, K., Smith, K., Khalsa, S., et al. “Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans” J Clin Endocrinol Metab. 2011 Mar.

Hamblin M. “Mechanisms and applications of the anti-inflammatory effects of photobiomodulation”. AIMS Biophys. 2017.

Zhao J., Tian Y., Nie J., Xu J., Liu D. “Red light and the sleep quality and endurance performance of Chinese female basketball players” Journal of Athletic Training. 2012, November-December.

Loeb LM, Amorim RP, et al. “Botulinum toxin A (BT-A) versus low-level laser therapy (LLLT) in chronic migraine treatment: a comparison.” Arquivos de neuro-psiquiatria. 2018 Oct;76(10):663-667.

Naeser MA, Zafonte R, et al. “Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study.” Journal of Neurotrauma. 2014 Jun 1;31(11):1008-17.

Wu JH, Chang YC. Effect of low-level laser stimulation on EEG power in normal subjects with closed eyes. Evidence Based Complementary and Alternative Medicine. 2013; 2013:476565.

Vadnie C, and McClung C. Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus. Neural Plasticity. 2017 November.

McClung C. How might circadian rhythms control mood? Let me count the ways. Biological Psychiatry. 2013 April.

Nutt D, Wilson S, et al. Sleep disorders as core symptoms of depression. Dialogues in Clinical Neuroscience. 2008 September.

Avci P, Gupta A, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Seminars in Cutaneous Medicine and Surgery. Mar 2013.

Light Therapy: The Emerging Market


Life without light is darkness. Light plays a vital role in our healthy life. Now the light is expanding the business scope in business for LIGHT THERAPY.

Light therapy also known as phototherapy is a simplified process, where the skin is precisely exposed before a light-emitting source on a routine. This light resembles natural light which helps to stimulate cells in the affected section.

Light Therapy has a notable history. It started back in 1903, when Niels Ryberg Finsen, developed a device that produced synthesized light. He was also awarded Nobel Prize in Medicine for this discovery.  Later in 1938, a hospital in Massachusetts performed effective testing on patients with colored lights.

Light therapy at the present considered as one of the standard of care for the treatment of various diseases by most of the healthcare professionals.

According to research, the global cosmetic products market is estimated to be valued at US$ 69 billion in the year 2025. One of the emerging business amongst the beauty and medical market is LIGHT THERAPY.

Light Therapy Market size was valued at USD 811.8 million in the year 2018 and is expected to witness a rise of 4.6% CAGR from 2019 to 2025.

Light Therapy Market
https://www.gminsights.com/industry-analysis/light-therapy-market

Drivers for the growth

The reason behind the growth of the market is driven by factors like the increase in dermatological disorders such as acne vulgaris, psoriasis, wrinkles. Light therapy market includes the usage of various lights like red, blue, green in dermatological as well as medical, health, sports industry too. The application of light therapy is vast and wide, which makes the market more diverge. It gives different companies an opportunity to participate and explore the market.

Additionally the rising disposable income, growth of upper middle-class population and increasing awareness of beauty products.

Also, modern users are more inclined towards the non-invasive treatment. With favorable reimbursement scenario in and advancement in the product technology, the liking of the light therapy has increased.

The Handheld devices for skin treatment (HDST) category held over 16.5% revenue share in 2018 and is now estimated to grow significantly by 2025. There is a wide adoption of handheld devices in home-care settings since the handheld devices have the ability to avoid the cell disruptions during light therapy treatment.


Germany Light Therapy Market Size, By Light Type, 2018 (USD Million)
https://www.gminsights.com/industry-analysis/light-therapy-market


Light Therapy Market, By Product

Handheld devices for skin treatment (HDST) segment held over 16.5% revenue share in 2018 and is projected to grow significantly by 2025. Ability of handheld devices to avoid cell disruption during light therapy device placement will upsurge its adoption in noninvasive interventions. Wide adoption of handheld devices in homecare settings will thus spur segment size.

Light visor segment is projected to witness robust CAGR of more than 4% over the forthcoming years. Adoption of portable lightening units such as light visors for effective patient management will accelerate segment growth over the coming years.

Light Therapy Market, By Application

Light therapy market is evolving day by day. In the past decade, there is a significant growth in this market. The wide range of applications in health, fitness, sports, beauty and medical field has increased the interest of buyers.

Sleeping disorder market segment was valued over USD 110 million in the year 2018 and is estimated to witness a similar trend during the upcoming years. The rising prevalence of sleep disorders such as Seasonal Affective Disorder (SAD), insomnia and jet lag and will uplift this segment growth. Additionally, the rising demand for light therapy for patients suffering from circadian rhythm will amplify the adoption of light therapy in the predictable future.

Another segmentation of application is the different forms where light therapy is being used like clinics, salons, home, hospitals etc. Dermatology clinics held more than 26% revenue share in 2018 as per a report. Also, the application at home is at soar. The end-users convenience is a major reason for the home-care setting application great market value which was around USD 495 million in 2018.

Light Therapy Market, By Light Type

Blue light segment accounted for more than 26% revenue share in 2018 and will exhibit substantial growth over the coming years. Extensive adoption of blue light in the treatment of sun damage as well as premalignant or malignant skin cancer should propel segment growth.

Red light segment is anticipated to witness around 4.5% CAGR over the forthcoming years. Wide application of red-light therapy in the treatment of orthopedic conditions such as joint pain, inflammation and arthritis will surge its adoption over the coming years.

Light Therapy Market, By End-use

Dermatology clinics held more than 26% revenue share in 2018 and will exhibit momentous growth over the forecast timeline. Rising incidence of skin disorders coupled with increasing demand for non-invasive procedures will foster segment growth during the forthcoming years.

Home-care settings segment was valued around USD 495 million in 2018 due to increasing patient preference towards home-care. Benefits offered by home-care settings such as quality treatment at affordable prices and reduced risk of dermatological clinics acquired infections will fuel the business growth.

Light Therapy Market, By Region

North America light therapy market will witness over 4% CAGR over the analysis timeline. Rising prevalence of skin disorders including eczema and skin cancer in North America is key factor driving light therapy business growth. Strong foothold of key industry players in the region will positively impact industry growth.

Asia Pacific light therapy market was valued more than USD 175 million revenue in 2018. Urbanization, changing lifestyle and increasing prevalence of depression and hypertension in the region will favor regional business growth. Increasing healthcare reforms in countries such as China will further drive Asia Pacific light therapy industry growth in the coming years.


Asia Pacific Light Therapy Market Size, By Country
https://www.gminsights.com/industry-analysis/light-therapy-market





References:

https://www.themarketreports.com/report/global-acne-light-therapy-devices-market-research-report

https://www.gminsights.com/industry-analysis/light-therapy-market

https://www.medgadget.com/2020/08/light-therapy-market-to-grow-at-a-cagr-of-5-1-by-2025-covid-19-impact-analysis-top-company-profile-global-share-industry-size-swot-analysis-regional-statistics.html

https://www.goldsteinresearch.com/report/cosmetics-industry-beauty-market-size-share-trends-demand

Best Practices for Leading Manufacturing Medical Device Teams During the COVID-19 Pandemic

COVID-19 has created challenges for nearly every market, and the medical device manufacturing industry is no exception. As the virus sweeps the globe, it’s becoming increasingly difficult for leaders to overcome the arising challenges and prepare for the future.

While I firmly believe the key to navigating this evolving landscape is putting quality at the forefront of all activities, a function made seamless through best of breed quality management tools, I was curious what other industry leaders had to say.

The following are some of their best tips for effectively leading and managing teams during the COVID-19 pandemic and preparing your organization for what’s to come.

Communication is the Key

Keep in touch. Let your people know where things stand with the business. At home or in the office practicing social distancing, each of your workers will be dealing with different issues, both private and professional. The distributed workforce requires even more channels to help people stay connected.

“Leadership needs to provide regular communication, be transparent about the impact of the pandemic on your company, and set expectations with your team, investors, partners, and customers. There is a great deal of uncertainty in the world, and clarity from management is one of the keys to a healthy organization.” — Paul Grand, CEO, MedTech Innovator

Be Sensitive to Personal Issues

Be sensitive to employees’ personal situations. Every member has their own worries and family needs during this crisis. Review goals and when needed realign expectations to match current circumstances.

Quick and Efficient Meetings

Balance the content. Focus on efficiency in meetings to ensure your team still has time to do their work and manage their personal situation. The recommended time for meetings should be 15 minutes with no more than 4 people per meeting

Manage your Expectations

Office time should be reduced. To avoid conflicts, make sure yo manage expectations. Be clear about your expectations and the expectation from your team during these challenging times. The last thing you want to do is have misunderstandings or conflicts with a good working team.

Be Mindful About the Mental Health

The key purpose of a leader is to continuously motivate and support the team. Talk about work-life structures, supporting flexible working arrangements, and vocalizing empathy towards your workmates. As a leader, you must empower them to deliver their best work while being absolutely empathetic towards challenges in their life.

Focus on the Future

Focus on the fact that COVID-19 is temporary. The natural instinct may be to slow down and withdraw resources. Instead, this is an excellent time to strategically plan and dedicate time, staff, and resources to ensuring that the post-pandemic time capitalizes on key changes.

Creative Research Methods

Just because you can’t conduct research the way you always have doesn’t mean you can’t conduct research at all. It is important to stay flexible with the research methods you use. Understanding the pros and cons of each method and their overall ability to contribute to your research goal is critical to conducting meaningful and useful research.

All companies are working to lead their teams through today’s challenges with confidence. By taking care of your team and keeping quality you will improve the teamwork collaboration, communication, and transparency.


The Top 100 Medical Device Acronyms you Should Know

In collaboration with the work of Jon Speer in July 19, 2020

Every industry in the world uses acronyms, and the overlap between multiple fields can be a source of confusion for professionals. There’s no room for confusion in the medical device industry, as a miscommunication could potentially lead to a product defect or adverse event with serious consequences.

Here the list:

21 CFR PART 11

Part 11 of Title 21 in the Code of Federal Regulations, commonly referred to as 21 CFR Part 11 or Part 11 for shorthand, establishes the acceptance criteria by FDA of electronic records, electronic signatures and handwritten signatures executed to electronic documents.

Compliance of quality systems with 21 CFR Part 11 requirements applies to the medical device industry, in addition to pharmaceutical, biotechnology, and other FDA-regulated industries.

21 CFR PART 820

FDA maintains quality system regulations, or QSR, found in 21 CFR Part 820, which establishes the quality system requirements for all medical device manufacturers in the United States. Manufacturers are required to establish and maintain a quality system that is appropriate for the medical device to ensure both the safety and efficacy for its intended use, per the requirements of 21 CFR Part 820.

483 OBSERVATION

A 483 observation, or “inspectional observation,” is a notice issued by an FDA inspector to flag potential regulatory violations found during a routine inspection. A Form 483 observation may be issued regarding any violation under FDA jurisdiction. Failure to demonstrate handling of the observed problems can be escalated to a warning letter.

510(K) PREMARKET NOTIFICATION

A 510(k) is a regulatory premarket submission made to FDA for a Class I, II, or III medical device that doesn’t otherwise require premarket approval. The purpose of a 510(k) submission must demonstrate a safe and effective device that is substantial equivalent to an existing legally marketed device.

APPLICATION LIFECYCLE MANAGEMENT (ALM)

Application Lifecycle Management, or ALM, involves the specification, design, development and testing of software tools. ALM systems are used to manage quality and demonstrate compliance during the software delivery process.

AUDITING ORGANIZATION (AO)

An Auditing Organization, or AO, is responsible for auditing medical device manufacturers to evaluate conformity with quality management system requirements and other medical device regulatory requirements. An AO may be an independent organization or a Regulatory Authority (RA).

AOs participating in the Medical Device Single Audit Program (MDSAP) may conduct a single regulatory audit of a manufacturer which satisfies the relevant requirements of RAs participating in MDSAP.

APPROVED SUPPLIER LIST (ASL)

An Approved Supplier List, or ASL, is an internal list kept by medical device manufacturers to record suppliers known to meet the quality and performance standards of the manufacturing organization.

BILL OF MATERIALS (BOM)

A Bill of Materials, or BOM, is a complete list of raw materials, assemblies, and subassemblies required to produce a device, as well as the quantities required for each. A BOM is required to carry out change management processes for a medical device.

COMPETENT AUTHORITY (CA)

A Competent Authority, or CA, is a body within the government of a Member State in the European Union. A CA transposes the requirements of Europe's medical device regulation (MDR) into the national law of each Member State. For example, the Federal Institute for Drugs and Medical Devices (BfArM) is the the CA for Germany.

CONFORMITY ASSESSMENT (CA)

A Conformity Assessment, or CA, is carried out by an EU Notified Body to determine that a medical device is safe and performs as intended by the manufacturer. Medical devices must pass a conformity assessment in order to obtain CE Marking.

COMPUTER-AIDED DESIGN (CAD)

Computer-Aided Design (CAD) software allows device manufacturers and designers to draft detailed designs, including precise specifications and measurements. CAD software files can be stored on a digital database for reference.

CORRECTIVE AND PREVENTIVE ACTION (CAPA)

Corrective and Preventive Action, or CAPA, is a quality system process carried out by a medical device organization to reduce and/or eliminate potential sources of risk and regulatory non-conformance or noncompliance.

CE MARKING (CE MARK)

A CE Marking, or CE Mark, certification must be obtained by medical device manufacturers for product distribution into the European Union (EU) marketplace. CE Marks are issued by third-party organizations, known as a Notified Bodies, and indicate compliance with the applicable EU medical device regulations (MDR).

EUROPEAN COMMITTEE FOR STANDARDIZATION (CEN)

The European Committee for Standardization, or CEN, is a public standards organization that develops standards for medical devices for sale in the European Union (EU). CEN can be compared to the Food and Drug Administration (FDA), which maintains and enforces medical device regulations in the U.S. marketplace.

CENTER FOR DEVICES AND RADIOLOGICAL HEALTH (CDRH)

The Center for Devices and Radiological Health, or CDRH, is a branch of the U.S. Food and Drug Administration (FDA) responsible for overseeing the approval of medical devices for sale in the U.S. market and also monitors the manufacturing, performance, and safety of those medical devices.

CLINICAL EVALUATION REPORT (CER)

A Clinical Evaluation Report, or CER, provides clinical evidence that a medical device will perform as expected, such that no safety issues occur while using it. European regulations require medical device manufacturers to perform a conformity assessment, of which include CER documentation, in order to legally market a product in the EU.

COST OF QUALITY (COQ)

Cost of Quality, or CoQ, is a system for measuring the financial impact that a quality system and its processes has on a business. Medical device companies can use CoQ to calculate potential savings and weigh those against the costs associated with internal process improvements.

COMPUTER SYSTEM VALIDATION (CSV)

Computer System Validation, or CSV, is a process used to demonstrate that computer systems, including hardware and software, used in medical device manufacture meet the regulations outlined in 21 CFR Part 11.

CURRENT GOOD MANUFACTURING PRACTICES (CGMP)

Current Good Manufacturing Practices, or cGMP, are minimum standards provided by FDA for manufacturing processes and facilities. The FDA cGMP standards establish a framework for medical device manufacturers to follow and allow for greater flexibility in achieving various quality requirements.

DOCUMENT CHANGE ORDER (DCO)

A Document Change Order, or DCO, is a formalized process in medical device change management. The DCO process involves change requests to be made within an organization to a document or system in a standardized, traceable manner.

DE NOVO

The De Novo regulatory pathway is a classification process that uses a risk-based methodology for novel medical device to be granted market entry for sale in the U.S. For a de novo submission to be granted by FDA, general controls must indicate that the device is safe and effective for its intended use.

DEMING CYCLE

The Deming Cycle is a methodology for monitoring quality efficacy and serves as a basis for traditional quality assurance. The Deming Cycle model is comprised of four parts: plan, do, study, and act. These parts are often summarized as PDSA.

DESIGN CONTROLS (DC)

Design Controls or DC, as defined by FDA in 21 CFR 820.30, are a systematic process that ensures specific design requirements are met by documented procedures that control the design of the medical device. The purpose of DCs is to demonstrate that a medical device is safe, effective, and performs as expected.

DESIGN DOSSIER (DD)

A Design Dossier, or DD, includes all contents of the technical file (TF), which describe a device’s design, manufacturing, and performance, as well as the documentation that demonstrates conformity with applicable regulatory requirements.

DESIGN OF EXPERIMENT (DOE)

A Design of Experiment, or DoE, is a method for medical device manufacturers and engineers to validate internal processes and predict process variability in order to improve and maintain product quality.

DESIGN FOR MANUFACTURE (DFM)

A Design for Manufacture, or DFM, is a process for optimizing the design of a medical device for manufacturing. A DFM takes into account the cost of manufacture, as well as regulatory compliance and product performance.

DESIGN HISTORY FILE (DHF)

A Design History File, or DHF, contains all documentation related to the design and development of a medical device. Medical device manufacturers in the U.S. market are required by law under FDA 21 CFR Part 820 to maintain a DHF.

DEVICE HISTORY RECORD (DHR)

The Device History Record, or DHR, acts as a record of production for a medical device and demonstrates it was manufactured according to information stored in the device master record (DMR). Manufacturers operating in the U.S. are required under CFR Part 820.184 to maintain a DHR, which contains information such as acceptance records for units or batches of products, unique product identifiers, and product counts.

DEVICE MASTER RECORD (DMR)

A Device Master Record, or DMR, is a record of all the information and specifications required to produce a medical device. The DMR contains instructions for manufacturing, drawings and specifications for devices, and requirements for labeling and packaging. Manufacturers are required by FDA to maintain a DMR under CFR Part 820.181.

DOCUMENT MANAGEMENT SYSTEM (DMS)

A Document Management System, or DMS, is a tool used to store and manage documents related to medical device development, as well as track any changes made to documents throughout the product lifecycle on an ongoing basis. A DMS is not synonymous with a Quality Management System, or QMS, which stores documents but also has a regulatory compliance focus.

ENGINEERING CHANGE ORDER (ECO)

An Engineering Change Order, or ECO, is a process that is triggered when an issue is raised with a medical device in terms of performance, cost-effectiveness, or the process of manufacturing the device. An ECO is typically followed by an analysis to determine whether action should be taken. Depending on the nature of the change, an ECO may lead to a CAPA investigation.

ESTABLISHMENT INSPECTION REPORT (EIR)

An Establishment Inspection Report, or EIR, is made by FDA in the event a Form 483 is issued following an inspection. The next steps after receiving an official EIR from FDA will be determined by the severity of the issues observed, as well as the 483 response. If significant deficiencies are observed, FDA may decide to issue a warning letter.

ENTERPRISE RESOURCE PLANNING (ERP)

Enterprise Resource Planning, or ERP, refers to the management of business processes within the organization of a medical device organization. This is often carried out with the use of ERP tools that gather and organize business data and automate processes related to human resources and business practices.

IN VITRO DIAGNOSTIC REGULATION (IVDR)

The European Commission's new IVDR 2017/746, which is shorthand for In Vitro Diagnostic Regulation, is Europe's new regulation for in vitro diagnostic devices that is scheduled to go into effect 26 May 2022. The IVDR requires all existing IVD devices being sold in the EU market to undergo recertification for compliance with the new requirements, which supersede the previously held directives for in-vitro diagnostic devices (IVDD).

EU MEDICAL DEVICE DIRECTIVE (MDD)

MDD is the Medical Device Directive for medical devices sold in the European marketplace, which was replaced in 2017 by the medical device regulation (MDR. The purpose of the directive was to harmonize laws and standards around medical devices marketed in the European Union.

EU MEDICAL DEVICE REGULATION (EU MDR)

EU MDR is a common abbreviation for the medical device Regulation (EU) 2017/745, which mandates the quality and safety requirements for medical devices produced and marketed in the European Union (EU). The EU medical device regulation supersedes the previously held medical device directives (MDD) that were in place up until 2017 and places strong emphasis on a total product lifecycle approach.

EUROPEAN DATABASE ON MEDICAL DEVICES (EUDAMED)

The European Database on Medical Devices, or EUDAMED, is a database developed by the European Commission to facilitate compliance with European medical device regulations. It's intended to function as a multipurpose system for registration, collaboration, and communication for multiple stakeholders in the medical device industry.

FOOD AND DRUG ADMINISTRATION (FDA)

The Food and Drug Administration, or FDA, is a federal agency of the U.S. Department of Health and Human Services. The FDA is responsible for approving medical devices for manufacture and distribution within the U.S. Medical device manufacturers operating within the U.S. market are subject to FDA inspections and compliance with the requirements outlined in Title 21 of the Code of Regulations.

FAILURE MODES AND EFFECTS ANALYSIS (FMEA)

Failure Modes and Effects Analysis, or FMEA, is a method used to identify failures in a design or process associated with a medical device. FMEA is distinct from ISO 14971, the international standard for medical device risk management. The FMEA method can be broken into two parts: PFMEA for processes, and DFMEA for designs.

FAULT TREE ANALYSIS (FTA)

Fault Tree Analysis, or FTA, is an analytical method aimed at identifying points of failure and risk within a quality system. In medical device manufacture, FTA can be applied throughout the course of risk management activities to identify possible sources of risk.

FREEDOM TO OPERATE (FTO)

Freedom to Operate, or FTO, refers to product infringement on intellectual property. Device manufacturers typically declare whether they have FTO in each market in which they plan to sell a new product.

GENERAL SAFETY AND PERFORMANCE REQUIREMENTS (GSPR)

Medical device manufacturers are required to comply with the General Safety and Performance Requirements (GSPRs) of the new EU MDR. The regulation splits GSPRs into three chapters, general requirements, requirements regarding design and manufacture, and requirements regarding the information supplied with the device.

HAZARD IDENTIFICATION (HID)

Hazard Identification, or HID, is a risk management process in which device manufacturers determine whether situations, processes, or items associated with the production of their device may have the potential to cause harm.

INVESTIGATIONAL DEVICE EXEMPTION (IDE)

An Investigational Device Exemption, or IDE, is an FDA exemption that allows an investigational device to be used for testing a device against premarket approval standards. An investigational device can be used to gather data on the safety and effectiveness of the device, and this data is submitted as an IDE for review by FDA.

IEC 60601

IEC 60601 is a standard pertaining to electrical medical equipment. Any medical device containing electronics must pass the necessary requirements outlined in IEC 60601.

Programmable Electrical Medical Systems, or PEMS, is a key part of what's covered in IEC 60601. PEMS consists of software, firmware, and equipment that can be programmed to carry out functions that aid medical care or treatment. The standard also covers mechanical safety, labeling, and risk management.

IEC 62304

IEC 62304 is a software framework that outlines software engineering and documentation practices. It is also recognized by FDA and provides a risk-based framework that can be used throughout entire medical device software lifecycle.

INSTRUCTIONS FOR USE (IFU)

Instructions for Use, or IFU, are instructional materials used to convey relevant information to the end user. These materials must take into account the capabilities and limitations of the end user in order to communicate instructions as concisely and objectively as possible.

INTERNATIONAL MEDICAL DEVICE REGULATORS FORUM (IMDRF)

The International Medical Device Regulators Forum, or IMDRF, is a voluntary working group of international medical device experts whose purpose is to harmonize medical device standards and regulations. The IMDRF supersedes the Global Harmonization Task Force.

INSTALLATION QUALIFICATION (IQ), OPERATIONAL QUALIFICATION (OQ), AND PERFORMANCE QUALIFICATION (PQ)

Installation Qualification, Operational Qualification, and Performance Qualification are terms that pertain to medical device software and equipment validation. IQ relates to the proper installment of software or equipment, OQ concerns meeting the necessary regulatory requirements, and PQ has to do with compliance of the software or equipment performance.

INSTITUTIONAL REVIEW BOARD (IRB)

An Institutional Review Board, or IRB, is a body that oversees human medical research in the U.S. and ensures that the human rights of all subjects are protected. An IRB has the authority to approve or disapprove research or to request modifications to research practices.

INTERNATIONAL ORGANIZATION FOR STANDARDIZATION (ISO)

The International Organization for Standardization, or ISO, is a non-governmental organization of experts providing voluntary international standards, based on the subject matter expertise of members, to enable and promote innovative solutions to worldwide challenges.

ISO 13485:2016

ISO 13485:2016 is the internationally harmonized standard for medical device quality management systems (QMS). To align with ISO 13485:2016, QMS contents should address the specific, applicable requirements outlined in the standard, in addition to the applicable regulatory requirements according to the markets where the medical device will be manufactured and marketed.

ISO 14971:2019

ISO 14971:2019 is the latest version of the international standard for medical device risk management. The globally recognized standard offers best practices for using a proactive approach to risk management throughout the entire lifecycle of a medical device.

ISO 9001

ISO 9001 is an international standard that specifies the requirements for a quality management system. Belonging under the umbrella of the ISO 9000 standard, 9001 is the only one that offers a certification pathway for manufacturers. This standard assumes a specialized focus on ensuring users receive good-quality products and services.

IN VITRO DIAGNOSTIC (IVD) DEVICES

IVD refers to In Vitro Diagnostic devices. As defined in IVDR (EU) 2017/746, IVD can describe devices or equipment “intended by the manufacturer to be used in vitro for the examination of specimens, including blood and tissue donations, derived from the human body.”

MANUFACTURER AND USER FACILITY DEVICE EXPERIENCE (MAUDE)

Manufacturer and User Facility Device Experience, or MAUDE, is a database for medical device electronic reporting (eMDR) submitted to the FDA by manufacturers, importers, device user facilities, health care professionals, patients, and consumers.

MEDICAL DEVICE REPORTING (MDR)

Medical Device Reporting, or MDR, refers to a surveillance tool maintained by FDA that is used to monitor the performance and safety of medical devices after being placed on the market. MDR provides voluntary reporting capabilities to both medical device manufacturers and consumers for public-use.

MEDICAL DEVICE SINGLE AUDIT PROGRAM (MDSAP)

The Medical Device Single Audit Program, or MDSAP, is a program allowing medical device manufacturers to gain access into multiple global markets through one audit event. There are currently five active participating regions of MDSAP, including Australia, Brazil, Canada, Japan, and the United States.

MEDICAL DEVICE USER FEE AMENDMENTS (MDUFA)

Medical Device User Fee Amendments, or MDUFA, refers to changes made to the fee structure in which medical device companies are expected to pay to FDA in order to register their establishments and devices. These fees also apply to application or notification submissions made to the FDA.

MEDICAL DEVICE QUALITY MANAGEMENT SYSTEM (MDQMS)

A Medical Device Quality Management System, or MDQMS, is a quality management system built from the ground up for the medical device industry. Unlike a legacy QMS or ad hoc system, a MDQMS typically includes templates and workflows that align with medical device industry requirements and best practices.

MANUFACTURING RESOURCE PLANNING (MRP)

Manufacturing Resource Planning, or MRP, is a way of compiling, organizing, and planning various activities carried out by a medical device manufacturer (or with any business). The method involves simulating hypothetical scenarios to ensure resources are being used effectively. This term has fallen out of use in recent years and may also be referred to as ERP.

NOTIFIED BODY (NB)

A Notified Body, or NB, is a third-party auditing organization that assesses the quality and conformity of medical device products seeking market entry into the European Union.

NONCONFORMANCE REPORT (NCR)

A Nonconformance Report, or NCR, is used to document non-conforming material observed during quality control activities or inspection. A NCR details the identified issue(s) of nonconformance, the severity and impact of the non-conformance, how it occurred, and how nonconformance will be managed to prevent recurrence.

NONSIGNIFICANT RISK (NSR)

Nonsignificant Risk, or NSR, is a measure of risk as outlined by ISO 14971. Determining whether a risk is significant or nonsignificant involves assessing the probability of direct harm, probability of harm from not using the device, and probability of harm from misinformation.

OWN BRAND LABELING (OBL)

Own Brand Labeling, or OBL, occurs when a manufacturer sells a medical device in the EU that already has a CE Marking and does so under its own brand.

ORIGINAL EQUIPMENT MANUFACTURER (OEM)

An Original Equipment Manufacturer, or OEM, is an organization that produces goods which are used as subparts in products of a third-party company, which then sells the end products to consumers.

PERSONS RESPONSIBLE FOR REGULATORY COMPLIANCE (PRRC)

The European Commission requires manufacturers to designate at least one person with the requisite expertise in the field of medical devices from within their organization as the Person Responsible for Regulatory Compliance (PRRC).

PRODUCT DEVELOPMENT (PD)

Product Development, or PD, is the pre-market process of building a medical device. In the medical device industry, this process encompasses the design and development of a product.

PRODUCT DATA MANAGEMENT (PDM)

Product Data Management, or PDM, is the handling of data as it relates to a medical device within a software system. Modern medical device companies often use PDM tools to compile product data and automate management protocols.

PRODUCT LIFECYCLE MANAGEMENT (PLM)

In the manufacturing sector, Product Lifecycle Management, or PLM, is a system for managing and overseeing the development and distribution of a product. This process applies to the inception, design, regulatory approval, manufacturing, marketing, and post-market phases of medical devices until the product is no longer on the market.

PREMARKET APPROVAL (PMA)

Premarket Approval, or PMA, is the regulatory pathway to market required for Class III devices under FDA regulations. The PMA submission process typically involves clinical trials with human participants, as well as laboratory testing, to demonstrate the safety and efficacy of the device.

POST-MARKET SURVEILLANCE (PMS)

Post-Market Surveillance, or PMS, is the process of monitoring a medical device after it has gained market entry for sale and distribution of use for use by patients within the marketplace. PMS involves gathering data and feedback on the performance of a device on the market, and it is a mandatory process for compliance with most regulations and standards, including 21 CFR Part 820, EU MDR, and ISO 13485:2016.

PROOF OF PRINCIPLE (POP)

Proof of Principle, or POP and also known as Proof of Concept, is the demonstration that the initial concept behind a medical device is feasible. The POP typically includes criteria for success that must be met in order to proceed with product development.

PRODUCTION PLANNING AND CONTROL (PPC)

Production Planning and Control, or PPC, is a process used to organize the production, including design and development activities, and the manufacture of a medical device. A PPC process is usually comprised of inputs, outputs, and control systems. Regulations for design and development planning are found under FDA CFR 21 Part 820.30.

QUALITY ASSURANCE (QA)

Quality Assurance, or QA, is a method used to prevent defective, nonconforming products. QA professionals engage in activities intended to improve the product development and testing processes, as well as maintaining compliant marketing and distribution processes.

A quality management system can be considered as a QA tool itself, as it serves as a single source of truth for all quality policies and procedures for the final product.

QUALITY CONTROL (QC)

While QA focuses on the process, Quality Control, or QC, focuses on the product. QC is system for identifying defects in a medical device during the post-production phase, prior to product distribution. The goal of quality control is to ensure the product conforms to specified requirements and will meet expected performance criteria upon end user interface. QC and QA are complementary aspects of a QMS.

QUALITY MANAGEMENT SYSTEM (QMS)

A Quality Management System, or QMS, is an organizational tool for implementing and maintaining activities, documents, and tasks as it relates to responsibilities, procedures, processes, and resources. A QMS is instrumental in achieving regulatory compliance and in producing safe and effective medical devices. At minimum, a quality system should include design controls, risk management, document control and records management, and supplier management.

QUALITY SYSTEM INSPECTION TECHNIQUE (QSIT)

The Quality System Inspection Technique, also known as the QSIT method, is a type of FDA inspection that uses a top-down approach to reviewing the four main subsystems within a company's QMS. The top-down approach used by the FDA inspector begins with reviewing the company's procedures before drilling down into the quality records for those processes. The quality records serve as proof the company is following its written procedures.

QUALITY SYSTEM RECORD (QSR)

A Quality System Record, or QSR, is a record that acts as a source file for all documentation, procedures, and records that are located within a QMS. Medical device companies can use their QSR as a reference to navigate other aspects of their QMS. QSR can also refer to Quality System Regulation, shown below.

QUALITY SYSTEM REGULATION (QSR)

The Quality System Regulation, or QSR, for medical devices in the U.S. is outlined in FDA 21 CFR Part 820. The QSR requirements are based on methods for facilities, and controls used for, carrying out all phases of processes throughout the lifecycle of a medical device. These aspects include design, manufacture, packaging, labeling, storing, installing, and servicing of medical devices intended for use by humans.

REGULATORY AFFAIRS (RA)

Regulatory Affairs, or RA, professionals in the medical device industry play a strategic role throughout the product lifecycle, such as ownership of a company's go-to-market strategy for satisfying legal requirements of product commercialization, regulatory submission protocol, and postmarket surveillance methods. The RA role serves a critical function for effectively communicating and executing appropriate regulatory strategies to ensure compliance.

RISK ANALYSIS (RA)

Risk Analysis, or RA, is a method used in risk management to identify specific risks associated with a design, procedure, or process used in the manufacture of a medical device. The RA process will include identifying the medical device, the persons involved, the scope of the risk analysis, and relevant date(s). Preliminary hazard analysis, FMEA, and fault tree analysis are all methods used to carry out risk analysis for a medical device.

RISK MANAGEMENT (RM)

Risk Management, or RM, is a process used by medical device companies to identify, control, and prevent hazards and risks/sources of harm that might arise during the use of a medical device. The internationally recognized standard for medical device RM processes are outlined in ISO 14971:2019.

RESEARCH USE ONLY (RUO)

Research Use Only, or RUO, is a term used to indicate that a medical device product or instrument does not have an intended medical purpose and instead is to be used for research purposes only. Devices used for research in IVD product development are often labeled RUO.

SOFTWARE AS A MEDICAL DEVICE (SAMD)

Software as a Medical Device, or SaMD, is a class of software used for medical functions, without needing a hardware component to serve that function. An application or software that's used to diagnose, cure, prevent, or mitigate disease are all considered to be classes of SaMD.

SUPPLIER CORRECTIVE ACTION REQUEST (SCAR)

A Supplier Corrective Action Request, or SCAR, is a formal notice sent to a supplier by a medical device company upon the observance of issues related to nonconforming products or materials. Such issues impact the quality of the provided goods, and the purpose of the SCAR is to solicit action from the supplier to identify and correct the issue(s) raised.

SUBSTANTIAL EQUIVALENCE (SE)

Substantial Equivalence, or SE, is a regulatory requirement by FDA for market clearance of new products through a 510(k) premarket submission. To declare substantial equivalence, a company must prove their device is as safe and effective as a similar predicate device. SE is required for regulatory submissions for which a premarket approval (PMA) is not required.

SAFE MEDICAL DEVICES ACT (SMDA)

The Safe Medical Devices Act, or SMDA, is a law which passed in 1990 establishing HHS as the governing authority over device user facilities to report incidents in which a medical device may have caused or contributed to the serious injury, illness, or death of a patient.

STANDARD OPERATING PROCEDURE (SOP)

A Standard Operating Procedure, or SOP, is an internal procedure created by an organization to standardize a routine process for ease of repeatable. A SOP is typically a written document comprised of a series of prescriptive instructions to be followed by individuals and teams. Medical device companies are required to create and maintain SOPs for routine processes as part of their QMS.

STATISTICAL PROCESS CONTROL (SPC)

Statistical Process Control, or SPC, is a method used to control a process through the use of statistical techniques. This involves compiling data from a process and building cause and effect models to predict and account for various outcomes.

SIGNIFICANT RISK (SR)

Significant Risk, or SR, is a measure of risk as defined by ISO 14971. Any device that poses a serious risk to the health or safety of a human subject is categorized as SR.

SINGLE-USE DEVICES (SUDS)

Single-Use Devices, or SUDs, are disposable devices intended to be used for a singular event or procedure for one patient only. These devices are to be disposed after use rather than sanitized and re-used.

SUMMARY TECHNICAL DOCUMENTATION (STED)

Summary Technical Documentation, or STED, is format manufacturers can use to record required information about how a medical device was designed, developed, and manufactured for submission to a Regulatory Authority or Notified Body to demonstrate conformity. The STED format represents the documentation required for Technical Files.

TECHNICAL FILE (TF)

A Technical File, or Design Dossier  for Class III devices, includes specific details about a medical device's design, composition, intended use, function, and clinical evaluation. TF are a key requirement of obtaining CE marking for a device.

UNIQUE DEVICE IDENTIFICATION (UDI)

Unique Device Identification, or UDI, is a system established by the FDA to catalog and identify each individual device for sale in the U.S. market by assigning a custom identifier that can be read by both humans and machines. A UDI is distinct from a Universal Product Code (UPC), as the UDI is used to identify a medical device on the FDA website via the AccessGUDID portal.

UNIVERSAL PRODUCT CODE (UPC)

A Universal Product Code, or UPC, is a code printed on retail packaging consisting of a barcode and a 12-digit number. The code can be used to track inventory for retailers and is considered to be an alternative tracking method to UDI, the official identification system used by FDA.

VERIFICATION AND VALIDATION (V&V)

Verification and Validation, also known as V&V, are activities for testing and confirming whether a medical device meets the design procedures and is ready to be released for manufacture. Design verification ensures you designed the device correctly and design validation ensures you designed the correct device. These processes tend to involve careful tests, trials, and analyses.

VOLUNTARY ACTION INDICATED (VAI)

Voluntary Action Indicated, or VAI, is a term used by the FDA in establishment inspection reports (EIR) to indicate regulatory action is not required, following the observance of objectionable conditions or practices during an inspection. On the contrary, Official Action Indicated (OAI) would indicate regulatory or administrative action is required by FDA to correct an issue found during an inspection.

WARNING LETTER (WL)

A Warning Letter (WL) is an official notice made by FDA in response to regulatory violations that have been escalated from a 483 observation. Violations may include anything from wrongful claims about the device to missing design controls. A WL will provide a detailed explanation of the violation and what is required of companies for a corrective action plan.

WORK IN PROGRESS (WIP)

Work in Progress, or WIP, is a term used to refer to partially finished goods in manufacturing or within a design history record (DHR). Inventory that has entered the manufacturing process and can no longer be classed as raw materials but is not yet a finished product is classed as WIP.

The information provided in this article is for educational purposes only and is not intended to support the safety or effectiveness of any medical device, or diagnose, treat, cure, audit, procedure, quality standard or prevent any disease.

Your Baby, Jaundice, and Light Therapy

Bilirubin is a yellow substance that comes from the normal breakdown of red blood cells. The liver removes bilirubin from the blood and passes it into the bowels so it can leave the body.

A newborn baby’s liver does not remove bilirubin, as well as an adult, does. Jaundice happens when bilirubin builds up faster than the liver can break it down and pass it from the body.

Most types of jaundice go away on their own. Others need treatment to lower bilirubin levels.

What Causes Jaundice?

Jaundice can be caused by different problems:

  • Physiological jaundice: The most common cause of newborn jaundice and occurs in more than 50% of babies. Because the baby has an immature liver. Jaundice first appears at 2 to 3 days of age. It usually disappears by 1 to 2 weeks of age, and the levels of bilirubin are harmless.
  • Breastfeeding jaundice: Breastfeeding jaundice may occur when your baby does not drink enough breast milk. It occurs in 5% to 10% of newborns.
  • Breast-milk jaundice: Breast-milk jaundice occurs in 1% to 2% of breast-fed babies. It is caused by a special substance that some mothers produce in their milk. This substance causes the baby’s intestine to absorb more bilirubin back into his body than normal. This type of jaundice starts at 4 to 7 days of age. It may last 3 to 10 weeks. It is not harmful.
  • Blood group incompatibility (Rh or ABO problems): If a baby and mother have different blood types, sometimes the mother produces antibodies that destroy the newborn’s red blood cells. This causes a sudden buildup of bilirubin in the baby’s blood. This serious type of jaundice usually begins during the first 24 hours of life. Rh problems formerly caused the most severe form of jaundice.

How Is Jaundice Diagnosed?

Doctors can tell if a baby has jaundice based on the yellowing of the skin and whites of the eyes. Usually, all newborns are checked for jaundice before leaving the hospital or birth center.

Babies with jaundice will get a blood test to check bilirubin levels. Sometimes, a light machine that measures bilirubin in the skin is used. But if the level is high, a blood test must confirm the result.

High bilirubin levels can lead to serious problems. So doctors carefully watch babies with jaundice.

Treatments for Jaundice

Some types of jaundice will disappear within a week or two without treatment. Other babies will require treatment because of the severity of jaundice.

Light treatment is the process of using light to eliminate bilirubin in the blood. The baby’s skin and blood absorb these light waves. These light waves are absorbed by your baby’s skin and blood and change bilirubin into products, which can pass through their system.

For many years, phototherapy treatment in the hospital has been provided by a row of lights or a spotlight suspended at a distance form a baby. This would provide light shining directly on an undressed baby (with a diaper on) whose eyes would need protection from the light with soft eye patches applied. Today, advancements in technology have led to a new phototherapy system that gives effective treatment without the inconveniences of conventional phototherapy treatment.

The Beauty and the Beam: the Magic of the Red Light Therapy.

Skeptical

While I was initially skeptical at the 8-minute treatment, after I started to calm my mind, I fell in love with it. From age spots, to dry skin and acne, it cures whatever ails you. Could sound like a magic potion from a princess but is just light therapy. Before you go with the “What the…?” face, it’s only a matter of time before it shows up in most of the celebrities’ social media.

Most of our users describe it as

“warm and relaxing, and allows you to go into a meditative state of mind.”

LED light therapy has an established history of skin uses. The U.S. Navy SEALs began using it in the 1990s to help heal wounds quickly and to help regenerate damaged muscle tissues.

Since then, the treatment has been researched for different situations in aesthetics. It’s mainly noted for increasing collagen and tissues.

There are different frequencies, or wavelengths, used with LED light treatment. These include red and blue light frequencies, which don’t contain ultraviolet rays and are readily absorbed into the skin.

Light therapy

Different than Daylight

Unlike ultraviolet rays from the sun which damage the DNA of skin cells, “light emitted in this spectrum is perfectly safe,” said Dr. Susan Bard, a board-certified dermatologist based in New York City.

That means there’s no tanning or burning when you’re exposed to red light. Its effects happen deep inside at the cellular level. All living things need to make ATP cellular energy to function and survive, and nearly all living things rely on natural light to power this process in our cells every day. Red and near-infrared wavelengths of natural light stimulate the mitochondria in your cells, the powerhouses responsible for taking light, oxygen, and the food we eat — and turning it into usable energy for our bodies through the process of cellular respiration.

Light therapy

Uses of Red Light

Red light therapy has been used to treat or improve the following:

  • pain
  • inflammation
  • healing
  • tissue regeneration
  • autoimmune diseases
  • brain disorders
  • athletic performance
  • eyesight
  • heating
  • cancer therapy side effects

“The number of conditions red light can treat is ‘continuously expanding”

said Michael R. Hamblin, PhD, a principal investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital and associate professor of dermatology at Harvard Medical School.

The Short Version

Light therapy delivers safe, concentrated wavelengths of natural light to your skin and cells, with no chemicals, UV rays, or excess heat. These red and near-infrared wavelengths of light stimulate the mitochondria in your cells similar to natural sunlight, reducing oxidative stress, and increasing circulation, so your body is able to make more core energy to power itself.

In Kaiyan medical, we believe in the benefits of light. We believe in healing without chemicals. With our lights, we want you to have the best version of yourself.