Lighting the Way Back for Astronauts - Light Therapy & NASA

In 1993, Quantum Devices, Inc. (QDI), of Barneveld, Wisconsin, began developing the HEALS (High Emissivity Aluminiferous Light-emitting Substrate) technology high-intensity, solid-state LED lighting systems for NASA Space Shuttle plant growth experiments. The company evolved out of cooperative efforts with the Wisconsin Center for Space Automation and Robotics (WCSAR) at the University of Wisconsin-Madison — a NASA center for the Commercial Development of Space. Ronald W. Ignatius, QDI’s president, and chairman represented one of WCSAR’s industrial partners at the time. WCSAR was conducting research on light sources for promoting food growth within closed environments where humans would be present for a long duration, such as the Space Shuttle and the International Space Station.

With the support of WCSAR, Ignatius experimented with LEDs, which provide high-energy efficiency and virtually no heat, despite releasing waves of light 10 times brighter than the Sun. Ignatius admits that some scientists involved in the project were skeptical at first, thinking that the idea of using LEDs to promote plant growth was far-fetched. However, the experiments demonstrated that red LED wavelengths could boost the energy metabolism of cells to advance plant growth and photosynthesis. This finding prompted Ignatius to develop a line of LED products that emit the exact wavelength of light that plants use in photosynthesis.

“Our company gives credit to Dr. Ray Bula, the director of WCSAR, for having the foresight to go against the prevailing dogma of the time and design the first plant experiment using monochromatic light to grow lettuce plants,” Ignatius proclaims.

In 1989, Ignatius formed QDI to bring the salt grain-sized LEDs to market. In October 1995, the light sources made their Space Shuttle flight debut on the second U.S. Microgravity Laboratory Spacelab mission (STS-73, Columbia).

Growing

When NASA determined that red LEDs could grow plants in space, Marshall Space Flight Center awarded QDI several Small Business Innovation Research (SBIR) contracts to investigate the broad-spectrum diodes' effectiveness in medical applications. The contracts, issued from 1995 to 1998, focused on increasing energy inside human cells. NASA hoped that the LEDs would yield medical benefits on Earth and stem bone and muscle mass loss in astronauts, which occurs during long periods of weightlessness. (In space, the lack of gravity keeps human cells from growing naturally.) Furthermore, since wounds are slow to heal in a microgravity environment, LED therapy could accelerate healing and keep what would be termed as minor wounds on Earth from becoming mission-catastrophic in space.

In addition to promoting cell growth, the red LEDs are capable of activating light-sensitive, tumor-treating drugs that, when injected intravenously, could destroy cancer cells while leaving surrounding tissue virtually untouched. The technique, approved by the U.S. Food and Drug Administration (FDA) for use in laboratory and human trials, is known as Photodynamic Therapy.

With the SBIR assistance from NASA, QDI set out to alter a surgical probe that could emit long waves of red light to stimulate a Benzoporphyrin-derivative drug called Photofrin, which delivers fewer post-operative side effects than comparable drugs. Ignatius also developed a friendly and successful working relationship with Dr. Harry Whelan, pediatric neurology and director of hyperbaric medicine at the Medical College of Wisconsin in Milwaukee. The two had met after Ignatius came across a newspaper article highlighting Whelan’s ground-breaking brain cancer surgery technique, which uses drugs stimulated by laser lights to accelerate healing. Accordingly, QDI provided more than $1.25 million from its SBIR contracts to support Whelan’s pioneering photobiomodulation research and bring him on board to help improve the surgical probe.

Collectively, Ignatius, Whelan, and researchers from NASA successfully altered the probe for pediatric brain tumors and the prevention of oral mucositis (a common side effect of chemotherapy and radiation treatments) in pediatric bone marrow transplant patients at the Medical College of Wisconsin. In May 1998, a 20-year-old female became the first patient to undergo surgery with the modified probe. The young woman had endured six brain surgeries and chemotherapy and radiation treatments over a span of 10 years, but her aggressive cancer kept coming back. Having exhausted all of her conventional treatment options, she turned to the NASA-sponsored Photodynamic Therapy technology.

During the procedure, surgeons excised as much of the recurring brain tumor as they could then injected the light-activated Photofrin into her bloodstream and inserted the LED probe into the remaining tumor tissue. The probe, which casts long wavelengths that generate less heat and penetrate deeper into tissue than the shorter wavelengths of traditional medical lasers, proved to be both safe and effective, as the tumor never returned, and the patient recovered with no complications. A second operation that took place 3 months later on a male patient was also deemed successful by Whelan and his Medical College of Wisconsin surgeons' team.

FDA-approved clinical trials continued at several other facilities over the next 3 years, including the Roswell Park Cancer Institute in Buffalo, New York; Rush-Presbyterian-St. Luke’s Medical Center in Chicago; and the Instituto de Oncologia Pediatrica in Sao Paulo, Brazil. QDI became recognized as a U.S. Space Foundation “Space Technology Hall of Fame” award recipient in 2000 and a Marshall Space Flight Center “Hallmark of Success” in 2004.

Product Outcome

The positive clinical trial results and continued support from NASA and follow-on research grants from the Defense Advanced Research Projects Agency helped QDI and the Medical College of Wisconsin fully transition space technology into a new, non-invasive medical device. The WARP 10 (Warfighter Accelerated Recovery by Photobiomodulation) is a high-intensity, hand-held, portable LED unit intended for the temporary relief of minor muscle and joint pain, arthritis, stiffness, and muscle spasms. It also promotes the relaxation of muscle tissue and increases local blood circulation. Unlike the surgical probe, the WARP 10 does not require intravenous medicine; instead, the unit can be placed directly on the skin where treatment is to occur.

The WARP 10 was designed to aid armed forces personnel on the front lines with immediate first aid care for minor injuries and pain, thereby improving combat endurance. The “soldier self-care” device produces 80 times more photon energy than a 250-Watt heat lamp, yet it remains cool to the touch. The power advantage reduces the time required for each therapeutic dose and provides for faster multi-dose exposures when needed, without the harmful effects of ultraviolet solar radiation. The U.S. Department of Defense and the U.S. Navy are currently issuing WARP 10 to crews on submarines and Special Forces operations.

QDI has introduced an FDA-approved consumer version sharing the same power and properties of the military model as an alternative to the cost and complications associated with the overuse of non-steroidal anti-inflammatory drugs (NSAIDs) for persistent pain relief. According to a Mayo Clinic study, adverse events associated with the use of NSAIDs are reported more frequently to the FDA than such events associated with any other group of drugs. Furthermore, conservative calculations for the United States estimate that approximately 107,000 patients are hospitalized each year for NSAID-related gastrointestinal complications. At least 16,500 NSAID-related deaths occur annually among arthritis patients alone, according to compiled research.

References

Beauvoit B., Evans S.M., Jenkins T.W., Miller E.E., Chance B., “Contribution of the Mitochondrial Compartment to the OpticalProperties of the Rat Liver: A Theoretical and Practical Approach,” Analytical Biochemistry 226, 167-174 (1995).Beauvoit B., Kitai T., Chance B., “Correlation between the Light Scattering and the Mitochondrial Content of Normal Tissues andTransplantable Rodent Tumors,” Biophysical Journal 67, 2501-25 10 (1994).Chance B., Nioka S., Kent J., McCully K., Fountain M., Greenfield R., Holtom G., “Time-Resolved Spectroscopy of Hemoglobin andMyoglobin in Resting and Ischemic Muscle,” Analytical Biochemistry 174, 698-707 (1988)Conlan M.J., Rapley J.W., Cobb C.M., “Biostimulation of wound healing by low-energy laser irradiation,” J.Clin. Periodont. 23, 492-496 (1996).Eggert H.R., Blazek V., “Optical Properties of Normal Human Brain Tissues In The Spectral Range of 400 to 2500 nm,” Advances inExperimental Medicine & Biology 333, 47-55 (1993).Karu T., “Photochemical Effects Upon the Cornea, Skin and Other Tissues (Photobiology Of Low-Power Laser Effects,” HlthPhysics 56, 69 1-704 (1989).Lubart R., Friedman H., Sinyakov M., Cohen N., Breitbart H., “Changes in Calcium Transport in Mammalian Sperm Mitochondriaand Plasma Membranes Caused by 780 nm Irradiation,” Lasers in Surg & Med 21, 493-499 (1997).Lubart R., Wollman Y., Friedman H., Rochkind S. Laulicht L., “Effects of visible and near-infrared lasers on cell cultures,” Journalof Photochemistry & Photobiology 12(3), 305-3 10 (1992).Salansky N., “Low energy photon therapy for wound healing.” Intnl Med Instr, Canadian Defense Ministry, PersonalCommunication. (1998).Schmidt M.H., Bajic D.M., Reichert K.W. II, Martin T.S., Meyer G.A., Whelan H.T., “Light –emitting diodes as a light source forintra-operative photodynamic therapy.” Neurosurg 38(3), 552-556 (1996).Schmidt M.H., Reichert K.W. II, Ozker K., Meyer G.A., Donohoe D.L., Bajic D.M., Whelan N. T., Whelan H. T., “PreclinicalEvaluation of Benzoporphyrin Derivative Combined with a Light-Emitting Diode Array for Photodynamic Therapy ofBrain Tumors.” Pediatr Neurosurg 30, 225-231 (1999).Whelan H.T., Schmidt M.H., Segura A.D., McAuliffe T.L., Bajic D.M., Murray K.J., Moulder J.E., Strother D.R., Thomas J.P., MeyerG.A., “The role of photodynamic therapy in posterior fossa brain tumors: A pre-clinical study in a canine glioma model.”Journal of Neurosurgery 79(4), 562-8 (1993).5Whelan H.T., Houle J.M., Donohoe D.L., Bajic D.M., Schmidt M.H., Reichert K.W., Weyenberg G.T., Larson D.L., Meyer G.A.,Caviness J.A., “Medical Applications of Space Light-Emitting Diode Technology—Space Station and Beyond.” SpaceTech. & App Int’l Forum 458, 3-15 (1999).Yu W., Naim J.O., Lanzafame R.J., “The Effect Of Laser Irradiation On The Release Of bFGF From 3T3 Fibroblasts.”Photochemistry & Photobiology 59, 167-70 (1994).

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The Road to Remission: Light Therapy Proves Effective for Cancer Survivors

It's common to describe cancer as something you battle, because dealing with the disease feels truly like something you have to conquer. It's a moment in life that forever changes you and the lives around you. Apart from physical health, cancer affects your mental health equally. It brings in a wide range of emotions and feelings that a person has probably never had to deal with until that moment. Up until the condition, people deal with hardships, but not like this. 

While getting used to intense medical treatments and significant lifestyle changes, these situational adjustments all fall heavy on the shoulders of those who are sick. 

Luckily beating the beast is possible. Fighting off and beating cancer can be done. 

The most common treatment and way of going against cancer is through chemotherapy. Chemotherapy is a form of therapy that works throughout the whole body, targeting the cells that divide equally fast during cancer. Certain chemotherapy drugs could lead to the damage of cells in your heart. Chemotherapy can also increase your odds of getting heart problems, such as weakening the muscle (cardiomyopathy) and general problems with your cardiac rhythm (arrhythmia).

It takes a long time for the body to heal and regenerate post-treatment, and sometimes an even longer time before people can feel like themselves again. Putting the body back in optimal health is crucial. This may be easier said than done, and maintaining the health of your immune system isn't something to take lightly. 

The immune system gets stronger over time, but it has to stay strong; which is the bigger challenge and one that, if failed, struggles to return. It is possible to upkeep the immune system, and many are looking towards non-invasive therapeutic options in this realm. For cancer survivors, many struggle to determine what’s next in their help journey. For many, they are seeking out non-invasive and non-pharmaceutical treatments as they enter remission, which is where light therapy comes in. 

The types of light therapy range from aiding in superficial skin problems and hair regrowth, to deeper cellular healing from within. The way that light therapy works is via our powerful cells. It targets and penetrates the cells, rejuvenating and provoking acceleration at the reproduction stage. Higher cell production equates to a faster rejuvenation of cells, which provides the body with stronger and healthier cells overall. The higher the cell count, the healthier the body, since light therapy helps with cellular healing via genetic material and ATP—the powerhouse of our entire system. 

Light therapy and cancer may sound completely unrelated; however, you may want to rethink that; in addition to help stimulate healthy cell turnover, light therapy can also be a tremendous aid in sleep disorders. During sleep, our bodies are naturally healing and in the process of regeneration, however, cancer, and cancer treatments and medications, can lead to a very disrupted circadian rhythm

Together, disturbance of circadian activity in adult or pediatric cancer patients has been associated with greater fatigue, poorer quality of life, impaired immune function, lower responsiveness to chemotherapy, earlier relapse, and higher risk of death than patients with robust (healthy) circadian activity rhythms.

Infrared light therapy has been studied for a while in cancer patients; one study, in particular, indicates that light therapy works on the corrupted genetic material that could kill cancer cells. In the study, circadian rhythms became more synchronized, and quality of life was better within the trial testing of light therapy's effect on cancer. 

Light therapy has a multitude of benefits for cancer survivors, providing them a non-invasive, non-pharmaceutical treatment that works at the cellular level. It can repair and maintain health just by improving circadian rhythms that lead to a healthier body and stronger immune system. And this is crucially important since sleep is one of the most important elements in staying strong and healthy post-recovery.

Kayian's light therapy devices are MDA-certified and FDA-certified, and are perfect for in-clinic or at-home treatments. We offer you the opportunity to treat yourself, or your patients, by stepping out of the traditional medical options, a place where many often feel powerless. Supplementing light therapy in treatment and recovery has proven to be a life-changing, safe, and powerful modality.

Back to Nature: The Healing Power of Bird Sounds

What is Sound Therapy?

Sound has been used to heal and calm people for thousands of years. Himalayan singing bowls used in Asia during prayer and meditation positively affect one’s health and well-being. This is just one example of age-old instruments from all over the world being applied as healing instruments.

Sound therapy is based on the premise that we are all made up of energy frequencies, and audio frequencies can interact with our body’s energy to rebalance our systems.

Since music is basically just organized sound, it can be deconstructed to affect our physical and psychological well-being positively.

Ailments Sound Therapy can Help:
  • Anxiety
  • Depression
  • Post-traumatic stress disorder
  • Autism and learning disabilities
  • Dementia
  • Behavior and psychiatric disorders
Five Other Benefits of Sound Therapy
  • Lower stress responses
  • A decrease in mood swings
  • Pain management
  • Improves sleep
  • Lowers blood pressure

How Does Bird Music Help in Sound Therapy?

Our body’s response to noise traces back to when humans began roaming the earth. Think about loud noises  such as your alarm clock in the morning, the rattling of a jackhammer, or the din of the open office. These sounds evoke an instinctive fight-or-flight reaction in our brains, causing a release of chemicals that stimulates immediate action. This reaction has been instrumental to our survival for eons and remains so to this day. The loud honk of a car horn immediately stimulates our brain and body to respond quickly and get us out of harm’s way.

The things we see, hear, and experience moment after moment not only change our mood but impact us on a deeper physical level; it alters the way our nervous, endocrine, and immune systems function.

Listening to birdsong is a wonderful way to reconnect with nature and shift your focus away from the clutter and chaos that is often part of our daily lives.

According to Eleanor Ratcliffe from the University of Surrey, in her thesis examining the restorative perceptions and outcomes associated with listening to birds, bird sounds have the ability to transport yours to nature.

So, not only does bird music affect us positively on a fundamental level of sound frequency, but it also has the capability to make you think you’re in a natural environment, which will in and of itself reduce stress, anxiety, and depression.

Why Is Bird Music So Powerful For Relaxation And Reducing Anxiety?

In today’s fast-paced world, it is vital to make lifestyle choices that will reduce stress and ultimately prolong your life. It has been revealed that listening to slow tempo, low-pitched music with no lyrics can reduce stress and anxiety in people who are to undergo invasive surgery. It also lessens the requirement of subsequent pain medication.

Now, the above are some proven benefits of listening to ordinary music. Just think how powerful it will be to add bird sounds to the mix?

Bird songs and calls are the sorts of natural sounds that most people associate with perceived stress recovery.

During semi-structured interviews conducted with twenty adult participants, Eleanor Ratcliffe determined the following reasons why bird song helps with relaxation and reducing anxiety.

1. Invokes Positive Memories

Bird sounds associated with enjoyable or special events help combat stress and anxiety and ease depressive episodes, as it creates positive emotions linked with particular places and times.

2. Shifts the Focus

Listening to bird music during trying times moves the focus away from the problems and leads to calm.

3. Change of Stimuli

We get used to the everyday sounds of city life. When we listen to bird music, it provides a break from the emotions associated with our surroundings. This short reprieve will help reduce stress.

4. Welcome Distraction

Bird music has the ability to effortlessly take you out of your current environment without you having to move a muscle.

As a symbol of nature, a bird song transports you far from the daily hustle and bustle and removes you from day-to-day demands that may be causing anxiety.

Although science hasn’t yet caught up with bird music believers’ confidence in its healing properties, the evidence speaks for itself since most support is anecdotal.

Bird music is by no means a miracle cure and should still be used in conjunction with medicine as prescribed by your general practitioner.

How Does Bird Music Work Scientifically?

Bird music can clearly have positive effects on a person’s mood, mental health, and physical well-being.

But what real scientific proof is there of music in general’s impact on mental states?

Below you will find some studies that back up what people have been saying for years — music has healing properties.

1. Changes Brain Function

Using electroencephalographs (EEGs) — a device that measures electrical impulses in the brain — established that music with a strong beat stimulates the brain. In contrast, slow beats encourage the brain to relax by promoting a meditative state. When you listen to faster beats, it can lead to deep concentration.

According to a psychologist who was one of the participating researchers, the human brain is usually locked into a specific functioning level. But by speeding up or slowing down the brainwaves, it is easier for the brain to change its speed in reaction to external and internal stimuli.

2. It Increases Blood Flow in the Brain

Thomas Budzynski, an affiliate professor of psychology at the University of Washington, found that the mind enjoys new stimuli. Whenever the brain experiences new sights or sounds, blood flow increases, equalling a better cognitive response. Some anecdotal evidence indicates that this increase in blood flow may help in repairing damaged brain cells.

3. Stimulates the Release of Internal Opioid Peptides

In a review titled The Neurochemistry of music, it is mentioned that listening to music lowers the need for pain medication due to the euphoria often experienced when listening to specific music.

4. Increases Dopamine Levels

Dopamine is responsible for body movements but also plays a role in a person’s emotional response. For this reason, should music raise dopamine, it will be an excellent thing, especially if you’re suffering from mood swings, depression, anxiety, and other mental illnesses or associated symptoms.

Using neuroimaging technology, the central dopamine release while listening to enjoyable music was measured, and the results are positive. The right type of music does increase dopamine.

No wonder listening to music is one of life’s most pleasurable and relaxing activities.

Kaiyan Medical

We are pioneers and architects of light therapy products. Slowly, we are implementing sounds into our devices. We no longer design for our skin and muscles but also our ears.

Light Therapy & Kids with Autism

Autism Spectrum Disorder (ASD)

Autism spectrum disorder (ASD) is a complicated syndrome of nervous system development characterized clinically by language impairment, dysfunction in social engagement, language, stereotypical movements and behaviors, and various cognitive deficits.

Light can have a deep influence on people. Different colored lighting can affect our moods, and a lack of natural light can cause depression. This especially applies to those with autism.

Children with autism are especially susceptible to mood changes due to lighting. Lights with mellow colors, like blue, can help a child relax and become creative. Flickering, humming, or harshly colored lights, on the other hand, can confuse and even hurt them. For this reason, it is important that lighting is controllable and monitored in the child’s rooms.

In addition to manufactured lighting, natural lighting also has its effects. Natural lighting has proven benefits for autistic children. Seasonal affective disorder, or SAD, caused by a lack of natural light during winter months, can foster behavioral issues and depression. Natural light has been shown to relieve these symptoms.

Light therapy has been used for more than to relieve these symptoms. Natural light can help regulate a child’s circadian rhythms. These rhythms govern our body’s “internal master clock.” For example, they tell us when it’s time to sleep. A lack of natural light can cause our rhythms to fall out of sync. Therefore, treatment can make a child with insomnia fall asleep without aids and become more alert during the day, among other benefits.

The best time for treatment is in the morning, soon after the child rises. Even spending just 30 minutes in the light can improve their mood and sleeping habits. 30 minutes might not be possible initially, so while building up to it, another session in the afternoon can help. But therapy at night can have negative effects, worsening a child’s routine and making it harder to fall asleep.

Clinical Study

A study examined the efficacy of low-level laser therapy, a form of photobiomodulation, to treat irritability associated with an autistic spectrum disorder in children and adolescents aged 5–17 years. Twenty-one of the 40 participants received eight 5-min procedures administered to the base of the skull and temporal areas across a 4-week period (test, i.e., active treatment participants). All the participants were evaluated with the Aberrant Behavior Checklist (ABC), with the global scale and five subscales (irritability/agitation, lethargy/social withdrawal, stereotypic behavior, hyperactivity/noncompliance, and inappropriate speech), and the Clinical Global Impressions (CGI) Scale including a severity-of-illness scale (CGI-S) and a global improvement/change scale (CGI-C). The evaluation took place at baseline, week 2 (interim), week 4 (endpoint), and week 8 (post-procedure) of the study. The adjusted mean difference in the baseline to study endpoint change in the ABC irritability subscale score between test and placebo participants was -15.17 in favor of the test procedure group. ANCOVA analysis found this difference statistically significant (F = 99.34, p < 0.0001) compared to the baseline ABC irritability subscale score. The study found that low-level laser therapy could be an effective tool for reducing irritability and other symptoms and behaviors associated with the autistic spectrum disorder in children and adolescents, with positive changes maintained and augmented over time.

A significant literature exists on Low-Level Laser Therapy (LLLT) ability, a form of photobiomodulation, to penetrate the skull in both diagnostic and therapeutic applications. Low energy laser passes the skull, and a therapeutic effect likely exists. Low energy laser systems employ the so-called quantum optical induced transparency (QIT)-effect. This effect, electromagnetically induced transparency (EIT), controls optical properties of dense media and can enhance transparency contrast by a factor of five. Therefore, the skull, spine, or joints can be penetrated even with moderate intensity light. Due to the QIT effect, the radiation should reach deep tissue layers in muscles, connective tissue, and even bone, enabling noninvasive transcranial treatments.

Conclusions

The study’s findings strongly illustrate that not only does the application of light therapy affect a sizable, statistically significant, and clinically meaningful improvement in all of the key evaluable behaviors characteristic of autism disorder in children and adolescents, but it continues to affect a progressive and meaningful improvement in symptoms for up to 6 months following completion of the procedure administration protocol.

LLLT can achieve a therapeutic effect by employing non-ionizing light, including lasers, light-emitting diodes, or broadband light in the visible red (600–700 nm) and near-infrared (780–1100 nm) spectra. LLLT is a non-thermal process beginning when a chromophore molecule is exposed to a suitable wavelength of light. Chromophores are responsible for the color associated with biological compounds such as hemoglobin, myoglobin, and cytochromes. When a chromophore absorbs a photon of light, an electron transits to an excited state. The physiologic effects of LLLT occur when photons dissociate the inhibitory signaling molecule, nitric oxide (NO), from cytochrome-C-oxidase, increasing: electron transport, mitochondrial membrane potentials production of mitochondrial products such as ATP, NADH, RNA, and cellular respiration. The leading hypothesis is that the photons dissociate inhibitory nitric oxide from the enzyme, leading to increased electron transport, mitochondrial membrane potential, and ATP production.

References

1. Abbott, A. E., A. C. Linke, A. Nair, A. Jahedi, L. A. Alba, C. L. Keown, I. Fishman, and R. A. Muller. 2018. 'Repetitive behaviors in autism are linked to imbalance of corticostriatal connectivity: a functional connectivity MRI study', Soc Cogn Affect Neurosci, 13: 32-42.
2. Batista-Garcia-Ramo, K., and C. I. Fernandez-Verdecia. 2018. 'What We Know About the Brain Structure-Function Relationship', Behav Sci (Basel), 8.
3. Brown, E. C., M. G. Aman, and S. M. Havercamp. 2002. 'Factor analysis and norms for parent ratings on the Aberrant Behavior Checklist-Community for young people in special education', Res Dev Disabil, 23: 45-60.
4. de Freitas, L. F., and M. R. Hamblin. 2016. 'Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy', IEEE J Sel Top Quantum Electron, 22.
5. Demirtas-Tatlidede, A., A. M. Vahabzadeh-Hagh, M. Bernabeu, J. M. Tormos, and A. Pascual-Leone. 2012. 'Noninvasive brain stimulation in traumatic brain injury', J Head Trauma Rehabil, 27: 274-92.
6. Emelyanov, A. N., and V. V. Kiryanova. 2015. 'Photomodulation of proliferation and differentiation of stem cells by the visible and infrared light', Photomed Laser Surg, 33: 164-74.
7. Freitas, L. F., M. R. Hamblin, F. Anzengruber, J. R. Perussi, A. O. Ribeiro, V. C. A. Martins, and A. M. G. Plepis. 2017. 'Zinc phthalocyanines attached to gold nanorods for simultaneous hyperthermic and photodynamic therapies against melanoma in vitro', J Photochem Photobiol B, 173: 181-86.
8. Hamblin, M. R. 2018. 'Photobiomodulation for traumatic brain injury and stroke', J Neurosci Res, 96: 731-43.
9. Heiskanen, V., and M. R. Hamblin. 2018. 'Photobiomodulation: lasers vs. light emitting diodes?', Photochem Photobiol Sci, 17: 1003-17.
10. Henderson, T. A., and L. D. Morries. 2015. 'Near-infrared photonic energy penetration: can infrared phototherapy effectively reach the human brain?', Neuropsychiatr Dis Treat, 11: 2191-208.
11. Hiwaki, O., and H. Miyaguchi. 2018. 'Noninvasive measurement of dynamic brain signals using light penetrating the brain', PLoS One, 13: e0192095.
12. Huang, Y. Y., A. Gupta, D. Vecchio, V. J. de Arce, S. F. Huang, W. Xuan, and M. R. Hamblin. 2012. 'Transcranial low level laser (light) therapy for traumatic brain injury', J Biophotonics, 5: 827-37.
13. Jiang, P., V. Vuontela, M. Tokariev, H. Lin, E. T. Aronen, Y. Ma, and S. Carlson. 2018. 'Functional connectivity of intrinsic cognitive networks during resting state and task performance in preadolescent children', PLoS One, 13: e0205690.
14. Kaat, A. J., L. Lecavalier, and M. G. Aman. 2014. 'Validity of the aberrant behavior checklist in children with autism spectrum disorder', J Autism Dev Disord, 44: 1103-16.
15. Karabekiroglu, K., and M. G. Aman. 2009. 'Validity of the aberrant behavior checklist in a clinical sample of toddlers', Child Psychiatry Hum Dev, 40: 99-110.
16. Khuman, J., J. Zhang, J. Park, J. D. Carroll, C. Donahue, and M. J. Whalen. 2012. 'Low-level laser light therapy improves cognitive deficits and inhibits microglial activation after controlled cortical impact in mice', J Neurotrauma, 29: 408-17.
17. Kotkowski, E., L. R. Price, P. Mickle Fox, T. J. Vanasse, and P. T. Fox. 2018. 'The hippocampal network model: A transdiagnostic metaconnectomic approach', Neuroimage Clin, 18: 115-29.
18. Lapchak, P. A., and P. D. Boitano. 2016. 'Transcranial Near-Infrared Laser Therapy for Stroke: How to Recover from Futility in the NEST-3 Clinical Trial', Acta Neurochir Suppl, 121: 7-12.
19. Leisman, G., C. Machado, Y. Machado, and M. Chinchilla-Acosta. 2018. 'Effects of Low-Level Laser Therapy in Autism Spectrum Disorder', Adv Exp Med Biol.
20. Machado, C., M. Estevez, G. Leisman, R. Melillo, R. Rodriguez, P. DeFina, A. Hernandez, J. Perez-Nellar, R. Naranjo, M. Chinchilla, N. Garofalo, J. Vargas, and C. Beltran. 2015. 'QEEG spectral and coherence assessment of autistic children in three different experimental conditions', J Autism Dev Disord, 45: 406-24.
21. Machado, C., M. Estevez, R. Rodriguez, and G. Leisman. 2017. 'Letter re: The autism "epidemic": Ethical, legal, and social issues in a developmental spectrum disorder', Neurology, 89: 1310.
22. Machado, C. J., and J. Bachevalier. 2003. 'Non-human primate models of childhood psychopathology: the promise and the limitations', J Child Psychol Psychiatry, 44: 64-87.
23. Machado, C., R. Rodriguez, M. Estevez, G. Leisman, R. Melillo, M. Chinchilla, and L. Portela. 2015. 'Anatomic and Functional Connectivity Relationship in Autistic Children During Three Different Experimental Conditions', Brain Connect, 5: 487-96.
24. Moreira, M. S., I. T. Velasco, L. S. Ferreira, S. K. Ariga, F. Abatepaulo, L. T. Grinberg, and M. M. Marques. 2011. 'Effect of laser phototherapy on wound healing following cerebral ischemia by cryogenic injury', J Photochem Photobiol B, 105: 207-15.
25. Morries, L. D., P. Cassano, and T. A. Henderson. 2015. 'Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy', Neuropsychiatr Dis Treat, 11: 2159-75.
26. Naeser, M. A., P. I. Martin, M. D. Ho, M. H. Krengel, Y. Bogdanova, J. A. Knight, M. K. Yee, R. Zafonte, J. Frazier, M. R. Hamblin, and B. B. Koo. 2016. 'Transcranial, Red/Near-Infrared Light-Emitting Diode Therapy to Improve Cognition in Chronic Traumatic Brain Injury', Photomed Laser Surg, 34: 610-26.
27. Poiani, Gdcr, A. L. Zaninotto, A. M. C. Carneiro, R. A. Zangaro, A. S. I. Salgado, R. B. Parreira, A. F. de Andrade, M. J. Teixeira, and W. S. Paiva. 2018. 'Photobiomodulation using low-level laser therapy (LLLT) for patients with chronic traumatic brain injury: a randomized controlled trial study protocol', Trials, 19: 17.
28. Primo, F. L., M. B. da Costa Reis, M. A. Porcionatto, and A. C. Tedesco. 2011. 'In vitro evaluation of chloroaluminum phthalocyanine nanoemulsion and low-level laser therapy on human skin dermal equivalents and bone marrow mesenchymal stem cells', Curr Med Chem, 18: 3376-81.
29. Raj, A., and F. Powell. 2018. 'Models of Network Spread and Network Degeneration in Brain Disorders', Biol Psychiatry Cogn Neurosci Neuroimaging, 3: 788-97.
30. Ranasinghe, K. G., L. B. Hinkley, A. J. Beagle, D. Mizuiri, S. M. Honma, A. E. Welch, I. Hubbard, M. L. Mandelli, Z. A. Miller, C. Garrett, A. La, A. L. Boxer, J. F. Houde, B. L. Miller, K. A. Vossel, M. L. Gorno-Tempini, and S. S. Nagarajan. 2017. 'Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants', Brain, 140: 2737-51.
31. Rochkind, S., A. Shahar, M. Amon, and Z. Nevo. 2002. 'Transplantation of embryonal spinal cord nerve cells cultured on biodegradable microcarriers followed by low power laser irradiation for the treatment of traumatic paraplegia in rats', Neurol Res, 24: 355-60.
32. Rojahn, J., and W. J. Helsel. 1991. 'The Aberrant Behavior Checklist with children and adolescents with dual diagnosis', J Autism Dev Disord, 21: 17-28.
33. Salehpour, F., J. Mahmoudi, F. Kamari, S. Sadigh-Eteghad, S. H. Rasta, and M. R. Hamblin. 2018. 'Brain Photobiomodulation Therapy: a Narrative Review', Mol Neurobiol, 55: 6601-36.
34. Scherman, M., O. S. Mishina, P. Lombardi, E. Giacobino, and J. Laurat. 2012. 'Enhancing electromagnetically-induced transparency in a multilevel broadened medium', Opt Express, 20: 4346-51.
35. Shen, C. C., Y. C. Yang, T. B. Huang, S. C. Chan, and B. S. Liu. 2013. 'Neural regeneration in a novel nerve conduit across a large gap of the transected sciatic nerve in rats with low-level laser phototherapy', J Biomed Mater Res A, 101: 2763-77.
36. Shen, C. C., Y. C. Yang, and B. S. Liu. 2013. 'Effects of large-area irradiated laser phototherapy on peripheral nerve regeneration across a large gap in a biomaterial conduit', J Biomed Mater Res A, 101: 239-52.
37. Stevens, E. J., and D. R. Tomlinson. 1995. 'Effects of endothelin receptor antagonism with bosentan on peripheral nerve function in experimental diabetes', Br J Pharmacol, 115: 373-9.

Light Therapy Used for Ulcerative Colitis & IBD Treatment

Living with any pain is miserable, and inflammatory digestive issues can be one of the most frustrating conditions out there — and it’s widespread, particularly as autoimmunity on the rise.

Inflammatory Bowel Disease (IBD) is a life-long chronic condition of the gastrointestinal tract. Among these conditions, various digestive system parts, including the bowels (intestines), become swollen, inflamed, and ulcerated. This inflammation leads to disruption of the natural processes of digesting food, absorbing nutrition, and healthily eliminating waste.

There are three forms of IBD: Crohn’s disease, Ulcerative colitis, and indeterminate colitis. The main differences between the three are in the areas affected and the depth of inflammation.

Friendly bacteria may cause it, but that doesn’t make it friendly one bit — ulcerative colitis is rather uncomfortable even if the symptoms are often mild. This condition happens when the immune system mistakes our bacteria, which aids in digestion as friendly, leading to the colon and rectum's inflammation.

The main symptoms of IBD are recurring diarrhea, which may contain blood, mucus, stomach, and abdominal pain, and needing to empty your bowels frequently. It is also possible to experience extreme tiredness (fatigue) and loss of appetite, leading to weight loss.

The severity of the symptoms varies, depending on how much of the rectum and colon is inflamed and how severe the inflammation is.

In 2015, an estimated 1.3% of US adults (3 million) reported being diagnosed with IBD (either Crohn’s disease or ulcerative colitis). This was a large increase from 1999 (0.9% or 2 million adults). In the latest years, autoimmune diseases have risen, including stress, diet, lack of exercise, insufficient sleep, and smoking. In general, people haven’t been leading healthy lifestyles, which results in a higher chance of developing an autoimmune disease. While there are ways to treat autoimmune diseases, they typically are conditions that stick with you as long as they can.

The number of ulcerative colitis cases was 40% higher, and Crohn’s disease was 80% higher in northern Europe than southern Europe. This gives more evidence to the theory of vitamin D deficiency coming from lack of light. In France, a study described a transparent north-south gradient for the incidence of Crohn’s disease, but not colitis.

Light therapy can help with a wide range of problems, autoimmune diseases being one of them. For different autoimmune conditions, incidences increase at ranges between 3% and 9% year on year. This includes a 7.0% increase per year of rheumatic diseases such as rheumatoid arthritis. 6.3% increase of endocrinological conditions such as type 1 diabetes.

This is where light therapy comes in as a form of non-invasive therapy. Aside from being non-invasive, it’s an excellent option for those seeking non-pharmaceutical treatment.

The Health benefits of led light therapy are many, and that’s because of how it works. In its essence, light therapy works directly on our cells. Light deposits into our skin cells, penetrating each cell in the targeted area. Then by activation of ATP, reproduction is accelerated, and cellular rejuvenation occurs throughout the whole body.

Use of light therapy at home is available simply by purchasing your own device, using it in the comfort of your own home. How does light therapy help with IBD and ulcerative colitis? Well, light therapy first and foremost helps with tissue repair. Again, through the process of cell rejuvenation and reproduction, our tissue gets the opportunity of healing as well.

By default, UV light is highly anti-microbial, which means it prevents the spread of microorganisms, which infiltrates and causes infection and inflammation. Making an adequate UV light means having the perfect wavelength, which isn’t corrupting to the genetic material and will penetrate and effectively work on the colon.

To alleviate autoimmune symptoms, red light therapy is the perfect non-invasive solution. By healing the body from the inside out, those suffering from autoimmune diseases can finally progress in the right direction. Kaiyan’s light therapy devices are MDA-certified and FDA-approved and perfect at-home treatments for people suffering from these conditions.

Light Therapy's Market Outlook Through 2026

Light therapy has been around for decades, and in the latest few, it’s been gaining momentum and the deserved acceptance from the medical community. The global light therapy market is booming, assumed to reach $1 billion by 2025. 

Some wonder about red light therapy's effectiveness and safety, but companies like Kayian receive FDA and MDA-certification to ensure consumers safety. Light therapy's medical benefits are extensive and range from aesthetics to deep full-body healing. Its countless benefits are why many are looking into this market for its wide range of possibilities. 

Being that it is a non-invasive and non-pharmaceutical form of therapy, light therapy has been challenged through the decades by the pharmaceutical industry. However, as you’re about to see, it’s clear that light therapy is making a breakthrough.

Light therapy's market was valued at over $1 billion in 2020 and is predicted to witness 5.1% CAGR from 2021 to 2027.

Rising incidences of skin-related disorders and growing awareness about care are the factors driving the sunshine therapy market growth.

North America dominated the worldwide light therapy market in 2018. The rise in the prevalence of skin disorders, including eczema and carcinoma in North America, drives the light therapy market. According to current studies by National Psoriasis Foundation, U.S., quite 8 million Americans have psoriasis. 

As per the American Academy of Dermatology (AAD), acne is the most common skin condition within the U.S., affecting up to 50 million Americans annually. An increase in investments from the government and various organizations is predicted to drive the light therapy market in North America.

There are many different product types within the light therapy market, but two main ones are infrared lamps and cold laser therapy. The difference is in the wavelengths. Both have a proven effect on ATP; the real differences preference since the benefits are mainly the same, albeit to a different degree. 

There are also light boxes, floor and desk lamps, light visors, HDST, dawn simulators, light therapy bulbs.

Handheld devices for skin (HDST) are projected to witness 5.6% growth rate till 2027. The light therapy market is estimated to attain a CAGR of 5.8% till 2027, accelerated by the increasing number of sleep disorders coupled with the growing use of light therapy to treat sleeping disorders.

Light therapy's main clinical applications are in biological time sleep disorders, dementia, mood disorders, and insomnia. With light therapy, 5000 lux/h administered daily over several weeks is common. Effects are long-term only if the therapy sessions are persistent and continuous.  

Light therapy is used in many areas of expertise but mainly in hospitals, surgical centers, and diagnostic centers. You can get treatment in a light therapy box perspired from a doctor. 

Some of the eminent players operating within the light therapy market are Beurer, Koninklijke Philips, Aura Daylight, Biophotas, Lucimed, Zepter International, Verilux, and Northern Light Technologies. 

The North American light therapy market size crossed USD 350 million in 2020 due to technological advancements, including growing light therapy applications. Moreover, the presence of major market players and merchandise availability will strengthen the regional market revenue growth.

The market is relied upon to predict vigorous development from constant mechanical headways. Symptoms and side effects of different procedures and constant advancement in light treatment therapy will move individuals' tendency towards light treatment.

In addition, expanding interest for cutting-edge skin and overall health management treatment, for example, blue light and red-light treatment, will help the market development. Also, the rising selection of non-intrusive treatments for different skin problems like wrinkles, facial redness, skin break out, and rosacea will significantly affect future market income.

The interest in blue light additionally expanded significantly during the COVID-19 pandemic. As indicated by medical care scientists, blue light act's as an antimicrobial against various microorganisms. It inactivates a few infections, including COVID and the basic seasonal infection.

Kaiyan Medical is a part of the booming market and our production of FDA-certified and MDA-certified light therapy devices are perfect for at-home treatments.

Incorporating Meditation into Your Light Therapy Ritual

It is said that stress is the precursor of all sickness. In a modern and increasingly fast society like ours, stress is responsible for many mental and physical health issues. Being stressed has become the norm, and yet we often waste our free time on things we don't even enjoy that much (social media scrolling, anyone)? 

We've all been there. We feel stressed as a result of family or relationship issues, or before a test or daunting event. On top of that, leading a hectic and unbalanced lifestyle doesn't help keep us calm and collected, but it rather intensifies the stress.

Stress is tied to a 36 percent greater risk of developing 41 autoimmune diseases, including rheumatoid arthritis, psoriasis, Crohn's disease, and celiac disease. We've become our own enemies. While we're rushing and running to get everything done, our bodies are developing serious problems, and we're not even noticing. 

Taking fifteen minutes out of your day to focus on yourself, your mind, and your body shouldn't be viewed as a luxury. In the time you spend complaining that it takes time out of your day, you could've paused and done it. So, why not change your narrative and allow yourself a little bit of relief? 

So, it’s time to invest in yourself. Light therapy is not only beneficial for our outer beauty but our inner balance as well. It works inward, directly targeting cells and promoting cellular rejuvenation. And there are many ways to use light therapy; from aiding in skincare problems to using our UV light therapy for wound healing.

The type of light therapy depends on your choice; there are a variety of colors that target different issues. Ranging from red and blue to yellow and purple, they all share the same benefit of light working on accelerating our adenosine triphosphate (ATP). ATP is the fuel of our cells and a better ATP production equates to a better organism in total. 

Light is known to trigger the release of serotonin in our brain. Serotonin is also known as the happy "feel-good" brain chemical. Light therapy is the perfect intervention when feeling down; it's also linked to improving other mental issues. 

It helps alleviate stress and is something that can be done at home with our light therapy devices. Not only are you reaping health and beauty benefits, but also you're promoting balanced brain activity. The beauty of doing the treatments yourself is that you get to choose when to do them and on what terms. Pairing your light therapy treatment with meditation could be the way to go.

Why do we mention meditation? Well, its benefits to the body and mind are infinite, and it can also help with your light therapy treatment. There are many different ways to incorporate meditation into your daily routine.

Meditation is, in general, a practice to achieve greater control of the activities of our mind so that it becomes capable of concentrating on a single thought, on a high concept, without overthinking and becoming still, peaceful. Akin to meditation is contemplation, which means letting the mind rest in its natural state. Therefore, it is a practice aimed at self-realization, which can have a religious, spiritual, philosophical purpose, or improve psychophysical conditions.

Pairing your time for light therapy with meditation will only compel your body even more to enter a state most pure to its well-being. Letting the outside world go and only focusing within while your cells truly are being rejuvenated is an incredible process, and a ritual you can incorporate into your daily or weekly self-care regimen.

We so often struggle to find a real escape when we could obtain one right within our homes. Scheduling light therapy-meditation sessions for yourself daily will give you a mindful time to look forward to. You can benefit both physically and mentally in your health, even now when that seems harder to accomplish each day. 

At Kaiyan, we’re dedicated to improving the body from the inside out. To help you achieve a balanced life, our MDA-certified and FDA-approved light therapy devices are the perfect at-home treatment. 

Beard Growth & Light Therapy

Beard Growth & Light Therapy

“The benefit of having a beard is protection, as well as aesthetics,” says Dave Harvey, M.D. “It's good protection against wind, chafing, and traumatic injury. It’s also a trend, so we see a lot of men with some form of facial hair.”

The Health Benefits of Beards

Beards can:

  • Protect skin from sun damage. Beards can help protect the skin from harmful UV rays, though the degree of protection may depend on hair density and thickness. “You’re going to have some protection because hair is a reflective medium,” says Dr. Harvey. “Even though some UV rays get through, there is some scattering of the light, and that’s how it helps protect against sun damage.”
  • Keep you warm. Beards can add a layer of protection to your chin and neck, thus keeping you warm in colder weather. The longer and fuller the beard, the better it will insulate your face.
  • Make you feel more attractive. A study conducted by the Official Journal of the Human Behavior and Evolution Society found that men with a moderately full beard are most attractive. Men with full beards may be perceived as better fathers who could protect and invest in their children. “Men with beards have a powerful look,” says Dr. Harvey. “And that’s an attractive thing.”

Common Problems for Beard Growers

Growing a beard is not always easy. And if your beard is not properly cared for, it can become a harbinger for bacteria.

“If you don’t clean your beard well, and you let it just do its own thing, sometimes you can accumulate yeast and get dandruff within the beard,” says Dr. Harvey. “With that, you’ll get a reactive scaling on the face and flaking like you would with dandruff. So those patients need to be put on antifungal shampoo.”

Beard growers also face the challenge of ingrown follicles that result in bumps known as acne keloidalis.

“Some men will get a raised scarring type of bump called an acne keloidalis of the neck,” he says. “So we offer them topical antibiotics or Retin A for those particular reasons.”

Low-Level Laser Therapy for Beards

Low-level laser therapy (LLLT) is an FDA-approved treatment using laser light energy to circulate blood flow to hair follicles. Laser therapy for hair growth can be used to stop hair loss in men and women. The non-invasive lasers stimulate hair follicles to induce regrowth, resulting in a thicker beard in several weeks of treatments.

Laser hair therapy is also called red light therapy. The process irradiates photons in skin tissue, resulting in photons being absorbed into weaker hair follicles and promoting hair growth.

How Successful Is Laser Hair Restoration?

Laser treatment for hair loss works because photons amp up circulation and stimulation, which brings back hair follicles that may have died off.

Clinical Study

Laser hair restoration therapy is continuing to develop. Still, the National Institutes of Health has conducted multiple studies on laser hair growth therapy to see if it works for those with alopecia and male pattern baldness.

The NIH study used a controlled clinical trial that found laser hair therapy works for men and women, and it’s safe.

Another study from 2013 included male participants aged 18 to 48. The result of laser hair therapy treatment included a 39 percent increase in hair growth for participants over four months.

However, laser therapy is just one piece of the puzzle. Many factors contribute to repeated hair loss, including:

  • Age.
  • Genetics.
  • Medical conditions like diabetes and lupus.
  • Hormones.
  • Poor diet.
  • Side effects of medications, such as chemotherapy.
  • Stress.

How Long Does Laser Hair Therapy Take To Work?

From your first treatment, it can take several weeks to see a noticeable difference. This is because red light therapy for hair loss must be administered multiple times over 4 to 6 weeks to begin working.

If you don’t see any growth after 90 days, it’s probably unlikely you’ll regrow hair with this method. You should consult your doctor about the growth cycle and see how long it will take.

One Tree Planted x Kaiyan: A Partnership for a Greener Future

With all of the environmental concerns surrounding pollution and climate change, the world is at great uncertainty. The list of issues with respect to the way we treat our environment is an increasingly long one. Eco-systems are being destroyed, making our planet less safely inhabitable for both humans and animals. 

For example, a decade ago, air pollution didn't seem so deadly, yet today, it's one of the most life-threatening problems we face. 

Eco-systems often cause and create their microclimates, and with their disappearance, the earth's climate is corrupted. Draught is more frequent around the world and the infamous temperature rise and warming of the climate. Our carbon footprint can and should be reduced, and even though it may seem difficult, the changes have to start somewhere.

The importance of companies taking charge lies in their global reach. Businesses worldwide are capable of spreading information globally, drawing attention to important matters that could make a vital change in the world. Companies staying aware and taking responsibility for their impact on the environment make us more aware of our responsibility. 

So, what’s our story? 

At Kaiyan we've been producing the highest quality light therapy devices for 15 years. Our products are MDA-certified and FDA-approved. First and foremost, our products are designed to improve our customers' well-being, not through gimmicks but science-backed LED therapy devices. 

Our products focus on bringing back balance into the body, inside and out—the natural way. The best part is light therapy is a non-invasive and long-term solution of helping with various health problems, from the inside out. The type of light therapy colors used offers a wide range of benefits. 

With skin, it works by smoothing it out and helping in the general glowing appearance. With light therapy, collagen production increases, which results in fewer wrinkles and fine lines. It helps with wound healing and scars and also with more serious skin problems such as eczema and psoriasis. 

But light therapy capabilities go beyond skin deep. Light therapy also helps with mental health issues such as depression and sleep disorders. Working the way it does, from within, means it penetrates directly into our cells. This way, our cells are rejuvenated, and ATP production boosted. By better cell reproduction, we have a better and healthier organism. 

Many people also struggle with vitamin D deficiency, which causes muscle and bone pains, alongside extreme fatigue. Vitamin d deficiency light therapy works by substituting the Sun. Where it lacks sunshine, our LED light therapy device helps create serotonin and melanin we’d usually get if there were no lack. 

So the health benefits of color light therapy are many, ranging from surface level problems such as skincare to deeper lever problems such as mental health disorders. Working at the cellular level helps our brain's chemical process, creating a better and healthier balance for our bodies. 

Though our focus is improving the human body, we also want to do our part to protect our planet. Kaiyan’s mission is to help with the environment by bringing balance and wellness to the world. This means creating the best and most effective light therapy products while ensuring the environment is kept in mind. 

Saving the Planet One Tree at a Time

One Tree Planted is a non-profit organization working as an environmental charity. Their mission is to help the environment, and they do so by helping us and providing an easier way for individuals or businesses to get involved. One Tree Planted takes online donations and uses the funds to invest in reforestation.

The organization started its project in 2014, and by 2020 the numbers increased from 50 thousand to 15 million. Creating a healthier climate and better world has never been easier. One Tree Planted puts effort into protecting biodiversity and natural habitats. They work with partners in the Americas, Asia, and Africa. Apart from creating new forests, they also restore forests damaged from floods or fires.  

With each Kaiyan manufacturing order, our clients are given the opportunity to select a location for a tree to be planted in their name. Trees help create more oxygen in the atmosphere, and even purify our air. It's an incredibly worthwhile, and impactful opportunity to do something for our mother earth. At the end of the day, sustainability is something we at Kaiyan are working towards passionately, and with our One Tree Planted Partnership, we're able to get our incredible clients involved in bettering the planet, as well.

Wellness Gurus: Who's Turning to Light Therapy for Full-Body Treatment

Light therapy has many benefits, working from the inside, out. It not only helps with our appearance but also internal wellness — because who said beauty's just skin deep? 

Many people find themselves turning to this new form of treatment since it's non-invasive and comes with long-term positive effects — something most people aren't used to hearing. 

While outwardly, the skin smooths out, pores are reduced, wrinkles diminished, and collagen restored. Inwardly, light therapy works directly with our cells, generating an increase of ATP, the energy that fuels us. 

LED Light Therapy uses color wavelengths of visible light, each with specific skin benefits. Due to sun damage, aging, skin disorders, healthy skin cells are compromised and have a more difficult time renewing themselves normally.

But why are wellness gurus going crazy for light therapy? 

Light therapy is not that new; however, it's been gaining popularity due to its benefits, especially in the wellness industry. While everyone is eager to look younger, going under the knife is very invasive. Light therapy is not only effective and easy to use; it's non-invasive. The device needed for light therapy is usually a lamp or light therapy box. 

Is light therapy good for skin? Absolutely. And one of the best things next to the long-term effects is that light therapy can be used as laser light therapy at home. This is the most comfortable way of having the benefits of light therapy. Many celebrities themselves are opting for this route as opposed to invasive treatments.

Light is used as a source of energy, and our skin soaks it up, turning it into ATP (our life fuel). Cells reproducing faster and more efficiently brings the repair and rejuvenation of damaged cells, or, in the case of treating acne, kill bacteria. This stimulates the production of collagen and elastin, boosts circulation, and accelerates tissue repair. You simply lie underneath a light screen during the treatment while the LED light device.

What can light therapy be used for you may be wondering? It isn't only beneficial for your skin; it works directly within our cells, accelerating ATP production. This makes it helpful with overall health, physical and mental. Light exposure has also been linked to being a trigger of serotonin, the way natural light does as well. Not only does it trigger serotonin, but also melatonin, which helps regulate your sleep cycle. 

Luckily, instead of having to go to a doctor for your treatments, you have your own LED light therapy mask or device in the comfort of your home. Allowing wellness gurus and everyday people to enjoy the benefits of red light therapy. 

Light therapy devices work not only the face but as a full body treatment that can help with muscle tension and fascia. Fascia is the connecting tissue that holds every organ, blood vessel, bone, nerve fiber, and muscle in place.

Gwyneth Paltrow even explores on goop.com the many different appealing sides to it. “Light acts as a mild stressor on the body in a dose-dependent manner. We always consider stress to be a bad thing, but at low levels, stress can be good for us. It conditions our tissues and stimulates endogenous protective responses that prime us for either existing or future insult.”

Kourtney Kardashian has taken her LED light therapy mask to the public as well, promoting the device and its benefits. She enjoys both red and blue light treatments, often posting her with her at-home mask. She’s mentioned retinol use alongside the regular treatments, and other skin rejuvenating products. 

But more and more celebrities and wellness gurus are turning to light therapy for a full body treatment. Jessica Alba, alongside celebrities including Emma Stone, Chrissy Teigen, Lena Dunham, Kelly Rowland, and Real Housewives of New York City’s Carole Radziwill, have openly discussed red light therapy treatment. 

Many top skincare and wellness brands are turning to Kaiyan for their red light therapy device production. And though we produce devices that are incredibly effective, our devices are also MDA-certified and FDA-approved, giving you security in knowing your devices not only are effective but are safe. 

Injecting UV Light? - Ultraviolet blood irradiation (UBI)

Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases, including septicemia, pneumonia, tuberculosis, arthritis, asthma, and even poliomyelitis. The early studies were carried out by several physicians in the USA and published in the American Journal of Surgery. However, with the development of antibiotics, UBI use declined, and it has now been called “the cure that time forgot.” Russian workers and other Eastern countries mostly performed later studies, and the modern view in Western countries is that UBI remains highly controversial.

No resistance of microorganisms to UV irradiation has been reported, and multi- antibiotic-resistant strains are as susceptible as their wild-type counterparts. Low and mild UV kill microorganisms by damaging the DNA, while DNA repair enzymes can rapidly repair any DNA damage in host cells. However, UBI treats septicemia cannot be solely due to UV-mediated killing of bacteria in the blood-stream, as only 5–7% of blood volume needs to be treated with UV to produce the optimum benefit. UBI may enhance the phagocytic capacity of various phagocytic cells (neutrophils and dendritic cells), inhibit lymphocytes, and oxidize blood lipids. The oxidative nature of UBI may have mechanisms in common with ozone therapy and other oxygen therapies.

Ultraviolet (UV)

Ultraviolet (UV) radiation is part of the electromagnetic spectrum with a wavelength range (100–400 nm) shorter than that of visible light (400–700 nm) but longer than x-rays (<100 nm). UV radiation is divided into four distinct spectral areas, including vacuum UV (100–200 nm), UVC (200–280 nm), UVB (280–315 nm), and UVA (315–400 nm). Only part of UVB and UVA can reach on earth because wavelengths shorter than 280 nm are filtered out by the atmosphere, especially by the “ozone layer.”

In the second half of the nineteenth century, the therapeutic application of sunlight known as heliotherapy gradually became popular. In 1855, Rikli from Switzerland opened a thermal station in Veldes in Slovenia to provide helio-therapy. In 1877, Downes and Blunt discovered by chance that sunlight could kill bacteria. They noted that sugar water placed on a window-sill turned cloudy in the shade but remained clear while in the sun. Upon microscopic examination of the two solutions, they realized that bacteria were growing in the shaded solution but not in the one exposed to sunlight.

Emmett K Knott in Seattle, WA, reasoned that the beneficial effects of UV irradiation to the skin obtained by Ude might be explained by the irradiation of blood circulating in the superficial capillaries of the skin. With his collaborator Edblom, an irradiation chamber was constructed to allow direct blood exposure to UV. The irradiation chamber was circular and contained a labyrinthine set of channels that connected the inlet and outlet ports. All these channels were covered with a quartz window that formed the top of the chamber. The irradiation chamber was designed to provide maximum turbulence of the blood flowing through. This was done to (a) prevent the formation of a thin film of blood on the chamber window that would absorb and filter out much of the UV light; (b) ensure that all the blood passing through the chamber was equally exposed to UV.

Mechanisms of Action of UBI

One of the major obstacles that UBI has consistently faced throughout the almost 90 years since the first patient was treated has been the lack of understanding of action mechanisms. Over the years, its acceptance by the broad medical community has been hindered by this uncertainty. Confusion has been caused by the widely held idea that since UV is used for sterilization of water and surgical instruments; therefore its use against infection must also rely on UV-mediated direct destruction of pathogens. Another highly confusing aspect is the wide assortment of diseases, which have been claimed to be successfully treated by UBI. It is often thought that something that appears to be “too good to be true” usually is.

UBI affects various functions of red blood cells and various leukocytes, as proven in various in vitro studies. A common model is stimulator cells in mixed leukocyte cultures; another is helper cells in mitogen-stimulated cultures. UV also reversed cytokine production and blocked cytokine release. UV can also disturb cell membrane mobilization.

Effects on Red Blood Cells

Anaerobic conditions strongly inhibited the process by which long-wave UV light induces the loss of K+ ions from red blood cells. Has been proved that UV-irradiation could affect the osmotic properties of red blood cells, the submicroscopic structure, and adenine nucleotides' metabolism. Irradiation times (60, 120, 180, 240, and 300 minutes) were used; during the irradiation, ATP decreased while the amounts of ADP, AXP, and adenine compounds increased. UV also increased hypotonic Na +, and K+ ion exchange and the hematocrit value increased.

A two-phase polymer system containing poly-dextran was used to show that circulating erythrocytes' cell surface was reduced after UV irradiation. This contributed to the prolongation of survival of transfused erythrocytes and was suggested to explain the more effective therapeutic activity of autotransfusion blood.

Effects on Lymphocytes (T-Cells and B-Cells)

UBI generally decreases lymphocyte viability. UVC irradiation is the most effective among the three UV spectral regions. UVB and UVC irradiation can abolish the proliferative and stimulatory ability and the accessory/ antigen-presenting ability of lymphocytes in vitro. The cell-surface properties, calcium mobilization, cytokine production and release, and other sub-cellular processes could all be changed by UV irradiation. Areltt et al. used the “Comet “assay to detect DNA-strand breakage (single-cell gel electrophoresis) as an indicator of excision repair to prove that circulating human T–lymphocytes were exquisitely hyper-sensitive to the DNA-damaging and lethal effects of UV-B radiation, raising the possibility that UV-B may contribute to immunosuppression via a direct effect on extra capillary T-lymphocytes.

Effects on Platelets

H2O2 production in platelets is low at a shallow UV dose, but it increased suddenly as the dose increased above 0.4 J/cm2. Pamphilon reported that platelet concentrates (PC) could become non-immunogenic after UVR and after being stored for 5 days in DuPont Stericell containers. Lactate levels, β-thrombomodulin, and platelet factor were higher after UV. In contrast, glucose levels decreased with an irradiation dose of 3000 J/m2 at a mean wavelength of 310 nm applied in DuPont Stericell bags. Ultraviolet B (UVB) irradiation of platelet concentrate (PC) accelerated downregulation of CD14 and nonspecifically increased the loss of monocytes by inhibiting the upregulation of ICAM-1 and HLA-DR. However, UV irradiation of platelet concentrates produced a reduction of immunological response in a cell suspension.

Things to consider before buying a UVC device

There are a few things you should consider before investing in a UVC wand or other UVC devices.

The first and most important thing to consider: safety. Experts have said UVC can affect skin cells the same way it kills bacteria; it can cause mutations in them and lead to skin cancer. Looking at UVC lights can cause irreversible blindness, too.

Here in Kaiyan Medical, we suggest that you look for UVC devices that come with safety switches — automatic “turn-off” buttons that halt the light emission as soon as you’re at risk of direct exposure.

The second thing to consider: the legitimacy of the product. We have seen some counterfeit UVC consumer products on the market. But unless you have a device at home that measures wavelength in realtime (aka a spectrometer), there’s no way of distinguishing products that use UVC rays versus other UV rays.

Conclusion

UV irradiation of blood was hailed as a miracle therapy for treating serious infections in the 1940s and 1950s. In an ironic quirk of fate, this historical time period coincided with the widespread introduction of penicillin antibiotics, which were rapidly found to be an even bigger medical miracle therapy. Moreover, another major success of UBI, which was becoming increasingly used to treat polio, was also eclipsed by the introduction of the Salk polio vaccine in 1955. UBI had originally been an American discovery but then was transitioned to being more studied in Russia and other eastern countries, which had long concentrated on physical therapies for many diseases, which were more usually treated with drugs in the West.

However, in the last decade, the problem of multi-antibiotic-resistant bacteria has grown relentlessly. Multidrug-resistant (MDR) and pan drug-resistant (PDR) bacterial strains and their related infections are emerging threats to public health throughout the world. These are associated with approximately two-fold higher mortality rates and considerably prolonged hospital admissions. The infections caused by antibiotic-resistant strains are often tough to treat due to the limited therapeutic options range. Recently in Feb 2015, the Review on Antimicrobial Resistance stated, “Drug-resistant infections could kill an extra 10 million people across the world every year by 2050 if they are not tackled. By this date, they could also cost the world around $100 trillion in the lost output: more than the size of the current world economy, and roughly equivalent to the world losing the output of the UK economy every year, for 35 years”.

References

1. Frercksa J, Weberb H, Wiesenfeldt G (2009) Reception and discovery: the nature of Johann Wilhelm Ritter’s invisible rays. Stud Hist Philos Sci Part A 40:143–156 [Google Scholar]

2. Bonnet A (1845) Traite des Maladies des Articulations. Bailliere, Paris [Google Scholar]

3. Barth J, Kohler U (1992) Photodermatologie in Dresden-ein historischer Abriss Festschrift anlasslich des 75. Geburtstages von Prof. Dr. Dr. Dr. h.c. H.-E. Kleine-Natrop (1917–1985). Dresden [Google Scholar]

4. Downes A, Blunt TP (1877) Researches on the effect of light upon bacteria and other organisms. Proc R Soc Lond 26:488–500 [Google Scholar]

5. Finsen NR (1901) Phototherapy. Edward Arnold, London [Google Scholar]

6. Ude WH (1929) Ultraviolet radiation therapy in erysipela. Radiology 13:504 [Google Scholar]

7. Knott EK (1948) Development of ultraviolet blood irradiation. Am J Surg 76(2):165–171 [PubMed] [Google Scholar]

8. Hancock VK, Knott EK (1934) Irradiated blood transfusion in the treatment of infections. Northwest Med 200(33) [Google Scholar]

9. Miley G, Christensen JA (1947) Ultraviolet blood irradiation further studies in acute infections. Am J Surg LxxIII (4):486–493 [PubMed] [Google Scholar]

10. Miley G Uv irradiation non healing wounds. Am J Surg LXV(3):368–372, 1944 [Google Scholar]

11. Miley GP (1946) Recovery from botulism coma following ultraviolet blood irradiation. Rev Gastroenterol 13:17–19 [PubMed] [Google Scholar]

12. Miley GP, Seidel RE, Christensen JA (1946) Ultraviolet blood irradiation therapy of apparently intractable bronchial asthma. Arch Phys Med Rehabil 27:24–29 [PubMed] [Google Scholar]

13. Miley G (1943) The control of acute thrombophlebitis with ultraviolet blood irradiation therapy. Am J Surg 60:354–360 [Google Scholar]

14. Miley G (1944) Efficacy of ultraviolet blood irraidation therapy in the control of staphylococcemias. Am J Surg 64:313–322 [Google Scholar]

15. Miley G (1944) Ultraviolet blood irraidation therapy in acute poliomyelitis. Arch Phys Ther 25:651–656 [Google Scholar]

16. Miley G (1943) Disapperance of hemolytic staphylococcus aureus septicemia following ultraviolet blood irradiation therapy. Am J Surg 62:241–245 [Google Scholar]

17. Miley G (1942) The knott technic of ultraviolet blood irradiation in acute pyogenic infections. New York state Med 42:38–46 [Google Scholar]

18. Miley G (1944) Present status of ultraviolet blood irradiation (Knott technic). Arch Phys Ther 25:368–372 [Google Scholar]

19. Miley G (1942) Ultravilet blood irradiation. Arch Phys Ther 536(23) [Google Scholar]

20. Miley G (1942) Ultraviolet blood irradiation therapy (knott technic) in acute pyogenic infections. Am J Surg 493(57) [Google Scholar]

21. Miley G (1943) The knott technic of ultraviolet blood irradiation as a control of infection in peritonitis. Rev Gastroenterol 1(10) [Google Scholar]

22. Miley GP, Seidel RE, Christensen JA (1943) Preliminary report of results observed in eighty cases of intractable bronchial asthma. Arch Phys Ther 533(24) [Google Scholar]

23. Barrett HA (1940) The irradiation of autotransfused blood by ultraviolet spectral energy. Result of therapy in 110 cases. Med clin N Am 721(24):1040 [Google Scholar]

24. Barrett HA (1943) Five years’ experience with hemo- irradiation according to the Knott technic. Am J Surg 61(1):42–53 [Google Scholar]

25. Rebbeck EW (1942) Double septicemia following prostatectomy treated by the knott technic of ultraviolet blood irradiation. Am J Surg 57(3):536–538 [Google Scholar]

26. Rebbeck EW (1943) Preoperative hemo-irradiations. Am J Surg 61(2):259–265 [Google Scholar]

27. Rebbeck EW (1941) Ultraviolet irradiation of autotransfused blood in the treatment of puerperal sepsis. Am J Surg 54(3):691–700 [Google Scholar]

28. Rebbeck EW (1942) Ultraviolet irradiation of autotransfused blood in the treatment of postabortional sepsis. Am J Surg 55(3):476–486 [Google Scholar]

29. Rebbeck EW (1943) Ultraviolet irradiation of blood in the treatment of escherichia coli septicemia. Arch Phys Ther 24:158–167 [Google Scholar]

30. Olney RC (1946) Ultraviolet blood irradiation in biliary disease; Knott method. Am J Surg 72:235–237 [PubMed] [Google Scholar]

31. Olney RC (1947) Ultraviolet blood irradiation treatment of pelvic cellulitis; Knott method. Am J Surg 74(4):440–443 [PubMed] [Google Scholar]

32. Olney RC (1955) Treatment of viral hepatitis with the Knott technic of blood irradiation. Am J Surg 90(3):402–409 [PubMed] [Google Scholar]

33. Kabat IA, Sysa J, Zakrzewska I, Leyko W (1976) Effect of UV-irradiation of shifts of energy-rich phosphate compounds: ADP, ATP and AXP in human red blood cells represented by a trigonometrical polynomial. Zentralbl Bakteriol Orig B 162(3–4):393–401 [PubMed] [Google Scholar]

34. Vasil’eva ZF, Samoilova KA, Shtil’bans VI, Obolenskaia KD, Vitiuk NG (1991) Changes of immunosorption properties in the blood and its components at various times after UV-irradiation. Gematol Transfuziol 36(5):26–27 [PubMed] [Google Scholar]

35. Samoilova KA, Snopov SA, Belisheva NK, Kukui LM, Ganelina IE (1987) Functional and structural changes in the surface of human erythrocytes after irradiation by different wave lengths of UV rays. III. The immediate effect of the autotransfusion of UV-irradiated blood. Tsitologiia 29(7):810–817 [PubMed] [Google Scholar]

36. Snopov SA, Aritsishevskaia RA, Samoilova KA, Marchenko AV, Dutkevich IG (1989) Functional and structural changes in the surface of human erythrocytes following irradiation with ultraviolet rays of various wave lengths. V. Modification of the glycocalyx in autotransfusions of UV-irradiated blood. Tsitologiia 31(6):696–705 [PubMed] [Google Scholar]

37. Ichiki H, Sakurada H, Kamo N, Takahashi TA, Sekiguchi S (1994) Generation of active oxygens, cell deformation and membrane potential changes upon UV-B irradiation in human blood cells. Biol Pharm Bull 17(8):1065–1069 [PubMed] [Google Scholar]

38. Savage JE, Theron AJ, Anderson R (1993) Activation of neutrophil membrane-associated oxidative metabolism by ultraviolet radiation. J Invest Dermatol 101(4):532–536 [PubMed] [Google Scholar]

39. Ivanov EM, Kapshienko IN, Tril NM (1989) Effect of the UV irradiation of autologous blood on the humoral link in the immune response of patients with chronic inflammatory processes. Vopr Kurortol Fizioter Lech Fiz Kult 1:45–47 [PubMed] [Google Scholar]

40. Artiukhov VF, Gusinskaia VV, Mikhileva EA (2005) Level of nitric oxide and tumor necrosis factor-alpha production by human blood neutrophils under UV-irradiation. Radiats Biol Radioecol 45(5):576–580 [PubMed] [Google Scholar]

41. Zor’kina AV, Inchina VI, Kostin Ia V (1996) Effect of UV-irradiation of blood on the course of adaptation to conditions of hypodynamia. Patol Fiziol Eksp Ter 2:22–24 [PubMed] [Google Scholar]

42. Deeg HJ (1988) Ultraviolet irradiation in transplantation biology. Manipulation of immunity and immunogenicity. Transplantation 45(5):845–851 [PubMed] [Google Scholar]

43. Arlett CF, Lowe JE, Harcourt SA et al. (1993) Hypersensitivity of human lymphocytes to UV-B and solar irradiation. Cancer Res 53(3):609–614 [PubMed] [Google Scholar]

44. Teunissen MB, Sylva-Steenland RM, Bos JD (1993) Effect of low-dose ultraviolet-B radiation on the function of human T lymphocytes in vitro. Clin Exp Immunol 94(1):208–213 [PMC free article] [PubMed] [Google Scholar]

45. Schieven GL, Ledbetter JA (1993) Ultraviolet radiation induces differential calcium signals in human peripheral blood lymphocyte subsets. J Immunother Emphasis Tumor Immunol 14(3):221–225 [PubMed] [Google Scholar]

46. Spielberg H, June CH, Blair OC, Nystrom-Rosander C, Cereb N, Deeg HJ (1991) UV irradiation of lymphocytes triggers an increase in intracellular Ca2+ and prevents lectin-stimulated Ca2+ mobilization: evidence for UV- and nifedipine-sensitive Ca2+ channels. Exp Hematol 19(8):742–748 [PubMed] [Google Scholar]

47. Pamphilon DH, Corbin SA, Saunders J, Tandy NP (1989) Applications of ultraviolet light in the preparation of platelet concentrates. Transfusion 29(5):379–383 [PubMed] [Google Scholar]

48. Lindahl-Kiessling K, Safwenberg J (1971) Inability of UV-irradiated lymphocytes to stimulate allogeneic cells in mixed lymphocyte culture. Int Arch Allergy Appl Immunol 41(5):670–678 [PubMed] [Google Scholar]

49. Slater LM, Murray S, Liu J, Hudelson B (1980) Dissimilar effects of ultraviolet light on HLA-D and HLA-DR antigens. Tissue Antigens 15(5):431–435 [PubMed] [Google Scholar]

50. Aprile J, Deeg HJ (1986) Ultraviolet irradiation of canine dendritic cells prevents mitogen-induced cluster formation and lymphocyte proliferation. Transplantation 42(6):653–660 [PubMed] [Google Scholar]

51. Kovacs E, Weber W, Muller H (1984) Age-related variation in the DNA-repair synthesis after UV-C irradiation in unstimulated lymphocytes of healthy blood donors. Mutat Res 131(5–6):231–237 [PubMed] [Google Scholar]

52. Genter EI, Zhestianikov VD, Mikhel’son VM, Prokof’eva VV (1984) DNA repair in the UV irradiation of human peripheral blood lymphocytes (healthy donors and xeroderma pigmentosum patients) in relation to the dedifferentiation process in phytohemagglutinin exposure. Tsitologiia 26(5):599–604 [PubMed] [Google Scholar]

53. Genter EI, Mikhel’son VM, Zhestianikov VD (1989) The modifying action of methylmethane sulfonate on unscheduled DNA synthesis in the UV irradiation of human peripheral blood lymphocytes. Radiobiologiia 29(4):562–564 [PubMed] [Google Scholar]

54. Volgareva EV, Volgarev AP, Samoilova KA (1990) The effect of UV irradiation and of UV-irradiated autologous blood on the functional state of human peripheral blood lymphocytes. Tsitologiia 32(12):1217–1224 [PubMed] [Google Scholar]

55. Deeg HJ, Aprile J, Graham TC, Appelbaum FR, Storb R (1986) Ultraviolet irradiation of blood prevents transfusion-induced sensitization and marrow graft rejection in dogs. Blood 67(2):537–539 [PubMed] [Google Scholar]

56. Oluwole SF, Iga C, Lau H, Hardy MA (1985) Prolongation of rat heart allografts by donor-specific blood transfusion treated with ultraviolet irradiation. J Heart Transplant 4(4):385–389 [PubMed] [Google Scholar]

57. Vasil’eva ZF, Shtil’bans VI, Samoilova KS, Obolenskaia KD (1989) The activation of the immunosorptive properties of blood during its UV irradiation at therapeutic doses. Biull Eksp Biol Med 108(12):689–691 [PubMed] [Google Scholar]

58. Green MH, Waugh AP, Lowe JE, Harcourt SA, Cole J, Arlett CF (1994) Effect of deoxyribonucleosides on the hypersensitivity of human peripheral blood lymphocytes to UV-B and UV-C irradiation. Mutat Res 315(1):25–32 [PubMed] [Google Scholar]

59. Samoilova KA, Obolenskaia KD, Freidlin IS (1987) Changes in the leukocyte phagocytic activity of donor blood after its UV irradiation. II. Simulation of the effect of the autotransfusion of UV-irradiated blood. Tsitologiia 29(9):1048–1055 [PubMed] [Google Scholar]

60. Obolenskaia KD, Freidlin IS, Samoilova KA (1987) Changes in the leukocyte phagocytic activity of donor blood after its UV irradiation. I. Its relation to the irradiation dose and initial level of phagocytic activity. Tsitologiia 29(8):948–954 [PubMed] [Google Scholar]

61. Simon JC, Tigelaar RE, Bergstresser PR, Edelbaum D, Cruz PD Jr (1991) Ultraviolet B radiation converts Langerhans cells from immunogenic to tolerogenic antigen-presenting cells. Induction of specific clonal anergy in CD4+ T helper 1 cells. J Immunol 146(2):485–491 [PubMed] [Google Scholar]

62. Pamphilon DH, Potter M, Cutts M et al. (1990) Platelet concentrates irradiated with ultraviolet light retain satisfactory in vitro storage characteristics and in vivo survival. Br J Haematol 75(2):240–244 [PubMed] [Google Scholar]

63. Fiebig E, Lane TA (1994) Effect of storage and ultraviolet B irradiation on CD14-bearing antigen- presenting cells (monocytes) in platelet concentrates. Transfusion 34(10):846–851 [PubMed] [Google Scholar]

64. Kahn RA, Duffy BF, Rodey GG (1985) Ultraviolet irradiation of platelet concentrate abrogates lymphocyte activation without affecting platelet function in vitro. Transfusion 25(6):547–550 [PubMed] [Google Scholar]

65. Andreu G, Boccaccio C, Klaren J et al. (1992) The role of UV radiation in the prevention of human leukocyte antigen alloimmunization. Transfus Med Rev 6(3):212–224 [PubMed] [Google Scholar]

66. Tandy NP, Pamphilon DH (1991) Platelet transfusions irradiated with ultraviolet-B light may have a role in reducing recipient alloimmunization. Blood Coagul Fibrinolysis 2(2):383–388 [PubMed] [Google Scholar]

67. Roshchupkin DI, Murina MA (1998) Free-radical and cyclooxygenase-catalyzed lipid peroxidation in membranes of blood cells under UV irradiation. Membr Cell Biol 12(2):279–286 [PubMed] [Google Scholar]

68. Gorog P (1991) Activation of human blood monocytes by oxidized polyunsaturated fatty acids: a possible mechanism for the generation of lipid peroxides in the circulation. Int J Exp Pathol 72(2):227–237 [PMC free article] [PubMed] [Google Scholar]

69. Salmon S, Maziere JC, Santus R, Morliere P, Bouchemal N (1990) UVB-induced photoperoxidation of lipids of human low and high density lipoproteins. A possible role of tryptophan residues. Photochem Photobiol 52(3):541–545 [PubMed] [Google Scholar]

70. Salmon S, Haigle J, Bazin M, Santus R, Maziere JC, Dubertret L (1996) Alteration of lipoproteins of suction blister fluid by UV radiation. J Photochem Photobiol B 33(3):233–238 [PubMed] [Google Scholar]

71. Artyukhov VG, Iskusnykh AY, Basharina OV, Konstantinova TS (2005) Effect of UV irradiation on functional activity of donor blood neutrophils. Bull Exp Biol Med 139(3):313–315 [PubMed] [Google Scholar]

72. Dong Y, Shou T, Zhou Y, Jiang S, Hua X (2000) Ultraviolet blood irradiation and oxygenation affects free radicals and antioxidase after rabbit spinal cord injury. Chin Med J 113(11):991–995 [PubMed] [Google Scholar]

73. Calabrese EJ, Dhawan G, Kapoor R, Iavicoli I, Calabrese V (2015) HORMESIS: a fundamental concept with widespread biological and biomedical applications. Gerontology 62:530. [PubMed] [Google Scholar]

74. Calabrese EJ (2014) Hormesis: from mainstream to therapy. J Cell Commun Signal 8(4):289–291 [PMC free article] [PubMed] [Google Scholar]

75. Zaky S, Kamel SE, Hassan MS et al. (2011) Preliminary results of ozone therapy as a possible treatment for patients with chronic hepatitis C. J Altern Complement Med 17(3):259–263 [PubMed] [Google Scholar]

76. Edelson RL (2014) Mechanistic insights into extracorporeal photochemotherapy: efficient induction of monocyte-to-dendritic cell maturation. Transfus Apher Sci 50(3):322–329 [PMC free article] [PubMed] [Google Scholar]

77. Child FJ, Ratnavel R, Watkins P et al. (1999) Extracorporeal photopheresis (ECP) in the treatment of chronic graft-versus-host disease (GVHD). Bone Marrow Transplant 23(9):881–887 [PubMed] [Google Scholar]

78. Atta M, Papanicolaou N, Tsirigotis P (2012) The role of extracorporeal photopheresis in the treatment of cutaneous T-cell lymphomas. Transfus Apher Sci 46(2):195–202 [PubMed] [Google Scholar]

79. De Waure C, Capri S, Veneziano MA et al. (2015) Extracorporeal Photopheresis for second-line treatment of chronic graft-versus-host diseases: Results from a health technology assessment in Italy. Value Health 18(4):457–466 [PubMed] [Google Scholar]

80. Patel J, Klapper E, Shafi H, Kobashigawa JA (2015) Extracorporeal photopheresis in heart transplant rejection. Transfus Apher Sci 52(2):167–170 [PubMed] [Google Scholar]

81. Reinisch W, Knobler R, Rutgeerts PJ et al. (2013) Extracorporeal photopheresis (ECP) in patients with steroid-dependent Crohn’s disease: an open-label, multicenter, prospective trial. Inflamm Bowel Dis 19(2):293–300 [PMC free article] [PubMed] [Google Scholar]

82. Ludvigsson J, Samuelsson U, Ernerudh J, Johansson C, Stenhammar L, Berlin G (2001) Photopheresis at onset of type 1 diabetes: a randomised, double blind, placebo controlled trial. Arch Dis Child 85(2):149–154 [PMC free article] [PubMed] [Google Scholar]

83. Edelson R, Berger C, Gasparro F et al. (1987) Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results. N Engl J Med 316(6):297–303 [PubMed] [Google Scholar]

84. Wollina U, Looks A, Meyer J et al. (2001) Treatment of stage II cutaneous T-cell lymphoma with interferon alfa-2a and extracorporeal photochemotherapy: a prospective controlled trial. J Am Acad Dermatol 44(2):253–260 [PubMed] [Google Scholar]

85. Niggli HJ, Rothlisberger R (1988) Cyclobutane-type pyrimidine photodimer formation and induction of ornithine decarboxylase in human skin fibroblasts after UV irradiation. J Invest Dermatol 91(6):579–584 [PubMed] [Google Scholar]

86. Vendrell-Criado V, Rodriguez-Muniz GM, Lhiaubet- Vallet V, Cuquerella MC, Miranda MA (2016) The (6–4) Dimeric Lesion as a DNA Photosensitizer. Chem Phys Chem 17(13):1979–1982 [PubMed] [Google Scholar]

87. Santella RM, Dharmaraja N, Gasparro FP, Edelson RL (1985) Monoclonal antibodies to DNA modified by 8-methoxypsoralen and ultraviolet A light. Nucleic Acids Res 13(7):2533–2544 [PMC free article] [PubMed] [Google Scholar]

88. Heald P, Rook A, Perez M et al. (1992) Treatment of erythrodermic cutaneous T-cell lymphoma with extra-corporeal photochemotherapy. J Am Acad Dermatol 27(3):427–433 [PubMed] [Google Scholar]

89. Hart JW, Shiue LH, Shpall EJ, Alousi AM (2013) Extracorporeal photopheresis in the treatment of graft-versus-host disease: evidence and opinion. Ther Adv Hematol 4(5):320–334 [PMC free article] [PubMed] [Google Scholar]

90. Rowen RJ (1996) Ultraviolet blood irradiation therapy (Photo-Oxidation) the cure that time forgot. Int J Biosocial Med Research 14(2):115–132 [Google Scholar]

91. Wu X, Hu X, Hamblin MR (2016) Ultraviolet blood irradiation: is it time to remember “the cure that time forgot”? J Photochem Photobiol B 157:89–96 [PMC free article] [PubMed] [Google Scholar]

92. Kraus CN (2008) Low hanging fruit in infectious disease drug development. Curr Opin Microbiol 11(5):434–438 [PubMed] [Google Scholar]

93. Munoz-Price LS, Poirel L, Bonomo RA et al. (2013) Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 13(9):785–796 [PMC free article] [PubMed] [Google Scholar]

94. Yoneyama H, Katsumata R (2006) Antibiotic resistance in bacteria and its future for novel antibiotic development. Biosci Biotechnol Biochem 70(5):1060–1075 [PubMed] [Google Scholar]

95. O’neill J (2015) Review on antimicrobial resistance: tackling a global health crisis. Initial Steps

All About Fascia and Light Therapy

Fascia is a layer of fibrous tissue – or the connective tissue structure that covers muscles, muscle groups, blood vessels, and nerves, joining some structures while allowing others to slide over each other gently. It’s essentially a band or sheet of connective tissue, mainly collagen, under the skin that attaches, stabilizes, encloses, and separates muscles and other internal organs. We classify it by layer as superficial fascia, deep fascia, visceral or parietal fascia.

And its function is significant in the human body. Fascia is what distributes water equally into our carefully structured skin system. It's mainly made up of collagen and ground substance. So how can fascia be harmful?

In itself, fascia isn’t something bad – in fact, is essential to a healthy body; but if it isn't functioning optimally, things can take an ugly turn. The dysfunction of our fascial system can cause great discomfort and pain. Fascia is ideally supposed to move around as we do, and yet there are many things that cause problems with this tissue. 

When fascia is in a shortened position for prolonged periods due to such a lifestyle and overall poor posture, it will adapt – shortening and tightening. Fascial restrictions can also occur from trauma, infection, inflammation, or surgery. These changes affect our fascia's regular movement, creating tension points in our body, pain, applying pressure to surrounding tissues. Therefore, it causes restriction of movement due to the pain and tightening that occurs. So – how can light therapy help?


Light Therapy for Fascia Treatment

Light therapy consists of exposure to a filtered light with an intensity of up to 10,000 lux emitted by a particular lamp. Through light, it can help with a number of problems and specifically offers great benefits to the skin. 

Light therapy treatment for fascia can be done any time of the day; however, it is best done in the early hours of the morning, with a duration of up to 30 minutes, and must be repeated for long-term effect. 

Next to doing stretches and trying other forms of relaxation methods to release tension, fascia can be treated with light therapy. The skin reacts biochemically to light therapy, directly improving cell functions. ATP, our energy source, increases in production with light therapy treatment, resulting in improved cell rejuvenation. Light therapy benefits are that they reduce the discomfort of pain and inflammation by increasing blood flow and tissue repair mechanisms in the body.

Apart from a healthy functioning body, keeping your fascia rejuvenated also helps with appearance. Body symmetry and alignment improve, the blood flow increases, which gives faster exercise recovery, stretch marks and cellulite get reduced, scar tissue breaks down easier, and overall less pain and better performance in the day-to-day tasks. 

Repairing connective tissue such as fascia helps with muscle recovery, which is why light therapy is also used in sports. In the release of ATP, our muscles gain their power back. With light therapy, the recovery is sped up; sessions improve the time it usually takes for our cells to do it themselves. 

Plantar fasciitis is often created from strain at the ligament of the sole of the foot. It's a pain in our heels, and with light therapy, tissue repair is accelerated. Light therapy is an overall regenerating way of treating any issue related to connective tissues. 

Light therapy can also help with cellulite. In itself, cellulite isn't a health issue, but since light therapy helps collagen production, in the same way it helps fascia, it can also be effective with cellulite. With higher collagen levels, skin appears smoother and tightens, which can reduce the appearance of cellulite. 

Light therapy, while treating fascia, can also treat other issues. There are different ways to use light therapy and different settings for different outcomes. Infrared light is used for tissue repair, pain reduction, and similar problems. Red light resolves problems such as inflammation, tissue repair at the surface level, general pain relief as well. Blue light is ideal for combating bacterial issues that lead to our skin becoming acne-prone even when we're past that stage. 

That said, you want to make sure you are using the right red light device. At Kaiyan Medical, we have MDA-certified and FDA-approved laser light therapy devices that will make sure you’re receiving medical-grade light therapy treatment for your fascia and other issues. 

SAD - Seasonal Affective Disorder 101

The first formal description of Seasonal Affective Disorder (SAD), the most well-known psychiatric condition associated with seasonality in humans, was introduced in the mid-1980s by Rosenthal, who described a group of 29 patients living in a temperate climate who experienced depressive episodes characterized by hypersomnia, hyperphagia, and weight gain in the fall or winter, and whose symptoms remitted by the next spring or summer.

SAD was incorporated into the Diagnostic and Statistical Manual (DSM) of Mental Disorders III-R when “seasonal pattern” was introduced as a specifier for Major Depression and Bipolar Disorders. Subsequent revision in DSM-IV described SAD as “a regular temporal relationship between the onset of Major Depressive Episodes in Bipolar I (BPI) or Bipolar II (BPII) Disorder or Major Depressive Disorder (MDD), recurrent, and a particular time of the year.”

Today, SAD, or MDD with seasonal pattern, is defined as recurrent episodes of major depression that meet the following criteria: at least two consecutive years where the onset and offset of depressive symptoms occur at characteristic times with no non-seasonal episodes, a temporal relationship between onset of symptoms and time of year, a temporal relationship between remission of symptoms and time of year, and an outnumbering of seasonal compared to non-seasonal episodes throughout the lifetime of the patient.

Pathophysiology of SAD

To date, the pathophysiology of SAD is unclear. Early research into the mechanism of SAD focused on day length or photoperiod. This hypothesis posited that shorter days in winter, possibly mediated by a longer duration of nocturnal melatonin secretion, leads to depressed mood in susceptible individuals. To date, there is little data to support this hypothesis. Furthermore, given that bright light in the evening has not been as effective as that given in the morning, it now seems unlikely that the photoperiod is the underlying pathological mechanism of SAD.

Although some animal studies have implicated a direct effect of light on the midbrain (Miller, Miller, Obermeyer, Behan, & Benca, 1999; Miller, Obermeyer, Behan, & Benca, 1998), the most prominent hypothesis driving human studies involves disruption of circadian rhythms. Research on the role of serotonin is also active.

Circadian Rhythm

A circadian rhythm refers to the approximately 24-hour cycle of physiological processes present in humans and other animals. This cycle is governed via clock gene expression by the suprachiasmatic nucleus (SCN), the master pacemaker located within the anterior hypothalamus. Though the SCN endogenously generates circadian oscillations, SCN endogenously generates circadian oscillations, and they need to be entrained to the 24-hour day by external cues. Light exposure is the most important synchronizing agent of endogenous circadian rhythms.

Downstream of the SCN, a collection of systemically active neurohumoral networks transduce circadian information to the rest of the body. For instance, via projections to the hypothalamus's paraventricular nucleus, the activation of the SCN leads to autonomic changes, including cardiovascular modulation, and together the central, peripheral, and autonomic nervous systems collaborate to affect systemic changes. Thus, the SCN receives information about the external day-night cycle directly through retinofugal pathways and indirectly through neuromodulatory signaling. Circadian information is then relayed systemically through neurohumoral networks.

The current primary hypothesis for the pathophysiology of SAD, known as the “phase-shift hypothesis,” posits that there is an optimal relationship in the alignment of the sleep-wake cycle and the endogenous circadian rhythm. During the fall and winter, as day length shortens, the circadian rhythm begins to drift later concerning clock time and the sleep-wake cycle. This phase delay is hypothesized to bring about mood symptoms. A pulse of morning bright light generates a circadian phase advance, which is thought to correct the discordance between sleep and circadian phase, thereby ameliorating depressive symptoms. However, the phase-shift hypothesis would predict that the amount of phase correction required for each patient would depend on an individual’s PAD, which has not yet been proven.

Serotonin

Several studies have also proposed that serotonin is implicated in the pathophysiology of SAD, as selective serotonin reuptake inhibitors (SSRIs) appear to be effective in the treatment of SAD. Supporting this hypothesis, one study used Positron Emission Tomography (PET) imaging to look at binding probability at synaptic serotonin transporters in 88 normal individuals living in the temperate climate of Toronto, Canada (Praschak-Rieder, Willeit, Wilson, Houle, & Meyer, 2008). The binding probability was increased during fall and winter compared to warmer months, thus eliciting an inverse correlation between binding potential and sunlight durationsunlight duration. Of note, the largest difference in transporter binding was found in the mesencephalon, a finding consistent with animal studies demonstrating the importance of direct effects of light to the midbrain on behavior. If increased transporter activity indicated greater reuptake of serotonin during the fall/winter, and if this resulted in a lower density of cleft serotonin, then the seasonal variation in transporter activity (i.e., higher transporter efficiency in the winter) would seem to leave susceptible individuals particularly prone to mood symptoms during the darker seasons. Moreover, following BLT and during periods of remission in the summer months, the synaptic transporter activity was shown to be reduced to control levels in these patients.

Eating Disorders

BLT has also been investigated to a lesser extent in eating disorders. Because binge eating episodes have been observed to increase in fall and winter in some patients, BLT has been examined as a treatment modality for anorexia nervosa (AN) and bulimia nervosa (BN). Thus, BLT's effects on patients with eating disorders remain enigmatic. Additional studies, including larger, randomized, blinded, and controlled trials, are needed to elucidate further the role of BLT in treating this patient population. Further research might also determine whether BLT would be a useful treatment in Binge-Eating Disorder, a diagnosis new to DSM-5.

Adult ADHD

Additionally, BLT has been studied in the context of adult Attention-Deficit/Hyperactivity Disorder (ADHD), where, in addition to normal ADHD symptoms, patients often have depressed mood and difficulties falling asleep, awakening on time, and maintaining arousal (Brown & McMullen, 2001). These symptoms are indicative of a possible delay in the circadian rhythm. A case report of symptom improvement following BLT in a child with ADHD who displayed signs of delayed sleep phase also supports the idea that BLT may be useful in treating symptoms of ADHD (Gruber, Grizenko, & Joober, 2007). Whether the pathways that subserve the improvement of mood symptoms in response to BLT are the same pathways that underlie the seemingly beneficial effects of BLT in ADHD remains to be studied. While these results are promising, further studies, preferably in randomized, blinded, and controlled studies will need to be performed.

Finally

A significant immediate reduction of depression scores with light treatment can be identified after 20 minutes and reaches the maximum at 40 minutes, with no additional benefit at 60 minutes. The rate of change is steepest during the first 20 minutes of light as compared with longer intervals. Comparing the clinical impact of these durations of administration may yield different results when measured after several daily sessions. The overnight effect on circadian rhythms and sleep was not assessed in our study and is thought to impact mood regulation in SAD. Larger, prospective, controlled, and hypothesis-driven studies in more naturalistic conditions would be desirable to replicate our study results and our study results and analyze the temporal dynamic of the persistence of the immediate mood-improvement effects. Besides, in larger samples, one could define early responders and nonresponders, analyze genetic (e.g., melanopsin related genes), demographic (children, adolescents, adults, elderly, gender), physiological (e.g., pupillary responses), and clinical (e.g., abundant atypical symptoms) predictors for early response. If proven effective and efficacious, shorter exposures to bright light could become a feasible and broadly employed intervention for immediate mood improvement as an early step on the road toward full antidepressant response and remission.


REFERENCES
  • Al-Karawi D, & Jubair L (2016). Bright light therapy for nonseasonal depression: Metaanalysis of clinical trials. J Affect Disord, 198, 64–71. doi:10.1016/j.jad.2016.03.016 [PubMed] [CrossRef] [Google Scholar]
  • American Psychiatric Association., & American Psychiatric Association. DSM-5 Task Force. (2013). Diagnostic and statistical manual of mental disorders : DSM-5 (5th ed.). Washington, D.C.: American Psychiatric Association. [Google Scholar]
  • American Psychiatric Association., & American Psychiatric Association. Task Force on DSM-IV. (1994). Diagnostic and statistical manual of mental disorders : DSM-IV (4th ed.). Washington, DC: American Psychiatric Association. [Google Scholar]
  • American Psychiatric Association., & American Psychiatric Association. Work Group to Revise DSM-III. (1987). Diagnostic and statistical manual of mental disorders : DSMIII-R (3rd ed.). Washington, DC: American Psychiatric Association. [Google Scholar]
  • Benedetti F, Barbini B, Fulgosi MC, Colombo C, Dallaspezia S, Pontiggia A, & Smeraldi E (2005). Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates. J Clin Psychiatry, 66(12), 1535–1540. [PubMed] [Google Scholar]
  • Braun DL, Sunday SR, Fornari VM, & Halmi KA (1999). Bright light therapy decreases winter binge frequency in women with bulimia nervosa: a double-blind, placebo-controlled study. Compr Psychiatry, 40(6), 442–448. [PubMed] [Google Scholar]
  • Brown TE, & McMullen WJ Jr. (2001). Attention deficit disorders and sleep/arousal disturbance. Ann N Y Acad Sci, 931, 271–286. [PubMed] [Google Scholar]
  • Center for Environmental Therapeutics. (2016). Retrieved from http://www.cet.org/
  • Colombo C, Lucca A, Benedetti F, Barbini B, Campori E, & Smeraldi E (2000). Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction. Psychiatry Res, 95(1), 43–53. [PubMed] [Google Scholar]
  • Daansen PJ, & Haffmans J (2010). Reducing symptoms in women with chronic anorexia nervosa. A pilot study on the effects of bright light therapy. Neuro Endocrinol Lett, 31(3), 290–296. [PubMed] [Google Scholar]
  • Dauphinais DR, Rosenthal JZ, Terman M, DiFebo HM, Tuggle C, & Rosenthal NE (2012). Controlled trial of safety and efficacy of bright light therapy vs. negative air ions in patients with bipolar depression. Psychiatry Res, 196(1), 57–61. doi:10.1016/j.psychres.2012.01.015 [PubMed] [CrossRef] [Google Scholar]
  • Deltito JA, Moline M, Pollak C, Martin LY, & Maremmani I (1991). Effects of phototherapy on non-seasonal unipolar and bipolar depressive spectrum disorders. J Affect Disord, 23(4), 231–237. [PubMed] [Google Scholar]
  • Eastman CI, Young MA, Fogg LF, Liu L, & Meaden PM (1998). Bright light treatment of winter depression: a placebo-controlled trial. Arch Gen Psychiatry, 55(10), 883–889. [PubMed] [Google Scholar]

Infographic: What is Red Light Therapy?

Follow the Numbers: Light Therapy's Projected Market Revenue Surges

Follow the numbers: light therapy's projected market revenue surges

Light therapy is used for many problems, such as skin conditions, eczema, vitiligo, acne, and rosacea. But it's also very popular as a skincare remedy for wrinkles, age spots, and collagen production.  While helping outwardly, it also works directly with mitochondria, the cells' powerhouse, improving our cell production and increasing cellular function. The non-invasive treatment is gaining popularity for its incredible benefits and cost-effectiveness. 

Light therapy also helps with our lack of vitamin D, and with the current world situation of quarantine and COVID-19, the lack has been more than evident. It helps with psychological conditions that have been rapidly increasing in the past few years, and the current situation only aids in the battle against winter blues and depression. This form of therapy increases melatonin levels and mood levels, helping with fatigue and sleep quality.

Since the market has been affected due to the pandemic, people have been turning to light therapy for its mental and physical benefits. The light therapy market is anticipated to reach 1,112.16 million dollars at a CAGR of 5.1%  by 2025, says Market Research Future (MRFR).

The American market is set to take the lead over in the next few years. Growing international curiosity for light therapy will also help the infrastructure, improve quality with more developers, stimulating substantial market growth. 

For winter blues, light therapy should experience a rise in growth by 5.1% till 2027. Due to less sunlight, light therapy proves as the ultimate fit for those in the Northern Hemisphere. The Asia Pacific light therapy market revenue surpassed USD 175 million in 2018, it is poised to expand at 5.7% CAGR through 2027. Their awareness of the growing patient pool and beauty conscious people fuel the demand for light therapy because of its amazing results in various skin conditions. 

Rising per capita income and the growing influence of social media are opening new avenues for the Asian Pacific market. The demand for light therapy is considerable among people in China and Japan. In addition, its popularity is also rising in developing nations owing to its advanced features and low cost. 

A segment of light therapy specializing in floor and desk lamps of the market was valued at more than 140 million dollars in 2018 and will witness a similar growth trend in the future. Similarly, large reflectors in the floor and desk lamps that diffuse bright light for accurate visualization are predicted to be in higher demand in the upcoming years.

Homecare settings portion had its share of revenue, counting more than 490 million dollars in 2018, and will exhibit a similar rising forecast in the upcoming timeline for light therapy. In 2020 these products held up to 60% of the market share. 

Demand for simplicity and more availability is what allows the rising demand for homecare handheld and user-friendly devices. It's predicted to grow gradually. Manufacturers will focus on developing light therapy devices that specifically solve health-related issues at home by providing easy access and improved patient management. 

North America light therapy market size crossed 350 million dollars in 2020 due to technological advancements paired with light therapy's growing use of light therapy.

Key developers in the U.S. have gained approvals from the FDA for new products, like Kaiyan Medical. With FDA-certified and MDA-approved devices, Kaiyan leads the light therapy devices industry and will continue to play a crucial role for the overall growth in the North American industry.


The Perfect Pair: Light Therapy & PRP

Platelet-Rich Plasma (PRP) Injections

In recent years, doctors have learned that the body has the ability to heal itself. Platelet-rich plasma therapy is a form of regenerative medicine that can harness those abilities and amplify the natural growth factors your body uses to heal tissue.

What is Plasma, and what are Platelets?

Plasma is the liquid portion of whole blood. It is composed largely of water and proteins, and it provides a medium for red blood cells, white blood cells, and platelets to circulate through the body. Platelets, also called thrombocytes, are blood cells that cause blood clots and other necessary growth healing functions. Platelet activation plays a key role in the body’s natural healing process.

What is Platelet-Rich Plasma (PRP), and what are PRP injections?

Platelet-rich plasma (PRP) therapy uses injections of a concentration of a patient’s own platelets to accelerate the healing of injured tendons, ligaments, muscles, and joints. In this way, PRP injections use each patient’s own healing system to improve musculoskeletal problems.

PRP injections are prepared by taking anywhere from one to a few tubes of your own blood and running it through a centrifuge to concentrate the platelets. These activated platelets are then injected directly into your injured or diseased body tissue. This releases growth factors that stimulate and increase the number of reparative cells your body produces.

Ultrasound imaging is sometimes used to guide the injection. The photographs below illustrate a PRP injection into a patient’s torn tendon. The ultrasound guidance is shown at the left, and the injection is shown at the right.

PRP harnesses the body’s own rejuvenating powers to stimulate hair growth naturally. The treatment involves drawing a small amount of blood from the patient’s arm. This blood is then spun in a centrifuge until the plasma is separated and growth factors and stem cells are extracted. This plasma, complete with growth factors and stem cells, is then injected into the patient’s scalp, stimulating hair growth.

Light Therapy

Red Light/Blue Light therapy uses light energy to stimulate hair growth. Red light/Blue Light therapy works using light delivered at specific therapeutic wavelengths within infrared and red-light spectrums. The energy from these lights stimulates the hair follicles so that they are constantly in the growth, or anagen, stage. This results in thicker, longer, and healthier hair.

Red light (630 nm) therapy stimulates ATP (cellular energy) production to stimulate hair follicle cells. It also increases blood flow to the hair root, which delivers more nutrients to the hair follicle cells. The increased blood flow is also thought to help flush away the damaging waste products that may affect hair growth.

Near-Infrared light (880 nm) therapy, which is an invisible light energy, promotes collagen and elastin production. It penetrates deeper into the scalp to help reduce inflammation, which causes thinning of hair.

Blue light (420 nm) therapy is especially effective for acne, penetrating molecules within the skin that cause P. acnes bacteria to form. These molecules react

Red Light Therapy & Vitamin D Production


Aside from nutrition and water, we need vitamin D to survive. In fact, almost every living creature on earth needs vitamin D to survive—it’s a crucial vitamin for all species. Vitamin D helps regulate the amount of calcium and phosphate in the body, which are responsible for the health of our muscles, bones, and teeth. 

In addition, Vitamin D fights disease, reduces depression, and aids in weight loss. When we lack vitamin D in our bodies, it can lead to a loss of bone density, which plays a significant role in osteoporosis and fractures. 

Naturally, a lot of our nutrients come from food; however, vitamin D is also produced in our skin’s response to sunlight. It wasn’t given the nickname the “sunshine vitamin” for nothing. Sitting outside (with sunscreen on, of course) can boost vitamin D levels in the body. By doing so, it can regulate moods and reduce depression. 

In one study, scientists found that people with depression who received vitamin D supplements improved their depression symptoms. While vitamin D supplements are an option, it can take between three to four months until you start to notice improvements. That’s a long time to wait, especially if you’re struggling with depression. However, there is a way to increase vitamin D production without having to wait months to improve. 

As we’ve discussed above, you don’t need sunlight for vitamin D production. You can either take vitamin D3 as a supplement, taking months to work, or through red light therapy, receiving quick results. So, how can you increase vitamin D through red light therapy? 

Before we get into it, it’s important to know that contrary to popular belief, not all forms of light can increase vitamin D in the body. The type of light used in light therapy devices is crucial. Natural sunlight contains both “red” and “infrared” light. These are the two forms of light that are needed in light therapy devices to increase vitamin D production in the body. 

Without red and infrared light, nothing is going to happen. These two forms of light have their own unique benefits to the human body. 

In one study published in Scientific Reports, it found that LED lights are more efficient than sunlight at producing vitamin D3 in skin samples. Tyler Kalajian and his team found that skin samples exposed to LED for 0.52 minutes produced more than twice as much vitamin D3 than samples exposed to 32.5 minutes of sunlight.

Another study focused on cystic fibrosis and short bowel syndrome patients who are unable to absorb vitamin D3 through food. The study used UV light to test whether it would affect vitamin D3 production in the patients’ bodies. It was found that the UV lamp emitted UV radiation similar to sunlight, producing Vitamin D3 in the skin. 

What’s amazing about these studies is that aside from showing light therapy’s effectiveness in producing vitamin D, they also prove light therapy is an excellent source of vitamin D during the winter season. 

During the winter, many people suffer from SAD (Seasonal Affective Disorder) and are unable to find a vitamin D source. But, through red light therapy, users are able to increase vitamin D production regardless of whether there’s sun outside or not. Instead of using antidepressants or slow-moving vitamin D supplements, red light therapy is a fast-acting alternative. 

With Kayian Medical’s MDA-certified and FDA-approved red light therapy devices, users can get their lives back and be in control of their health with effective and quick light therapy treatment.


Creating Your Custom LED Mask

When we talk about skincare, we usually don’t think about customizing skincare products. The options available on the market are produced for the masses rather than for the individual. Many people with multiple skin issues struggle to find skincare products that truly speaks to their needs. However, light therapy masks can be customized to fit the individual customer’s needs.

If you’re working in the skincare industry, light therapy devices are a revolutionary step forward, as you’ll be able to provide your customers with a unique light therapy mask.

But what’s the process of creating a custom light therapy mask? Here are the six steps you need to consider when developing a customized light therapy mask.

The Six Steps to Create Your Custom Led Mask

While going through these six steps, keep your vision of your mask in mind. This will help you answer some of the questions that are going to be asked below.

What’s your Goal?

It would help if you determined your product’s goals. Who are your clients? What are their unique skincare challenges? By understanding the basics, you’ll help your company determine the right strategy when creating your customized product. Light therapy masks can be made using different LED colors for a full range of beauty treatments, including acne reduction, anti-aging treatment, and collagen production.

What Material will you Use?

You need to select the right material. Facial masks can be made from a variety of materials, each with its own advantages and versatility. There are three types of light therapy masks to consider: flexible, semi-hard, and hard.

Flexible allows users to wear it while doing their daily activities. The patented air cushions and emitting SMD LEDs are ideal for indoor and daily skincare. Semi-hard masks are for professional use and have a hard shell, while soft inside. Hard masks are powerful facial masks for professional use and come with selectable light area options. They offer a deeper light therapy experience for clients.

What Kind of Shape will your Mask be in?

Light therapy masks don’t have to come in a traditional one-size-fits-all design. Depending on your target market, you’ll be able to choose where the placement for the cheeks, forehead, and eyes will be on the mask. This gives you more control over how the mask will fit on your client’s face.

What Areas Will your Mask Treat?

A traditional mask will cover the full face. However, you may not necessarily want your mask to provide full coverage. Consider the areas of the face you’d like to treat, as you may only want to create a mask for a specific target area.

Apply for a Prototype

You’ve answered all the questions above and have a vision of how you want your mask to look. From here, we help you take your vision and use our creativity and 14 years of experience in the industry to create a mask that fits your goals.

Launch & Listen

Now that the product is created, it’s time to launch it. Before the launch, we produce pre-pilot quantities that allow us to fine-tune our devices and ensure high-quality from start to finish.

Creating a light therapy facial mask is one thing, but you want to make sure it’s achieving your goals and making your customers happy. Once your product is launched, it’s crucial to monitor product performance and listen to customer feedback.

Naturally, you don’t want your light therapy mask to be like all the others on the market. Our masks are MDA-certified and FDA-approved light therapy devices, ensuring you medical-grade quality devices for your business.


Why Chiropractors Love Light Therapy

Chiropractors Lead the Way

LED light therapy is not new to the medical industry and certainly not new to doctors of chiropractic.

Studied for decades, the use of low-level light therapy (LLLT) — both LED and laser — has been making its way into the medical mainstream in the U.S. since the 1990s. And chiropractors have taken the lead in the clinical use of LED light therapy and are advancing the use of this technology for new applications.

This is no surprise to industry professionals and medical providers because this technology is a perfect pairing to what chiropractors advocate and bring to the medical community: healthy, drug-free healing and pain management options that are highly efficacious. Compared to the high cost and side-effect spectrum of many pharmaceutical drugs, LED light therapy can be a cost-effective alternative to drugs and surgery.

LED light therapy has the ability to increase blood flow and lymphatic circulation, decrease pain, and stimulate many cellular processes that accelerate healing. Plus, it has a high safety level, no known negative side effects is easy to administer, and is non-invasive.

Because LED light therapy can provide pain relief, wound healing and address neuropathy discomfort and various musculoskeletal issues, it is a mainstay in many clinics. Some patients also purchase light therapy systems from their chiropractors for in-home use between office visits for long-term therapy needs such as chronic pain and neuropathy.

It is also an attractive option for new chiropractors just getting started because it can bring substantial benefits to their patients while offering a fast ROI.

How it Works

LEDs deliver wavelengths of incoherent (diffused) light to the body. LEDs are similar to laser diodes, but their light spreads out, unlike the highly focused beam of coherent light that emits from a laser. This more diffused light makes administration exceptionally safe.

This therapy is also known as photobiomodulation — meaning that light can produce a cellular change in the body. Photons of light stimulate the release of nitric oxide, which

is the body’s natural vasodilator, greatly increasing circulation in the local treatment area. Blood flow is increased to nerves and other tissues, improving tissue oxygenation that stimulates healing. This boost persists for several hours after a therapy session.

Research indicates that the benefits of LED light therapy include

  • Increased circulation
  • Decreased inflammation
  • Increased ATP production
  • Collagen production
  • Accelerated exercise recovery time
  • Increased relaxation
  • Decreased stress

LEDs have low power requirements and high efficiency with minimal heat production. Power levels are measured in mW/cm2 (milliwatts per centimeter squared). And LED lifetimes are rated up to 100,000 hours and can last for decades.

The most common device wavelengths are the following:

  • Near-infrared: Many LED therapy devices use the 800 nanometers (nm) range; however, infrared include a much wider spectrum with deep penetration up to 100 mm.
  • Red: 630 to 700 nm, with penetration up to 10 mm.
  • Blue: 405 to 470 nm, with penetration up to 3 mm (beneficial for skin and wound healing).
  • Pulsed frequency(s) or continuous wave devices provide timed sequences of light turning on and off during application, which is thought to accelerate change in the tissues.
  • Continuous-wave devices are always on; no frequency is added to the light.
Applications for Use

Light therapy is commonly used to treat acute and chronic joint pain in the neck, back, leg, shoulder, wrist, knee, and ankle. It can be helpful for arthritis pain, bruises, carpal tunnel syndrome, and musculoskeletal conditions. It is also used to treat skin conditions such as pressure ulcers, wound healing, and scar tissue reduction.

Even NASA has good things to say about light therapy. NASA issued a news release in December 2000, which stated that doctors at Navy Special Warfare Command centers in Norfolk, Virginia, and San Diego reported a 40 percent improvement in patients who had musculoskeletal training injuries treated with light-emitting diodes.1

There are distinct advantages to using LED therapy devices in your clinical practice. For example, Patients can be left unattended during therapy, maximizing staff resources. Large surface areas can be covered by the LED pad or panel, delivering therapeutic photons broadly and safely to the body's targeted area. And systems are generally portable and user friendly.

Moreover, LED light therapy can help you enter niche markets, such as peripheral neuropathy and brain injuries. These are areas where LED light therapy is appearing to be more effective than pharmaceutical approaches.

Brain injuries

An increasing number of scientific studies show expanded indications for LED light therapy to treat neurologic conditions, especially brain injuries and degeneration. The advanced research being done by Michael Hamblin, Ph.D., and his group and by Margaret A. Naeser, Ph.D., at Boston University demonstrates that LED light therapy can positively affect the brain. Naeser’s 2017 study with veterans showed significant improvement after 12 weeks of transcranial photobiomodulation.

Increased function, better sleep, fewer angry outbursts, and less anxiety and wandering were reported with no negative side effects.2

Preliminary brain studies conducted by other groups using transcranial LED light therapy show impressively improved brain blood flow verified before and after single-photon emission computerized tomography (SPECT) brain scans. These brain studies have implications for patients presenting with such conditions as traumatic brain injury (TBI), PTSD, Alzheimer’s, Parkinson’s, concussions, strokes, and depression.

Nearly all neurological disorders have one thing in common: diminished blood flow. And increased circulation and blood flow are precisely what LED light therapy promotes.

Peripheral Neuropathy

More than 3 million new cases of peripheral neuropathy are diagnosed each year in the U.S. alone. LED light therapy has shown significant results in relieving this condition's discomfort and improving sensation, as evidenced by several studies.

Adding LED light therapy systems can help you offer neuropathy therapy as a substantial part of your practice.

FDA Approved

LED light therapy devices have received FDA clearances that temporarily increase local circulation; and the temporary relief of pain, stiffness, and muscle spasms. Many practitioners are hopeful that the FDA will keep expanding clearances for this cutting-edge healing technology.

References
NASA/Marshall Space Flight Center. “NASA Space Technology Shines Light On Healing.” ScienceDaily. http://www.sciencedaily.com/ releases/2000/12/001219195848.htm. Published Dec. 2000. Accessed Jan. 2018.

Salmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation:

Case Series Report. Photomed Laser Surg. 2017;5(8):432–441.

Fallah A, Mirzaei A, Gutknecht N, Demneh AS. Clinical effectiveness of low-level

laser treatment on peripheral somatosen- sory neuropathy. Lasers Med Sci. 2017 Apr;32(3):721–728.

Mandelbaum-Livnat MM, Almog M, Nissan M, Loeb E, Shapira Y, Rochkind

Photobiomodulation Triple Treatment in Peripheral Nerve Injury: Nerve and Muscle Response. Photomed Laser Surg. 2016;34(12):638–645.



50% Greater Growth in Muscles with Red Light Therapy

One study randomly divided participants into two separate groups for an 8-week training program. One group received a red light treatment before every training session, while the other group did the same training without the light treatment. They found that the group receiving the light therapy improved muscle growth 50% greater than those with muscle training alone. Pretty amazing, right?

Another randomized, double-blind, placebo-controlled study using red and infrared light on the biceps demonstrated peak and average performance of more than 12% more than the control group. But while this is all very interesting, I’m sure you’re wondering whether Red Light Therapy is worth it and what it can do for YOU. First of all, I’m sure many of you appreciate the science breakdown, but some of you may not be able to follow, so here’s a simple explanation.

Scientists have discovered that our cells show an incredible response to light, but not just any light. Only in the 660–850 nanometer (nm) range which is the so-called red light range. This type of light energy penetrates deep into the skin, muscle, and joint tissue and stimulates ATP production, which you should think of as your body’s way of transporting energy to where it needs to go. More ATP means more efficient energy transfers in layman's terms, which translates to various benefits at a cellular level.

So, by exposing our body to the therapeutic red light, our cells receive this rejuvenating, anti-aging energy boost that enables them to perform every single function at a heightened level and now that you understand the science behind it, let’s a look at the 5 reasons why it might be a good idea for you to invest in this technology.

Increased Energy & Testosterone

Sometimes we feel lethargic and out of energy, like our body is constantly running on empty. Then you spend some time outside on a nice hot summer day, and you all of a sudden feel amazing? It’s because our bodies rely on light as a source of energy, helping our glands to regulate adrenaline, testosterone, metabolism, and several other functions, and it has been shown that Red Light Therapy can increase testosterone production, which in turn can increase overall energy levels and even improve peak muscle performance.

Reduced Muscle Recovery Time

After a challenging workout, your body works around the clock to repair and strengthen torn muscle fibers. We know this. We also know that nutrition plays a huge role in providing the body with the resources it needs for this process. But what most of you don’t know is that specific wavelengths of light play a role in this process. By enhancing mitochondrial function, red light has been proven to produce measurable gains in peak strength and reduced recovery times.

Faster Healing For Joint & Muscle Injuries

Injuries, repetitive motion, or aging, in general, can lead to severe joint pain and tissue damage. But the body’s natural healing response can be greatly accelerated by red and infrared light. Also, relief from pain, faster recovery times, and reduced arthritis symptoms are just a few more of Red Light Therapy's benefits. For bodybuilders, yes, Red Light is also great for reducing Delayed Onset Muscle Soreness or DOMS. After all, it’s a type of muscle tissue injury as well.

Healthier & Younger-Looking Skin

Red Light Therapy can improve skin clarity, tone, and texture, reduce fine lines, wrinkles, and puffy eyes, help fade scars, acne, and stretch marks, even enhance wound healing and circulation, simply by increasing the production of collagen and elastin.

Remember, collagen is a long-chain amino acid and the most abundant protein in the body. It’s responsible for giving skin its elasticity, hair its strength, and connective tissue its ability to hold everything in place. In fact, the collagen protein makes up 30% of the total protein in the body and 70% of the protein in the skin!

Now while collagen is beneficial to the entire body, it’s most noticeably beneficial to the skin. This is because as we age, the epidermic (or outer layer of skin) thins and loses elasticity in a process known as elastosis. As this happens, we tend to show more aging signs and acquire more wrinkles and stretch marks. But by restoring normal cellular function, because red light stimulates collagen production, red light therapy can help keep your skin looking healthier and younger for LONGER.

Stress Relief

You can’t argue that our minds and body are under constant stress because of our busy lives. Well, Red Light Therapy has been proven to calm our physical and mental state by reducing oxidative stress. Now, I cannot personally attest to that, simply because my stress is through the roof, and other times, I get my mind right and relax, but it makes sense. Oxidative stress is not just harmful to our physical health but also our mental state as well.


Amethyst and Light Therapy

Amethyst crystals have an extremely high heat absorption rate, which accounts for this stone's violet color. When a crystal reflects and absorbs energy or has a near-surface layer of the metal, it will “bounce” this energy back into its surroundings. However, only when a crystal is exposed to heat for long enough time actually radiates heat.

If there are no layers, then the crystal must be emitting radiant light. If we were to look into this infrared mystery further, we would find that the amethyst and several other quartz crystals actually contain carbon crystals, which are also coated in a thin layer of silicon.

These carbon crystals will all convert the infrared light that hits them into visible light, and this infrared radiation has a frequency that can be easily absorbed by the quartz coating.

Therefore, it makes perfect sense that amethyst can emit infrared light and that we might find such gemstones in our day-to-day lives.

Amethyst has been used for many purposes by both the ancient Egyptians and Greeks. It was believed by the ancient Egyptians that amethyst can help in raising the body’s temperature and that it will protect you from fiery stones such as quartz.

The ancient Greeks also believed that amethyst’s color has magical powers because of its beautiful purple color. In fact, the ancient Greeks used amethyst to cast spells; if you boil amethyst in water, place it under a flame for some time, and then remove it, an individual who takes the tea will experience magical visions and feelings.

The boiling water causes the amethyst to release its color into the water, and the hot color in the water symbolizes the fire that the tea burns. The use of amethyst in ancient times has been attributed to the belief that it can produce a mind-body connection.

The color blue inside the amethyst helps the gemstone absorb light, making the amethyst one of the best colors for absorbing infrared energy. Ancient people were the first to use gemstone to cure certain diseases. It was used in ancient times to treat epilepsy, eye problems, memory loss, and pain.

One of the benefits of amethyst to the human body is that it increases the amount of vitamin C distributed throughout the body. This helps prevent the onset of colds and flu.

People who wear amethyst jewelry are less likely to contract skin cancer, which is another common disease. Amethyst jewelry is often recommended for those who have a hard time relaxing, who experience high-stress levels, and for women who are pregnant or nursing.

Amethyst Amplifies Heat Energy Into Far Infrared Rays

Amethyst gemstones can absorb heat energy in the far-infrared rays, known as the “white light” spectrum. This absorption of heat energy by amethyst decreases the gemstone's internal pressure, which increases the amount of radiant energy emitted from it. As a result, the gemstone’s translucency, color, cut, and overall appearance is greatly enhanced. Amethyst also has the unique property of being able to refract microwave radiation.

Far infrared rays are beneficial for many scientific experiments. They are essential for scientific imaging as they allow scientists to view microscopic objects and structures under the microscope.

The properties of amethyst make it particularly effective for infrared images of gemstones. For example, amethyst allows the scientist to see minute bubbles and cavities that would otherwise not be visible to the human eye.

Researchers use amethyst in a variety of medical research-related activities, including cancer treatment. Since amethyst also absorbs heat energy, it is used for skin tanning. Another valuable medical application of amethyst is for treating high blood pressure.

High blood pressure causes many health problems, and the reduced pressure brought about by amethyst helps alleviate these problems.

Amethyst Heated With Electric Heating Power and Emits Far Infrared Rays — A Natural Treatment to Boost Energy

Amethyst, better known as the “stars of quartz” or “sperms of quartz,” is one such green mineral that emits far-infrared rays under the spectrum of visible light.

The crystals of amethyst also have a nearly transparent color, though their color can vary from nearly transparent to a slightly translucent pink.

Humans have used amethyst for centuries as a gemstone. Its healing properties are attributed to its ability to cure various physical ailments like headaches, colds, fevers, nausea, stress, insomnia, digestive disorders, eye problems, and vomiting.

Amethyst’s innate ability to cure these ailments, along with its beautiful color, has made it very popular as a gemstone.

In fact, amethyst is one of the most popular gemstones sold in the world. This is perhaps why amethyst is charged with electric heating power and emits far-infrared rays are so highly sought after.

This stone's powerful rays can help the body get rid of various ailments that may have plagued us for many years.

There are several ways to purify your home environment using amethyst. For instance, you can place small pieces of amethyst on dark areas of the floor, such as dark corners of rooms, hallways, and basements.

Another way of using amethyst is to place small pieces of amethyst on top of hot coals.

Amethyst charged with electric heating power and emitted far-infrared rays is an exceptional aid in keeping any home or space fresh, clean, and safe.

Killing Cancer Cells with the Help of Infrared Light

Researchers at NCI’s Center for Cancer Research have found that a technique called near-infrared immunotherapy for treating cancer has the potential to kill cancer cells in record time, essentially destroying them with the flick of a light switch. Scientists were not certain of the underlying mechanisms of this approach. Still, they succeeded in elucidating this technique in detail at the cellular and molecular level, gaining insights that could help scientists further boost the novel treatment's effectiveness. The laboratory and mouse findings, by Hisataka Kobayashi, M.D., Ph.D., Senior Investigator in the Molecular Imaging Program, and colleagues appeared November 6, 2018, in ACS Central Science.

Near-infrared immunology is an emerging technique for treating cancer that is already being studied in clinical trials. It involves identifying a protein called an antibody that recognizes and targets a specific type of cancer cell. The antibody is joined to a compound that’s sensitive to light and then administered to a patient. Within the body, the drug seeks out and attaches to only cancer cells, not healthy ones. Next, doctors apply a beam of infrared light to the cancer site, either externally or directly, using a fiber optic needle, which activates the drug and causes them to die. Research by Dr. Kobayashi and his colleagues reveals new details into how this cell death occurs.

To learn more about this phenomenon's molecular mechanisms, they studied the effects of a near-infrared immunotherapy agent called antibody-IR700 on a plate simulating human cancer cells in a petri dish using sophisticated microscopes. The researchers discovered that exposure to near-infrared light causes the immunotherapy agent to change its form from Y-shaped to globular dramatically. When it is embedded in a cancer cell's cell membrane, this warping causes scratches along the cell's protective casing. Once enough scratches occur, liquid bursts through the cell’s membrane, causing the cell to rupture in less than a minute following exposure to the light.

The researchers also studied this technique in a mouse with multiple tumors, applying different light intensity amounts to each tumor. They found that higher light intensity resulted in more cancer cells being eliminated. In mice, they detected the “leftovers” of the immunotherapy agent in the mouse’s urine just hours after near-infrared light was applied to the cancer site — a strong indication that the cancer cells were killed.

Dr. Kobayashi notes that this technique doesn’t just target cancer cells or boost the immune system to attack cancer cells — it does both. “All the cell’s proteins and even its DNA are exposed to the immune system. The immune system will recognize that [the proteins and DNA are] coming from the dying cell, and then the immune system will react only to the dying cancer cells,” he explains.

Near-infrared immunotherapy could be applied to any cancer if the right antibody is identified and used. In this study, the researchers analyzed the near-infrared immunotherapy agent IR-700, which is about to be tested in phase III clinical trials for head and neck cancer.

Although the concept of near-infrared immunotherapy is compelling, understanding why it works is critical for several reasons. Kobayashi explains, “Based on these new insights, we might be able to design a new, superior IR700 that would be improved in many respects, such as activation wavelength, stability, and cytotoxic efficacy.”

Immunological consequences after NIR

Destroying cancer cells without damaging normal cells nor compromising the host immune system is a significant benefit of NIR-PIT. Additionally, NIR-PIT induces ICD; that is, it initiates host immunity against targeted cancer cells. NIR-PIT-treated cancer cells release death signals, including calreticulin, ATP, and HMGB1, which can activate adjacent immature DCs even in tumor beds. These signals promote the maturation of immature DCs, which engulf cancer-specific antigens that are released from the ruptured tumor cell, and these mature DCs prime and educate naive T cells to become cancer-specific CD8+ T cells. Such newly primed cancer-specific CD8+ T cells proliferate and attack other cancer cells, resulting in an amplified host anti-tumor immune response. This consequential process could convert some non-immunogenic tumors into immunogenic tumors by recognizing massively released neo-antigens.

This anti-tumor immune activation occurs first in the treated tumor site. Eventually, it extends to other cancer sites because immune cells migrate throughout the body, resulting in a systemic immune response. Therefore, although NIR-PIT is a local therapy, the effect of NIR-PIT can be systemic and may affect distant metastatic sites. Indeed, some tumor-bearing mice and cancer patients achieve complete remission after a single therapy of cancer-cell-targeted NIR-PIT.

An important feature of host immune activation induced by NIR-PIT is that this therapy simultaneously activates the immune system against multiple antigens released from ruptured cancer cells. Most current targeted immunotherapies, including cancer vaccines or CAR-T therapies, identify a single target molecule to base the therapy. Having multiple clones of anti-tumor T cells, each responding to unique antigen, results in a more comprehensive response to tumors expressing a broad spectrum of cancer-specific neo-antigens.

NIR-PIT has demonstrated a profound immune response in humans. First-in-human Phase 1 and Phase 2 clinical trials of NIR-PIT with cetuximab–IR700 targeting EGFR in patients with recurrent and advanced head and neck squamous cell cancer were completed in 2016 and late 2017, respectively. Several complete remissions and multiple significant partial remissions were reported in these studies. The results far exceeded those of pre-clinical models in immune-deficient host xenograft models. Once the models were transferred to syngeneic models, a robust immune response was demonstrated. There is considerable evidence that this same response is seen in humans.

Preparing your Skin for Light Therapy

Can I Use Serum With LED Mask?

It is a question that many people have asked — Can I use the serum with LED light therapy?

Our skin is exposed to harsh environmental factors such as sun, wind, cold, and dust daily. These factors tend to attack our immune system causing it to weaken over time.

When this happens, it allows harmful viruses and bacteria to attack our body, leading to acne breakouts and other skin issues such as dark spots and wrinkles. Acne creams are one way of reducing the symptoms associated with this skin condition. However, these can be irritating to your skin, resulting in unwanted side effects such as redness, irritation, and dryness.

The same can also be said for light therapy, which can have its own side effects. Side effects of LED light therapy include itching, burning, and pain. In fact, most users had reported experiencing these side effects when they first started using LED technology. If you were to use any acne medication type, whether prescribed by your doctor or over the counter, the results would depend largely on the person using the medication.

For example, it could take anything from a few days to a few weeks for acne to clear up. Another point to remember is that while certain medications do show better results for some people, they may not work for you at all.

This is because everyone has different skin types, responds differently to treatments, and requires different times to clear away acne completely.

Some people have found success in using LED therapy with a variety of skin creams. However, there is a downside to using this method. LED light therapy does not help remove excess dead skin cells, as some acne medications do. This means that the acne cream will just be left in place and continue to produce side effects for all patients. Besides, side effects can be more severe than a single acne medication dose when used over a long time when used over a long time.

Before you try to use a serum with an LED mask, you should consult with a dermatologist who can advise you on whether or not LED light therapy is right for you. LED light therapy is safe when administered by a certified medical professional. It can be used safely, even if you have sensitive skin, as long as you choose your doctors wisely. Before any treatment is begun, the medical professional will test your skin to determine what type of acne you have. Testing will determine whether your skin is allergic to any light-emitting diodes in the device used.

The last question to answer is, “How effective is Acne treatment with LED Light?” To answer this question, you will need to look at the results you get from the treatment. If you see immediate results after the treatment, it will likely react to the device's light and not the treatment itself.

However, if you don’t see good results after a month of continuous treatment, it is important to determine why the treatment is not working. It may be that you are allergic to any of the ingredients in the product, or it may be that your skin is not receptive to the treatment.

Hydrated Face For LED Mask Results

The serum is good for hydrated face for LED Mask. It can hydrate the skin by absorbing moisture, providing a slight lift to the skin, and removing any oil or makeup that you are using. The serum also contains vitamins and antioxidants that will help fight against free radicals in your body. Free radicals are harmful agents that have been linked with causing cancer.

By fighting against these harmful agents, Serum is good for hydrated face for LED Mask. People who have used Serum have claimed that the hydrated face and LED Mask work very well together. I have also used Serum on my skin, and I must say that the results were really amazing. In fact, I would go on to say that Serum is so good for hydrated face for LED Mask that I will be using it every single night before bed.

If you don’t have much experience making skin look hydrated, this is the forum for you. Let us first examine the ingredient list of Serum.

This product's main ingredients are Hyaluronic Acid, Vitamin C, Retinol A, Alpha Hydroxy Acids, Vitamin E, DMAE, Peptides, and Glycerin, Ferulic Acid, Aloe Vera.

  • AHA kills the bacteria causing acne and helps to get rid of blackheads.
  • Sodium Laureth Sulfate helps in cleaning the skin by getting rid of dead skin cells and excess oil.
  • Salicylic Acid gets rid of pimples and acne scars, and Glycolic Acid is good in treating acne scars.

All of these ingredients are perfectly good for your hydrated face for LED Mask.

  • Now let us move on to how does Serum works to get rid of the facial puffiness.
  • When you are applying Serum on your hydrated face for LED Mask, you are putting on a layer of serum to the surface of your face.
  • As the serum gets applied, it works its way down into your skin and starts working as a moisturizer.
  • This is why this particular product is top-rated as it works as a good moisturizer without over-drying the skin.
How to Prepare Your Skin For a Red Light Therapy Session?

There are different methods used to prepare your skin, but essentially they all work in the same way: removing all the oil and dirt from the skin and then cleaning it. When I talk about cleansing, I’m talking about daily skincare maintenance products. If you want to know how to prepare your skin for a red light therapy session, this is the part that you need to read.

Most people have no idea how their skin looks like, so when they go into the doctor’s office and they've asked if they’ve had a photodynamic therapy or a laser treatment, they’re not aware of what treatment they might have received.

  • The skin absorbs red light from the sun, and in return, it produces negative ions.
  • These are similar to the particles produced by an activated oxygen generator (you know those things at the gym).
  • During photodynamic therapy, the skin cells absorb the energy from the lasers' red light, which causes the release of more negative ions, which then penetrate deeper into the skin.
  • They’re working like the “batteries” on your car — they give the batteries extra power and allow the car to run much longer.
  • If you want to learn how to prepare your skin for a red light therapy session, you must remove all the grime from your face and neck before the session.
  • Cleansing is one of the most important steps to remember in preparation.
How to Prepare Your Skin for Red Light Therapy Session by Using Non-Dry Cleanser

You might need more than just a good cleanser when trying to prepare your skin for red light therapy. Your cleanser is your friend when you are trying to remove all the dirt and excess oil from your face, but what if your cleanser is too harsh on your skin? If you have dry skin, using a cleanser containing too harsh ingredients may cause dryness, making it harder for you to remove those excess oils from your face.

When you prepare your skin for red light therapy session using the non-drying cleanser, make sure that you would be using a toner with antioxidants and anti-inflammatory ingredients to increase the collagen level the skin.

This will help keep your skin healthy and younger-looking.

Caution: Lotion and Moisturizers For LED Masks Are Not Recommended

The use of moisturizers and lotions is not recommended for LED masks because it will damage your skin. There are also cases wherein people who used such products ended up suffering from adverse effects.

The ingredients in these products may be too strong for the skin to be able to absorb.

You can prevent this by using only non-comedogenic lotions and moisturizers for LED masks.

  • This way, the product is less likely to irritate your skin. In addition to that, you can also use other types of products designed for sensitive or dry skins to use on your face during the event's preparation.
  • However, there are cases wherein people who have been using such moisturizers and lotions as part of their LED facial make-up mask ended up suffering from adverse effects.
  • In these cases, the products were not properly applied to the skin, and the amount that was applied was also insufficient.
  • Because the skin did not get sufficient moisture, the cells underneath the skin's surface could not repair themselves properly.
  • This will result in damaged skin, which will cause more breakouts than before.

Aside from lotion and moisturizers, it would help if you also stayed away from mineral oil, alcohol, and preservatives. These ingredients are not good for your skin, as they can cause dryness and irritation. It would help if you also stayed away from using creams and lotions with fragrance, which can only irritate your skin even more. Instead, look for serums.

If you want to have a glowing complexion without enduring any adverse effects, use a good quality face serum.

Prepare Your Skin For Red Light Therapy by Removing Sunscreen

You probably have heard that it is unsafe to use the sun’s UV rays at home, especially if you use a tanning lotion or a self-tanning lotion. But did you know that it is also not safe to use self-tanning products like tan accelerators and sunless tanning pills to prepare your skin for red light therapy sessions?

This defeats the purpose of using red light therapy, and you must remove sunscreen so that your face and skin are completely ready to receive the red light therapy. This is because self-tanning products contain ingredients that can affect the skin in adverse ways and block the beneficial deep penetrating infrared wavelength from 650nm to 850nm.

How to Prepare Your Skin For Red Light Therapy by Removing Makeup

If you have chosen to have laser acne treatment and you are wondering how to prepare your skin for the red light therapy, you will want to take a moment to learn how red light therapy works before getting started.

Before your session begins, you will be given a short amount of time to get ready for the procedure. This is because your skin needs to be very clean and free of any makeup. Your skin needs to be completely dry before the procedure can begin.

If there is any moisturizer on your skin when you arrive for your appointment, you will have to remove it before your treatment.

Your doctor will ask you several questions about your skin during your appointment, including what type of skin you have and whether or not you have any allergies. During this time, they will also determine if you are a good candidate for the procedure. If you are cleared for the procedure, your skin will be exposed to an intense red light level. This is one of the most effective ways to get rid of acne, and it can also help prevent scars and aging from occurring on your face.

The amount of time that it takes to get your skin prepared for red light therapy varies. In most cases, it is normal to have it take from fifteen to thirty minutes to prepare your skin for the procedure. You may have to remove any makeup at this time as well.

How to Prepare Your Skin For Red Light Therapy by Exfoliating?

When a patient is getting a therapy session done, they will be required to go to the spa or beauty clinic to be given a facial.

A therapist will then start by cleaning the face thoroughly. After the initial cleaning process, the therapist will apply a chemical that will help exfoliate the skin.

This process can irritate the skin, so it is important to prepare your skin before undergoing this procedure. Some common preparations that people use include salicylic acid, alpha hydroxy acid, retinoids, glycolic acid, and other peel-type products.

The exfoliating procedure aims to help the skin cells shed off dead skin cells and replace them with new cells.

This is why it is important to remove all traces of dead skin cells from your face before undergoing the procedure.

It may seem odd at first, but if you want to get the best results from the procedure, you need to gently exfoliate your skin.

Prepare Your Skin For Red Light Therapy With Moisturizers

When you prepare your skin for red light therapy, you are basically preparing to expose the blue spectrum laser's high intensity and the eventual dry out of the epidermis. The skin must be prepared using a good cream containing Reductase or Salicylic Acid, or by exfoliating the skin using a scrub.

After the procedure, you will need to have topical products applied to your skin to prevent the skin from cracking and peeling. This will also help improve your appearance and prevent future scarring. Removing moisturizers before the therapy can be helpful. This is because the skin’s cells will still be in a dormant state when you receive the treatment; therefore, your skin is not at risk for the dryness associated with moisturizers.

This will also improve your skin's look, especially for those who have undergone this procedure many times. However, you must be youthful if e to remove moisturizers in preparation for the session, as some creams may cause excessive dryness and irritation. Once you are prepared for the session, you can expect the doctor to start the red light therapy by generating a small amount of blue light on your skin's top layer.

The light then travels through the skin, reaching the deepest layers where most of the damage occurs. When the blue light is emitted, it is believed that the cells below the surface of the skin begin to absorb the red light, helping to repair the skin. The increased circulation and nutrient absorption help to rejuvenate your skin, leaving it looking younger and healthier than ever before.


Effectiveness of a Light Emitting Diode System on Tooth Bleaching

The first commercial marketing of a 10% carbamide peroxide whitener occurred in 1989. Nowadays, various treatment modalities are available, which include over-the-counter bleaching (self-administered), in-office bleaching (professionally administered), and dentist-supervised take-home bleaching (professionally dispensed). Modern society desires to see the effect of bleaching immediately, resulting in higher concentrations of chemicals used in the whiteners' composition with different light sources believed to accelerate the bleaching process. These high concentrations should only be applied by qualified people to control and prevent possible damage to oral soft tissue. Today in-office bleaching mainly uses carbamide peroxide (CP) or hydrogen peroxide (HP), which might be activated by heat or light (with a chemical catalyst) to catalyze the tooth bleaching process. It is believed that most light sources decompose peroxide faster (by increasing the temperature) to form free radicals, which whiten teeth. Various light sources are available, for example, light-emitting diodes (LED’s), lasers, halogen lamps, and plasma arc lamps (PAC). All available in Kaiyan.

A laboratory study using six different photoactivation systems on three different 35% hydrogen peroxide whiteners found that only the diode laser, halogen lamp, and LED lamp showed significant color changes. Here, the light source is more important than the bleaching agent in the whitening process. Kossatz (2011) reported a larger difference in bleaching with a light-emitting diode than without it (on 35% HP gel), with a shade guide value change of 4.8 vs. 3.8 units. However, tooth sensitivity was higher (53% subjects) for the LED treated group but only 26% for the non-activated group after 24 hours of treatment. Tooth sensitivity was also found to be persistent and higher when the LED activation was used.

In a recent (2011) critical appraisal of power bleaching it was stated that light sources used in tooth whitening do not generate sufficient heat to damage teeth. They concluded that high concentrations of chemicals are responsible for faster whitening and that light sources are therefore superfluous in the whitening process.

Today LED lights are available across the visible, ultraviolet and infrared spectrum of wavelengths. In Kaiyan Medical we can provide you with all the right devices and wavelengths. The LED light system investigated for this article is marked as a blue LED light which means the wavelength should be between 450 and 500 nm. It is also reported that LEDs can emit light of an intended color without using any color filters as in traditional lighting methods. This Kaiyan tooth whitening system is claimed to have an activating gel which prevents heat formation, has no sensitivity to teeth, prevents pulp damage, has a blue LED light with a tailored wavelength to activate their custom made gel and can whiten teeth with up to 11 shade tabs within 20 minutes.

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The EA-05 model is one of our best selling teeth, whitening lights. All of the parts are made from aluminum and stainless steel.
The LED head unit reduces heat for maximum comfort during treatment.

The EA-05 comes with an aluminum wheelbase that can be easily assembled and disassembled in minutes — and comes in an aluminum wheeled carry case.

1. German Osram LEDs for performance and reliability

2. LED life expectancy > 50.000 hours

3. Ideal for beauty salons, mobile practitioners, and clinics

4. Can be easily assembled/disassembled for mobility

References

1. Khin PW, Barnes DM, Romberg E, Peterson K. A clinical evaluation of 10% vs. 15% carbamide peroxide tooth-whitening agents. J Am Dent Assoc. 2000;131:1478–84. [PubMed] [Google Scholar]

2. Sulieman M, Addy M, MacDonald E, Rees JS. The effect of hydrogen peroxide concentration on the outcome of tooth whitening: an in vitro study. J Dent. 2004;32:295–9. [PubMed] [Google Scholar]

3. Buchalla W, Attin T. External bleaching therapy with activation by heat, light or laser: a systematic review. Dent Mat. 2007;23:586–96. [PubMed] [Google Scholar]

4. Zhang C, Wang X, Kinoshita, et al. Effects of KTP laser irradiation, diode laser and LED on tooth bleaching: a comparative study. Photomed Laser Surg. 2007;25:91–5. [PubMed] [Google Scholar]

5. Joiner A. Tooth colour: a review of the literature. J Dent. 2004;32:3–12. [PubMed] [Google Scholar]

6. Lima DA, Aguiar FH, Liporoni PC, Munin E, Ambrosano GM, Lovadino JR. In vitro evaluation of the effectiveness of bleaching agents activated by different light sources. J Prosthodont. 2009;18:249–54. [PubMed] [Google Scholar]


With Autoimmunity on the Rise, Light Therapy is Here to Aid in Prevention and Treatment

The medical industry has taken great strides in helping to improve our understanding of the human body. We’ve found an effective treatment for Hepatitis C, eradicated smallpox and rinderpest, and are working on treatments to cure cancer. No one can say we haven’t been successful in the medical world, particularly with the help of incredible research and technology. 

However, there is one family of disease that continues to be somewhat of a mystery in the medical world. And while it’s being highly studied, more and more people are being diagnosed with it. 

What’s the mystery disease? It’s autoimmunity. 

Now, autoimmune diseases can vary greatly, as it's an umbrella term for many autoimmune-based disorders. However, they all have one common thread, in that the body's natural defense system cannot tell the difference between your own cells and foreign cells. This causes the body to attack its own cells healthy unknowingly. 

Under the term "autoimmune diseases," there are around 80 different types that affect various parts of the body, with some of the most common forms manifesting as celiac, IBS, multiple sclerosis, and rheumatoid arthritis.  

The symptoms of autoimmune diseases aren’t pleasant ones by any means. However, they do range depending on the specific condition. Many people with an autoimmune disease experience multiple symptoms such as severe inflammation, joint and pain swelling; as well as skin conditions, recurring fever, swollen glands, and digestive issues. 

Though we know the symptoms of autoimmune diseases, the underlying cause can be difficult to determine for patients – exact cause of autoimmune disorders is unknown. 

More importantly, autoimmune disorder cases are rising. A study published this year showed a staggering rise in autoimmunity in the U.S., particularly in the rate of people testing positive for antinuclear antibodies (ANA), the most common marker of autoimmunity. Over the course of 25 years, the researchers found an overall 50 percent increase. That is astounding. 

Even though we understand these diseases are increasing, we don't know why.

But there is more and more evidence that the balance of microbiome in our guts plays a significant role. Having a diverse range of microbes positively influences our immune systems. People living in developed countries have higher rates of autoimmune diseases due to our less microbially environments. In other words, we're inside more, overuse antibiotics, live with chronic stress, and have poor diets. Not a great combination for a long and healthy life. 

Autoimmune disorders are a reflection of the unhealthy environment we've created for ourselves. We're overworked, stressed, and not supplying our bodies with the proper nutrients. Of course, a lifestyle change is necessary to reduce autoimmune disorders cases and symptoms. But there's another thing you can do to help yourself, and that's by undergoing at-home light therapy treatment

First, light therapy helps to improve immune cells, which is crucial for those with autoimmune disorders. When undergoing red light therapy, cells respond to the wavelengths. Pro-inflammatory cytokine TNF-α is released from the cells, and leukocytes (white blood cells) can enter the body's tissue to promote healing. In addition, red light therapy aids in activating lymphocytes, which increases the movement of epithelial cells, thus healing wounded areas quickly and increasing cell turnover rates. 

But there are other symptoms red light therapy focuses on, and it's joint pain and inflammation. For people who have rheumatoid arthritis, fibromyalgia, and other autoimmune diseases, inflammation and pain are a daily struggle. One study found that light therapy significantly improved inflammatory cells during both the early and late stages of Rheumatoid arthritis. 

By using Lunas’ red light therapy devices, you’re able to tackle multiple symptoms of autoimmune disease, reduce your stress levels, and improve your immune system by investing a few minutes sitting or standing in front of your red light device.

How Light Therapy can Help you Manage Holiday Stress

If there's one thing that many of us experience during the holiday season, it’s stress. As much as it can be a time of joy, there’s a lot of pressures that come along with this time of the year. And now, the holidays come with yet another set of stressors that we're not so unaccustomed to: an ongoing global pandemic. None of us have gone through a holiday season during lockdowns and quarantines, making it stressful and difficult to navigate. 

With many of us unable to see our families, we are potentially having to spend the holidays alone, only seeing our loved ones over Zoom or Skype. It’s an unusual time we’re living in right now and it can bring up various emotions. The chronic stress we’re currently living in can lead to serious health problems, including inflammation, headaches, insomnia, digestion issues, and loss of sexual desire. 

On top of everything, the winter season brings SAD (seasonal affective disorder), resulting in many people suffering from low energy, depression, and appetite changes. So, as you can see, we’re dealing with a lot this holiday season, and it’s evermore important to take care of ourselves. 

Of course, the fact that we're separated from our families is difficult, and sadly, there's not much we can do about it. However, we can help ourselves find mental, emotional, and physical balance during these stressful times, and reduce inflammation stemming from stress in the body.

If you're suffering from inflammation and have experienced pain, heat, swelling, and discomfort, you've probably done some Googling to find the cause. As you know, endless search results point to diet, weight, and exercise, which are all valid causes, but they are not the only ones. But there's one main cause we tend to ignore: stress. 

What happens to us when we’re stressed? When we're stressed, our inflammatory response jumps into action and our body enters allostasis. Allostasis is the process of adapting to acute stress by producing stress-related hormones such as cortisol and adrenaline. In other words, our bodies go into "flight or fight" mode. 

This isn't necessarily unhealthy; this is part of the natural human response. However, the problem comes when we're experiencing chronic stress as our bodies cannot return to homeostasis. This causes the body to believe we're fighting for our lives continually, and ultimately causes inflammation. 

Naturally, in today’s world, you’re going to experience stressful situations. And yes, yoga and meditation help to reduce stress, but they don’t reduce inflammation entirely. So, what can you do? When it comes to bringing your body back to a state of balance, red light therapy works wonders.

If you've ever visited the doctor for inflammation issues, you've probably been prescribed nonsteroidal anti-inflammatory drugs or steroids. Though they're useful, they don't deal with the root cause of your inflammation.

Red light therapy does combat the root of inflammation by sending wavelengths of red and near-infrared (NIR) light to the skin and cells, cutting down the oxidative stress and enhancing cellular energy to boost your immune system, even preventing diseases that are caused by chronic inflammation. In addition, red light therapy also increases the cell's healing process, improving blood flow and reducing any existing inflammation. 

Aside from the inflammation, red light therapy also aids in treating seasonal affective disorder (SAD). Red light therapy’s benefits are particularly powerful during the winter season, as you can eliminate or reduce winter-related conditions such as inflammation and SAD. 

Inflammation is a natural part of the human body, but chronic inflammation can cause serious health risks that can significantly reduce the quality of your life. Therefore, we’re intent on helping people reduce inflammation at Lunas through our state-of-the-art red light therapy devices that are MDA and FDA approved and can be used from the comfort of your home during this holiday season. 

Winter can be a dreary and gloomy time of year, but that doesn’t mean you need to feel poorly, too. With red light therapy, you’ll be able to reduce inflammation, eliminate symptoms and get your life back. 

How to Integrate Light Therapy into your Lifestyle

Our lives are busier than ever, and even though red light therapy sounds like something that could significantly benefit you, we know you might be thinking: “when will I have time for red light therapy?” 

Part of the beauty of red light therapy is that you don't need to change your current routine or lifestyle to enjoy its benefits: if you're someone whose day is busy in front of a desk, you can turn the device on while you work; or if you have easy-going mornings but hectic afternoons, you can enjoy your morning coffee while using our red light therapy device. Or, you can turn on the panel while you’re unwinding with a movie in the evenings –– the options are endless.  

Red light therapy treatment isn’t supposed to take over your day and cause an inconvenience. With an at-home red light therapy device, you make the rules. 

That said, you may be wondering what’s the best time of day to use our red light therapy devices. Well, there are a couple of ways you can integrate red light therapy into your lifestyle. 

There are three main parts of the day: morning, midday, and evening. Though you’re able to use red light therapy any time of the day, some parts of the day can be more effective than others, particularly given your personal health and wellness needs. 

If you’re someone who’s suffering from a sleep disorder, then you may want to focus on using red light therapy during the mornings and evenings. For sleep conditions, using red light therapy around sunrise or sunset are the best times of the day. Why is that? 

It has to do with our biological circadian rhythm, which is the natural internal process that helps regulate your sleep cycle within a 24-hour day. To optimize your circadian rhythm and improve your sleep cycle, you need to sync with your natural sleep rhythm. By doing so, you reduce sleep inertia, insomnia, and other sleep disorders. 

When regulating your circadian cycle, your body releases a hormone called melatonin. This particular hormone is the highest in the blood at night and optimal for helping you fall asleep. When using red light therapy at night, it can help you enhance your natural melatonin production

When using red light therapy in the morning, exposure to light helps stop melatonin production, giving your body a natural energy boost. So, either time of the day––morning or night––can be an incredible time to help your body reset its circadian rhythm. 

You don’t need to schedule off your morning for red light therapy treatment. While you’re eating your breakfast or going through your emails, you simply turn on your red light therapy device and enjoy 10 to 15 minutes of treatment. 

Or, in the evenings when you’re cozied up on the course, washing the dishes, or sitting in bed with a book, turn on your red light therapy panel to help regulate your sleep cycle, mood, and overall health. 

If you can’t manage to use red light therapy in the morning or evening, you can always have a treatment in the afternoon, as well. If you’re dealing with a sleep disorder or seasonal depression, we recommend morning or evening treatment. However, midday treatment will also provide you with a load of benefits, including collagen production, decreasing symptoms of depression, improving sleep disorders, and non-seasonal Bipolar depressive episodes. 

Whatever the condition may be, whether it's a sleeping disorder, skin condition, or depression, Lunas red light therapy devices promote cellular healing from the inside out. What’s important is you find the time of the day that best suits your body’s needs. Everyone is different, so it’s important to find out what works for you and your unique routine and lifestyle.

Light Therapy and Orthopedic Surgery

At some point in most of our lives, we’re all going to encounter a visit with an orthopedic doctor. As a society, we’re constantly straining our muscles, joints, ligaments, and tendons. 

In addition, nutrient deficiencies are incredibly common as more people resort to eating processed and fast food for their meals. With a lack of nutrition, our bones, joints, and muscles do not receive what they need to sustain themselves and remain healthy. 

Conditions such as Osteroporsosis—or bone loss—can create pain, inflammation, and bone breakage. Other nutrition deficiencies can cause low immunity, muscle weakness, and joint issues. 

Of course, nutritional deficiency isn’t the only reason someone can suffer from joint, muscle, tendon, or ligament issues. Aside from doing repetitive movements, athletes are more prone to muscle, tendon, ligament, and joint injuries. 

Whatever the cause may be, there’s one thing they all have in common: people with these types of injuries often need to be seen by an orthopedic surgeon. 

For some people, physical therapy can help; however, more people have to undergo orthopedic surgeries. Today, the most common orthopedic surgeries are ACL reconstruction, knee, hip, and shoulder replacements. If there’s one thing everyone who’s experienced orthopedic surgery can say, it’s that recovery can be extremely challenging and lengthy. 

Sadly, there’s not much one can do when recovering from orthopedic surgery. You simply have to wait until the operated area heals naturally. But, there is one specific treatment that aids the post-recovery period and prevents future joint issues. What is it? It’s red light therapy, of course! 

Red light therapy works by enhancing energy within your body’s cells, which works to repair any damaged cells in the body. By repairing damaged cells in the body, it reduces pain and inflammation, increasing the recovery period. 

Red light therapy has proven to achieve a few things:

  • It stimulates cells to remove toxins
  • Increases oxygen flow to the cells
  • Blocks pain signals in the brain and releases endorphins and enkephalin (a natural pain killer in the body)
  • Jumpstarts the body’s healing process by stimulating the mitochondria in the cells.

That said, red light therapy can be used to treat a wide range of joint, muscle, tendon, ligament, and bone injuries. The reason why it works on a wide scale of injuries is due to the fact it can treat various tissues within the body, reducing inflammation and pain. 

A review by Harvard Medical School and the University of Sydney found that laser therapy can be effective for treating:


  • Post-surgical pain
  • Tendonitis
  • Muscular back pain
  • Carpal tunnel syndrome
  • Cervical or lumbar radiculopathy
  • Epicondylitis
  • Osteoarthritis and rheumatoid arthritis
  • Whiplash injury
  • Frozen shoulder
  • Tendinopathy
  • Fibromyalgia
  • Sprains and strains

Red light therapy is also highly used within the athletic community to speed up the healing process, help players get back on the field, and prevent future injuries. 

Through red light therapy, it prevents muscle soreness, fatigue, and aids in recovery. By having the muscles recover quickly, red light therapy reduces inflammation, allowing the muscle to heal and avert future injuries.

From mild to severe joint, muscle, ligaments, bone, and tendon conditions, red light therapy improves recovery time and aids the healing process. The beauty is that this therapy is entirely possible to undergo from the comfort of your own home.
Lunas red light therapy devices provide high-quality at-home treatments to help you make the most out of your recovery. With red light therapy, not only will you recover from surgery, but you’ll feel even better than before.

Can Red Light Help Supplement a Keto Weight-loss Diet?

Weight loss is something that many people struggle with, and our modern day lifestyles can make it challenging to prioritize healthy eating and movement. We’re living fast lives, often resorting to highly-processed foods, and skipping out on exercising, all of which are the main contributors to weight gain. 

In 2020, the obesity rate in the U.S. was 42.4%. Though it’s often overlooked, people with a high BMI are at very high risk for cardiovascular diseases, hormonal issues, diabetes, cancer, and musculoskeletal disorders. 

However, in recent years, there’s been a shift in people’s mentalities. Yes, many are still opting for meal replacements and weight loss surgeries; however, others are focusing on eating clean and eliminating preservatives from their diet. Instead of doing quick diet fads, many are trying to change their lifestyle, even turning to alternative eating methods such as the ketogenic diet – a low-carb, high- fat diet that shares similarities to the Atkins diet. Essentially, you eat fewer carbs and replace them with fat. By doing this, the body goes into a state of ketosis, enabling the fat from your diet and body to be burned into energy. 

However, the keto diet does more than just help people lose weight. It reduces blood sugar and insulin levels, sleep disorders, seizures, and other brain disorders. It’s clear that the keto diet does have health benefits aside from weight loss. This diet alone has changed the lives of millions of people around the world. But wait...what does this all have to do with red light therapy? 

Before we talk about red light therapy working alongside keto, it’s crucial to understand the importance of natural light to the human body. Our bodies respond to light the same way it does to carbs, proteins, and fats. Our bodies are built to function with an optimal amount of natural light so that our cells can produce energy

We need light like we need fruits and vegetables. Similar to when we eat junk food, if we’re exposed to an abundance of artificial light, our bodies don’t function optimally. However, we’re spending more time inside than ever, meaning we’re not getting enough natural light. Simply put: it isn’t good for our bodies and minds.

So how do the two work together? If you’re on the keto diet, your body will go into a state of ketosis, which promotes increased weight loss, specifically in the abdominal area. When the body is able to burn fat efficiently, the body works better—this the same goes for red light therapy. 

Red light therapy strengthens the mitochondria inside our cells. The mitochondria are the powerhouse of the cells where energy is created. By improving the function of the mitochondria, a cell produces more ATP (adenosine triphosphate). With an increase in energy, the cells function optimally and are able to regenerate at a faster pace. 

Keto and red light therapy work to naturally enhance our body’s functionality as both operate to enhance the mitochondria. Keto works to burn fatty acids and ketones instead of glucose. With red light therapy, it decreases oxidative stress that slows energy systems. When using red light therapy during a keto diet, your cells are able to work efficiently as both increase energy, physical performance, and weight loss

But red light therapy does more than just enhance your body’s energy and physical performance. Red light therapy improves sleeping patterns by adjusting your circadian rhythm and helping the brain produce natural melatonin. Developing a regular sleep pattern on top of losing weight will only help improve your weight loss journey, as well as balance your hormones. Red light therapy also reduces inflammation and joint pain, which helps the overall weight loss experience. 


If you’re on the keto diet or considering giving it a try, consider easing into the process by supplementing with Lunas’ MDA and FDA-approved red light therapy devices to help aid your weight loss journey.

Light Therapy - An Alternative to Botox and Fillers?

It’s safe to say that most people would prefer to slow down the physical signs of aging, particularly on their faces – and the proof is in the numbers. In 2018, the global anti-aging market was estimated to be worth around $50.2 billion U.S. dollars. Now that's a lot of skin cream and Botox. And those numbers are only increasing: by 2027, the anti-aging product industry is projected to be worth $83.2 billion U.S. dollars. 

Of course, a large portion of sales are going to anti-aging creams and serums; however, there's been an increase in soft-tissues cosmetic procedures like Botox and filler treatments. A report from the American Society of Plastic Surgeons from 2018 reported around 7.4 million injections of botulinum toxin (Botox) and 2.6 million dermal filler injections we used that year. 

In America alone, Botox and fillers ranked the second most popular, minimally-invasive cosmetic procedures. But why are they so popular? Due to their invasiveness, they're more effective than anti-aging creams. However, that comes at a potentially risky and painful price. 

Botox's side effects include bruising and swelling at the injection site, fever, chills, and headaches. Some side effects are specific to the area of injection and include drooping eyelids, excessive tearing, and uneven eyebrows and other facial muscles. More importantly, research on the long-term side effects of Botox and fillers is limited. There are immediate results, yes; however, there's an unclear understanding of what Botox and fillers do to the body in the long-term.

Aside from health concerns, Botox and fillers can quickly add up financially, too. The most common Botox and filler treatments cost hundreds of dollars per session. Women and men around the world are risking their health and money to look youthful, but what they don't realize is there's non-invasive alternatives to these procedures, including light therapy. 

Aside from light therapy’s plethora of benefits for the human body, it is an amazing anti-aging alternative for those looking for non-invasive and natural anti-aging results. Light therapy reduces fine lines and wrinkles, but goes beyond just skin deep. 

While Botox and fillers work to cover the symptoms of aging skin, light therapy solves the problem at a cellular level. As we age, our body’s collagen production decreases, leaving our skin less plump and full. However, through light therapy, you’re actually stimulating collagen production beneath the skin to receive natural and similar results to Botox and fillers. 

Light therapy works by delivering wavelengths of red and near-infrared light to our skin and cells. Red light enhances our cellular function, stimulating the cell's mitochondria to produce ATP (adenosine triphosphate) energy. This boost of cell energy promotes collagen and elastin production, bringing the plumpness back into your skin. 

A 2014 study found that users of red light therapy experienced significantly improved skin complexion and increased collagen. Angela Lamb, M.D. and associate professor of the Department of Dermatology at the Icahn School of Medicine at Mount Sinai Hospital in New York City, stated that "Science shows that red light therapy protects existing collagen and boosts new production. Plus, it helps with texture, tone, pore size, and wrinkles."

However, there are more benefits to red light therapy than natural collagen production. Light therapy also aids in diminishing fine lines and wrinkles, reduces scarring, fights acne, treats inflammation, and aids in muscle recovery.

The proof is in the research, and study after study has shown the same results: red light therapy works for anti-aging. Rhonda Klein, M.D., a board-certified dermatologist in Connecticut, said that “Realistically, you can expect RLT to improve your skin’s tone and texture. We know that it soothes inflammation, improves mild acne, and proactively treats fine lines and wrinkles, in addition to other benefits.”

Lunas’ red light therapy devices are both MDA and FDA-approved, assuring you receive the highest quality of red light treatments available on the market, which is essential in receiving the best, most efficacious results.

Laser and Light-based Treatment of Keloids

Keloids are an overgrowth of fibrotic tissue outside the original boundaries of an injury and occur secondary to defective wound healing. Keloid scars commonly grow beyond the wound boundaries, while hypertrophic scars are confined to the wound’s original area. Both types of scars arise as a result of impaired fibroblastic proliferation and collagen deposition after skin injury. Keloids often have a functional, aesthetic, or psychosocial impact on patients, as highlighted by quality-of-life studies. They can greatly affect the patient’s quality of life and emotional wellbeing by causing intense pain, itching, unappealing red appearance, and inexorable spread. Interestingly, keloids and hypertrophic scars are exclusively found in humans and do not occur in animals naturally. The lack of suitable animal models that recapitulate the key processes in keloidal/hypertrophic scarring has greatly hampered our understanding and treatment of these scars.

Treatments for keloids include surgical excision, intralesional or topical corticosteroids, other intralesional therapies: 5-fluorouracil (5-FU), bleomycin, and interferon, topical imiquimod, compression, cryotherapy, radiation, silicone sheeting, and laser or light-based therapies. Recurrence is common, even with combination therapy. Laser and other light-based technology have introduced new ways to manage keloids that may improve aesthetic and symptomatic outcomes and decrease keloid recurrence. Laser and light-based therapies for keloids can be grouped into three categories: ablative lasers, non-ablative lasers, and non-coherent light sources.

Non-ablative lasers target hemoglobin or melanin. 585 or 595-nm pulsed-dye lasers (PDL) are non-ablative, and the major chromophore is oxyhemoglobin. PDL also targets melanin; therefore, care must be taken to avoid pigmentary alterations. PDL is hypothesized to treat keloids by selective damage of blood vessels that supply the scar. The 980-nm diode laser targets hemoglobin and melanin. The 1064-nm neodymium-doped: yttrium, aluminum, and garnet laser and the 532-nm neodymium-doped: vanadate laser is hypothesized to primarily treat keloids by damaging deep dermal blood vessels.

Non-laser light sources are also used to treat keloids. These techniques include intense pulsed light therapy (IPL), light-emitting diode (LED) phototherapy, also known as low-level light therapy, and photodynamic therapy (PDT). These modalities utilize light energy that may cause keloid fibroblast functional modification. IPL emits non-coherent, broadband wavelength, pulsed light, and targets pigmentation and vasculature. LED phototherapy is hypothesized to photomodulate mitochondrial cytochrome C oxidase altering intracellular signaling. PDT requires the application of a photosensitizer, commonly 5-aminolevulinic acid or methyl aminolevulinic acid, that is preferentially absorbed by highly vascularized or metabolically active tissue and converted to protoporphyrin IX. Upon exposure to light, PpIX causes reactive oxygen species free radicals that have a cytotoxic effect. PDT may also cause alterations in extracellular matrix synthesis and degradation and modulate cytokine and growth factor expression.

The mechanisms by which topical PDT improves abnormal scars are largely unknown. However, they probably involve downstream responses to the ROS produced by the photodynamic reactions: the ROS induces membrane and mitochondrial damage, which activates signaling molecules such as TNF-α and interleukins 1 6 and cell death. The cell death may be via apoptosis, necrosis, and/or autophagy. These changes may alter growth factor and cytokine expression in the lesion, thereby modulating collagen production and extracellular matrix organization.

Notably, the shallowness of PDT suggests that it may be useful as an adjunct treatment of the wound area after keloid resection. In this setting, PDT may help to prevent postoperative keloid recurrence.

The Children of Fire - Infrared Light & Fire

The control of fire by early humans was a turning point in the technological evolution of human beings. Fire provided a source of warmth, protection from predators, a way to create more advanced hunting tools, and a method for cooking food. These cultural advances allowed human geographic dispersal, cultural innovations, and changes to diet and behavior. Additionally, creating fire allowed human activity to continue into the evening's dark and colder hours.

Claims for the earliest definitive evidence of fire control by a member of Homo range from 1.7 to 2.0 million years ago. Evidence for the “microscopic traces of wood ash” as the controlled use of fire by Homo erectus, beginning some 1,000,000 years ago, has wide scholarly support. Flint blades burned in fires roughly 300,000 years ago were found near fossils of early but not entirely modern Homo sapiens in Morocco.

The fire was used regularly and systematically by early modern humans to heat treat silcrete stone to increase its flake-ability for toolmaking approximately 164,000 years ago at the South African site of Pinnacle Point.[5] Evidence of widespread control of fire by anatomically modern humans dates to approximately 125,000 years ago.They also used fire for light.

Infrared Light from Fire

The burning of wood (or other organic materials) releases energy in the form of infrared light. When you take a photo of someone with an infrared camera, what do you see? A heat “signature” that correlates (approximately) to their metabolic activity.

What is infrared light? It is a spectrum of light that we can’t see but that powerfully shapes our biology. You sense infrared light as “heat.” The heat you feel from the sun — that’s the sensation of infrared light. The feeling of heat you get when you put your hand close to an oven, toaster, or fire — that is also infrared light. The heat of another person’s body — infrared light again. Hot springs transfer heat to your body in the form of infrared light stored in the water itself. When you take a hot shower or hot bath, the same principle is at work.

Infrared light has been used for decades as a heat source for saunas. Before IR saunas, we had sweat lodges and traditional stone saunas. In traditional saunas and sweat lodges, stones absorb energy from either an electronic heating unit (in the case of a sauna) or a fire. The light is stored in the stones and gradually released during the sweat lodge or the sauna. Both methods use light to heal the human body.

And infrared light doesn’t just transfer “heat” to your body — it turns the water in your cells into batteries. This is likely why ancient cultures recognize the importance of fire, sweat lodges, and saunas, especially in winter.

It is not a coincidence that sitting down next to a fire is so comfortable. Firelight is natural and helps to manage melatonin production as well as keeping our circadian rhythms under control.

A fireplace or fire-pit isn’t just an ornamental detail of your home, and it’s a tool you can use to live a healthier life.

References

  1. James, Steven R. (February 1989). “Hominid Use of Fire in the Lower and Middle Pleistocene: A Review of the Evidence” (PDF). Current Anthropology. 30 (1): 1–26. doi:10.1086/203705. Archived from the original (PDF) on 12 December 2015. Retrieved 4 April 2012.
  2. ^ Luke, Kim. “Evidence That Human Ancestors Used Fire One Million Years Ago.” Retrieved 27 October 2013. An international team led by the University of Toronto and Hebrew University has identified the earliest known evidence of the use of fire by human ancestors. Microscopic traces of wood ash, alongside animal bones and stone tools, were found in a layer dated one million years ago.
  3. ^ Miller, Kenneth (May 2013). “Archaeologists Find Earliest Evidence of Humans Cooking With Fire”. Discover.
  4. ^ Jump up to: a b Zimmer, Carl (7 June 2017). “Oldest Fossils of Homo Sapiens Found in Morocco, Altering History of Our Species”. The New York Times. ISSN 0362–4331. Retrieved 6 July 2017.
  5. ^ Brown, Kyle S.; Marean, Curtis W.; Herries, Andy I.R.; Jacobs, Zenobia; Tribolo, Chantal; Braun, David; Roberts, David L.; Meyer, Michael C.; Bernatchez, J. (14 August 2009), “Fire as an Engineering Tool of Early Modern Humans”, Science, 325 (5942): 859–862, Bibcode:2009Sci…325..859B, doi:10.1126/science.1175028, PMID 19679810, S2CID 43916405

Blue & Red Light for Rosacea

Rosacea is a common inflammatory skin condition affecting approximately 5% of the world population. Therapeutic approaches to rosacea are focused on symptom suppression employing anti-inflammatory agents. Photodynamic therapy, especially light-emitting diodes, has been introduced as a valid alternative to conventional therapy.

Because of rosacea's potential complexity, it has been classified into subtypes according to signs and symptoms that often occur together. Patients may have characteristics of more than one subtype at the same time. Although the cause of rosacea is unknown, several possibilities are currently being studied, including flushing, inflammatory pathways, and Demodex mites. Simultaneously, a growing range of therapies is available to address rosacea's signs and symptoms. While your doctor will tailor medical therapy to your individual case, treatment options may often be keyed to standard subtypes and level of severity.1

As with any medical therapy, outcomes of rosacea treatment may vary from case to case. Compliance with therapy — using your medication as your doctor prescribes — is an important key to success. Please consult a dermatologist or other physician to determine the appropriate therapy for your individual case.

Subtype 1: Facial Redness

Subtype 1 (erythematotelangiectatic) rosacea is characterized by flushing and persistent facial redness. Visible blood vessels may also be present, and facial discomfort is common.

Research into the physical processes involved in rosacea has recently led to new prescription therapy to relieve facial redness. It may also be important for you to identify and avoid lifestyle and environmental factors that trigger flushing or irritating your skin. The most common factors are covered in Rosacea Triggers, and a Rosacea Diary is available to help you identify and avoid those factors that affect your individual case.

The appearance of flushing, redness, and visible blood vessels may also be concealed with cosmetics, and facial discomfort may benefit from appropriate skincare, both discussed under Skin Care & Cosmetics.

Visible blood vessels and severe background redness may be reduced with lasers or intense pulsed light therapy. Several sessions are typically required for satisfactory results, and touch-up sessions may later be needed as the underlying disease process is still present.

In specific cases, extensive flushing may be moderated somewhat through the use of certain drugs.

Subtype 2: Bumps and Pimples

Subtype 2 (papulopustular) rosacea is characterized by persistent facial redness and acne-like bumps and pimples and is often seen after or at the same time as subtype 1. Fortunately, however, several medications have been extensively studied and approved for this common form of rosacea and may also be used on a long-term basis to prevent symptoms recurrence.

In mild to moderate cases, doctors often prescribe oral and topical rosacea therapy to bring the condition under immediate control, followed by long-term use of topical therapy alone to maintain remission. A version of oral therapy with less risk of microbial resistance has also been developed specifically for rosacea and is safe for long-term use.

Higher doses of oral antibiotics may be prescribed, and other drugs may be used for patients who are unresponsive to conventional treatments.

Subtype 3: Skin Thickening

Subtype 3 (phymatous) rosacea is characterized by skin thickening and enlargement, most frequently around the nose. This condition develops primarily in men. Although mild cases may be treated with medications, moderate to severe manifestations, typically require surgery.

A wide range of surgical options is available, including cryosurgery, radiofrequency ablation, electrosurgery tangential excision combined with scissor sculpturing, and skin grafting. A surgical laser may be used as a bloodless scalpel to remove excess tissue and recontour the nose, often followed by dermabrasion.

Subtype 4: Eye Irritation

Subtype 4 (ocular) rosacea is characterized by any one of many eye symptoms, including a watery or bloodshot appearance, foreign body sensation, burning or stinging, dryness, itching, light sensitivity, and blurred vision. A history of having styles is a strong indication and has “dry eye” or blepharitis.

Treatment for mild to moderate ocular rosacea may include artificial tears, oral antibiotics, and the eyelashes' daily cleansing with baby shampoo on a wet washcloth. More severe cases should be examined by an eye specialist, who may prescribe ophthalmic treatments, as potential corneal complications may involve visual acuity loss.

Treatment and Conditions


Currently, there are two traditional treating methods, such as medications and physical treatment. Doctors can prescribe medications. Usually, the medications are antibiotics. The thing is, however, there are side effects from the antibiotics. Additionally, there is no proof that Rosacea is a bacterial condition. So the effectiveness of treatment could remain uncertain. Plus, going to see a doctor can be time-consuming & money consuming.

Physical treatment can be soup or gel to help better improve the skin. However, people have different skin types. Usually, it is super expensive to diagnose the skin condition in great detail; people have different skin types. The wrong usage of beauty products could lead to worsen skin problems or increase sensitivity.

Several therapeutic approaches are currently available for treating rosacea, and they are mainly aimed at controlling disease symptoms. The therapeutic plan has to be adapted to the rosacea subtype and tailored according to the patient's dominant manifestations. In general, the reduction of oral therapy in favor of topical or physical therapy is desirable to reduce side effects for patients and increase the treatment's safety.

The therapeutic approach has blue (480 nm ± 15 nm) and red (650 ± 15 nm) LED light-based therapy in patients affected by rosacea. Previous research reported the efficacy of red and blue light coupled with mild to moderate acne lesions. Blue light (400–470 nm), due to its lower penetration, is useful in such skin conditions related to the skin's epidermis layer; therefore, it can also interfere with human sebocyte proliferation. On the other hand, red light (630 nm) is reported to affect sebum production significantly. The benefits deriving from PDT using LEDs are not limited to its efficacy but are also related to its safety and tolerance by patients; therefore, its advantages can be extended to a broad range of dermatological conditions.

References:

Two AM, Wu W, Gallo RL, Hata TR. Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors. J Am Acad Dermatol. 2015;72(5):749–58. quiz 759–60. PMID: 25890455

Plewig G, Kligman AM. History of Acne and Rosacea. In: ACNE and ROSACEA. Berlin: Springer; 2000.

Odom R, Dahl M, Dover J, Draelos Z, Drake L, Macsai M, Powell F, Thiboutot D, Webster GF, Wilkin J. Standard management options for rosacea, part 2: Options according to subtype. Cutis, 2009;84:97–104.

Kolontaja-Zauber, I., Ināra Ančupāne, Andra Dērveniece, Aija Žileviča, & Ilze Ķikuste. (, 2018). Impact of intense pulsed light therapy on the quality of life of rosacea patients. Proceedings of the Latvian Academy of ences Section B Natural Exact and Applied sciences, 72(1), 9–15.

Kim, B. Y., Moon, H. R., & Ryu, H. J. . (2018). Comparative efficacy of short-pulsed intense pulsed light and pulsed dye laser to treat rosacea. Journal of Cosmetic & Laser Therapy, 1–6.

Bo, Young, Kim, Hye-Rim, Moon, & Hwa, et al. (2018). Comparative efficacy of short-pulsed intense pulsed light and pulsed dye laser to treat rosacea. Journal of Cosmetic & Laser Therapy Official Publication of the European Society for Laser Dermatology.

Smith, J. P. K. . (1984). The eyes have it: young children’s discrimination of age in masked and unmasked facial photographs. Journal of Experimental Child Psychology.


Light Therapy & Diabetes

DAccording to the Centers for Disease Control and Prevention (CDC), more than 100 million adults in the United States suffer from diabetes or pre-diabetes. A chronic disease characterized by elevated blood glucose levels (blood sugar), diabetes develops because the body doesn’t make enough insulin, a hormone produced by the pancreas. Low insulin levels cause glucose to build up in the blood, resulting in various health problems, some severe.

There are three types of diabetes: type 1, type 2, and gestational. Whichever type you may have, light therapy could be the treatment solution you’ve been looking for. This article will explore red light and near-infrared (NIR) light for diabetes: a novel solution that helps treat this disease's complications at the cellular level — healing from the inside out.

Red and Near-Infrared Light for Diabetes

While some people with type 2 diabetes (also called adult-onset diabetes) can achieve target blood sugar levels with lifestyle changes, diabetes medications, or insulin therapy may also be needed to control blood sugar. Many medications cause serious side effects. Diabetes has no cure, and symptom management is the only way to coax the disease into remission.

Red and NIR light has been used successfully to treat the complications associated with diabetes. Before we delve into that, let’s do a quick overview of what this treatment method actually is.

Red light therapy, also called low-level light therapy (LLLT) or photobiomodulation, is an umbrella term referring to the red light and NIR light. It uses powerful light-emitting diode (LED) bulbs to deliver intense beams of red and NIR wavelengths to bare skin.

Wavelengths of light are measured in nanometers (nm). Research has shown that red wavelengths from 630nm to 660nm, and NIR wavelengths from 810nm to 850nm, have the greatest scope of benefits — and come with no side effects.

Although studies often focus on either red or near-infrared wavelengths, experts say the best treatment approach is to use both. Doing so will provide skin-deep as well as deep-tissue benefits. For example, the 630nm to 660nm wavelengths address the skin's health, and the longer 810nm to 850nm NIR wavelengths penetrate deeper into the body. NIR wavelengths can even penetrate bone and hard connective tissue like cartilage.

Increase Capillary Formation for Improved Blood Flow

Thomas Burke, Ph.D., a retired physiologist with the University of Colorado Medical School, has studied blood flow — specifically changes in blood flow — for more than 30 years. Dr. Burke’s extensive research into the effects of red light therapy on circulation has led him to conclude that infrared light increases blood flow in any site in the body to which it is applied. This has profound implications for treating slow-healing wounds such as diabetic foot ulcers, which affect approximately 15 percent of patients with diabetes.

One effect of diabetes is meager amounts of nitric oxide produced by the body, which hinders normal blood flow. This is one reason people with diabetes often develop a circulatory condition called peripheral arterial disease, in which narrowed blood vessels reduce blood flow to the limbs. Many diabetes patients also develop diabetic neuropathy, a peripheral nervous system disorder that causes loss of feeling in the extremities, especially the feet.

The combination of poor blood flow and neuropathy can make people with diabetes more susceptible to ulcers or infections in the feet that, if allowed to spread, may require extreme measures such as amputation. LLLT can help circulation by stimulating the formation of tiny capillaries in areas treated by the light. This allows for better oxygen and nutrient delivery to the body’s peripheral regions, including the feet, which seem to bear the brunt of diabetic complications.

Increased Cellular Metabolism and Energy

The decreased blood flow that’s characteristic of diabetes interferes with the proper functioning of mitochondria, the “energy factories” inside most body cells. When mitochondria function normally, their primary job is to produce adenosine triphosphate (ATP), an energy-rich molecule that serves as fuel for cells. ATP is essential for normal cellular functioning, including repair and replication.

Poor cellular energy, officially known as mitochondrial dysfunction, is one of the main causes of diabetic neuropathy, so restoring normal mitochondrial function is essential. When there’s a chronic blood sugar imbalance, cells become stressed, unable to function properly, and unable to repair themselves.

Low-level light therapy addresses mitochondrial dysfunction by increasing ATP production. This, in turn, energizes cells and sparks a chain reaction of beneficial biological processes and improved health. When mitochondrial function is returned to normal, it supports skin ulcers and neuropathic pain and helps restore normal peripheral nervous system functioning.

Restored Normal Nerve Functioning

Until LLLT was developed, loss of sensation in the feet of diabetics was considered progressive and irreversible. Even today, the recommended treatment is often anti-inflammatory drugs that interrupt pain pathways. These drugs do not address the underlying problem: abnormal nerve signaling due to inflammation and mitochondrial dysfunction.

Today, diabetic neuropathy can be treated using near-infrared light. According to a 2015 study by medical researchers from Iran, NIR light therapy effectively reduces neuropathic pain and promotes damaged nerve cells' regeneration.

An earlier study by researchers from Japan also focused on LLLT’s effects on nerve regeneration. It is known that disrupted blood sugar levels can lead to oxidative stress, which can cause inflammation. The study revealed that NIR light acts as an antioxidant and reduces inflammation, conducive to nerve regeneration.

Increased Collagen Production

Diabetes can cause uncomfortable, often painful changes in the skin, including severe dryness, peeling, cracking, and abnormal callus growth. Red light therapy boosts the body’s natural collagen production so that as skin cells are renewed, the damaged skin can be gradually replaced by healthy skin. Improved blood flow and cellular functioning also support healthy skin growth.

Reduced Inflammation for Faster Wound Healing

Diabetic foot ulcers may form due to a combination of poor circulation, immune system deficiency that makes it hard for the body to fight off infection, diminished foot sensitivity (diabetic neuropathy), and ill-fitting shoes. Infected and dead tissue will need to be removed. The growth of healthy new tissue needs to be supported with blood sugar management and optimal mitochondrial functioning, and collagen production.

A Stronger Immune System

Improving health requires a robust immune system, and LLLT can help in several significant ways. For instance, it stimulates the production of stem cells, which are the body’s master cells with the potential to develop into many different types of cells. Stem cells remain in a dormant, non-specialized state until they are needed, when they are mobilized into action and carried to various parts of the body where they take on specialized roles.

Also essential for a healthy immune system is the thyroid, which LLLT helps to balance. People with diabetes have an increased risk of developing hypothyroidism, which is an underactive thyroid. Hypothyroidism results in mitochondrial dysfunction and poor cell functioning.

Also, research has shown that LLLT supports liver regeneration for more efficient waste disposal. This helps treat systemic inflammation and supports the workings of the immune system.

Consistency

LLLT is not an instant cure for any condition. You may experience relief after just one session, but the greatest results will come with time as the body’s cells regenerate and optimize their functioning. This can take a few weeks to a few months. Several sessions per week can help manage and minimize diabetic complications and keep the disease in remission on an ongoing basis.

Laser Acupuncture Treatment?

Acupuncture under traditional Chinese medicine is an alternative medicine that treats patients by needle insertion and manipulation at acupoints (APS) in the body. Acupuncture causes collagen fiber contraction, resulting in soluble actin polymerization and actin stress fiber formation, affecting the nervous and immune systems. Besides, acupuncture leads to molecular changes at APs in tissues at the cellular level. The local physicochemical reactions at the APs send signals to the organs via the tissue fluid and blood circulatory systems for optimal adjustment of the body’s organs.

It is believed to have been practiced for more than 2500 years, and this modality is among the oldest healing practices in the world. Acupuncture is based on the idea that living beings have Qi, defined as inner energy, and that it is an imbalance in Qi or interruption in the flow of Qi that causes illness and disease. Acupuncture therapy is focused on rebalancing the flow of Qi, and the practice is progressively gaining credibility as a primary or adjuvant therapy by Western medical providers.

Laser Acupuncture

Kaiyan Medical has been working to create ergonomic laser pens to simulate the acupuncture process. Laser acupuncture (LA) — non-thermal, low-intensity laser irradiation to stimulate acupuncture points — has become more common among acupuncture practitioners in recent years. LA is a safer, pain-free alternative to traditional acupuncture, with minimal adverse effects and greater versatility. LA has many features that make it an attractive option as a treatment modality, including minimal sensation, short duration of treatment, and minimal risks of infection, trauma, and bleeding complications.

What is the Difference

In acupuncture, needles are inserted at specific acupoints, which may be manually stimulated in various ways, including gentle twisting or up-and-down movements. Besides, the depth of needle penetration is also manipulated by the acupuncture practitioner. The patient may report sensations of De Qi, which are feelings of pressure, warmth, or tingling in the superficial layers of the skin. Many theories to explain how acupuncture works have been proposed, including the gate-control theory of pain and the endorphin-and-neurotransmitter. Others have postulated that acupuncture modulates the transmission of pain signals and alters the release of endogenous endorphins and neurotransmitters, resulting in physiologic changes.

One clear difference between needle acupuncture and LA is that LA does not physically penetrate the skin. Despite a greater understanding of LA, it is unclear how non-thermal, low-intensity laser irradiation stimulates acupoints. The mechanism of LA may be entirely separate from our present understanding of acupuncture. Current theories postulate that LLLT could positively affect modulating inflammation, pain, and tissue repair, given appropriate irradiation parameters.

Anti-Inflammatory Effect of Lasers

Inflammation reduction comparable to that of non-steroidal anti-inflammatory drugs has been reported with animal studies that used red and near-infrared LLLT, with laser outputs ranging from 2.5 to 100 mW and delivered energy doses ranging from 0.6 to 9.6 Joules. Human studies have shown similar anti-inflammatory effects with LLLT, which may account for many associated positive clinical results.

Cellular Effects of LLLT

LLLT improves cell physiology by increasing the overall cell redox potential toward greater oxidation and increased reactive oxygen species while simultaneously decreasing reactive nitrogen species. These redox state changes activate numerous intracellular-signaling pathways, including nucleic acid synthesis, protein synthesis, enzyme activation, and cell cycle progression.17 LLLT also alters the expression of genes that can enhance cell growth and inhibit cell apoptosis.16 These cellular effects of LLLT might reflect its ability to induce long-term changes in cells and LLLT’s benefits for wound healing, nerve regeneration, and inflammation reduction.

LLLT Characteristics

Red and infrared laser wavelengths are absorbed by cytochrome C oxidase protein in the mitochondrial cell membranes. This absorption is associated with increased adenosine triphosphate production by the mitochondria, which. In turn, it increases intracellular calcium (Ca2+) and cyclic adenosine monophosphate, which serve as secondary messengers that aid in regulating multiple body processes, including signal transfer in nerves and gene expression.

The power density of a laser, defined as laser energy supplied per area (W/cm2), influences its energy penetration depth. A 50-mW laser with a beam size of 1 cm2 has an energy density of 0.05 W/cm2. In contrast, the same power laser with a beam size of 1 mm2 has an energy density of 5 W/cm2 — a higher energy density results in deeper energy penetration through the skin.

Energy transmission through the skin is also affected by the absorption of light energy by skin structures. Light wavelengths from 650 to 900 nm have the best penetration through the skin. Lower wavelengths are absorbed by melanin and hemoglobin, and wavelengths longer than 900 nm are absorbed by water. With a well-focused laser beam, red wavelengths (~ 648 nm) can penetrate 2–4 cm beneath the skin surface, and infrared wavelengths (~ 810 nm) can penetrate up to 6 cm.

Now Kaiyan has made LLLT easier to use. Kaiyan medical devices can treat multiple acupoints simultaneously at the same time.


Bear, Wolf, Lion or Dolphin: How Understanding your Sleep Type Will Change your Life

Sleep is big business these days — one in three people are believed to experience sleep deprivation — and everyone is keen to rely on the latest fashionable theory.

For years, sleep cycles were divided into two categories. People who enjoy mornings were known as “early birds.” And those of us who prefer staying up late were labeled “night owls.”

Well, step-aside birds. Mammals are the new name of the game. That’s right; scientists now believe there are four ways to classify sleep/wake cycles. In the science world, these classifications are known as chronotypes.

Chronotypes describe the periods when your body wants to sleep and when it wants to be awake. And to make it easier, the chronotype categories are named after animals. Our natural sleep tendencies are now categorized as bear, wolf, lion, and dolphin.

It is crucial to understand your animal chronotype. Once you do, you can start to schedule your life around your body’s natural cycles. Kaiyan Medical suggests that this may help you sleep better and feel more productive at work.

Two Animals are not Enough

People have different circadian rhythms. That’s just a fact of life.

Science shows that:

“The human circadian system actively synchronizes to the 24-h day via environmental signals of light and darkness.”

Circadian? A 24-hour cycle. It’s your body clock. Sleep psychologists reckon they can determine our natural sleeping patterns. By understanding our own, we can have a happier, more productive life.

Now, Chronotype is a term that describes a person’s natural rhythm. And it doesn’t only relate to sleep. Chronotypes influence all primal instincts.

Author Michael Breus, Ph.D., recently suggested that there are 4 natural chronotypes. And he named these after 4 animals that follow similar sleep/wake patterns. So, say goodbye to night owls and early birds. Wolves, lions, bears, and dolphins are the new circadian rhythm mascots.


The Chronotypes

Check out the chronotypes below and let us know in the comment section which one sounds like you!

Wolves

Alright, night owls, this is your group. Just like these nocturnal creatures, you are most alert at night. Wolves tend to stay up later and struggle with waking up early.

Only about 15% of the population falls into this group. Wolves are more productive in the later afternoon and evening.

Sleep experts recommend that wolves set their alarm for 7 a.m. (snooze for 30 minutes) and go to sleep by midnight.

Lions

Lions are the new early birds. Like these wild cats, you are most alert in the morning. You have no trouble waking up and getting to work. But, lions tend to feel the afternoon slump. And by the evening, they feel drained.

About 15% of the population identifies as a lion. Sleep experts recommend that lions wake up around 5:30 a.m. and go to sleep by 10:30 p.m.

Bears

No, you don’t need to hibernate. But, like these diurnal (awake during the day, asleep at night) creatures, you follow the solar cycle. Bears generally feel awake during the day and need 8-hours of solid sleep at night.

About 50% of the population falls into this category. This group is productive in the morning and struggles with the mid-afternoon slump. Sleep experts recommend that bears wake up around 7 a.m. and go to sleep by 11 p.m.

Dolphins

Dolphins “only sleep with half of their brain at a time?” Sound familiar? Well, this is the insomniac (often self-diagnosed) group. You might be anxious and have trouble turning your brain off at night. Dolphins usually don’t get a complete night’s sleep.

About 10% of the population falls in this category. And even though they wake-up tired, dolphins are most productive by mid-morning.

Sleep experts recommend that dolphins get up around 6 a.m. and try to sleep around midnight.

Sleep Like an Animal

Who doesn’t want a better night’s sleep and a more productive day? Start scheduling your days based on your chronotypes! Once you know more about your chronotype, you can form sleep patterns that work with (not against!) your body’s natural rhythms.

So what are you waiting for? Here in Kaiyan, we are embracing our inner animals and start following our optimal sleep schedule.



Sources:

Fischer, Dorothee et al. "Chronotypes in the US – Influence of age and sex." PubMed, 21 Jun. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5479630/

Bellis, Rich. "How To Design Your Ideal Workday Based On Your Sleep Habits." Fast Company, 26 Nov. 2017, www.fastcompany.com/40491564/how-to-design-your-ideal-workday-based-on-your-sleep-habits

Levi, Anthea. "This Is the Best Time of Day to Do Everything, According to Your Chronotype." Health.com, 31 Oct. 2016, www.health.com/mind-body/how-to-get-more-energy-chronotype

Could Red Light Therapy be the Cure for Low Libido?

We’re animals of habit. When it comes to intimacy, it’s a night-time activity. Published findings on The Daily Mail discovered that most people have sex between 9:30 p.m. to 10:30 p.m. But what most people don’t realize is that for improved sex, you need the light.

Low libido (sex drive) has been a physical issue for both men and women. In the United States, sexual dysfunction affects 43% of women and 31% of men alone. However, further studies have shown this is a global issue. A study with 5,255 male participants from Croatia, Norway, and Portugal found that 14.4% reported a lack of sexual desire lasting two months or longer.

It’s clear low libido isn’t an issue within one gender; it’s a health concern that both men and women grapple with. For women, one survey at Hackensack University Medical Center, New Jersey, found that 36% of women between 18-to-3-years-old and 65% of women between 46-to-54-years-old reported low sexual desire.

But why are we losing our libido?

A loss of libido is a common issue linked to both the physical and the psychological self. Physical issues linked to low libido include low testosterone, alcohol and drug use, medication, and too little or too much exercise. At the same time, psychological issues can include stress, mental health, depression, and relationship issues.

Where do many of these problems stem from? Well, it certainly doesn’t help that we’re living our lives in overdrive: we’re working more; we’re chronically stressed, and generally living in ways that aren’t natural to our species.

However, where we live also plays a crucial role. Andrea Fagiolini, M.D., said, “In the Northern hemisphere, the body’s testosterone production naturally declines from November through April, and then rises steadily through the spring and summer with a peak in October. You see the effect of this in reproductive rates, with June showing the highest rate of conception.”

Since our body’s testosterone production naturally declines during winter and spring, many people are looking for treatment. As a result, many opt for hormone replacement therapy. It’s a controversial treatment that comes with a heavy dose of side effects, including prostate or breast cancer, sleep apnea, liver toxicity, and cardiovascular events.

Are people supposed to adjust to living with a low libido if they don’t want to undergo a dangerous treatment? Of course not. Luckily, red light therapy has been proven through various clinical studies to improve low libido levels.

At the University of Siena, Italy, scientists tested sexual and psychological responses to bright light. They discovered that regular, early-morning use of light therapy increases testosterone levels and sexual satisfaction.

So how does red light therapy increase testosterone in the body, exactly?

When your body is exposed to bright light, it produces a chemical called luteinizing hormone (LH). The more LH produced in the body leads to a higher testosterone increase, said the lead researcher Andrea Fagionlini, M.D.

Other studies in animals suggested that red light therapy influences Leydig cells — the body’s sperm producers located in the testicles.

“We found fairly significant differences between those who received the active light treatment and the controls,” Fagiolini stated. Dr. Brad Anawalt, an endocrinologist and professor of medicine at the University of Washington in Seattle provides two possible explanations for red light therapy’s effect on testosterone.

Since testosterone levels are the highest in the morning, a lack of daylight can reduce morning levels. Dr. Anawalt said, “[So] exposure to bright light might raise testosterone concentrations, leading to improved libido.” He added that “many men, and women, with low libido, suffer from depression. The bright light that mimics sunshine may help alleviate depression. Improved mood results in improved sex drive.”

Red light therapy can increase testosterone levels and reduce some of the causes of low libidos, such as depression, anxiety, and overall fatigue.

Lunas red light therapy panels have many benefits — even on our sex and love lives — which is an integral component to our well-being.

Red Light Therapy and Sun Damage

When summer rolls around, we all head outside, absorbing as many rays as we can. And the proof is in the numbers, with the top five summertime activities being barbeques, going to the beach, attending festivals, going for a hike, and exploring nature. When the sun comes out, people flock to the outdoors with good reason. We need the sun’s rays to survive.

However, many of us go a little overboard. Some lather on tanning oil or skip sunscreen to make sure we receive as much pigmentation as possible. And yes, we need vitamin D, but overexposure leads to sun damage, including sunspots and wrinkles.

However, it doesn’t end there. Neglectful sun exposure can also lead to skin cancer. While the damage has already been done from years of sunbathing and tanning oils, there are ways we can repair sun-damaged skin, reduce wrinkles and sunspots.

It can help repair the sun damage done to our skin and turn back the clock with red light therapy.

What is Sun Damage?

In the end, skin damage comes from overexposure to ultraviolet (UV) light. When we sunbathe, our skin naturally responds to the sun by protecting itself from UV light. What does our body do? Well, it produces melanin, which darkens the skin to reflect the UV light. So your summer tan is actually a defense mechanism. There are a few different types of sun damage to be aware of:

Melasma: It’s an overproduction of melanin that causes brown or gray patches to form on the skin.

Wrinkles: UV light breaks down the collagen and elastin in the skin, losing its firmness and causing wrinkles.

Sunburn: Sunburns are an inflammatory reaction to UV radiation damage to the skin. The body responds by repairing or removing the damaged cells, which results in redness and peeling.

Sun Spots: Overexposure to UV rays causes an increase of melanin production that builds up in clusters, producing dark spots on the skin.

Actinic Keratosis (AK): Causes a scaly patch of skin on the body from overexposure to UV light. This is particularly dangerous as around 10% of actinic keratosis becomes cancerous.

How Red Light Therapy Reverses Sun Damage

If you’re wondering whether sun damage is reversible or not, the answer is yes. Red light therapy uses infrared and red light to enhance the body’s healing process. Red light therapy increases the body’s collagen, elastin, and immune response; it can remove and repair dead or damaged skin cells.

By increasing collagen production, it’ll help smooth and firm the skin, reducing the appearance of fine lines and wrinkles. Besides, red light therapy also protects existing collagen, which helps keep the skin’s elasticity.

However, red light therapy doesn’t only reduce fine lines and wrinkles. It can also help with more serious skin conditions such as actinic keratosis. It can aid in removing actinic keratosis spots from the skin with photosensitizing medication and red light therapy.

Sun damage is the main cause of aging skin and can lead to serious health issues. Naturally, some sun damage forms cannot be treated, especially for those who work consistently outdoors. However, tackling sunspots, wrinkles, sunburns, and actinic keratosis is achievable through red light therapy treatment.

It’s important to point out that while red light therapy does reverse sun damage, it can prevent future damage — but you should always wear a broad-spectrum sunscreen when outdoors and reapply after swimming or sweating.

Reversing past mistakes are possible with light therapy, but we also want to look at the future. Luna’s red light therapy will tackle previous sun damage and rejuvenate the skin, while sunscreen will prevent future damage.

We hope you continue to enjoy the sun’s incredible rays safely while enjoying the incredible skincare results of Lunas light panels.

Understanding the Basics of Design Thinking

In his book The Sciences of the Artificial, Herbert Simon started what we now refer to as design thinking. Since then, numerous other works have been published detailing design thinking concepts and how it relates to all manner of different business models. One of the most famous icons to design thinking in the modern era is probably Apple, Inc. Let’s ask ourselves:

· Did you feel you needed an iPod before Apple created?

· Did you feel you needed an iPhone before Apple created it?

Apple’s genius during the early 2000s was not in creating new products that no one had ever heard of. There were dozens of cell phone manufacturers making quality cell phones before the iPhone landed. There were dozens of MP3 players on the market before the original iPod.

But, once Apple entered the arena, none of that mattered. Why? Because Apple understood the unarticulated needs (and in fact, you could even argue that Apple’s real genius was creating a need for a product by releasing that product!) of its customers. How were they able to do this?

How can we solve a problem for our customer in such a way that they don’t even know the problem exists until we show the solution?
The Five Phases of Design Thinking

Design thinking is a process of five distinct phases of execution. Those phases are:

· Empathize

· Define

· Ideate

· Prototype

· Test

Looking at that list, it seems to be a mix of skills from various disciplines. “Prototype” and “test” seem to be drawn from engineering and product development, whereas “empathize” and “ideate” come from a more psychological, social methodology.

Phase 1 — Empathize

Empathizing immediately sets design thinking apart from most of the other business models out there. True, most business models strive to understand their ideal client’s needs and wants, but few do it from a relational perspective. This is what Simon Sinek talks about in his book Start With Why: That people don’t buy what you do, they buy why you do it. For Apple, that meant understanding the desire of their customers to be a part of something. They weren’t buying things because it was the best. They were buying it because of the reasons behind WHY Apple made it. When the corporate world was turning its back on customer relations and focused more on profits than on value, Apple communicated a different mission and mindset, which allowed their sales to skyrocket.

Phase 2 — Define (The Problem)

Another crucial part of design thinking. The problem. The majority of creators will fail at this part because they think about problems as nouns. Problems are verbs. If you see a little girl trying to get cookies from the shelf, people will start listing the problems as:

· She needs a cookie

· She needs an adult

· She needs a ladder

· Maybe she needs milk with those cookies

While the truth is, she needs to reach. Reaching is the problem, not the cookies. If you solve the reaching problem, you solve anything she will want to reach in the future. Once we understand others' unarticulated needs through authentically empathizing, it’s time to define the problem.

Phase 3 — Ideate

Ideation, the process of coming up with potential solutions to your customers’ unarticulated needs, can only occur after those needs have been identified through empathy and the problem defined. Do we solve the problem through a product, or a relationship, or a service? Is it through expanding our business model to include other forms of retail or consumer service? As an operations manager, the unarticulated needs that I wasn’t meeting for my fellow workers were found in the way I was focused on problems, not on them personally. I felt like, and if nothing was going wrong, there was nothing for me to do. What was going on underneath the surface, and what I was failing to do, was to spend time with them, to learn their processes to the point that I could spot potential problems before they actually became problems. Again, this human-centered approach must consider, above all else, the user's experience, whether customer, employee, or client.

Phase 4 — Prototype

Prototyping doesn’t necessarily have to involve models or scaled-down products. Prototyping also applies to non-physical solutions as well, in terms of how we construct frameworks to solve problems. Obviously, there are times when physical prototyping is important, but the overarching goal of prototyping is to apply solutions in a controlled environment to allow for testing, the fifth phase.

Phase 5 — Test

The final and simplest phase of design thinking. Since design thinking doesn’t flow like time in a strictly linear fashion between stages, there are times when prototyping leads back to ideation and when defining the problem actually requires more time spent empathizing to reassess the customer’s needs. Because of this frequently recursive nature, by the time we arrive at the design thinking process's final phase, sometimes testing merely confirms the last step in our solution. Other times, it can restart the entire process from the beginning. The importance of moving fluidly throughout all five phases.

Conclusion

Creativity is about doing, not thinking. Design thinking as well is about playing and acting. Those actions will swing between a process-oriented approach and a human-oriented approach depending on the project. At the end of it all, whether we are talking about coworkers or customers, the one thing they all have in common is that they are people looking for solutions to their problems. Solving the problem without addressing the people will only lead to frustration and failure. Providing a solutions-based approach to problems rather than a problems-based approach to problems will guarantee a greater chance of lasting implementation and effectiveness of whatever problem we’re solving.

Sources:

· https://www.ideou.com/pages/design-thinking

· https://www.creativityatwork.com/design-thinking-strategy-for-innovation/

· https://dschool.stanford.edu/resources-collections/a-virtual-crash-course-in-design-thinking

· https://www.interaction-design.org/literature/article/5-stages-in-the-design-thinking-process

· https://hbr.org/2008/06/design-thinking

Light & Food Preservation

Consumers demand high-quality processed foods with minimal changes in nutritional and sensory properties. Nonthermal methods are considered to keep food quality attributes better than traditional thermal processing. Pulsed light (PL) is an emerging non-thermal technology for decontamination of food surfaces and food packages, consisting of short time high-peak pulses of broad-spectrum white light. It is considered an alternative to continuous ultraviolet light treatments for solid and liquid foods. This paper provides a general review of the principles, mechanisms of microbial inactivation, and PL treatments applications on foods. Critical process parameters that are needed to be optimized for better efficiency of PL treatments are also discussed. PL has considerable potential to be implemented in the food industry. However, technological problems need to be solved to avoid food overheating and achieve better penetration and treatment homogeneity. Besides, more extensive research is needed to understand how PL affects quality food attributes.

Nonthermal technologies

Nonthermal technologies are being applied in food processing as a viable alternative to thermal processing. Traditionally, most foods are thermally processed by subjecting them to temperatures between 60 °C for a few minutes and 100 °C for a few seconds. During this period, a large amount of energy is transferred to the food, which may trigger reactions that lead to undesirable changes or by-products formation. During nonthermal processing, food temperature is held below that achieved in thermal treatments. Thus, vitamins, essential nutrients, and flavors are expected to undergo minimal or no changes.

Pulsed light (PL) is used for the rapid inactivation of microorganisms on food surfaces, equipment, and food packaging materials. The terms high-intensity broad spectrum pulsed light and pulsed white light are synonymous with PL.

Inert-gas flash lamps generate intense and short pulses of ultraviolet (UV) light for microbial inactivation started during the late 1970s in Japan. In 1988, extensive experimentation carried out by PurePulse Technologies Inc. provided a pulsed light process called PureBright® to sterilize pharmaceuticals, medical devices, packaging, and water. The process's efficacy was tested against a broad range of microorganisms, including bacteria (vegetative cells and spores), fungi, viruses, and protozoa. However, the food industry adopted the technology only in 1996, when the Food and Drug Administration approved the use of PL technology for the production, processing, and handling of foods.

Description of PL

PL involves the use of intense pulses of short duration and a broad spectrum to ensure microbial inactivation on the surface of either foods or packaging materials. Electromagnetic energy is accumulated in a capacitor during fractions of a second and then released in the form of light within a short time (nanoseconds to milliseconds), resulting in an amplification of power a minimum of additional energy consumption (Dunn et al. 1995). Typically, the equipment used to produce PL comprises one or more adjustable xenon lamp units, a power unit, and a high-voltage connection that allows the transfer of a high current electrical pulse. As the current passes through the lamp unit's gas chamber, a short, intense burst of light is emitted. The light produced by the lamp includes broad-spectrum wavelengths from UV to near-infrared. The wavelength distribution ranges from 100 to 1,100 nm: UV (100–400 nm), visible light (400–700 nm), and infrared (700–1,100 nm). Pulses of light used for food processing applications typically emit 1 to 20 flashes per second at an energy density in the range of about 0.01 to 50 J cm−2 at the surface (Barbosa-Canovas et al. 1998).

Liquid Foods

Many fluids, such as water, have a high degree of transparency to a broad range of wavelengths, including visible and UV light. Other liquids, such as sugar solutions and wines, exhibit more limited transparency. Increasing the number of solids will diminish the intensity of UV radiation's penetration. In an aqueous solution, the lower the transparency, the less effective the PL treatment. Liquids with high UV absorbance must be treated as a thin layer to reduce the liquid's radiation absorption. In this manner, the liquid's UV absorption is low, and bacteria are more likely to be subjected to lethal doses. The absorbance of clarified fresh juices and juices containing pulp varies considerably. Clarified apple juice has a low absorbance, with absorption coefficients about 11 cm−1, whereas absorbance of orange juice can achieve values close to 50 cm−1. A positive correlation between vitamin C content and the absorption coefficient of clear apple juices was observed.

Conclusions

PL is a novel non-thermal technology to inactivate pathogenic and spoilage microorganisms on foods. The significant microbial reductions in short treatment times, the limited energy cost of PL, the lack of residual compounds, and its great flexibility are some of the technique's major benefits. This method is clearly efficient in inactivating microorganisms in vitro, but its potential for real foods is still under investigation. Further studies need to be conducted to assess PL treatments' effects on food properties beyond safety and spoilage. There is a need for optimizing the critical process factors to achieve the target inactivation level for specific food applications without affecting quality. PL equipment with good penetration and short treatment times need to be designed for commercial purposes. Also, the applicability of PL treatments on an industrial scale needs to be compared with other nonthermal or conventional thermal processes.

References

Anderson, J. G., Rowan, N. J., MacGregor, S. J., Fouracre, R. A., & Farish, O. (2000). Inactivation of food-borne enteropathogenic bacteria and spoilage fungi using pulsed-light. IEEE Transactions on Plasma Science, 28(1), 83–88. doi:10.1109/27.842870.

Baka, M., Mercier, J., Corcruff, R., Castaigne, F., & Arul, J. (1999). Photochemical treatment to improve storability of fresh strawberries. Journal of Food Science, 64, 1068–1072. doi:10.1111/j.1365–2621.1999.tb12284.x.

Barbosa-Canovas, G. V., Pothakamury, U. R., Palou, E., & Swanson, B. G. (1998). Nonthermal preservation of foods pp. 139–161. New York: Marcel Dekker.

Barka, E. A. (2001). Protective enzymes against reactive oxygen species during ripening of tomato (Lycopersicon esculentum) fruits respond to low amounts of UV-C. Australian Journal of Plant Physiology, 28, 785–791.

Bialka, K. L., & Demirci, A. (2007). Decontamination of Escherichia coli O157:H7 and Salmonella enterica on blueberries using ozone and pulsed UV-light. Journal of Food Science, 72(9), 391–396. doi:10.1111/j.1750–3841.2007.00517.x.

Bialka, K. I., & Demirci, A. (2008). Efficacy of pulsed UV-light for the decontamination of Escherichia coli O157:H7 and Salmonella enterica on raspberries and strawberries. Journal of Food Science, 00(0), 1–7.

Bialka, K. I., Demirci, A., & Purl, V. M. (2008). Modeling the inactivation of Escherichia coli O157:H7 and Salmonella enterica on raspberries and strawberries resulting from exposure to ozone or pulsed UV-light. Journal of Food Engineering, 85(3), 444–449. doi:10.1016/j.jfoodeng.2007.08.007.

Bintsis, T., Litopoulou-Tzanetaki, E., & Robinson, R. (2000). Existing and potential applications of ultraviolet light in the food industry — A critical review. Journal of the Science of Food and Agriculture, 80, 637–645. doi:10.1002/(SICI)1097–0010(20000501)80:6<637::aid-jsfa603>3.0.CO;2–1</637::aid-jsfa603>.

Cantos, E., Espin, J. C., & Tomas-Barbaran, F. A. (2002). Postharvest stilbene enrichment of red and white table grape varieties using UVC irradiation pulses. Journal of Agricultural and Food Chemistry, 50, 6322–6329. doi:10.1021/jf020562x.

Chung, S. Y., Yang, W., & Krishnamurthy, K. (2008). Effects of pulsed UV-light on peanut allergens in extracts and liquid peanut butter. Journal of Food Science, 73(5), 400–404. doi:10.1111/j.1750–3841.2008.00784.x.

Dhallewin, G., Schirra, M., Manueddu, E., Piga, A., & Ben-Yehoshua, S. (1999). Scoparone and scopoletin accumulation and ultraviolet-C induced resistance to postharvest decay in oranges as influenced by harvest date. Journal of the American Society for Horticultural Science, 124, 702–707.

Dong, Y. H., Mitra, D., Kootstra, A., Lister, C., & Lancaster, J. (1995). Postharvest stimulation of skin color in Royal-gala apple. Journal of the American Society for Horticultural Science, 120, 95–100.

Dunn, J. (1996). Pulsed light and pulsed electric field for foods and eggs. Poultry Science, 75(9), 1133–1136.

Dunn, J., Bushnell, A., Ott, T., & Clark, W. (1997). Pulsed white light food processing. Cereal Foods World, 42, 510–515.

Dunn, J. E., Clark, R. W., Asmus, J. F., Pearlman, J. S., Boyer, K., Painchaud, F., et al. (1989). Methods for the preservation of foodstuffs. US Patent number 4871559.

Dunn, J. E., Clark, R. W., Asmus, J. F., Pearlman, J. S., Boyer, K., Painchaud, F., et al. (1991). Methods for the preservation of foodstuffs. US patent number 5034235.

El Ghaouth, A., Wilson, C. L., & Callahan, A. M. (2003). Induction of chitinase, beta-1,3-glucanase, and phenylalanine ammonia-lyase in peach fruit by UV-C treatment. Phytopathology, 93, 349–355. doi:10.1094/PHYTO.2003.93.3.349.

Elmnasser, N., Guillou, S., Leroi, F., Orange, N., Bakhrouf, A., & Federighi, M. (2007). Pulsed-light system as a novel food decontamination technology: A review. Canadian Journal of Microbiology, 53, 813–821. doi:10.1139/W07–042.

Elmnasser, N., Dalgalarrondo, M., Orange, N., Bakhrouf, A., Haertlé, T., Federighi, M., et al. (2008). Effect of pulsed-light treatment on milk proteins and lipids. Journal of Agricultural and Food Chemistry, 56, 1984–1991. doi:10.1021/jf0729964.

Fine, F., & Gervais, P. (2004). The efficiency of pulsed UV light for microbial decontamination of food powders. Journal of Food Protection, 67, 787–792

Food and Drug Administration. (, 2000). Kinetics of microbial inactivation for alternative food processing technologies: pulsed light technology. Available at: http://vm.cfsan.fda.gov/∼comm/ift-puls.html. Accessed 2 May 2008.

Gómez-López, V. M., Devlieghere, F., Bonduelle, V., & Debevere, J. (2005a). Factors affecting the inactivation of microorganisms by intense light pulses. Journal of Applied Microbiology, 99, 460–470. doi:10.1111/j.1365–2672.2005.02641.x.

Gómez-López, V. M., Devlieghere, F., Bonduelle, V., & Debevere, J. (2005b). Intense light pulses decontamination of minimally processed vegetables and their shelf-life. International Journal of Food Microbiology, 103, 79–89. doi:10.1016/j.ijfoodmicro.2004.11.028.

Gómez-López, V. M., Ragaert, P., Debevere, J., & Devlieghere, F. (2007). Pulsed light for food decontamination: A review. Trends in Food Science & Technology, 18, 464–473. doi:10.1016/j.tifs.2007.03.010.

Guerrero-Beltrán, J. A., & Barbosa-Cánovas, G. V. (2004). Review: Advantages and limitations on processing foods by UV light. Food Science and Technology International, 10, 137–147. doi:10.1177/1082013204044359.

Hillegas, S. L., & Demirci, A. (2003). Inactivation of Clostridium sporogenes in clover honey by pulsed UV-light treatment. Agricultural Engineering International, V. Manuscritp FP 03 009.

Hiramoto, T. (1984). Method of sterilization. US Patent number 4464336.

Hollósy, F. (2002). Effects of ultraviolet radiation on plant cells. Micron, 33, 179–197. doi:10.1016/S0968–4328(01)00011–7.

Article Google Scholar

Hoornstra, E., de Jong, G., & Notermans, S. (2002). Preservation of vegetables by light. In Conference frontiers in microbial fermentation and preservation (pp. 75–77). The Netherlands: Wageningen.

Google Scholar

Jun, S., Irudayaraj, J., Demirci, A., & Geiser, D. (2003). Pulsed UV-light treatment of cornmeal for inactivation of Aspergillus niger spores. International Journal of Food Science & Technology, 38, 883–888. doi:10.1046/j.0950–5423.2003.00752.x.

Koutchma, T. (2008). UV light for processing foods. Ozone: Science & Engineering, 30, 93–98. doi:10.1080/01919510701816346.

Koutchma, T., Keller, S., Parisi, B., & Chirtel, S. (2004). Ultraviolet disinfection of juice products in laminar and turbulent flow reactors. Innovative Food Science & Emerging Technologies, 5, 179–189. doi:10.1016/j.ifset.2004.01.004.

Krishnamurthy, K., Demirci, A., & Irudayaraj, J. (2004). Inactivation of Staphylococcus aureus by pulsed UV-light sterilization. Journal of Food Protection, 67, 1027–1030.

Krishnamurthy, K., Demirci, A., & Irudayaraj, J. M. (2007). Inactivation of Staphylococcus aureus in milk using flow-through pulsed UV-light treatment system. Journal of Food Science, 72(7), M233–M239. doi:10.1111/j.1750–3841.2007.00438.x.

Krishnamurthy, K., Tewari, J. C., Irudayaraj, J., & Demirci, A. (2008). Microscopic and spectroscopic evaluation of inactivation of Staphylococcus aureus by pulsed UV light and infrared heating. Food and Bioprocess Technology. doi:10.1007/s11947–008–0084–8.

Lagunas-Solar, M. C., Piña, C., MacDonald, J. D., & Bolkan, L. (2006). Development of pulsed UV light processes for surface fungal disinfection of fresh fruits. Journal of Food Protection, 69(2), 376–384.

Lamikanra, O., Kuenemon, D., Ukuku, D., & Bett-Garber, K. L. (2005). Effect of processing under ultraviolet light on the shelf life of fresh-cut cantaloupe melon. Journal of Food Science, 70(9), C534–C539.

Shama, G. (1992). Ultraviolet irradiation apparatus for disinfecting liquids of high ultraviolet absorptivities. Letters in Applied Microbiology, 15, 69–72. doi:10.1111/j.1472–765X.1992.tb00727.x.

Shama, G. (2007). Process challenges in applying low doses of ultraviolet light to fresh produce for eliciting beneficial hormetic responses. Postharvest Biology and Technology, 44, 1–8. doi:10.1016/j.postharvbio.2006.11.004.

Sharma, R. R., & Demirci, A. (2003). Inactivation of Escherichia coli O157:H7 on inoculated alfalfa seeds with pulsed ultraviolet light and response surface modeling. Journal of Food Science, 68, 1448–1453. doi:10.1111/j.1365–2621.2003.tb09665.x.

Shuwaish, A., Figueroa, J. E., Silva, J. L. (2000). Pulsed light treated prepackaged catfish fillets. IFT Annual Meeting, 10–14 June 2000, Dallas, USA.

Smith, W. L., Lagunas-Solar, M. C., & Cullor, J. S. (2002). Use of pulsed ultraviolet laser light for the cold pasteurization of bovine milk. Journal of Food Protection, 65(9), 1480–1482.

Takeshita, K., Shibato, J., Sameshima, T., Fukunaga, S., Isobe, S., Arihara, K., et al. (2003). Damage of yeast cells induced by pulsed light irradiation. International Journal of Food Microbiology, 85, 151–158. doi:10.1016/S0168–1605(02)00509–3.

Tonon, F., & Agoulon, A. (2003). Lumiere pulse, principe et application au cas des solutions liquids. Industries Agro-alimentaires, la conservation de demain, 4e edition, 20 November 2003, Talence, France.

Turtoi, M., & Nicolau, A. (2007). Intense light pulse treatment as an alternative method for mold spores destruction on paper-polyethylene packaging material. Journal of Food Engineering, 83, 47–53. doi:10.1016/j.jfoodeng.2006.11.017.

Uesugi, A. R., Woodling, S. E., & Moraru, C. I. (2007). Inactivation kinetics and factors of variability in the pulsed light treatment of Listeria innocua cells. Journal of Food Protection, 70(11), 2518–2525.

Wang, T., MacGregor, S. J., Anderson, J. G., & Woolsey, G. A. (2005). Pulsed ultra-violet inactivation spectrum of Escherichia coli. Water Research, 39, 2921–2925. doi:10.1016/j.watres.2005.04.067.

Wekhof, A. (2000). Disinfection with flash lamps. PDA Journal of Pharmaceutical Science and Technology, 54, 264–276.

Wekhof, A. (2003). Sterilization of packaged pharmaceutical solutions, packaging and surgical tools with pulsed UV light. In: Proceedings of the Second International Congress UV Technologies, 9–11 July 2003, Vienna, Austria.

Wekhof, A., Trompeter, F. J., & Franken, O. (2001). Pulse UV disintegration (PUVD): A new sterilization mechanism for packaging and broad medical-hospital applications. In: Proceedings of the First International Conference on Ultraviolet Technologies, 14–16 June 2001, Washington, DC, USA.

Woodling, S. E., & Moraru, C. I. (2005). Influence of surface topography on the effectiveness of pulsed light treatment for the inactivation of Listeria innocua on stainless-steel surfaces. Journal of Food Science, 70(7), M345–M351. doi:10.1111/j.1365–2621.2005.tb11478.x.

Wright, J. R., Summer, S. S., Hackney, C. R., Pierson, M. D., & Zoecklein, B. W. (2000). Efficacy of ultraviolet light for reducing Escherichia coli O:157:H7 in unpasteurized apple cider. Journal of Food Protection, 63(5), 563–567.

Wuytack, E. Y., Phuong, L. D. T., Aertsen, A., Reyns, K. M. F., Marquenie, D., De Ketelaere, B., et al. (2003). Comparison of sublethal injury induced in Salmonella enterica serovar typhimurium by heat and by different nonthermal treatments. Journal of Food Protection, 66, 31–37.

Stretch Marks & Light Therapy

Why Do We Get Stretch Marks?

A stretch mark is a type of scar called striae, meaning “thin, narrow scar”. In people who develop stretch marks, the skin has stretched faster than it can grow, such as during pregnancy, growth spurts, or rapid fat or muscle gain. The abrupt stretching causes the collagen and elastin proteins responsible for the skin’s structure and elasticity to rupture. This, in turn, causes the dermis to tear.

As the dermis tears, the body’s healing mechanisms spring into action to close the wound as quickly as possible to prevent infection and further damage.

Normally, as the skin regenerates and grows, it’s an elegantly organized latticework of collagen and elastin proteins. But when the skin tears, the body doesn’t have time to build an elegant structure to fill in the gap. Time is of the essence in any wound repair, including torn skin.

The collagen clumps together hurriedly, aiming for efficient closure of the wound before infection can set in. “Scarring is the result of a system that has learned to respond extremely quickly to a wound,” says Dr. John Newman, a cosmetic surgeon and researcher at the Laser Center of Virginia in Virginia Beach.

This haphazard process results in tough and functional but unattractive tissue — what we know as a scar. “It is kind of like nailing down a crisscross of two-by-fours over a hole in a deck,” says Newman. “It seals the hole, but it doesn’t look very nice.”

Newly formed stretch marks are darker than the surrounding skin and can be slightly raised, itchy, or painful. If they’re left untreated, they become permanent scars. Their color will lighten, and their appearance will fade below the top layer of the surrounding skin.

The bigger mystery is why stretch marks don’t disappear over time as the skin regenerates. The key lies in the information that emerging cells receive from adult cells in the area. Skin cells, whether they’re normal cells or scar cells, regenerate about once every 30 days. Growth of new skin cells begins at the bottom-most layer of the scar, and older (dying) cells are pushed to the surface where they naturally slough off.

However, Neuman explains that that that that emerging cells “learn” from their immediate neighbors and predecessors and develop the same characteristics as ir replacement their replacement cells. As a result, any emerging cell in contact with scar cells will become new scar tissue rather than normal skin tissue.

Red Light Therapy For Stretch Marks

If you have tried to get rid of stretch marks, perhaps you’ve used specialized creams that contain retinoids. These work to some extent, but only if you catch your stretch marks early and treat them while they’re still forming. Retinoids work by stimulating collagen production. However, they can irritate sensitive individuals, and doctors often recommend that pregnant women avoid anything containing retinoids.

Another common treatment, known as microdermabrasion, essentially involves “sandblasting” the skin with tiny crystals. This sloughs off dead skin

cells and stimulates the production of collagen. Microdermabrasion is a fairly harsh treatment that can lead to irritation and damage, especially to sensitive skin.

The most extreme treatment for stretch marks is plastic surgery, such as a mini tummy tuck. This may be effective, but there are risks associated with any invasive procedure and the high cost.

Is there a better option for restoring the appearance of the skin? The answer is yes, absolutely. Also known as photobiomodulation and low-level light therapy (LLLT), red light therapy improves skin appearance, reduces signs of aging, treats chronic skin conditions, reduces scarring, and promotes skin wound healing.

When red light therapy is used, visible red light and invisible near-infrared (NIR) light are applied to the skin with LED bulbs' devices. Wavelengths of light are measured in nanometers (nm), with red light ranging from 630nm to 660nm and NIR light ranging from 810nm to 850nm. Human cells respond favorably to these wavelengths, similar to how natural sunlight affects plant cells by stimulating more energy and optimization of cell function.

When the red light is shone on bare skin, it soaks into the mitochondria, colloquially referred to as the powerhouses of cells' energy factories. The mitochondria are, in turn, stimulated to produce more adenosine triphosphate (ATP), which is the primary cellular fuel. This energizes cells to perform their normal functions, from fighting off pathogens to performing repair and regeneration.

Improved Blood Flow

Proper healing relies on good circulation to the skin. Red light promotes the proliferation of endothelial cells, which make up the inner layer of capillaries (the tiny blood vessels that deliver oxygen and nutrients throughout the body). This was the focus of a 2017 study by a team of researchers from Austria, who found that red light consistently increased migration and proliferation of endothelial cells.

Without proper blood circulation, there would be no healing since endothelial cells also deliver white blood cells to the sites they need. In skin wound healing, white blood cells are necessary to protect the vulnerable area from infection while the wound closes up.

Reduced Inflammation

Acute inflammation results in the redness that’s noticeable in fresh stretch marks. This is a normal and necessary part of the tissue regeneration scar's process. Acute inflammation, which is a function of the immune system, actually sets the stage for normal tissue repair and regeneration. Inflammation is quickly followed by the production of new skin structures — which, as previously described, are hastily assembled to ensure that the torn skin doesn’t become infected.

But sometimes, the inflammatory process continues after the wound has healed, leading to chronic inflammation. It can lead to a variety of widespread problems throughout the body, including disease. “Some inflammation is good,” says Dr. Robert H. Shmerling, an associate professor of medicine at Harvard Medical School. “Too much is often bad. The goal is to recognize when inflammation is simply doing its job, and when it can potentially cause problems.”

Hundreds of studies have shown how red light therapy can significantly reduce inflammation. Many of these were conducted by Dr. Michael A. Hamblin, an associate professor of dermatology at Harvard Medical School and a noted expert on red light therapy. In the final report of a 2017 study, Hamblin refers to red light therapy’s “pronounced anti-inflammatory effects.”

Mobilize Stem Cells

During the skin-rebuilding phase, stem cells, which are unspecialized “master” cells, mobilize to the site and develop into most any type of specialized cells that are needed by the body. Ideally, they develop into normal skin cells, rather than scar tissue, to replenish damaged or destroyed cells due to skin tearing.

Red light has been shown to activate stem cells. As Barbara Gefvert, editor-in-chief of BioOptics World, explains: “Recent research shows … that noninvasive application of light can boost the natural growth of an individual’s own stem cells to enable exciting new treatments.” Stem cells can assist with the tissue regeneration process and stimulate normal and healthy behavior in existing cells. This can prevent the formation of new stretch marks and gradually reduce the appearance of existing stretch marks.



Photodynamic Therapy for Cancer

Photodynamic therapy (PDT) is a treatment that uses a drug, called a photosensitizer or photosensitizing agent, and a particular type of light. When photosensitizers are exposed to a specific wavelength of light, they produce a form of oxygen that kills nearby cells

Each photosensitizer is activated by light of a specific wavelength. This wavelength determines how far the light can travel into the body. Thus, doctors use specific photosensitizers and wavelengths of light to treat different areas of the body with PDT.

How is PDT Used to Treat Cancer?

In the first step of PDT for cancer treatment, a photosensitizing agent is injected into the bloodstream. The agent is absorbed by cells worldwide but stays in cancer cells longer than it does in normal cells. Approximately 24 to 72 hours after injection, when most of the agent has left normal cells but remains in cancer cells, the tumor is exposed to light. The photosensitizer in the tumor absorbs the light and produces an active form of oxygen that destroys nearby cancer cells.

In addition to directly killing cancer cells, PDT appears to shrink or destroy tumors in two other ways. The photosensitizer can damage blood vessels in the tumor, thereby preventing cancer from receiving necessary nutrients. PDT also may activate the immune system to attack the tumor cells.

The light used for PDT can come from a laser or other sources. Laser light can be directed through fiber optic cables (thin fibers that transmit light) to deliver light to areas inside the body. For example, a fiber optic cable can be inserted through an endoscope (a thin, lighted tube used to look at tissues inside the body) into the lungs or esophagus to treat cancer in these organs. Other light sources include light-emitting diodes (LEDs), which may be used for surface tumors, such as skin cancer.

PDT is usually performed as an outpatient procedure. PDT may also be repeated and used with other therapies, such as surgery, radiation therapy, or chemotherapy.

Extracorporeal photopheresis (ECP) is a type of PDT in which a machine is used to collect the patient’s blood cells, treat them outside the body with a photosensitizing agent, expose them to light, and then return them to the patient. The U.S. Food and Drug Administration (FDA) has approved ECP to help lessen the severity of skin symptoms of cutaneous T-cell lymphoma that has not responded to other therapies. Studies are underway to determine if ECP may have some application for other blood cancers and help reduce rejection after transplants.

What Types of Cancer are Currently Treated with PDT?

To date, the FDA has approved the photosensitizing agent called porfimer sodium, or Photofrin®, for use in PDT to treat or relieve the symptoms of esophageal cancer and non-small cell lung cancer. Porfimer sodium is approved to relieve esophageal cancer symptoms when cancer obstructs the esophagus or when cancer cannot be satisfactorily treated with laser therapy alone. Porfimer sodium is used to treat non-small cell lung cancer in patients for whom the usual treatments are not appropriate and relieve symptoms in patients with non-small cell lung cancer that obstruct the airways. In 2003, the FDA approved porfimer sodium to treat precancerous lesions in patients with Barrett esophagus, a condition that can lead to esophageal cancer.

What are the Limitations of PDT?

The light needed to activate most photosensitizers cannot pass through more than about one-third of an inch of tissue. For this reason, PDT is usually used to treat tumors on or just under the skin or on the lining of internal organs or cavities. PDT is also less effective in treating large tumors because the light cannot pass far into these tumors. PDT is a local treatment and generally cannot treat cancer that has spread.

Does PDT have any Complications or Side Effects?

Porfimer sodium makes the skin and eyes sensitive to light for approximately 6 weeks after treatment. Thus, patients are advised to avoid direct sunlight and bright indoor light for at least 6 weeks.

Photosensitizers tend to build up in tumors, and the activating light is focused on the tumor. As a result, damage to healthy tissue is minimal. However, PDT can cause burns, swelling, pain, and scarring in nearby healthy tissue. Other side effects of PDT are related to the area that is treated. They can include coughing, trouble swallowing, stomach pain, painful breathing, or shortness of breath; these side effects are usually temporary.

What Does the Future Hold for PDT?

Researchers continue to study ways to improve the effectiveness of PDT and expand it to other cancers. Clinical trials (research studies) are underway to evaluate PDT's use for cancers of the brain, skin, prostate, cervix, and peritoneal cavity (the space in the abdomen that contains the intestines, stomach, and liver). Other research is focused on the development of more powerful photosensitizers, more specifically target cancer cells, and are activated by light that can penetrate tissue and treat deep or large tumors. Researchers are also investigating ways to improve equipment and the activating light's delivery.

Lighting the Way Back for Astronauts - Light Therapy & NASA

In 1993, Quantum Devices, Inc. (QDI), of Barneveld, Wisconsin, began developing the HEALS (High Emissivity Aluminiferous Light-emitting Substrate) technology high-intensity, solid-state LED lighting systems for NASA Space Shuttle plant growth experiments. The company evolved out of cooperative efforts with the Wisconsin Center for Space Automation and Robotics (WCSAR) at the University of Wisconsin-Madison — a NASA center for the Commercial Development of Space. Ronald W. Ignatius, QDI’s president, and chairman represented one of WCSAR’s industrial partners at the time. WCSAR was conducting research on light sources for promoting food growth within closed environments where humans would be present for a long duration, such as the Space Shuttle and the International Space Station.

With the support of WCSAR, Ignatius experimented with LEDs, which provide high-energy efficiency and virtually no heat, despite releasing waves of light 10 times brighter than the Sun. Ignatius admits that some scientists involved in the project were skeptical at first, thinking that the idea of using LEDs to promote plant growth was far-fetched. However, the experiments demonstrated that red LED wavelengths could boost the energy metabolism of cells to advance plant growth and photosynthesis. This finding prompted Ignatius to develop a line of LED products that emit the exact wavelength of light that plants use in photosynthesis.

“Our company gives credit to Dr. Ray Bula, the director of WCSAR, for having the foresight to go against the prevailing dogma of the time and design the first plant experiment using monochromatic light to grow lettuce plants,” Ignatius proclaims.

In 1989, Ignatius formed QDI to bring the salt grain-sized LEDs to market. In October 1995, the light sources made their Space Shuttle flight debut on the second U.S. Microgravity Laboratory Spacelab mission (STS-73, Columbia).

Growing

When NASA determined that red LEDs could grow plants in space, Marshall Space Flight Center awarded QDI several Small Business Innovation Research (SBIR) contracts to investigate the broad-spectrum diodes' effectiveness in medical applications. The contracts, issued from 1995 to 1998, focused on increasing energy inside human cells. NASA hoped that the LEDs would yield medical benefits on Earth and stem bone and muscle mass loss in astronauts, which occurs during long periods of weightlessness. (In space, the lack of gravity keeps human cells from growing naturally.) Furthermore, since wounds are slow to heal in a microgravity environment, LED therapy could accelerate healing and keep what would be termed as minor wounds on Earth from becoming mission-catastrophic in space.

In addition to promoting cell growth, the red LEDs are capable of activating light-sensitive, tumor-treating drugs that, when injected intravenously, could destroy cancer cells while leaving surrounding tissue virtually untouched. The technique, approved by the U.S. Food and Drug Administration (FDA) for use in laboratory and human trials, is known as Photodynamic Therapy.

With the SBIR assistance from NASA, QDI set out to alter a surgical probe that could emit long waves of red light to stimulate a Benzoporphyrin-derivative drug called Photofrin, which delivers fewer post-operative side effects than comparable drugs. Ignatius also developed a friendly and successful working relationship with Dr. Harry Whelan, pediatric neurology and director of hyperbaric medicine at the Medical College of Wisconsin in Milwaukee. The two had met after Ignatius came across a newspaper article highlighting Whelan’s ground-breaking brain cancer surgery technique, which uses drugs stimulated by laser lights to accelerate healing. Accordingly, QDI provided more than $1.25 million from its SBIR contracts to support Whelan’s pioneering photobiomodulation research and bring him on board to help improve the surgical probe.

Collectively, Ignatius, Whelan, and researchers from NASA successfully altered the probe for pediatric brain tumors and the prevention of oral mucositis (a common side effect of chemotherapy and radiation treatments) in pediatric bone marrow transplant patients at the Medical College of Wisconsin. In May 1998, a 20-year-old female became the first patient to undergo surgery with the modified probe. The young woman had endured six brain surgeries and chemotherapy and radiation treatments over a span of 10 years, but her aggressive cancer kept coming back. Having exhausted all of her conventional treatment options, she turned to the NASA-sponsored Photodynamic Therapy technology.

During the procedure, surgeons excised as much of the recurring brain tumor as they could then injected the light-activated Photofrin into her bloodstream and inserted the LED probe into the remaining tumor tissue. The probe, which casts long wavelengths that generate less heat and penetrate deeper into tissue than the shorter wavelengths of traditional medical lasers, proved to be both safe and effective, as the tumor never returned, and the patient recovered with no complications. A second operation that took place 3 months later on a male patient was also deemed successful by Whelan and his Medical College of Wisconsin surgeons' team.

FDA-approved clinical trials continued at several other facilities over the next 3 years, including the Roswell Park Cancer Institute in Buffalo, New York; Rush-Presbyterian-St. Luke’s Medical Center in Chicago; and the Instituto de Oncologia Pediatrica in Sao Paulo, Brazil. QDI became recognized as a U.S. Space Foundation “Space Technology Hall of Fame” award recipient in 2000 and a Marshall Space Flight Center “Hallmark of Success” in 2004.

Product Outcome

The positive clinical trial results and continued support from NASA and follow-on research grants from the Defense Advanced Research Projects Agency helped QDI and the Medical College of Wisconsin fully transition space technology into a new, non-invasive medical device. The WARP 10 (Warfighter Accelerated Recovery by Photobiomodulation) is a high-intensity, hand-held, portable LED unit intended for the temporary relief of minor muscle and joint pain, arthritis, stiffness, and muscle spasms. It also promotes the relaxation of muscle tissue and increases local blood circulation. Unlike the surgical probe, the WARP 10 does not require intravenous medicine; instead, the unit can be placed directly on the skin where treatment is to occur.

The WARP 10 was designed to aid armed forces personnel on the front lines with immediate first aid care for minor injuries and pain, thereby improving combat endurance. The “soldier self-care” device produces 80 times more photon energy than a 250-Watt heat lamp, yet it remains cool to the touch. The power advantage reduces the time required for each therapeutic dose and provides for faster multi-dose exposures when needed, without the harmful effects of ultraviolet solar radiation. The U.S. Department of Defense and the U.S. Navy are currently issuing WARP 10 to crews on submarines and Special Forces operations.

QDI has introduced an FDA-approved consumer version sharing the same power and properties of the military model as an alternative to the cost and complications associated with the overuse of non-steroidal anti-inflammatory drugs (NSAIDs) for persistent pain relief. According to a Mayo Clinic study, adverse events associated with the use of NSAIDs are reported more frequently to the FDA than such events associated with any other group of drugs. Furthermore, conservative calculations for the United States estimate that approximately 107,000 patients are hospitalized each year for NSAID-related gastrointestinal complications. At least 16,500 NSAID-related deaths occur annually among arthritis patients alone, according to compiled research.

References

Beauvoit B., Evans S.M., Jenkins T.W., Miller E.E., Chance B., “Contribution of the Mitochondrial Compartment to the OpticalProperties of the Rat Liver: A Theoretical and Practical Approach,” Analytical Biochemistry 226, 167-174 (1995).Beauvoit B., Kitai T., Chance B., “Correlation between the Light Scattering and the Mitochondrial Content of Normal Tissues andTransplantable Rodent Tumors,” Biophysical Journal 67, 2501-25 10 (1994).Chance B., Nioka S., Kent J., McCully K., Fountain M., Greenfield R., Holtom G., “Time-Resolved Spectroscopy of Hemoglobin andMyoglobin in Resting and Ischemic Muscle,” Analytical Biochemistry 174, 698-707 (1988)Conlan M.J., Rapley J.W., Cobb C.M., “Biostimulation of wound healing by low-energy laser irradiation,” J.Clin. Periodont. 23, 492-496 (1996).Eggert H.R., Blazek V., “Optical Properties of Normal Human Brain Tissues In The Spectral Range of 400 to 2500 nm,” Advances inExperimental Medicine & Biology 333, 47-55 (1993).Karu T., “Photochemical Effects Upon the Cornea, Skin and Other Tissues (Photobiology Of Low-Power Laser Effects,” HlthPhysics 56, 69 1-704 (1989).Lubart R., Friedman H., Sinyakov M., Cohen N., Breitbart H., “Changes in Calcium Transport in Mammalian Sperm Mitochondriaand Plasma Membranes Caused by 780 nm Irradiation,” Lasers in Surg & Med 21, 493-499 (1997).Lubart R., Wollman Y., Friedman H., Rochkind S. Laulicht L., “Effects of visible and near-infrared lasers on cell cultures,” Journalof Photochemistry & Photobiology 12(3), 305-3 10 (1992).Salansky N., “Low energy photon therapy for wound healing.” Intnl Med Instr, Canadian Defense Ministry, PersonalCommunication. (1998).Schmidt M.H., Bajic D.M., Reichert K.W. II, Martin T.S., Meyer G.A., Whelan H.T., “Light –emitting diodes as a light source forintra-operative photodynamic therapy.” Neurosurg 38(3), 552-556 (1996).Schmidt M.H., Reichert K.W. II, Ozker K., Meyer G.A., Donohoe D.L., Bajic D.M., Whelan N. T., Whelan H. T., “PreclinicalEvaluation of Benzoporphyrin Derivative Combined with a Light-Emitting Diode Array for Photodynamic Therapy ofBrain Tumors.” Pediatr Neurosurg 30, 225-231 (1999).Whelan H.T., Schmidt M.H., Segura A.D., McAuliffe T.L., Bajic D.M., Murray K.J., Moulder J.E., Strother D.R., Thomas J.P., MeyerG.A., “The role of photodynamic therapy in posterior fossa brain tumors: A pre-clinical study in a canine glioma model.”Journal of Neurosurgery 79(4), 562-8 (1993).5Whelan H.T., Houle J.M., Donohoe D.L., Bajic D.M., Schmidt M.H., Reichert K.W., Weyenberg G.T., Larson D.L., Meyer G.A.,Caviness J.A., “Medical Applications of Space Light-Emitting Diode Technology—Space Station and Beyond.” SpaceTech. & App Int’l Forum 458, 3-15 (1999).Yu W., Naim J.O., Lanzafame R.J., “The Effect Of Laser Irradiation On The Release Of bFGF From 3T3 Fibroblasts.”Photochemistry & Photobiology 59, 167-70 (1994).

How Red Light Therapy Combats Arthritis Pain & Stiffness

When it comes to muscle and joint stiffness, osteoarthritis, and arthritis, the one thing in common is pain and inflammation. When suffering from joint and muscular conditions, a person’s range of motion decreases, and swelling and skin redness increase, making everyday tasks a struggle.

Many young to middle-aged people are unaware of these conditions as they’ve been labeled as conditions mainly for the elderly; however, things have changed.

Though these conditions are common within the elderly community, we’re seeing an increase among young adults. In the United States alone, 23% of adults — over 53 million people — have arthritis, according to the Centers for Disease Control and Prevention (CDC). In other words, joint pain isn’t just for old age, as we once thought.

Rheumatoid arthritis (RA) appears in every 8 in 100,000 people between 18 and 34 years old. Of course, no one — young or old — wants to wake up feeling joint stiffness, swelling, or pain every morning.

However, the old myth that arthritis is untreatable is about to be debunked with light therapy.

Naturally, a medical professional will have to make a conclusive arthritis diagnosis. However, once diagnosed, many people find home treatments to deal with the pain — like light therapy. And the people who are undergoing light therapy are receiving incredible pain relief from their treatment. For example, a study published in the Turkish Journal of Physical Medicine and Rehabilitation found that infrared light treatment on inflammatory arthritis of the spine (spondylitis) encouraged increased function and improved quality of life for participants.

But what’s the science behind red light therapy treating joint conditions? Red light therapy uses low levels of red light to stimulate a natural response to cell performance. The light penetrates through the layers of the dermis, entering the muscles and nerves. As the cells absorb the energy, they become more active, with increased blood flow to the treated area, promoting cell regrowth and regeneration. Through this combination of increased blood flow and cellular activity, it rapidly reduces inflammation and pain.

With the recent advancements in modern technology, those who have arthritis or other joint conditions no longer need to opt for nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids. These forms of the medication come with serious side effects such as edema, heartburn, stomach ulcers, cataracts, bone loss, and elevated blood clots. This alternative non-invasive treatment allows people to choose a drug-free treatment that reduces swelling, inflammation, and pain through red light therapy.

A study published in the National Library of Medicine found that elderly patients who underwent red and infrared therapy treatment had reduced their pain by 50%. Besides, they found participants who underwent red and infrared light therapy had a significant improvement in function. Another study from 2016 saw a substantial reduction in pain and an increased range of motion after five to seven red light therapy treatments for Bouchard’s and Heberden’s osteoarthritis. These studies are only a few examples of how red light therapy shows results as an effective treatment.

A little red light can go a long way for your body, mind, and soul. More and more people recognize the benefits of red light therapy as a natural home treatment. For people suffering from any joint condition, red light therapy will reduce inflammation, eliminating joint and muscle pain.

But there’s more to red light therapy than this. It’s important to be reminded that light therapy also heals other ailments in the body. Red light therapy is effective for injuries, muscle recovery, cancer side effects, skincare, and depression.

With an FDA-approved and MDA-certified Lunas red light therapy device, users can achieve optimal therapeutic results by merely exposing their bare skin to the light for a few minutes per day. Healing yourself doesn’t need a lot of time or money; you need the right tools. Lunas light therapy devices have the power to heal bodies and minds all around the world.

Red Light Therapy and Quarantine

If there’s one thing most of us likely haven’t had enough of in 2020, it’s natural light. The pandemic has changed our lives in so many ways, particularly concerning the drastic increase in the amount of time spent indoors and home. Most of us are stationed at our computers all day, only to log off just in time for dinner. At that point, it’s already dark, and we’re likely ready to decompress and relax.

Throw a lockdown on top of this, and we’re lucky if we even get to see the sky that day.

Our current lifestyle, specifically in quarantine, makes natural daylight a rare sight, and this can be extremely detrimental to our mental and physical health — but why?

Without a sufficient amount of light, your circadian rhythm becomes out of sync, as does our hormone production levels. And if you’ve been experiencing poor sleep, lack of light is likely the reason why. A study from the Journal of Clinical Sleep Medicine found that employees who work near windows receive twice as much sunlight as those who don’t receive natural light — they also receive 46 more minutes of sleep on average.

So: darkness isn’t the determiner of sleep; rather, light is.

It’s clear how our daily routines have become more indoors-bound, yet there seems to be no way to reduce these light-limiting circumstances. The lack of sleep disrupted hormones, and constant uncertainty has a severe effect on our bodies, which we’re all experiencing during this time. So, how do we overcome these health concerns with limited options?

This is where red light therapy plays a crucial role in improving health. With the average American spending 90 percent of their time indoors, red light therapy allows you to receive light in your own environment. But just because we’re staying at home due to quarantine doesn’t mean we can’t supplement the natural light we need.

Red light therapy works by increasing energy production at a cellular level. The more energy our cells produce, the better our bodies feel as there’s sufficient blood flow. However, there’s more to it than just feeling good.

For people working in front of the computer all day, carpal tunnel syndrome, muscle fatigue, and arthritis are serious concerns. And since we’re working from home, our screen time has significantly increased. Red light therapy can also alleviate these issues by increasing circulation, repairing tissue, and relieving stiffness.

And while some may have received more natural light during quarantine in the summer, winter is right around the corner. During the winter months, Seasonal Affective Disorder (SAD) affects around 5% of people in general. However, with quarantine, these numbers are increasing. Thankfully, SAD symptoms can be significantly reduced, as light therapy mimics the sun’s light.

With COVID-19, it’s also incredibly difficult to manage mental and emotional health with the current circumstances. Before quarantine, if someone was stressed, they could reduce their symptoms by working out, going to yoga class, or enjoying nature with friends. But these activities have been either eliminated or significantly reduced. So, the reality is that we’re sitting at home all day, stressed, overworked, and fatigued.

Red light therapy is a game-changer for mitigating stress levels, as light cultivates calmness within the body. And since light therapy aids with cell production, it helps the body bounce back after experiencing stress or illness. In these times, red light therapy can aid with stress and help people recover from COVID-19 by reducing lung inflammation, pneumonia, and other acute respiratory disorders.

So although the quarantine presents many new challenges, we can be empowered to control our own health and wellness during these times. At Lunas, we’re passionate about helping people achieve their balance and intend to have our light panels in homes around the world, particularly during this challenging period. We hope to help everyone around the world find their light — literally!



Light and the Moon

The moon shines because its surface reflects light from the sun. And even though it sometimes seems to shine very brightly, the moon reflects only between 3 and 12 percent of the sunlight that hits it.

The moon’s perceived brightness from Earth depends on where the moon is in its orbit around the planet. The moon travels once around Earth every 29.5 days, and during its journey, it’s lit from varying angles by the sun.

This moon’s movement around the Earth — and the simultaneous orbiting of Earth around the sun — account for the moon’s different phases (full moon, quarter moon, etc.). At any given point in the moon’s trajectory around the Earth, only half of its surface is facing the sun, and therefore, only half of the moon is lit up. The other half of the surface faces away from the sun and is in shadow.

Now, I took my first moonlight photograph in 1998, using my father’s old Kodak camera. The results were almost invisible, of course. It was pretty clear that I had no idea what I was doing. But I did know that the feeling of being out under the stars was one that I needed to capture somehow, and I had to find a way to go about doing it.

I left the moonlight photography for a while. Some years later, I read that the brightness of moonlight is extremely variable over a range of many stops and that it was nearly impossible to figure out the brightness of a given scene was going to be ahead of time. The brightness of moonlight under clear skies is as easily predictable as is the brightness of sunlight under similar conditions.

Several things cause moonlight brightness to vary. The most obvious is the moon’s phase. The brightness of moonlight varies by approximately a factor of 10 between the quarter phase and full moon, based on a diffuse reflection and the geometry of the positions of the earth, sun, and moon alone. This is about three and a half stops of light, which is substantial. Another factor is the distance between the earth, moon, and sun, which changes due to the earth and lunar orbits not being perfect circles. The distance from the earth to the sun varies from 0.9833 Astronomical Units at perihelion to 1.0167 Astronomical Units at aphelion. The earth’s distance to the moon varies from 356,400 kilometers at extreme perigee to 407000 kilometers at extreme apogee. The amount of light that falls on a body varies with the inverse square of the distance from the light source, so the combined effect of these distance variations can be quite pronounced. The range of lunar illumination variation is 6.9% for variation in sun distance and 30% for moon distance variation. This amounts to about one-third stop of brightness, which enough to change the mood of a photo when slide films are used.

The third factor in moonlight brightness is the so-called opposition effect. The surface of the moon is covered with small glassy particles that can serve as wonderful retro-reflectors. If you are within a small angle to the line between the sun and moon, the amount of light coming from the moon increases dramatically relative to what you would expect from a diffuse reflection alone. There is quite a range in the magnitude of this effect presented in scientific literature, ranging from a factor of 1.35 to 20! Whatever value you choose to use, the effect is at least one-third stop of light, making it significant to use slide film.

The final parameter that introduces variation into moonlight brightness is atmospheric attenuation, or atmospheric extinction, to use astronomer’s jargon. This accounts for the amount of light absorbed or scattered when light from the moon passes through the earth’s atmosphere. There are two factors involved: the amount of reduction per a given amount of air transited by the light (the “extinction coefficient”) and the amount of air in the light path (“air mass”). Three principal phenomena contribute to the extinction coefficient: molecular absorption, molecular (Rayleigh) scattering, and aerosols’ scattering (particles larger than molecules). See my web page on atmospheric attenuation for more on these individual factors. Overall, an extinction coefficient value is small for dry, clear air but can be huge for moist, dusty air. And the amount of air the light passes through can vary from one “air mass” with the moon directly above you to forty “air masses” when the moon is on the horizon.

So how bright can moonlight be? The brightest moonlight occurs with the moon at perigee and the earth at perihelion, right at the full moon phase. You can never have the moon at its theoretically fullest phase, right opposite the earth from the sun, because whenever the moon goes there, it enters the earth’s shadow, and we get a lunar eclipse! But assuming the eclipse didn’t happen, we could assume the following: a phase angle of zero, apparent air with an “extinction coefficient” of 0.11 magnitudes per air mass, the moon on the zenith so that the moonlight passes through a single “air mass,” the brightness would be 0.0462-foot-candles (LV -2.0), neglecting “the opposition effect.” If we include “the opposition effect,” the brightness could be anywhere from 35% to 20 times brighter (note that 35% is the more accepted value in the scientific literature, which would give an LV of -1.7). I once measured moonlight brightness with a Gossen Luna-Pro incident light meter in mid-winter on the Kelso Dunes at LV=-2.2, so this is a believable result.

There is a rule of thumb, sometimes called the Looney 11 Rule, which says we should treat the moon as being 250,000 times dimmer than the sun. This would have us use a shutter speed 18 stops slower than the 1/(film speed) value that is used in the “Sunny 16 Rule”, which works out to about 44 minutes at f/16 under moonlight conditions with the film having an ISO speed rating of 100 (uncorrected for reciprocity failure!). This is close enough to be useful under full moonlight conditions given an average earth-moon and earth-sun distance, with the moon high in the sky and clear air. Actually, since the sun has an astronomical visual magnitude of -26.74 and the full moon an astronomical visual magnitude of -12.73, the sun is more like 402,000 times brighter than the moon 18.6 stops. Thus using this rule pretty much ensures a minimum of 2/3 stop underexposure — which may actually be fine, since most of the time you want an underexposure to give the impression of the night in the image.

Surprisingly, the moonlight is actually a slightly warmer color than sunlight, as the moon reflectance is higher for longer wavelengths. Yet, on clear nights, with the full moon high in the sky (as little atmospheric influence as possible), the landscape around us appears blueish because of the Purkinje effect: at low illumination levels, our red color sensitivity decreases (as our vision system gradually switches from daylight (cones) to night time vision (using rod cells)).

That’s why the sunlight looks “warm” (more yellow), and the moonlight looks “cold” (bluer — because the insufficient light level changes our color perception), even though the real colors are pretty much the same.

In fact, this is can even become a real problem when taking very long exposure photos at night! They look almost like daylight photos, destroying the intended atmosphere of mystery. Objectively, the photograph is correct, but it is not what we see with our own eyes. Add some blue tint and the night feeling is back.

References

The Sun and Us

Nothing is more important to us on Earth than the Sun. Without the Sun’s heat and light, the Earth would be a lifeless ball of ice-coated rock. The Sun warms our seas, stirs our atmosphere, generates our weather patterns, and gives energy to the growing green plants that provide the food and oxygen for life on Earth.

We know the Sun through its heat and light, but other, less obvious aspects of the Sun affect Earth and society. Energetic atomic particles and X-rays from solar flares and other disturbances on the Sun often affect radio waves traveling the Earth’s ionosphere, causing interference and even blackouts of long-distance radio communications. Disturbances of the Earth’s magnetic field by solar phenomena sometimes induce huge voltage fluctuations in power lines, threatening to blackout cities. Even such seemingly unrelated activities as the flight of homing pigeons, transatlantic cable traffic, and the control of oil flow in the Alaska pipeline apparently are interfered with by magnetic disturbances caused by events on the Sun. Thus, understanding these changes — and the solar events that cause them — is important for scientific, social, and economic reasons.

We have long recognized the importance of the Sun and watched it closely. Primitive people worshiped the Sun and were afraid when it would disappear during an eclipse. Since the early seventeenth century, scientists have studied it with telescopes, analyzing the light and heat that manage to penetrate our absorbing, turbulent atmosphere. Finally, we have launched solar instruments and ourselves-into space to view the Sun and its awesome eruptions in every aspect.

Once we looked at the Sun by the visible light that reached the ground, it seemed an average, rather stable star. It was not exactly constant, but it seemed to vary in a fairly regular fashion, with a cycle of sunspots that comes and goes in about eleven years. Now the Space Age has given us an entirely different picture of the Sun. We have seen the Sun in other forms of light-ultra violet, X-rays, and gamma rays that never reach the ground from space. This radiation turns out to be far more responsive to flare eruptions and other so-called solar activity.

We now see the Sun as a place of violent disturbances, with wild and sudden movements above and below its visible surface. Besides, solar activity's influence seems to extend to much greater distances than we had believed possible. New studies of long series of historical records reveal that the Sun has varied in the past in strange and unexplained ways. Scientists wonder how such variations might affect the future climate on Earth.

We have obtained a clearer picture of the scope of the Sun’s effects. Its magnetic field stretches through interplanetary space to the outer limits of the solar system. Steady streams and intense storms of atomic particles blow outward from the Sun, often encountering our Earth's atmospheres and the other planets. The spectacular photos of the Earth from space show only part of the picture. Instruments carried on satellites reveal a wide variety of invisible phenomena — lines of magnetic force, atomic particles, electric currents, and a huge geocorona of hydrogen atoms — surrounding the Earth. Each is as complex and changing as the visible face of the globe. The Earth’s magnetic field extends tens of thousands of miles into space, and many different streams of electrons and protons circulate within it. Huge electric currents flow around the Earth, affecting their high-altitude surroundings as well as our environment at ground level.

Space observations have greatly expanded our ability to look at the Sun, interplanetary space, and the Earth's immediate surroundings. We can now “see” many phenomena that are completely undetectable from the Earth’s surface, and we now have a much better, more complete, and more coherent picture of how events in one part of our solar system relate to activity in another.

The Sun as a Star

We sometimes forget that there is one star that is easily visible in the day time: our Sun. The Sun is the only star close enough to be studied in detail, but we are confident that all the processes in the Sun must also occur in billions of distant stars throughout the universe. To understand the nature and behavior of other stars, we must first understand our own. At the same time, observations of other kinds of stars help put the Sun in perspective.

The Sun is a relatively typical star among the approximately 100 billion stars in our Milky Way galaxy. The masses of most other stars that we see range from approximately one-tenth of the mass of the Sun to about 30 solar masses. The surface temperatures of most stars range from about 2000° C to 40,000° C. Although the Sun is somewhat on the cool side at about 6000° C, hot stars are rare, and most normal stars are cooler than the Sun. Compared to some of the explosive stars — novae, and supernovae — which sometimes appear in the sky, the Sun is stable and ordinary.

This long-term stability of our Sun probably was crucial for the development of life on Earth. Biologists believe that a relatively stable average temperature had to prevail on Earth during the past 3 billion years for life to evolve to its present state. The relative stability of the Sun is also important to astronomers trying to understand the basic nature of it and other stars. Violent activity in the Sun could mask the more subtle and long-enduring processes, which are the basic energy transport mechanisms of our star. Fortunately, they are not hidden, and we have been able to map the trend in solar properties with height above the visible surface.

Above the minimum temperature region in the photosphere, we have measured how the gas gets hotter as it thins out with height. The chromosphere and corona, each hotter than the layer below, are warmed by the transfer of energy from below through processes that are still not well understood.

Until space observations became possible, we knew nothing about coronae in any other stars and had only marginal information about stellar chromospheres' properties. Now, space observations have shown us that a large fraction of the stars in the sky have chromospheres and coronae.

On several dozen stars, we have even detected activity that may be connected with sunspot (or “starspot”) cycles like those of our own Sun. X-ray telescopes carried on satellites have recorded flares in other stars that are far more powerful than the already impressive flares of the Sun. By observing the strength and frequency of these events on stars with masses, ages, and rotation rates which differ from those of the Sun, we search for answers to such basic questions as: “How does the sunspot cycle period depend on the star’s rotation rate?” or “What is the relation between the temperature of a star’s corona and the strength of its magnetic field?” By deciphering the general pattern of stellar properties, we can better understand what makes things happen on the Sun.

The Sun presents us with a bewildering variety of surface features, atmospheric structures, and active phenomena. Sunspots come and go. The entire Sun shakes and oscillates in several different ways at the same time. Great eruptions called prominences hang high above the Sun’s surface for weeks, suspended by magnetic force, and sometimes shoot abruptly into space from the corona. The explosions called solar flares emit vast amounts of radiation and atomic particles in short periods of time, often with little or no warning.

Space observations have discovered many new aspects of solar events hidden from ground-based observatories—the Sunshine's hottest spots primarily in ultraviolet and X-rays, rather than in visible light. Thus, only from space can we map high-temperature solar flares' true structure and determine their physical conditions. Space observatories have shown us the higher, hotter layers of the Sun’s atmosphere that normally are invisible from the ground. Instruments on satellites revealed that in flares and other violent disturbances, the Sun acts like an atomic accelerator, driving electrons and protons to velocities approaching the speed of light. At such high speeds, the particles emit the high-energy X-rays and gamma rays measured by our satellites. Sometimes they even induce nuclear reactions on the surface of the Sun.

Two aspects of our improved knowledge of the Sun deserve special attention. One is the role of magnetic fields in determining virtually all aspects of the Sun’s upper atmosphere's structure and behavior. The other is discovering the solar wind, a stream of atomic particles that constantly evaporate from the Sun’s atmosphere and are accelerated to speeds of hundreds of kilometers per second, escaping into space in all directions.

The Earth-Sun Battle

For any solar particle to reach the Earth, it must first pass through the Earth’s magnetic field. Before the solar wind was discovered, the Earth’s field was thought to be symmetrical, resembling a huge bar magnet, fading off indefinitely into space. However, we now know that the solar wind shapes the Earth’s magnetic field's outer regions and is sharply bounded. Outside the boundary, space is dominated by the solar wind and the interplanetary magnetic field. Inside the boundary is the region or magnetosphere dominated by the Earth’s magnetic field. The measurements from many space missions have been combined to reveal that the solar wind blows out the Earth’s magnetosphere into a teardrop shape. The head of the drop extends only about 10 Earth radii, or about 65,000 kilometers (40,000 miles) “upwind” toward the Sun. The tail of the drop stretches away in the direction opposite the Sun, actually reaching beyond the Moon’s orbit. This long magnetotail extends more than 600,000 kilometers (370,000 miles) from the Earth.

At the boundary of the magnetosphere, there is a constant struggle between the Earth's magnetic field and the forces of the Sun. Buffeted by fluctuations in the solar wind velocity and density, the magnetosphere’s size and shape are continuously changing. When the solar wind strikes the magnetosphere, shock waveforms are analogous to the sonic boom preceding a supersonic airplane. Inside the boundary with the solar wind, the magnetosphere remains an active region. It contains two belts of very energetic charged atomic particles trapped in the Earth’s magnetic field hundreds of miles above the atmosphere. These belts were discovered by Professor James Van Allen of the University of Iowa and his colleagues in 1958, using simple radiation detectors carried by Explorer 1, the first U.S. satellite.

The Northern and Southern Lights: Gifts from the Sun

The structure of the Earth’s magnetosphere also controls aurorae's behavior, seen in our night skies. Pre-Space Age textbooks stated that aurorae are produced by photons emitted from the Sun and reach the Earth’s upper atmosphere through gaps in the Earth’s magnetic field at the north and south magnetic poles. According to the theory, these protons strike oxygen atoms in the atmosphere, and the collisions cause the glow, which we call the Northern Lights.

This view has changed in the Space Age. The data collected by many spacecraft showed that the situation is more complicated. Particles from both the solar wind and from the Earth’s atmosphere apparently are stored in the magnetotail. From there, they periodically are violently ejected into the northern and southern polar regions of the atmosphere along the Earth’s magnetic field. They are accelerated to high speeds by a process not yet fully explained. The magnetotail is, in effect, a reservoir of particles that is periodically refilled. When the Sun is active during maximum sunspot years, this process is especially intense and frequent, and the aurorae are brighter and move closer to the equator.

Bipolar Disorder & Light Therapy

I have a friend who often shows extreme shifts in moods. Sometimes I see an extremely elevated mood, and sometimes, it's depression. On some days, I see episodes of uplifted feelings and depression at the same time.

Strange right!

Later I figured out that she was going through a mental illness called bipolar disorder. This isn’t a rare brain disorder. In fact, about 15 million U.S adults suffer from this disorder.

Bipolar disorder is a mental illness characterized by dramatic transfer in mood and behavior. Bipolar depression can last from several days to years, depending on the person's type and state.

Let’s put light on some of the unknown facts of Bipolar Disorder.

  • Firstly we need to understand that bipolar depression has several types. It is distinguished by profuse behaviors, moods, depression, and, yes, mixed emotions. The symptoms of this illness can present at different severities and in many combinations in different people. So, it may not be the same for every person who has Bipolar disorder.

We basically classify the states into two broad classes:

  • Manic — overly elevated emotions, increase in energy, higher self-confidence, and decreased need for sleep.
  • Depression — sad, worthless, suicidal, low feelings
  • It is possible that people can experience symptoms of mania and depression at the same time.
  • The length of mood episodes and varying behavior can vary from person to person.
  • There is no known single cause of this mental illness.
  • Not only adults but children and teenagers can have bipolar disorder too.
Light Therapy — the Bipolar Disorder Soother!

If we compare other types of depression, there are fewer treatments available for bipolar disorder.

Hence, it is important to find an effective treatment for your illness.

Antidepressant medications, on the other hand, are not clearly effective. They may aggravate the mood cycling in people with bipolar disorder. Also, many people with bipolar disorder are prescribed to take other medications like mood stabilizers.

That’s why it is important to go for a non-medication treatment, like light therapy!

But why is it recommended? Light therapy is more effective, non-invasive, and absolutely safe because it can be used without worrying about additional drug interactions.

But How Light Therapy Helps?

Humans have natural 24-hour clocks, which are disrupted in bipolar disorder. One way of treating bipolar disorder is to handle the circadian rhythm (24*7 natural cycle that regulates the physical, mental, and behavior changes). And this can be achieved with bright light therapy.

The light emitted during light therapy activates the retina in the eye, resulting in a stimulus being transmitted from the eye to the brain's hypothalamus. The hypothalamus is a part of the brain that has a vital role in regulating mood. It also helps control many bodily functions, such as the release of hormones from the pituitary gland and channelizing the mood.

The light acts through the eyes to regulate the biological clock located in a tiny brain region. There are disturbances in the biological clock that affect circadian rhythms in people with bipolar disorder, including hormonal rhythms, sleep, feelings, cognition, and other behaviors.

Light therapy triggers the hypothalamus and helps bipolar patients to calm their emotional flow and have normal behavior.

Studies have shown that light can affect the major neurotransmitters, or chemical messengers, involved in mood and behavior, e.g., serotonin and dopamine. So, light therapy may act similarly to antidepressants by directly working on these neurotransmitters.

We found trials of light therapy compared to a placebo in people with bipolar depression. The studies' results displayed a significant improvement in depressive symptoms with bright light compared to placebo conditions.

I recommended my friend to you light therapy, and that really helped her. The quality of personal life is great since then. If you are also like my friend who is dealing with bipolar disorder, you possibly got the remedy.

Remember, your Mental Health matters!!

References:

Brainwaves - Get to Know your Brain

Brain waves are oscillating electrical voltages in the brain, measuring just a few millionths of a volt. At the root of all our thoughts, emotions, and behaviors are the communication between neurons within our brains. Brainwaves are produced by synchronized electrical pulses from masses of neurons communicating with each other.

Brainwaves are detected using sensors placed on the scalp. They are divided into bandwidths to describe their functions but are the best thought of as a continuous spectrum of consciousness, from slow, loud, and functional — to fast, subtle, and complex.

It is a handy analogy to think of brainwaves as musical notes — the low-frequency waves are like a deeply penetrating drum beat, while the higher frequency brainwaves are more like a subtle high pitched flute. Like a symphony, the higher and lower frequencies link and cohere with each other through harmonics.

Our brainwaves change according to what we’re doing and feeling. When slower brainwaves are dominant, we can feel tired, slow, sluggish, or dreamy. The higher frequencies are dominant when we feel wired or hyper-alert.

The descriptions that follow are only broad descriptions — in practice, things are far more complex, and brainwaves reflect different aspects of different locations in the brain.

Brainwave speed is measured in Hertz (cycles per second), and they are divided into bands delineating slow, moderate, and fast waves.

Infra-low (

Infra-Low brainwaves (also known as Slow Cortical Potentials) are thought to be the basic cortical rhythms that underlie our higher brain functions. Very little is known about infra-low brainwaves. Their slow nature makes them difficult to detect and accurately measure, so few studies have been done. They appear to play a major role in brain timing and network function.

Delta (δ) Waves (0.5 TO 4HZ) — Sleep

Delta brainwaves are slow, loud brainwaves (low frequency and deeply penetrating, like a drumbeat). They are generated in deepest meditation and dreamless sleep. Delta waves suspend external awareness and are the source of empathy. Healing and regeneration are stimulated in this state, and that is why deep restorative sleep is so essential to the healing process.

Theta (θ) Waves (4 TO 8 HZ) — Deeply Relaxed, Inward-focused

Theta brainwaves occur most often in sleep but are also dominant in deep meditation. Theta is our gateway to learning, memory, and intuition. In theta, our senses are withdrawn from the external world and focused on signals originating from within. Twilight states that we normally only experience fleetingly as we wake or drift off to sleep. In theta, we dream; vivid imagery, intuition, and information beyond our normal conscious awareness. It’s where we hold our ‘stuff,’ our fears, troubled history, and nightmares.

Alpha (α) Waves(8 TO 12 HZ) — Very relaxed, Passive Attention

Alpha brainwaves are dominant during quietly flowing thoughts and in some meditative states. Alpha is ‘the power of now,’ being here, in the present. Alpha is the resting state of the brain. Alpha waves aid overall mental coordination, calmness, alertness, mind/body integration, and learning.

Beta (β) Waves(12 TO 35 HZ) — Anxiety dominant, Active, External Attention

Beta brainwaves dominate our normal waking state of consciousness when attention is directed towards cognitive tasks and the outside world. Beta is a ‘fast’ activity, present when alert, attentive, engaged in problem-solving, judgment, decision making, or focused mental activity.

Beta brainwaves are further divided into three bands; Lo-Beta (Beta1, 12–15Hz) can be thought of as a ‘fast idle’ or musing. Beta (Beta2, 15–22Hz) is the high engagement or actively figuring something out. Hi-Beta (Beta3, 22–38Hz) is a highly complex thought, integrating new experiences, high anxiety, or excitement. Continual high-frequency processing is not a very efficient way to run the brain, as it takes a tremendous amount of energy.

Gamma (γ) Waves(35 TO 42 HZ) — Concentration

Gamma brainwaves are the fastest brain waves (high frequency, like a flute) and relate to the simultaneous processing of information from different brain areas. Gamma brainwaves pass information rapidly and quietly. The most subtle of the brainwave frequencies, the mind has to be quiet to access gamma.

Gamma was dismissed as ‘spare brain noise’ until researchers discovered it was highly active in states of universal love, altruism, and the ‘higher virtues.’ Gamma is also above the frequency of neuronal firing, so how it is generated remains a mystery. It is speculated that gamma rhythms modulate perception and consciousness and that a greater presence of gamma relates to expanded consciousness and spiritual emergence.

New Trial to Test Brain Wave Stimulation as Alzheimer’s Preventative

With a new $1.8 million grant from the Part the Cloud-Gates Partnership Grant Program of the Alzheimer’s Association, researchers at Massachusetts Institute of Technology and Massachusetts General Hospital are launching a new clinical trial to test whether stimulating a key frequency of brain waves with light and sound can prevent the advance of Alzheimer’s disease pathology even before volunteers experience symptoms such as memory impairment.

“Because Alzheimer’s disease leads to neurodegeneration and cognitive decline, the best time for intervention may be before those symptoms even begin,” said Dr. Li-Huei Tsai, Picower Professor of Neuroscience and director of The Picower Institute for Learning and Memory at MIT. “We are hopeful that our safe, non-invasive approach of sensory stimulation of 40Hz gamma brain rhythms can have a preventative benefit for patients. We are very grateful to Part the Cloud-Gates Partnership Grant Program for their support in funding rigorous research to test this exciting possibility.”

In extensive testing in Tsai’s lab with multiple mouse models of Alzheimer’s, the light and sound stimulation technique, called Gamma ENtrainment Using Sensory Stimuli (GENUS), improved cognition and memory, prevented neurodegeneration, and reduced amyloid and tau protein buildups. The research showed that increasing 40Hz brain rhythm power and synchrony stimulated the brain’s immune cells and blood vessels to clear out the toxic proteins. Early results from human testing at MIT show that GENUS is well tolerated and increases 40Hz power and synchrony, just like in the mice.

The new study, conducted in collaboration with neurologist Dr. Keith Johnson at MGH, will enroll 50 volunteers aged 55 or older who show signs of amyloid protein plaque buildup in PET scans but remain cognitively normal. Experimental volunteers will receive an hour of GENUS light and sound stimulation in their homes daily for a year. At regular checkups, the team will monitor GENUS's effect on amyloid buildup via PET scans as well as other biomarkers such as tau and for changes in cognition, sleep, structural and functional MRI, and other indicators of brain function and health.

The trial will be double-blinded, randomized, and controlled, meaning that some volunteers will be exposed to non-GENUS light and sound during the trial to provide a non-treatment comparison group. To ensure that bias does not influence the results, neither the volunteers nor the experimenters will know which group's volunteers are.

References

https://picower.mit.edu/news/new-trial-test-brain-wave-stimulation-alzheimers-preventative

https://brainworksneurotherapy.com/what-are-brainwaves

Muse - The Brain Sensing Headband

Overview

Muse is a wearable device in the form of a headband that senses the brain's electrical rhythms (EEG). The headband is coupled with a smartphone app (Calm) that monitors the user’s brain electrical activity and gives immediate feedback to achieve a “calm” or meditative pattern. Over time, the use of this device is thought to help reduce distractibility, improve stress control, and improve mood.

Use

The headband is light and comfortable but requires a bit of experience to fit properly and to transmit reliable signals by BlueTooth to the associated smartphone app. The device will not work with older versions of many smartphones (such as the iPhone 4). The instructions for use are straightforward and easy to follow, and the program is up and running within minutes. Once one gets started, it is straightforward to adjust settings and to personalize the program.

UI

The user is asked to sit quietly with eyes closed and to focus on counting expirations. The app displays one of two pleasant visual backgrounds associated with wind or water sounds. The volume and frequency of these weather sound decrease as the EEG rhythm become the “calm” state. Therefore, one gets immediate and easy to understand feedback as to how one is doing. The sessions can be set to last from 3 minutes to 45 minutes.

Appropriateness

Immediately after finishing a session, the app provides a graphical depiction of one’s EEG rhythm, grouped into “calm,” “neutral,” or “active” bands. The app calculates the amount of time spent “calm” and awards points for “calm” time. The points are associated with certain awards and expressions of positive feedback. Besides, the app graphically displays the percentage of time spent “calm” over variations and prescribes several challenges to increase time performance. All times performance of this is lovely and easy to understand and to manipulate.

Account Management

The company’s website provides a great deal of information regarding frequently asked questions and troubleshooting. When I submitted a question to the company over the website, I received an answer within hours. The app allows one to permit for session data to be aggregated by the company for research purposes. I think it is useful to share personal data because they may ultimately determine how effective the device might be.

Scientific Basis

The Muse headband is a remarkable technological advance over earlier versions of EEG neurofeedback technologies. Neurofeedback is a technique that has been employed for mental health conditions for more than a decade and formerly required a link between traditional EEG recording devices with desktop or laptop computers. Through operant conditioning, these techniques seek to alter brain functioning by giving live feedback about EEG rhythms to the patient. Patients are rewarded if they can achieve certain EEG rhythm characteristics, such as decreased theta activity (4–7 cycles per second) or an increase in alpha activity (12–15 cycles per second). A higher proportion of alpha wave activity is thought to be associated with focused attention and a feeling of calm or well-being.

Traditional neurofeedback techniques have never been fully tested in psychiatric conditions for several reasons. First, these techniques are not protected by exclusive intellectual property, so industrial funding for large-scale trials has not been available. Similarly, devices designed to deliver neurofeedback have not been seen as unique medical devices by the FDA, which could be protected by patents. Furthermore, there is some disagreement about which pattern of EEG rhythms would be most therapeutic for particular groups of patients. I was not able to locate references to clinical trials using Muse technology specifically.
Although not formally approved for clinical use by the FDA, many clinics currently offer neurofeedback treatments. However, widespread clinical adoption of neurofeedback has not occurred due to concerns about cost relative to the uncertainties about efficacy. Most protocols recommended that individuals come to a supervised clinical setting for multiple sessions per week over several months. This is a time consuming and expensive endeavor which, due to lack of published scientific data on efficacy, is not reimbursed by insurance companies. With the Muse technology, EEG neurofeedback has entered the world of self-directed activity using a wearable device coupled with a smartphone app. Therefore, the cost is much reduced, and it becomes feasible to decide individually whether the techniques are a worthwhile investment of time.

Cost

The Muse headband costs $299, and the app is free. This appears to be a very reasonable cost, given the complexity of the technology and the amount of information obtained with its use.

Reviewed April 2015

References
  • ADHD
    Neurofeedback has been studied most extensively in Attention Deficit Hyperactivity Disorder, for which at least 5 randomized controlled trials with mixed results have been published.
    Bink M, van Nieuwenhuizen C et al: Neurocognitive effects of neurofeedback in adolescents with ADHD: A randomized controlled trial. J Clin Psychiatry 75:535–542, 2014
  • Major Depression
    Peeters F, Oehlen M, et al.: Neurofeedback as a treatment for the major depressive disorder — a pilot study. PLoS One. 2014 Mar 18;9(3):e91837. DOI: 10.1371/journal.pone.0091837. eCollection 2014
  • Performance Anxiety
    Gruzelier JH, Thompson T et al: Application of alpha/theta neurofeedback and heart rate variability training to young contemporary dancers: state anxiety and creativity. Int J Psychophysiol 93:105–111, 2014
  • Obsessive-Compulsive Disorder
    Koprivova J, Congedo M et al: Prediction of treatment response and the effect of independent component neurofeedback in obsessive-compulsive disorder: a randomized, sham-controlled, double-blind study. Neuropsychology 67:210–223, 2013
  • Reading Disabilities
    Nazari MA, Mosanezhad E et al.: The effectiveness of neurofeedback training on EEG coherence and neuropsychological functions in children with reading disability. Clin EEG Neurosci, 43:315–322, 2012
  • Autism Spectrum Disorders
    Kouijzer ME, van Schie HT et al.: Is EEG-biofeedback an effective treatment in autism spectrum disorders? A randomized controlled trial. Appl Psychophsiolo Biofeedback 38:17–28, 2013
  • Traumatic Brain Injury
    Nelson DV, Esty ML: Neurotherapy of traumatic brain injury/posttraumatic stress symptoms in OEF/OIF veterans. J Neuropsychiatry Clin Neurosci 24:237–240, 2012
  • Insomnia
    Hammer BU, Colbert AP, et al.: Neurofeedback for insomnia: a pilot study of Z-score SMR and individualized protocols. Appl Psychophysiol Biofeedback 36:251–264, 2011.
  • Several other studies have proposed benefits in cognitive performance for normal subjects or in meditators.
  • Gruzelier JH: EEG-neurofeedback for optimizing performance. I: A review of cognitive and affective outcomes in health participants. Neuroscience and Biobehavioral Reviews 44:124–141, 2014
  • Ros T, Munneke MAM, Ruge D, Gruzelier JH, and Rothwell JC: Endogenous control of waking brain rhythms induces neuroplasticity in humans. European Journal of Neuroscience, 31:770–778, 2010
  • Vidyarthi J and Riecke BE: Interactively mediating experiences of mindfulness meditation. International Journal of Human-Computer Studies 72:674–688, 2014


Hyperbaric Chambers - Oxygen Therapy

Hyperbaric Oxygen Therapy

Hyperbaric oxygen therapy involves breathing pure oxygen in a pressurized environment. Hyperbaric oxygen therapy is a well-established treatment for decompression sickness, potential risk of scuba diving. Other conditions treated with hyperbaric oxygen therapy include serious infections, bubbles of air in your blood vessels, and wounds that may not heal due to diabetes or radiation injury.

In a hyperbaric oxygen therapy chamber, the air pressure is increased two to three times higher than normal air pressure. Under these conditions, your lungs can gather much more oxygen than would be possible breathing pure oxygen at normal air pressure.

When your blood carries this extra oxygen throughout your body, this helps fight bacteria and stimulate the release of substances called growth factors and stem cells, which promote healing.

Your body’s tissues need an adequate supply of oxygen to function. When tissue is injured, it requires even more oxygen to survive. Hyperbaric oxygen therapy increases the amount of oxygen your blood can carry. With repeated scheduled treatments, the temporary extra high oxygen levels encourage normal tissue oxygen levels, even after the therapy is completed.

Hyperbaric oxygen therapy is used to treat several medical conditions. And medical institutions use it in different ways. Your doctor may suggest hyperbaric oxygen therapy if you have one of the following conditions:

  • Severe anemia
  • Brain abscess
  • Bubbles of air in your blood vessels (arterial gas embolism)
  • Burns
  • Carbon monoxide poisoning
  • Crushing injury
  • Deafness, sudden
  • Decompression sickness
  • Gangrene
  • Infection of skin or bone that causes tissue death
  • Non-healing wounds, such as a diabetic foot ulcer
  • Radiation injury
  • Skin graft or skin flap at risk of tissue death
  • Traumatic brain injury
  • Vision loss, sudden and painless
Risks

Hyperbaric oxygen therapy is generally a safe procedure. Complications are rare. But this treatment does carry some risk.

Potential risks include:

  • Middle ear injuries, including leaking fluid and eardrum rupture, due to changes in air pressure
  • Temporary nearsightedness (myopia) caused by temporary eye lens changes
  • Lung collapse caused by air pressure changes (barotrauma)
  • Seizures as a result of too much oxygen (oxygen toxicity) in your central nervous system
  • Lowered blood sugar in people who have diabetes treated with insulin
  • In certain circumstances, fire — due to the oxygen-rich environment of the treatment chamber.
How to Prepare

You’ll be provided with a hospital-approved gown or scrubs to wear in place of regular clothing during the procedure.

For your safety, items such as lighters or battery-powered devices that generate heat are not allowed into the hyperbaric chamber. You may also need to remove hair and skin care products that are petroleum-based, as they are a potential fire hazard. Your health care team will provide instruction on preparing you to undergo hyperbaric oxygen therapy.

During Hyperbaric Oxygen Therapy

Hyperbaric oxygen therapy is typically performed as an outpatient procedure but can also be provided while hospitalized.

In general, there are two types of hyperbaric oxygen chambers:

  • A unit designed for 1 person. In an individual (monoplace) unit, you lie down on a table that slides into a clear plastic chamber.
  • A room designed to accommodate several people. In a multi-person hyperbaric oxygen room — which usually looks like a large hospital room — you may sit or lie down. You may receive oxygen through a mask over your face or a lightweight, clear hood placed over your head.

Whether you’re in an individual or multi-person environment for hyperbaric oxygen therapy, the benefits are the same.

During therapy, the room's air pressure is about two to three times the normal air pressure. The increased air pressure will create a temporary feeling of fullness in your ears — similar to what you might feel in an airplane or at a high elevation. You can relieve that feeling by yawning or swallowing.

For most conditions, hyperbaric oxygen therapy lasts approximately two hours. Members of your health care team will monitor you and the therapy unit throughout your treatment.

After Hyperbaric Oxygen Therapy

Your therapy team assesses you, including looking in your ears and taking your blood pressure and pulse. If you have diabetes, your blood glucose is checked. Once the team decides you are ready, you can get dressed and leave.

You may feel somewhat tired or hungry following your treatment. This doesn’t limit normal activities.

Conclusions

To benefit from hyperbaric oxygen therapy, you’ll likely need more than one session. The number of sessions is dependent upon your medical condition. Some conditions, such as carbon monoxide poisoning, might be treated in three visits. Others, such as non-healing wounds, may require 40 treatments or more.

To effectively treat approved medical conditions, hyperbaric oxygen therapy is usually part of a comprehensive treatment plan provided with other therapies and drugs designed to fit your individual needs.

Light Therapy — Wound Healing in Horses

LED light therapy is really a way to help the body heal itself. In Kaiyan, we have used specific wavelengths of light absorbed by a photo acceptor, cytochrome c oxidase, within the cell's mitochondria. The energy (photons) from the lights increases the energy within the cell, which speeds up the healing process. The lights must be specific wavelengths and must be delivered at a specific dosage. We use two wavelengths in our light therapy pads, a visible red and a near-infrared wavelength. Using both red and near-infrared lights is beneficial because different depths of tissue absorb the wavelengths. The combination of the two work in concert to provide benefits for soft tissue injuries, inflammation, ligament soreness, tendon problems, sore backs, splints, strains, stifle issues, sprains, swelling, shoulder pain, hip pain, sore backs, sore necks, salivary gland problems, wounds, cuts, scrapes, arthritis pain and for trigger points and acupuncture points. Visible red light (660nm) is absorbed by skin layers very efficiently and best for uses such as stimulating trigger and acupuncture points and treating wounds and infections. Near-infrared light (850nm) penetrates to a deeper level has been used to treat concerns of tendons, ligaments, bones, joints, and muscle.

When nursing skin wounds of horses, such as lacerations or deep abrasions, owners often seek ways to maximize healing and minimize scarring, particularly when high-motion areas are involved.

“In horses, dermal injuries can be slow to heal, cause excessive scarring, and prolong a horse’s layup. In some cases, especially wounds of the limbs, proud flesh may develop in response to exuberant healing efforts,”

Said Catherine Whitehouse, M.S., an advisor for Kentucky Equine Research.

Medical-grade honey, fly larvae, and other strategies have been tested to speed wound healing. Most recently, Swedish researchers explored the use of irradiation with light-emitting diodes (LEDs), called photobiomodulation, in jump-starting wound repair. The LED used in the study features a pulsating visible red light and near-infrared (NIR) light.

“Some research shows that LEDs stimulate wound healing and decrease swelling and inflammation. With this in mind, veterinarians were hopeful that low-level light treatment could expedite wound repair in horses,” Whitehouse explained.

In this study, researchers created two circular skin wounds on the necks of eight healthy horses. One wound was treated with a combination of red light and NIR light for 4 minutes and 40 seconds on specific treatment days during the 25-day study period. The other wound on each horse remained untreated. The researchers photographed and assessed the wounds for the degree of swelling using ultrasound.

Area and degree of swelling did not differ between treated and untreated wounds, prompting researchers to conclude that red light and NIR light had no clinically relevant positive effect on horses' wound healing.

A veterinarian should examine all significant wounds. Extensive wounds with significant blood loss or tissue damage should be considered medical emergencies.

*Michanek, P., T. Toth, E. Bergström, H. Treffenberg-Pettersson, and A. Bergh. 2020. Effect of infrared and red monochromatic light on equine wound healing. Equine Veterinary Journal. doi:10.1111/eve.13266.


Light to Manage Neuropathic Pain

Imagine that the movement of a single hair on your arm causes severe pain. For patients with neuropathic pain — a chronic illness affecting 7 to 8% of the European population, with no effective treatment — this can be a daily reality.

Scientists from EMBL Rome have now identified a special population of nerve cells in the skin that are responsible for sensitivity to gentle touch. These are also the cells that cause severe pain in patients with neuropathic pain. The research team, led by EMBL group leader Paul Heppenstall, developed a light-sensitive chemical that selectively binds to this nerve cell type. By first injecting the affected skin area with the chemical and then illuminating it with near-infrared light, the targeted nerve cells retract from the skin’s surface, leading to pain relief. Nature Communications publishes the results on 24 April 2018.

The Spicy Effect

By clipping off the nerve endings with light, the gentle touch that can cause severe pain in neuropathic patients is no longer felt. “It’s like eating a strong pepper, which burns the nerve endings in your mouth and desensitizes them for some time,” says Heppenstall. “The nice thing about our technique is that we can specifically target the small subgroup of neurons, causing neuropathic pain.”

There are many different nerve cells in your skin, which make you feel specific sensations like vibration, cold, heat, or normal pain. These cells are not affected by the light treatment at all. The skin is only desensitized to the gentlest touch, like a breeze, tickling, or an insect crawling across your skin.

Illumination vs. Drugs

Previous attempts to develop drugs to treat neuropathic pain have mostly focused on targeting single molecules. “We think, however, that there’s not one single molecule responsible. There are many,” Heppenstall explains. “You might be able to succeed in blocking one or a couple, but others would take over the same function eventually. With our new illumination method, we avoid this problem altogether.”

Touch and pain were assessed by measuring reflexes in mice affected by neuropathic pain in their limbs. Affected mice will normally quickly withdraw their paw when it is gently touched. After the light therapy, however, they exhibited normal reflexes upon gentle touch. The therapy's effect lasts for a few weeks, after which the nerve endings grow back, and gentle touch causes pain again.

The team also investigated human skin tissue. The tissue's overall makeup and the specifics of the neurons of interest appear to be similar, indicating that the method might be effective in managing neuropathic pain in humans. “In the end, we aim to solve the problem of pain in both humans and animals,” says Heppenstall. “Of course, a lot of work needs to be done before we can do a similar study in people with neuropathic pain. That’s why we’re now actively looking for partners and are open for new collaborations to develop this method further, with the hope of one day using it in the clinic.”

Parkinson's: From the Gut to the Brain

Margaret Jarrett was diagnosed with Parkinson’s disease eight years ago. And although she was bothered by many of the symptoms that commonly afflict people living with Parkinson’s — resting tremor, uncertain gait, and terrible nightmares — the thing that bothered her the most was the loss of her sense of smell. An avid gardener, she took great pride in her roses but being unable to inhale their perfumed scent really got her down.

“You take something like your sense of smell for granted,” Jarrett, 72, said. “You don’t realize how precious something is until it’s gone.”

Parkinson’s disease combines movement disorders, including resting tremors, muscle rigidity, impaired balance, and movement slowness. It can also cause neurological problems such as depression, insomnia, memory loss, and confusion.

Its cause is unknown, but it is associated with dopamine depletion and destruction of neurons in the brain's basal ganglia region.

The current mainstay of treatment for Parkinson’s disease involves physical therapy and medications that act to increase dopamine levels in the brain. One relatively new therapy for Parkinson’s is exposure to infrared light.

Dr. Ann Liebert, co-ordinator of photomolecular research at the Australasian Research Institute, has been exploring the idea of using infrared light to modulate the gastrointestinal tract’s microbiome in humans.

The gut’s microbiome — composing trillions of bacteria, fungi, and protozoa from hundreds of different species that normally inhabit our gastrointestinal tract — has come under increasing scientific attention over the past decade, with links being established between the microbiome and several conditions including obesity, type 2 diabetes, cardiovascular disease, and depression. Several studies have also observed that the gut microbiome is markedly altered in patients with Parkinson’s disease. Fecal microbiota transplantation can have a protective effect in animal models of Parkinson’s.

The reason for this is unknown. However, an interesting observation is that another common pathology seen in Parkinson’s disease is the accumulation of misfolded proteins, called Lewy bodies, in the brain. It has been shown that certain sensory cells of the gut contain these same proteins.

Researchers have hypothesized that abnormal forms of the protein could travel from the gut to the brain through the vagus nerve, a phenomenon observed in animal models of Parkinson’s. Further support for this theory comes from findings that people who have had a surgical vagotomy — where branches of the nerve are cut — have a lower lifetime risk of developing Parkinson’s.

“We know that infrared light can reduce Parkinson’s symptoms and offer protection to brain cells. So, we wanted to test if it could modulate the gut’s microbiome as well,” Liebert said.

Provisional results from the first half dozen Adelaide participants, including Margaret Jarrett, have been promising.

“The six patients . . . showed an increase by up to 20 percent in the favorable microbiome that is associated with obesity reduction and short-chain fatty acid production. And the bacteria associated with rheumatoid arthritis, Crohn’s disease and insulin resistance were all decreased,” said Hosen Kiat, a professor of cardiology at Macquarie University, who oversaw the trial.

“For the last three years, I haven’t been able to smell flowers,” Jarrett said. “But several weeks into the trial, I started to smell my roses, daphnes, and gardenias again, and it was wonderful.”

Another participant, Barry Weldon, 70, had a similar experience. “My sense of smell improved significantly,” he said. “One day, I walked into the house, and for the first time in a long time, I could actually smell the soup my wife was cooking.”

Ron Till, 68, had an even more dramatic improvement. “The trial gave me the ability to sleep again,” he said. “It was amazing.”

Till’s neurologist cautioned him not to get his hopes up before the trial but changed his mind when he saw the results. “He told me it was voodoo medicine and probably wouldn’t work,” Till recalled. “But after the trial, I went back for my three-monthly assessment with him, and he said to me, ‘You’re actually testing better than when you first started with me ten years ago.’”

Retired geologist Sean Kennedy, 76, also experienced an improvement in his coordination and balance. “My juggling skills have improved,” he said.

In a review published in Photobiomodulation, Photomedicine and Laser Surgery, Liebert and her co-authors acknowledge that while the exact mechanism by which light therapy alters the microbiome is unknown, there is definite potential in light therapy.

“The ability of PBM [light therapy] to influence the microbiome (if proven to apply to humans) will allow an additional therapeutic route to target multiple diseases, including cardiovascular disease and Parkinson’s disease, many of which have thus far eluded effective treatment approaches,” the paper concludes.

Kiat is excited by light therapy’s potential. “If we can create non-­invasively a metabolically healthier microbiome through this extremely cheap and easy way, then inflammatory diseases and neurodegenerative diseases should be positively influenced,” he said.

Gold Coast-based GP Mark Jeffery is a clinician who has been using lasers in his practice for more than four years. He says the research supports the use of light therapy for a wide range of diseases, including Parkinson’s, Alzheimer’s, depression, and chronic pain.

“The reality is there are no real side effects from low-level laser therapy, and it’s one of the safest treatments you can ever do,” he says.

Liebert says the promising results they have seen thus far will inform a large, double-blinded randomized control trial planned for this year. “It has the potential to apply to huge fields of medicine,” she said.

Weldon’s neurologist, Chris Kneebone, is keeping an open mind on infrared light therapy’s potential. “We all just have to wait and see what the trial results tell us,” he said.

His advice for people who wish to give it a try for their Parkinson’s? “If you want to give it a go, give it a go,” he said. “I’ve got no reason not to recommend it, but at this stage, I’ve got no reason to think it is helpful either.”

As for Jarrett, she has no doubts that infrared light therapy has helped her. She enjoys pottering around in her garden again and has more energy than she has had for a long time.

“I feel like I could take on the world again,” she said. “My garden has never looked better.”

References

https://pubmed.ncbi.nlm.nih.gov/30074108/

https://pubmed.ncbi.nlm.nih.gov/29247431/

How Intense Light can Protect Against Heart Attacks

Researchers at the University of Colorado Anschutz Medical Campus have found that intense light amplifies a specific gene that bolsters blood vessels and offers protection against heart attacks.

"We already knew that intense light can protect against heart attacks, but now we have found the mechanism behind it.”

Study’s senior author Tobias Eckle, MD, PhD, professor of anesthesiology, University of Colorado School of Medicine

The study was published recently in the journal Cell Reports.

The scientists discovered that housing mice under intense light conditions for one week robustly enhances cardioprotection, which resulted in a dramatic reduction of cardiac tissue damage after a heart attack. They also found that humans could potentially benefit from a similar light exposure strategy.

To find out why they developed a strategy to protect the heart using intense light to target and manipulate the function of the PER2 gene, which is expressed in a circadian pattern in the part of the brain that controls circadian rhythms.

By amplifying this gene through light, they found that it protected cardiovascular tissues against low oxygen conditions like myocardial ischemia, caused by reduced oxygen flow to the heart.

They also discovered that the light increased cardiac adenosine, a chemical that plays a role in blood flow regulation.

Mice that were blind, however, enjoyed no cardioprotection indicating a need for visual light perception.

Next, they investigated whether intense light had similar effects on healthy human volunteers. The subjects were exposed to 30 minutes of intense light measured in lumens. In this case, volunteers were exposed to 10,000 LUX, or lumens, on five consecutive days. Researchers also did serial blood draws.

The light therapy increased PER2 levels as it did in mice. Plasma triglycerides, a surrogate for insulin sensitivity and carbohydrate metabolism, significantly decreased. Overall, the therapy improved metabolism.

Eckle has long known that light plays a critical role in cardiovascular health and regulating biological processes. He pointed out that past studies have shown an increase in myocardial infarctions during darker winter months in all U.S. states, including sunnier places like Arizona, Hawaii, and California. The duration of the light isn’t as important as the intensity, he said.

“The most dramatic event in the history of the earth was the arrival of sunlight,” Eckle said. “Sunlight caused a great oxygen event. With sunlight, trillions of algae could now make oxygen, transforming the entire planet.”

Eckle said the study shows, on a molecular level, that intensive light therapy offers a promising strategy in treating or preventing low oxygen conditions like myocardial ischemia.

He said if the therapy is given before high-risk cardiac and non-cardiac surgery, it could offer protection against injury to the heart muscle, which can be fatal.

“Giving patients light therapy for a week before surgery could increase cardioprotection,” he said. “Drugs could also be developed that offer similar protections based on these findings. However, future studies in humans will be necessary to understand the impact of intense light therapy and its potential for cardioprotection.”

Source:

University of Colorado Anschutz Medical Campus

Journal reference:

Oyama, Y. et al. (2019) Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Reports. doi.org/10.1016/j.celrep.2019.07.020.


Fetuses May be Able to See More Light than you Think

By the second trimester, long before a baby's eyes can see images, they can detect light.

But the light-sensitive cells in the developing retina -- the thin sheet of brain-like tissue at the back of the eye -- were thought to be simple on-off switches, presumably there to set up the 24-hour, day-night rhythms parents hope their baby will follow. University of California, Berkeley, scientists have now found evidence that these simple cells actually talk to one another as part of an interconnected network that gives the retina more light sensitivity than once thought, and that may enhance the influence of light on behavior and brain development in unsuspected ways.

In the developing eye, perhaps 3% of ganglion cells -- the retina cells that send messages through the optic nerve into the brain -- are sensitive to light. To date, researchers have found about six different subtypes that communicate with various places in the brain. Some talk to the suprachiasmatic nucleus to tune our internal clock to the day-night cycle. Others send signals to the area that makes our pupils constrict in bright light.

But others connect to surprising areas: the perihabenula, which regulates mood, and the amygdala, which deals with emotions.

Recent evidence suggests that in mice and monkeys, these ganglion cells also talk with one another through electrical connections called gap junctions, implying much more complexity in immature rodent and primate eyes than imagined.

"Given the variety of these ganglion cells and that they project to many different parts of the brain, it makes me wonder whether they play a role in how the retina connects up to the brain," said Marla Feller, a UC Berkeley professor of molecular and cell biology and senior author of a paper that appeared this month in the journal Current Biology. "Maybe not for visual circuits, but non-vision behaviors. Not only the pupillary light reflex and circadian rhythms, but possibly explaining problems like light-induced migraines, or why light therapy works for depression."

Parallel systems in developing retina

The cells, called intrinsically photosensitive retinal ganglion cells (ipRGCs), were discovered only 10 years ago, surprising those like Feller, who studied the developing retina for nearly 20 years. She played a major role, along with her mentor, Carla Shatz of Stanford University, in showing that spontaneous electrical activity in the eye during development -- so-called retinal waves -- is critical for setting up the correct brain networks to process images later on.

Hence her interest in the ipRGCs seemed to function in parallel with spontaneous retinal waves in the developing retina.

We thought they (mouse pups and the human fetus) were blind at this point in development. We thought that the ganglion cells were there in the developing eye, that they are connected to the brain, but that they were not really connected to much of the rest of the retina, at that point. Now, it turns out they are connected to each other, which was a surprising thing."

Marla Feller, the Paul Licht Distinguished Professor in Biological Sciences and a member of UC Berkeley's Helen Wills Neuroscience Institute.

UC Berkeley graduate student Franklin Caval-Holme combined two-photon calcium imaging, whole-cell electrical recording, pharmacology, and anatomical techniques to show that the six types of ipRGCs in the newborn mouse retina link up electrically, via gap junctions, to form a retinal network that the researchers found not only detect light but respond to the intensity of the light, which can vary nearly a billionfold.

Gap junction circuits were critical for light sensitivity in some ipRGC subtypes. Still, not others, providing a potential avenue to determine which ipRGC subtypes provide the signal for specific non-visual behaviors that light evokes.

"Aversion to light, which pups develop very early, is intensity-dependent," suggesting that these neural circuits could be involved in light-aversion behavior, Caval-Holme said. "We don't know which of these ipRGC subtypes in the neonatal retina actually contributes to the behavior, so it will be fascinating to see what role all these different subtypes have."

The researchers also found evidence that the circuit tunes itself in a way that could adapt to the intensity of light, which probably has an important role in development, Feller said.

"In the past, people demonstrated that these light-sensitive cells are important for things like the development of the blood vessels in the retina and light entrainment of circadian rhythms, but those were kind of a light on/light of the response, where you need some light or no light," she said. "This seems to argue that they are actually trying to code for many different intensities of light, encoding much more information than people had previously thought."
Source:

University of California, Berkeley

Journal reference:

Caval-Holme, F., et al. (2019) Gap Junction Coupling Shapes the Encoding of Light in the Developing Retina. Current Biology. doi.org/10.1016/j.cub.2019.10.025.


How Light Ignites an Internal Fire - Lack of Exposure to Light may Increase Metabolic Syndrome Risk

Yes, fat cells deep under your skin can sense light. And when bodies do not get enough exposure to the right kinds of light, fat cells behave differently.

This discovery, published Jan. 21, 2020, in the journal Cell Reports, was uncovered by scientists at Cincinnati Children’s who were studying how mice control their body temperature. What they found has implications far beyond describing how mice stay warm.

The study shows that light exposure regulates how two kinds of fat cells work together to produce the raw materials that all other cells use for energy. The study authors say that disruptions to this fundamental metabolic process appear to reflect an unhealthy aspect of modern life — spending too much time indoors.

Our bodies evolved over the years under the sun’s light, including developing light-sensing genes called opsins. But now we live so much of our days under artificial light, which does not provide the full spectrum of light we all get from the sun.”

Richard Lang, PhD, developmental biologist and senior author of the study.

Lang directs the Visual Systems Group at Cincinnati Children’s and has authored or co-authored more than 120 research papers, including many related to eye development and how light interacts with cells beyond the eye.

“This paper represents a significant change in the way we view the effects of light on our bodies,” Lang says.

Shining New Light on the Role of Light

Many people understand that certain wavelengths of light can be harmful, such as gamma radiation from a nuclear bomb or too much ultraviolet light from the sun burning our skin. This study from Lang and colleagues describes a different, healthy role for light exposure.

Despite the fur of a mouse or a person's clothing, light does get inside our bodies. Photons — the fundamental particles of light — may slow down and scatter around once they pass the outer layers of skin, Lang says. But they really do get in, and when they do, they affect how cells behave.

In this direction, Lang’s work dates back to 2013 when he led a study published in Nature, which demonstrated how light exposure affected fetal mice's eye development. More recently, in 2019, Lang and colleagues published two more papers, one in April in Nature Cell Biology that reported possible benefits of light therapy for eye development in preterm infants, and another study in October in Current Biology that details how light receptors in the skin help mice regulate their internal clocks.

The new study in Cell Reports includes important contributions from Russell Van Gelder, MD, Ph.D., and Ethan Buhr, Ph.D., from the University of Washington, Randy Seeley, Ph.D., University of Michigan.

“This idea of light penetration into deep tissue is very new, even to many of my scientific colleagues,” Lang says. “But we and others have been finding opsins located in a variety of tissue types. This is still just the beginning of this work.”
How Light Ignites an Internal Fire

In the latest findings, the research team studied how mice respond when exposed to chilly temperatures — about 40° F. They already knew that mice, much like humans, use both a shivering response and an internal fat-burning response to heat themselves.

Deeper analysis revealed that the internal heating process is compromised in the absence of the gene OPN3 and exposure, specifically to a 480-nanometer wavelength of blue light. This wavelength is a natural part of sunlight but occurs only at low levels in most artificial light.

When light exposure occurs, OPN3 prompts white fat cells to release fatty acids into the bloodstream. Various types of cells can use these fatty acids as energy to fuel their activities. But brown fat literally burns the fatty acids (in a process called oxidation) to generate heat that warms up the chilly mice.

When mice were bred to lack the OPN3 gene, they failed to warm up other mice when placed in chilly conditions. But surprisingly, even mice with the correct gene failed to warm up when exposed to light that lacked the blue wavelength.

This data prompted the team to conclude that sunlight is required for normal energy metabolism. At least in mice. While the scientists strongly suspect that a similar light-dependent metabolic pathway exists in humans, they need to complete another series of experiments to prove it.

“If the light-OPN3 adipocyte pathway exists in humans, there are potentially broad implications for human health,” the study states. “Our modern lifestyle subjects us to unnatural lighting spectra, exposure to light at night, shift work, and jet lag, all of which result in metabolic disruption. Based on the current findings, insufficient stimulation of the light-OPN3 adipocyte pathway may be part of an explanation for the prevalence of metabolic deregulation in industrialized nations where unnatural lighting has become the norm.”

What’s Next?

It likely will require several years of study to flesh out this discovery. Someday, in theory, “light therapy” could become a method for preventing metabolic syndrome from developing into diabetes. Replacing indoor lights with better, full-spectrum lighting systems also could improve public health, Lang says.

However, more study is needed to pin down the potential therapeutic value of light therapy. Questions to answer include determining how much sunlight is needed to support a healthy metabolism and whether people battling obesity might lack a functional OPN3 gene in their fat cells. Also unknown: when would light therapy matter most: for pregnant mothers? For infants and children? Or for fully developed adults?

Source:

Cincinnati Children’s Hospital Medical Center

Journal reference:

Opsin 3-Dependent Adipocyte Light Sensing enhances Nayak, G., et al. (2020) Adaptive Thermogenesis in Mice. Cell Reports. doi.org/10.1016/j.celrep.2019.12.043.

Light Therapy can Benefit Patients with TBI (Traumatic Brain Injury)

According to a pioneering study by researchers from the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH), light therapy is safe and has measurable effects on the brain.

Senior investigators Rajiv Gupta, MD, Ph.D., director of the Ultra-High Resolution Volume CT Lab at MGH and Benjamin Vakoc, Ph.D., at the Wellman Center led the study, which was supported by a grant from the Department of Defense (DOD) and published in JAMA Network Open September 14th.

This study is one of the first, if not the first, prospective, randomized, interventional clinical trials of near-infrared, low-level light therapy (LLLT) in patients who recently suffered a moderate brain injury. If further trials support these findings, light therapy could become the first widely-accepted treatment for this type of injury.

TBI is the leading cause of traumatic injury worldwide, and an estimated 69 million people experience such an injury every year. However, there are no treatments for this condition yet, largely because the underlying biological mechanisms are not well understood. It is so challenging to do studies with actual patients in the acute stage of trauma.

"The Gulf War put TBI in the headlines because body armor had been greatly improved by then. But there were still brain injuries caused by the shock waves from high powered explosives.”

Rajiv Gupta, MD, PhD, Director, Ultra-High Resolution Volume CT Lab

For various reasons, the number of TBIs has increased around the globe since then, but effective treatments are still sorely needed. For this study, a special helmet had to be designed specifically to deliver the therapy, an undertaking that required a mix of medical, engineering, and physics expertise.

This multidisciplinary team included Gupta, a neuroradiologist, Vakoc, an applied physicist, and others specializing in developing and translating optical instrumentation to the clinic and biologic laboratories. Both Gupta and Vakoc are also associate professors at Harvard Medical School.

“For this study, we designed a practical, near-infrared treatment based on Wellman Center research and working directly with DOD on the vexing problem of TBI, a condition faced by so many,” says Rox Anderson, MD, the center’s director.

Another challenge was optimizing the wavelength of the near-infrared LLLT.

“Nobody knows how much light you need to get the optimal effect,”

explains Lynn Drake, MD, one of the study co-authors and director of business development at the Wellman Center.

“We tried to optimize the wavelength, dosing, timing of delivery, and length of exposure.”

This was done through a series of pre-clinical experiments led by Anderson. These included multiple preclinical studies led by Michael Hamblin, Ph.D. Anderson and Hamblin are both co-authors of this paper.

Near-infrared LLLT has already been considered for multiple uses, but to date, few if any studies of this technology have been tested and none in patients with TBI.

It has been studied in stroke patients, and Wellman's basic laboratory research suggests it is neuroprotective through a mechanism mediated by specialized intracellular organs called mitochondria. It took several years of research at Wellman to understand the basic mechanism before the clinical trial.

The randomized clinical trial included 68 patients with moderate traumatic brain injury who were divided into two groups. One group received LLLT via the special helmet, which delivered the light. Patients in the control group wore the helmet for the same amount of time but did not receive the treatment.

Vakoc’s team at Wellman designed the helmet. During the study, the subjects’ brains were tested for neuron activity using quantitative magnetic resonance imaging (MRI) metrics, and the subjects also underwent neurocognitive function assessment.

MRI was performed in the acute (within 72 hours of the injury), early subacute (2–3 weeks), and late subacute (approximately three months) stages of recovery. During each visit and at six months, clinical assessments were performed using the Rivermead Post-Concussion Questionnaire, with each item assessed on a five-point scale.

Twenty-eight patients completed at least one LLLT session, and none reported any adverse reactions. Also, the researchers found that they could measure the effects of transcranial LLLT on the brain.

The MRI studies showed statistically significant differences in myelin's integrity surrounding the neurons of treated patients versus the control group. Both these findings support follow-up trials, especially since there are no other treatments for these patients.

The study also showed that light does impact the cells. While it is well established that cells have light receptors, “going into this trial, we had several unanswered questions such as whether the light would go through the scalp and skull, whether the dose was sufficient, and whether it would be enough to engage the neural substrates responsible for repair after TBI,” says Gupta.

It’s important to note, and he adds that for this initial study, the researchers focused on patients with moderate traumatic brain injury. That helped ensure their study could have statistically significant findings because patients in this category are more likely to demonstrate a measurable effect.

“It would be much more difficult to see such changes in patients with mild injuries, and it is quite likely that in patients with severe brain injuries, the effect of light therapy would be confounded by other comorbidities of severe trauma,”

says Gupta.

He adds that researchers are still very early in the development of this therapy. It is unknown if it could be applied to other types of brain injury, such as chronic traumatic encephalopathy (CTE), which has received a lot of public attention over the last few years.

CTE is a progressive degenerative disease associated with a history of repetitive brain trauma such as that experienced by certain athletes, most notably football players.

This study opens up many possibilities for the broader use of photomedicine. “Transcranial LED therapy is a promising area of research, with potential to help various brain disorders where therapies are limited,” says Margaret Naeser, Ph.D., a prominent researcher in photomedicine and research professor of Neurology at Boston University School of Medicine. She was not affiliated with this particular study.

Source:

Massachusetts General Hospital

Journal reference:

Longo, M, G. F., et al. (2020) Effect of Transcranial Low-Level Light Therapy vs. Sham Therapy Among Patients With Moderate Traumatic Brain Injury. doi.org/10.1001/jamanetworkopen.2020.17337.

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Half a Trillion-Dollar Market  —  Men.

There’s an emerging disruptor in the beauty industry as companies target a different consumer type to expand the half a trillion-dollar market — men.

Across the globe, men’s adoption of beauty use is already starting to take off. But the trend comes in many different shapes and forms. For beauty companies struggling to find new avenues of growth, it’s a huge opportunity to see whether men are looking for traditional grooming products, discreet moisturizers, beauty balms, or popular light therapy.

According to Allied Market Research, the men’s personal care industry is predicted to hit $166 billion by 2022. According to market researcher NPD Group, just last year, men’s skin-care products alone saw a more than 7% jump in sales and with the category currently valued at $122 million.

“In recent years, the notion that men can’t or shouldn’t be using skin-care products or caring more in general about all aspects of their appearance has been receding,”

Said Andrew Stablein, a research analyst at Euromonitor International, in a research note.

The success of digitally native brands catered directly to men such as Harry’s and popular subscription service Dollar Shave Club reveal

“the average men’s grooming routine isn’t about just shaving, but can be aided by using skin-care products,”

Stablein said.

Even high-end designers like Chanel have jumped on the trend, launching its first made-for-men skincare and cosmetics line known as “Boy De Chanel” last September.

“It seems that mass players are trying to expand their market and gain share in a slowing market by growing their user base,”

Said Alison Gaither, beauty and personal care analyst at Mintel.

This includes tutorials from U.K. makeup artist Charlotte Tilbury and Rihanna’s Fenty brand, which have both put out instructions for guys who want to use makeup subtly for a more groomed appearance.

According to Coresight Research, the Asia Pacific market is now one of the fastest-growing regions for men’s grooming and cosmetic product use. Jason Chen, general manager for Chinese online retail site Tmall, told Coresight that “supply cannot meet the demand for male make-up products across China.”

However, recent data suggests the new generation of beauty consumers prefer a non-binary approach altogether. According to NPD’s iGen Beauty Consumer report, nearly 40% of adults aged 18–22 have shown interest in gender-neutral beauty products and holistic products.

“There are so many … [people] growing up with the idea that you’re not tied to the gender you’re born with,”

Said Larissa Jensen, a beauty industry analyst at NPD.

“Beauty is no longer what you’re putting out as ‘ideal beauty.’ Beauty can be anything, anyone, and any gender.”

In 2016, shortly after Coty acquired CoverGirl, the brand made history with its first-ever “CoverBoy” featuring popular YouTube makeup artist James Charles.

Charles recently found himself in a very public spat with Tati Westbrook, another YouTube beauty vlogger. Coverage of the feud, which began after Charles backed a vitamin brand that was a rival to Westbrook’s own, has been widespread and shows the influence these internet personalities have and how the business has evolved over the past two years.

While Charles may be having his struggles now, as he has lost millions of subscribers, the attention he originally received from CoverGirl sparked similar collaborations by major brands including L’Oreal, who featured beauty blogger Manny Gutierrez, known under the moniker Manny MUA, as the face of its Maybelline Colossal mascara campaign in 2017.

“I think a lot of people misconstrue a man wearing makeup as someone that is transgender or someone that wants to be a drag queen, but it’s not that,”

Guitterez, founder and CEO of Lunar beauty told CNBC.

“I think right now people are still intimidated by the aspect of it.”

Gutierrez’s makeup tutorials and product reviews have attracted nearly 5 million subscribers to his YouTube page. According to a note by the NPD Group, one setting powder product saw a 40% surge in sales after Gutierrez promoted it on his YouTube channel.

“It’s all about inclusivity and encouraging people to be a little more inclusive with both men and women,”

Said Gutierrez.

“I think that as time progresses and you see more men in beauty, it’ll get a little bit better and better.”



How Effective is Blue Light Therapy for Spider Veins?

Medical spas often recommend Blue light therapy for spider veins because they don’t have to be administered by trained doctors. And, yes, after several expensive sessions, you might start seeing a difference. The most effective method to treat spider veins is Sclerotherapy. We’ll also discuss the benefits of using Sclerotherapy is an effective alternative.

What are Spider Veins?

Before discussing how to treat spider veins with blue light therapy or sclerotherapy, we need to discuss what causes spider veins.

Spider Veins, scientifically called Telangiectasias, are a small network of blood vessels visible just under the skin's surface. They are called “spider veins” because they look like red spider webs.

Spider veins generally occur on the legs, feet, thighs, and face. They can also cause slight pain and discomfort.

Causes and Dangers of Spider Veins

While spider veins aren’t dangerous in and of themselves, they can indicate underlying vein disease.

Vein Disease, also known as Chronic Venous Insufficiency, is a disease in which the valves in the veins malfunction. The valves are usually supposed to act as one-way doors and facilitate blood flow to the heart. However, when they malfunction, blood flows back down and pools around the legs. This can put pressure on the veins and lead to spider veins or varicose veins.

While spider veins themselves aren’t dangerous, vein disease is hazardous and needs to be treated immediately. If left untreated, venous insufficiency can result in bleeding, skin infections, and ulcers.

In the worst-case scenario, vein disease can also lead to Deep Vein Thrombosis, a medical condition in which blood clots in the veins. If the clotted blood breaks, it can get carried to the lungs, leading to a potentially fatal condition called Pulmonary Embolism.

What is Blue Light Therapy for Spider Veins?

Blue Light Therapy for spider veins is a method in which blue light or laser is used to treat spider veins. The laser is non-UV in nature and emits photons that generate heat. The heat can destroy the damaged blood vessel over time. As such, the damaged vein shrinks and eventually dissolves.

Advantages of Blue Light Therapy for Spider Veins

The only time that blue light therapy for spider veins has an advantage over sclerotherapy is when it comes to the foot or face.

Both the face and the foot are dense with venous-arterial connections. When using Sclerotherapy, the Sclero has to be injected into the veins. Injecting it into the arteries can be dangerous. Most conservative physicians prefer not to use Sclerotherapy for spider veins in the face or foot.

As such, it’s better to go for blue light therapy for spider veins in the face or foot.

Sclerotherapy: An Alternative to Blue Light Therapy for Spider Veins

Sclerotherapy is the most effective and permanent method to treat spider veins. It is a minimally-invasive procedure in which a medicine called Sclerosant is injected into the damaged vein.

The Sclerosant inflicts some chemical damage to the veins, which leads to the vein walls sticking together and eventually closing up. The blood is then routed to healthier veins, and the damaged vein eventually gets reabsorbed.

Advantages of Sclerotherapy for Spider Veins

There are multiple advantages of using Sclerotherapy to treat spider veins:

  • The process is minimally-invasive and non-surgical in nature.
  • Sclerotherapy doesn’t hurt or cause much discomfort.
  • It works immediately, and you don’t need to come back for multiple treatment sessions.
  • It can get rid of spider veins permanently.
  • The entire process takes just about 30 minutes.
  • You can resume your daily activities immediately after.
  • It is cheaper than Blue Light Therapy.


Red Light Therapy Can Help Reduce Inflammation

We can usually identify inflammation when we see it. The inflamed part of the body looks red and swollen, and it feels hot and painful. But in this article, we’ll find out why we experience inflammation, as well as its causes, risk factors, and how red light therapy devices can help reduce it.

What Really is Inflammation?

Inflammation is our body’s natural response to pain, irritation, damaged cells, exposure to germs, and potential danger. There are two types of inflammation:

1. Acute inflammation

This type of inflammation happens as our body’s healthy response to injury or stress. We mean “healthy” because it helps the body recover faster. The inflammation happens only for a few hours and then starts to repair the damaged tissue.

2. Chronic inflammation

On the other hand, chronic inflammation can be excruciating and may cause discomfort or inconvenience. It causes an imbalance in the body, making it operate inefficiently over time. Chronic inflammation can be caused by viral infections, repetitive tissue damage, autoimmune reactions, and persistent and recurring acute inflammation. At its worse, this type of inflammation may lead to more serious diseases and/or conditions such as cancer, stroke, depression, and heart disorder.

Common Causes of Inflammation

Anything that causes stress on your body may lead to inflammation. These include:

  • Bruises
  • Bumps
  • Burns
  • Chemical irritants
  • Dehydration
  • Diseases
  • Excessive alcohol
  • Infection
  • Irritants
  • Poor nutrition
  • Poor sleep
  • Splinters
  • Toxin exposure
  • Wounds and injuries

Signs of Inflammation

There are five common signs of inflammation:

  • Heat on the inflamed area
  • Loss of function (i.e., you can’t move your arms or legs)
  • Pain
  • Redness
  • Swelling
Treatment Options for Inflammation

For acute inflammation, doctors normally recommend nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and paracetamol. Meanwhile, chronic inflammation may also be prescribed with NSAIDs, along with steroids and supplements.

However, these common treatment options help prevent inflammation symptoms but do not deal with the root cause, including improper cellular function, biological imbalance, and damaged tissues. This is also why lifestyle changes (improved diet, regular exercises, and high-quality sleep) and red light therapy could be of great help.

How Red Light Therapy Works Against Inflammation

Red light therapy, also referred to as low-level laser therapy (LLLT) or photobiomodulation (PBM), is a non-invasive treatment option. This kind of therapy delivers wavelengths of red and near-infrared (NIR) light to your skin and cells for multiple benefits. When it comes to inflammation, it can help cut down oxidative stress and activate protective cellular mechanisms to boost your immune system and protect you from diseases that may cause inflammation. It can also boost the generation of healing agents and antioxidants in the body to speed up damaged tissues' healing process.

Red light therapy can give your body the light exposure needed to function more efficiently, improve blood flow, and limit inflammation.

Conclusion

Inflammation is a natural part of our biological processes, but chronic cases may also lead to serious health risks that can affect the quality of your life. Therefore, if you’re experiencing signs of inflammation, regardless if it’s acute or chronic, please schedule an appointment with your doctor to get the care and treatment you need as early as possible.

In the meantime, to protect your body from the stress that may cause inflammation, you can do red light therapy either through a health provider or from the comfort of your home. If you need to purchase red light therapy devices, you can browse through our catalog to see the brands and products that we offer.


Keep Your Skin Healthy with Red Light Therapy

Skincare doesn’t just affect the way you look. It also plays a huge role in your overall health — from body temperature to hormone regulation to your immune system. If you’re into skincare as much as we are, one of the many ways that can help you keep your skin healthy is red light therapy. In this article, we’ll take a deep dive into why you should take care of your skin, and we’ll also discuss how red light therapy devices can help you achieve your skin goals.

Are you ready? Let’s go straight into it.

Why Do You Need to Take Care of Your Skin?

As the largest organ in our body, your skin is your body’s first defense line to bacteria, germs, viruses, etc. It’s a vital part of the immune system and some processes in your body, such as temperature control, blood circulation, and hormone production.

Main Functions of the Skin

Let’s take a look at the skin's main functions to help you understand how essential it is for you to take care of this vital organ.

1. Defense and Immunity

The skin is an active immune organ, and it serves as our physical barrier from the dangers of the environment. It helps protect our bodies from diseases, germs, viruses, dirt, UV radiation, and potential thermal and physical injuries. It also helps detect and fight off infection, toxins, allergens, hazardous substances, and carcinogens.

2. Temperature Regulation

Aside from protecting us from extreme cold or heat, the skin also helps prevent moisture loss, keeping us from being dehydrated.

3. Sense of touch

The skin has a somatosensory system that is composed of touch receptors and nerve endings. This system is responsible for the sensations we feel, including pain, pressure, vibrations, smoothness, roughness, heat, cold, tickle, itch, and more.

4. Storage and Production of Vitamin D

Your body also uses your skin's deeper layers to store metabolic products, fat, and water. The skin is also responsible for producing vitamin D, supplied in the body when the skin gets enough sunlight exposure.

5. Beauty

Need we say more? Your skin plays a huge part in your appearance. Of course, when your skin is healthy, you also look glowing, radiant, and definitely more attractive.

Red Light Therapy and Keeping Your Skin Healthy

Before we proceed with the “how,” let’s first define what red light therapy is. Red light therapy is a non-invasive treatment option for different kinds of medical conditions. It is also used for health improvement and various aesthetic procedures.

Decades ago, red light therapy machines were only available in clinics, high-end salons, and spas. Nowadays, red light therapy devices can be bought and used by anyone. In fact, you can do red light therapy at the comfort of your home and incorporate it into your skincare routine.

How Does Red Light Therapy Work?

Red light therapy works by delivering wavelengths of red and near-infrared (NIR) light to our cells and skin. Besides helping enhance cellular function, red light therapy also helps stimulate the mitochondria and produce ATP (adenosine triphosphate) energy. This treatment option usually takes only about 10 minutes per session.

How Does Red Light Therapy Help Keep Your Skin Healthy?

Our skin relies on millions of cells to be able to perform its functions. When our cells experience homeostasis or a state of balance, our skin and body perform (and look) better. And as mentioned above, red and NIR light enhances cellular function while also preventing inflammation and oxidative stress. Red light therapy helps make your skin look and feel softer, smoother, and healthier.

Besides, red light therapy also helps damaged tissues heal and regenerate faster. It also has anti-inflammatory benefits, potentially increasing blood flow to damaged and inflamed tissues and reducing oxidative stress.

Final Thoughts

Skincare is self-care, as keeping your skin healthy also produces multiple benefits to your health. Thankfully, aside from proper hygiene, regular exercise, a balanced diet, and an established skincare routine, red light therapy can also improve your overall skin health.

For more information about red light therapy or to view our catalog of red therapy devices, click here.

Sources:

https://www.hse.gov.uk/skin/professional/causes/structure.htm

Red Light Therapy for Enhanced Cellular Function

The one thing we have in common with animals, plants, and other living organisms is that we are all made of tiny little cells. The intricate human body in itself houses trillions of cells. Without cells, there wouldn’t be any life on Earth at all.

In this article, we discuss cellular anatomy and cellular function. Here, we understand how light plays a role in the support and acceleration of cellular respiration.

What is a cell?

Think of cells as the basic building block of all living organisms. As the smallest unit of life, cells contain many parts, each with a different and specific function. The command center of the cell is called the nucleus that contains the human DNA.

As these cells combine to form into an organism, they become responsible for vital activities like nutrient intake, energy production, structure building, and hereditary material processing. They make sure that your body gets enough energy and nutrients to function 24/7.

What is ATP?

One essential activity that our cells do for us is by taking in oxygen and nutrients to fuel body energy. This energy unit that is converted by the cells is called Adenosine Triphosphate (ATP) Energy.

The ATP itself is a molecule packed with high energy that empowers cellular function. ATP is required by the body to do every activity. Other cells that do more strenuous activities like muscle cells would need more ATP than others. The ideal optimal cellular function would allow cells to produce and use enough energy to achieve body balance or homeostasis.

How is ATP produced?

The mitochondria are the powerhouses of the cell. They are responsible for the production of ATP. Aside from cellular energy, this double-membrane powerhouse does protein synthesis, cell signaling, and cell apoptosis. ATP is produced with oxygen (aerobic) or without oxygen (anaerobic), the former being more beneficial because it converts more energy. Thus, 95% of cellular energy goes through an aerobic process.

Our cells go through a process called Aerobic cellular respiration to convert oxygen, food, and water into the body’s energy currency, which is ATP. This process is a well-organized metabolic pathway that consists of four stages. Our bodies take in nutrients from the food we eat for the first two stages to convert them into carbon compounds. Then for the next steps, these carbon compounds are transformed into the energy that our cells use.

How does light therapy support cellular function?

Light can sometimes be less attributed to improve our body’s physiology. However, light has benefits that go beyond aesthetic and technological purposes. Just like how light plays a role in plants' photosynthesis, it also benefits human cellular function.

Red light therapy from Kaiyan Medical composes of Red and Near-Infrared Wavelengths that aid in the Mitochondria's function to produce more ATP energy. It works by increasing the number of Mitochondria in our cells and by boosting their function.

The electron transport chain heavily governs the cellular respiration process. Red Light therapy has photons that can boost the mitochondria to function better through the Cytochrome C Oxidase. It plays an essential role in the cellular respiration process by improving the cell's electron transfer process. In this way, more ATP can be produced by the body for an enhanced cellular function.

As mentioned earlier, oxygen plays an essential role in the cellular respiration process. The infamous Nitric Oxide can take the rightful place of oxygen to limit ATP production that causes stress and cellular death. Red light therapy also gets rid of a harmful roadblock to ATP in the dissociation of Nitric Oxide and the Cox. The photons from Red light therapy prohibits the production of nitric oxide.

The effect that Red Light therapy does on our body is that by improving cellular function, our body can achieve these benefits:

  • Improved blood Flow
  • Increased Energy Build up
  • Enhanced Healing Response
  • Reduced Inflammation
  • Reduced Stress
  • Balanced Cellular Function

As you do daily activities such as eating, drinking, walking, or working out, think of the massive role that your cellular system plays to make these activities possible. In this way, you can put conscious efforts into improving your cellular system through a healthy diet and lifestyle and by integrating Red Light Therapy.

References:

https://www.healthline.com/health/red-light-therapy#how-does-it-work?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/

https://www.medicalnewstoday.com/articles/325884

https://www.britannica.com/science/cell-biology

https://www.britannica.com/science/mitochondrion

https://www.nationalgeographic.org/media/cellular-respiration-infographic/

The Light for your Wounds

I remember how I used to come home with a bruise or cut every day after playing basketball in my childhood. Cuts and bruises were a part of the game, but my mother never took them lightly.

They may not seem like a tiny problem, but sometimes even a small wound can affect critical ways. It can lead to an infection as the cut exposes your body to external bacteria. This is why it important not to neglect the wounds.

What Happens When we Get a Cut?

Do you know what exactly happens when we get a cut?

In a small cut, the skin gets punctured, and the regular blood vessels get damaged. The effect is on the dermis layer. Whereas in the case of a deep cut, the impact is majorly on the tissues and the blood vessels break down completely results bleeding.

How our Body Reacts to Wounds?

When you get a cut, the body gets help from cells like neutrophils and immune cells. The section starts clotting the blood and reduces the blood flow. Antibodies, proteins clean up the site and eat the dead skin cells and other wastes.

Once the cut is free from germs, the skin growth gets started, and your body starts to rebuild the lost tissues and fix the broken blood vessels with the new ones. This repair work is done by cells called fibroblasts. In the last stage of wound healing, a lot of remodeling done to make the vessels and tissue functional again.

(Image source: https://askabiologist.asu.edu/)

The Light on the Wounds

No wonder science and technology have covered a long way to make human life easier. Now wounds can be treated with light therapy.

Yes, light therapy!!

That sounds out of the ordinary. But light therapy can heal your wounds by 200%!!

Wounds that Can be Treated by Light Therapy

Since wounds are of different types, wounds can be open or closed wounds. According to reports, LED light therapy can treat non-healing wounds, i.e., that doesn’t heal after 4 weeks. People with the following types of wounds can be healed from LED light therapy:

• Diabetic ulcers

• Venous ulcers

• Pressure ulcers

• Non-healing surgical wounds

• Serious burns

• Oral sores from chemotherapy/radiation

• Metabolic-disease-related wounds

• Wounds that repeatedly break down

How Red and Near-Infrared light Works for Wound

Light therapy a broad range of light having different wavelengths. Red light (620 nm — 680 nm) is visible red light, whereas Near-Infrared light (700nm — 1100nm) is invisible. Many studies reported that biologists have found that treating the cells with near-infrared light can grow 150% to 200% faster than cells not stimulated by light.

Biologically the Near-Infrared light boosts microcirculation and formation of new capillaries at the wound section.

Infrared light rays increase cellular energy that speeds up any healing process and penetrates deeper into the skin. As a result, the wound section receives more oxygen and nutrients to naturally help with the wound's healing process.

The light nurtures the lymph system activity. This assists with the detoxification process of the wound without overtaxing the lymph system and prevents lymphedema. The near-infrared rays also clean up the dead or damaged cells, making a clear blood circulation path.

Another benefit of Infrared therapy is that it helps release ATP (raw cellular energy), which gives energy to the damaged cells in the wound to heal better and faster (study).

Not only this, the studies have shown that the wound size also decreased by up to 36%.

Source: www.slideshare.net/amintalebi1/light-and-wound-healing

So, next time you encounter a wound, put a light on it!!

Let your cut heal through LIGHT THERAPY!

References:

http://www.jofamericanscience.org/journals/am-sci/am0706/36_5769am0706_203_208.pdf

https://www.infrared-light-therapy.com/red-light-therapy-wound-healing/

https://pubmed.ncbi.nlm.nih.gov/25363448/

https://pubmed.ncbi.nlm.nih.gov/25654197/

https://iopscience.iop.org/article/10.1088/1054-660X/24/8/083001

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/

https://pubmed.ncbi.nlm.nih.gov/24155549/

Improving Mental Acuity with Light Therapy

It’s common knowledge that as we age, our normal brain function gets disrupted. We tend to find it harder to recall information, memorize names, and respond with reason. The decline of our mental acuity causes these commonplace mental problems. Contrary to popular belief, aging is not the sole culprit for mental deterioration. Many factors, such as aging, lifestyle changes, and environmental stress, contribute to the decline of mental acuity.

As cognitive decline progresses, significant mental changes can result in disorders such as dementia, Alzheimer’s disease, and Parkinson’s disease. While these can be common aspects of life, they aren’t inevitable. Many medical experts believe that there are many lifestyle changes that you can take to prevent the degradation of Mental Acuity.

What is Mental Acuity?

Mental acuity is known as the sharpness of the mind. It involves our cognitive ability to concentrate, process, understand, reason, and memorize. On the other hand, intelligence means the extent to which our brains absorb and process a specific amount of information at a given amount of time. Mental acuity is a natural and essential aspect of our brain health and is not a measure of how “smart” we are.

Mental acuity allows us to perform daily activities effectively and efficiently. When our cognitive ability functions well, we’re more capable of doing things without damage or conflict.

What are the symptoms of a Deteriorating Mental Acuity?

Some signs of a deteriorating cognitive ability may be subtle. However, when left untreated could progress over time to more serious mental disorders. According to the National Institute on Aging, 8 out of 10 people who experience amnestic mild cognitive impairment develop into having Alzheimer’s disease.

Here are some early symptoms of a deteriorating mental acuity:

  • Absent-mindedness and having trouble concentrating
  • Forgetfulness of specific details like names, dates, events, and facts
  • Inability to reason and make vital decisions
  • Difficulty in retrieving information
  • Memory loss
  • Difficulty in following simple instructions

How to Improve Mental Acuity

Prevention is better than cure when it comes to developing chronic brain disorders. Here’s how you can take your brain health into your own hands by observing these lifestyle habits:

  1. Ensure a well-balanced diet

Getting enough nutrition is the key to ensure mental sharpness. Making sure you eat a well-balanced diet can help your body supply enough nutrients to your brain. Omega 3 Fatty Acids are essential nutrients that help build and restore brain cells. The brain also needs antioxidants to prevent inflammation.

Excessive intake of toxins such as alcohol and drug can depreciate your mental ability. Experts agree that poor gut health also results in a weakened immune system. As a result, it weakens your body’s inflammatory response. A poor inflammatory response causes mental disorders such as schizophrenia and dementia.

  1. Have Enough Sleep

Irregular sleep patterns and sleep deprivation disrupt your body’s circadian rhythm that can lead to short-term mental problems as well as long-term chronic health problems.

Your body’s circadian rhythm is a natural body clock that controls your sleep-wake schedule as well as your digestive patterns. When you’re sleep-deprived, these rhythms get disturbed. As a result, you experience headaches, mood swings, and difficulty to focus and recall information. Aside from these unwanted effects, not having enough sleep also negatively impacts your overall brain health.

  1. Get Yourself Moving

Exercise isn’t just for physical and aesthetic purposes. It also affects brain function in multiple ways. When you exercise, your body pumps more oxygen into your brain through an increased heart rate. Exercise allows your body to release hormones that are vital in nourishing your brain cells. It also promotes growth factors in your brain to assist in the growth of neuronal connections.

A study at the University of Georgia shows that a 20-minute exercise daily can improve memory retention and information processing. Many experts agree that a sedentary lifestyle may accelerate your way into cognitive decline.

  1. Use Red Light Therapy

Red Light therapy is a more modern approach to non-invasive and low-risk medical treatments. It is a form of photobiomodulation that allows light to change human cells' physiology that causes a wide range of benefits such as biological balance and cellular energy.

Kaiyan Medical is one of the pioneers of Red light therapy that uses red wavelengths to deliver benefits to the skin and near-infrared lights to penetrate deeper within the skin’s surface. This dual technology allows for better absorption and effectiveness of the benefits of Red light therapy.

As near-infrared wavelengths penetrate the brain’s cellular system, it promotes energy production by stimulating the mitochondria. It also prevents stress by keeping away oxidative stress. Thus, it delivers multiple benefits such as better blood flow, faster cell regeneration, and improved healing.

A study shows that red light therapy has significantly improved brain function when given to patients with cognitive dysfunction. All these benefits are vital in promoting and maintaining a healthy mental acuity. Red light therapy delivers all these cellular benefits to promote better sleep quality and a more balanced circadian clock.

As you maintain these lifestyle changes, you can experience a more improved brain function and better brain health. Now you can defy all odds and allow your brain to perform at its peak by having a healthy lifestyle and a balanced body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043367/

https://www.medicalnewstoday.com/articles/324044#oily-fish

https://pubmed.ncbi.nlm.nih.gov/12595152/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403829/

https://www.healthline.com/health/mental-health/brain-exercises

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870908/


Animal Wellness: Red Light Therapy for Dogs

Certified pup parents know pets could easily sense when we’re feeling sad, happy, scared, or sick. Our furry friends could probably read us better than we could read them. However, active pets are also prone to injuries, cuts, wounds, inflammation, and infections like human beings.

If you’re a pet owner, you’d always want to give your pets the best care possible to make sure they are healthy and happy at all times. Thankfully, medicine has innovated well enough to find more advanced treatments and maintenance tools for our canine friends. In recent years, pet owners and some veterinarians have been using safe, non-invasive, and high-tech treatments for pets and domestic animals such as Red-Light therapy.

What is Red Light Therapy?

Red light therapy has been utilized by the veterinary world to deliver similar benefits to pets, just like humans. Red light therapy is a non-invasive treatment and a form of photobiomodulation that alters animal cells' physiology.

Light therapy produces wavelengths of photons that the photoreceptors in the animal’s bodies can absorb. The light provides alteration to the animal cells that result in numerous benefits such as better blood circulation and natural cellular regeneration.

Multiple studies support the efficacy of red-light therapy to animals. A 2017 study shows how Red Light therapy promoted faster healing for dogs that underwent bone surgery. The findings were also complemented by another study that suggests near-infrared wavelengths promoted bone cell reproduction for dogs.

Red Light Treatment for Dogs?

When our pets sprain their ankles or cut their pads, their cells become damaged. As a result, their bodies need cell energy in the form of adenosine triphosphate (ATP) to repair damaged cells and tissues.

The photoreceptors in their body absorb red light. The light stimulates ATP production in the animal’s body that results in faster delivery of nutrients and better excretion of toxins. All of these processes are essential for the body’s healing.

Red Light also promotes better circulation as it stimulates Nitric Oxide production to help blood vessels remain flexible. Injured or damaged cells need proper blood flow for healing. Light therapy helps in the healing process by increasing blood flow to ensure enough nutrients and oxygen in the affected area.

Red light is beneficial for surface healing by helping tissues that are potent in hemoglobin. On the other hand, near-infrared light can work better on deeper wounds as it can pass through the animal’s body's deeper tissues.

Innovators like Kaiyan Medical uses the FDA-cleared Red Light Therapy pad that utilizes the combined technology of Red Light-emitting diodes that can penetrate the skin and infrared wavelengths that can heal muscles, ligaments, and tendons. Red light and near-infrared wavelengths are the ideal combination of surface and inner healing.

Aside from providing the cells with energy, the light also stimulates collagen production, which aids in repairing damaged tissues. Collagen is an essential protein that can help get rid of scars and wounds.

What are the conditions that can be addressed by Red Light Therapy?

Skin and Surface issues

  • Surface wounds
  • Hair loss
  • Eczema
  • Other Skin Conditions
  • Wounds and Cuts

Deeper surface issues

  • Arthritis
  • Soft tissue injuries
  • Ligament injuries
  • Post-surgery Inflammation
  • Pain, Inflammation, and Swelling
  • hip dysplasia
  • Tendon problems
  • Strains and sprains
  • Salivary gland problems

General Maintenance

  • Maintenance of healthy joints and Bones
  • Maintenance of healthy Cardiovascular system
  • Maintenance of healthy Digestive system
  • Healthy Vision
  • Prevention of anxiety

Light therapy can be your best therapeutic tool in boosting your pet’s overall wellbeing. As a general rule, light therapy is a safe and non-invasive option for treating minor issues and maintaining their overall health. However, if your pet is undergoing more severe health problems, it’s best to consult your veterinarian for a more conducive treatment plan. While red light therapy is not a panacea for all your dog’s health issues, it’s a low-risk and pain-free option to complement treatments and to promote overall wellness for your beloved pet.

References:

https://www.jstage.jst.go.jp/article/islsm/13/1/13_1_73/_article/-char/ja/

https://onlinelibrary.wiley.com/doi/full/10.1111/vde.12170?deniedAccessCustomisedMessage=&userIsAuthenticated=false

https://www.thieme-connect.com/products/ejournals/abstract/10.3415/VCOT-15-12-0198

https://www.degruyter.com/view/journals/plm/1/2/article-p117.xml

https://onlinelibrary.wiley.com/doi/abs/10.1053/jvet.1999.0292?deniedAccessCustomisedMessage=&userIsAuthenticated=false

How Does Red Light Therapy Relate with Ketogenic Diet?

Red light therapy is an easily accessible and affordable clinical device that boosts metabolism and increases ATP energy production. It is a non-invasive modulator of metabolism that delivers proper frequency, power, and luminance by shifting the mitochondria's function organically.

Ketogenic Diet and Red Light Therapy

A ketogenic diet involves the consumption of low-carb, high-fat meals. When practiced together with red light therapy, it can amplify your metabolic flexibility. It also helps cells burn more sugar and fat efficiently. Good levels of ATP energy production (empowered by mitochondria by converting oxygen and nutrients to ATP) can help prevent high-blood or low-blood pressure conditions. The process of creating ATP energy works best when our body and cells are well-balanced, reaching a state called homeostasis.

One thing to consider in following a diet plan is over-nutrition, which may lead to metabolic inflexibility. When over-feeding happens, the production of ATP energy may result in metabolic congestion. Red light therapy can help alleviate this metabolic congestion by focusing amplification of ATP energy levels. Insulin can mediate metabolic congestion by the fluidity between glucose, fatty acids, and amino acids. An important step for ATP energy production is forming the COX enzyme, which can aid metabolism by pairing oxygen neutralized into the water with high-energy electrons.

If the COX enzyme goes out of sync with electrons' flow, the high-energy electrons won’t effectively be neutralized into water. Red light can help regulate the healthy formation of the COX enzyme, efficiently oxidizing fat. The ketogenic diet triggers cells to insulin by stimulating ATP energy production by increasing metabolic flexibility, reducing carbon combustion, and helping clear metabolic congestion.

Significance to Healing

The chemical DHEA (dehydroepiandrosterone) plays numerous vital roles in health. It helps with the metabolism of cholesterol that produces hormones such as progesterone, estrogen, and testosterone. As we age, our levels of DHEA decreases, as well as the synthesis of such hormones. Low levels of progesterone can affect women in their peri-menopausal and post-menopausal stages. This is a function of the decline in mitochondria, which then affects ATP energy levels.

Low levels of DHEA may contribute to the insufficiency of adrenaline and estrogen dominance, which is common to middle-aged women at the peri-menopausal or post-menopausal stage. Women rely on the production of adrenaline and DHEA to keep their progesterone levels and prevent estrogen dominance.

Lower production of DHEA and progesterone can be an effect of elevated secretion of cortisol that is caused by acute/chronic stress. When high levels of stress reduce the adrenal glands' proper functions due to the decrease of synthesis of the adrenal cortex steroid hormones in the mitochondria, it results in adrenal insufficiency.

Based on health professionals' studies, when cortisol levels drop, it inhibits the synthesis and secretion of DHEA/progesterone, resulting in pathophysiological changes caused by stress. Enzyme activation and regulatory signaling can affect the fluidity dynamics between cortisol, DHEA, and other hormones such as progesterone, estrogen, and testosterone.

Red light therapy and ketogenic diet can mediate inflammatory stress and regulate the healthy production of DHEA.

Estrogen Levels

Estrogen is a master regulator of female metabolism. A youthful and regulatory expression of estrogen is the production of 17B-estradiol (E2). It modulates the menstrual cycle to ensure the healthy release of the corpus luteum, which secretes progesterone.

On the other hand, progesterone helps maintain a healthy uterus lining. When the expression of E2 is sufficient, progesterone secretion also increases. Having high progesterone levels means having lower estrogen and a lesser risk of getting diseases like breast, ovary, and colon cancer. E2 also contributes to potential partition fuel, orchestrating metabolic flexibility, and increasing energy levels that lead to optimal cerebral glucose metabolism.

The decline in the peripheral steroidogenesis of E2, progesterone, and testosterone is common as time goes by.

Testosterone Levels

A 12-week ketogenic diet may increase testosterone levels in men due to an increase in cholesterol and DHEA. Red light therapy also improves the mitochondrial synthesis of testosterone from DHEA.

For males, testosterone naturally converts to E2, but healthy testosterone levels stipulate a hormonal challenge to the synthesis of E2. An enlarged prostate can be caused by estrogen dominance when there is no testosterone/estrogen ratio balance. Having healthy testosterone levels may lead to a decline of estrogen dominance, as it is for progesterone in women.

Other Healing Benefits

Healthcare professionals strongly believe that red light therapy can be a powerful healing agent that may help prevent diabetic ulcers and lower chances of extremity amputations when practiced together with a ketogenic diet.

Diabetic ulcers usually result to lower limb amputations in the long-run. Studies show that diabetic foot ulcers and lower extremity amputations are increasing in number. In fact, having unhealed wounds can be alarming as the post-amputation survival rate for people with diabetes averages to only five years. Statistics show the urgent need to prevent, detect, and prove that treatments for lower limb ulcers should be highly considered. Red light therapy has been proven to increase the circulation of blood flow and healthier skin.

Innovation

Red light therapy and ketogenic diets are considered to be disruptive innovators in the healthcare system. Apart from the fact that red light therapy is non-invasive, such treatment shows great potential in helping lengthen the lifespan and improve people's overall health. Red light therapy also promotes a more affordable and accessible treatment that can be done in the comfort of your home.

Here at Kaiyan Medical, we offer red light therapy devices to help you achieve your health and aesthetic goals. To learn more about the brands and products we offer, please click here.

More References

https://perfectketo.com/red-light-therapy/

https://perfectketo.com/keto-diet-plan-for-beginners/

https://www.rejuvcryo.com/the-science/2019/8/14/article-the-surprising-synergy-between-keto-and-red-light-therapy-rejuvcryo-north-county-san-diego

Deuterium and Red Light Therapy

As the most accessible element in the globe, hydrogen plays a huge role in our biological processes. However, you may not know that hydrogen usually brings an uninvited guest in your body, and we call it deuterium. Having high deuterium levels may change the chemical reactions in your cells and affect your bodily functions and metabolism, leading to unwanted health consequences.

What is Deuterium?

Deuterium is also known as a “heavy hydrogen” and is one of the two stable hydrogen isotopes. We commonly have it in our bodies — in fact, it helps children grow. However, adults may have too much deuterium because of dietary and environmental factors. As mentioned above, this may lead to chemical reactions at a cellular level and lead to health risks.

How Can Deuterium Affect Your Health Negatively?

Hydrogen is necessary for our day-to-day bodily functions. Our biological processes require it, and we usually get it from what we eat or drink. Upon intake, hydrogen goes to the mitochondria, also known as the powerhouse of the cells.

Our mitochondria can be compared to thousands of engines that continually run to produce the ATP energy we need to survive daily. The majority of people eat only three to five pounds of food each day, but we usually make more than 170 pounds of ATP energy at the same time.

On the other hand, deuterium is like hydrogen’s “evil” sibling. And we repeat, excess deuterium is harmful to our bodies. Because it is twice as heavy and large as hydrogen, it may damage the nanomotors in your mitochondria and slow down ATP energy production. As time goes by, the wear and tear on your nanomotors caused by the heavy hydrogen atoms may completely break your nanomotors. This damage may cause muscle pain, dehydration, impaired memory, poor sleep, headaches, and lymph nodes.

How Can You Measure the Level of Deuterium in Your Body?

Two “D-terminator” diagnostic tests can help measure the deuterium levels in your body. Advanced technology, such as magnetic resonance imaging (MRI), can also be used to visualize and track deuterium patterns in your body, whether it’s in your bodily fluids, DNA, or even your hair and nails. Based on these tests, your doctor will be able to determine your deuterium levels. And when it shows to be excessive, he/she may come up with a plan to deplete deuterium in your body.

Why Do We Get Overloaded with Deuterium?

We experience high deuterium levels because of what we eat or drink and some other environmental factors. For instance, carbohydrates, processed foods, and synthetic supplements contain high levels of deuterium. Tap, ocean, and river water also have high deuterium levels, so when you’re exposed to these things regularly, you may experience an overload of this hydrogen isotope.

How Can You Deplete Deuterium?

Nutrition is the baseline of depleting deuterium. Based on your test results, your doctor may recommend consuming food groups that contain lower levels of deuterium, such as proteins, green vegetables, and healthy fats. You may also be advised to drink deuterium-depleted water to lower your deuterium levels.

Health experts say that a body that functions properly can naturally regulate deuterium levels and produce healthy amounts of ATP energy.

How Does Red Light Affect Deuterium?

Red and near-infrared light can affect our body’s hydrogen bonds in a process quite similar to photosynthesis. The water inside our cells usually becomes less harmful when our bodies absorb wavelengths of red and near-infrared light between 600–950 nanometers. This helps with proper cellular respiration and helps increase ATP energy production in your body.

Changing the water's resistance in your body, red, and near-infrared light can help reduce the amount of friction at the cellular level, promote cellular longevity, and lead to higher outputs of good energy.

To learn more about the benefits of red light therapy or to see what kind of red and near light therapy devices you can use to lower your deuterium levels, click here.


More References

https://www.nature.com/articles/s41598-020-61983-3

https://doi.org/10.1038/s41598-020-61983-3

Wang, M.; Audi, G.; Kondev, F. G.; Huang, W. J.; Naimi, S.; Xu, X. (2017). "The AME2016 atomic mass evaluation (II). Tables, graphs, and references" (PDF). Chinese Physics C. 41 (3): 030003-1–030003-442. doi:10.1088/1674-1137/41/3/030003.

https://www.hindawi.com/journals/tswj/2018/5454367/

Answering FAQs About Hyperpigmentation

You might have heard about hyperpigmentation from your dermatologist or a skincare company. But if you didn’t completely understand this skin condition — and you want to know how it develops, how to remove it, etc. — or if you have questions about this skin condition, this article can be of help.

What is Hyperpigmentation?

Hyperpigmentation can be one or multiple skin patches or spots that appear much darker than your skin color. It is a cell mutation caused by changes in hormones, an injury like sunburn, acne, peeling from chemicals or any treatments, or inflammation. The darker areas of hyperpigmentation are excess deposits of melanin. And although it is harmless and common, having hyperpigmentation can make people more conscious about their looks. In fact, some people try to conceal it with cosmetic products, while some try to deal with it with professional help.

What are the Common Causes of Hyperpigmentation?

Age spots: As we age, brown, black or tan skin spots may develop on our hands, face, and/or head. These mostly affect light-skinned individuals and are caused by too much exposure from the sun.

Melasma: Usually caused by hormonal changes, melasma is common in women, especially those who are pregnant. It is composed of large patches of darkened skin that can appear on the face or stomach. Those with darker skin are more likely to have melasma.

Inflammation: This is caused by autoimmune reactions from skin conditions like acne and eczema or a skin injury. Post-inflammatory hyperpigmentation appears on the face and neck, and its appearance may vary depending on the skin tone. Inflammation can happen to anyone, regardless of skin color and origin.

How Can I Treat Hyperpigmentation?

There are different treatment options for hyperpigmentation, depending on your skin tone. Fair skin can be treated by most hyperpigmentation procedures, such as laser treatments and micro peeling. Medium skin usually reacts better with chemical peels and microdermabrasion therapy. Darker skin can benefit from using glycolic acid, kojic acid, microdermabrasion in a low setting, lower-strength chemical peels, and low-intensity laser treatments.

Some important things to watch out for when treating hyperpigmentation include:

  • Take a lot of vitamin C, an antioxidant that helps fight dark spots. Vitamin C helps prevent melanin production by inhibiting tyrosinase enzymes, causing lighten pigmentation and making normal skin brighter.
  • Another way to treat hyperpigmentation is to re-injure the skin's affected area, flushing the pigment to the surface.
  • There are topical creams or even home remedies (i.e., aloe vera, green tea, and licorice) that can be used to help heal hyperpigmentation. Some people find them effective, while others find other treatments with the same purpose as these treatments more effective. Red light therapy is one example.
  • Dark skin should be treated more carefully to prevent hypopigmentation, development of white spots that cannot be reversed.
Is Light Therapy Effective in Treating hyperpigmentation?

Photobiomodulation is another name for red light therapy. It may help the body produce more energy and regenerate the skin by using natural light. This can also be used on hyperpigmentation and other skin injuries like acne, inflammation, burns, and scars. When used consistently, light therapy is highly effective in reducing and healing hyperpigmentation patches and helping them return to normal pigment levels.

Red light therapy is a powerful, advanced relief for skin inflammation. Skin cells heal and rejuvenate better when exposed to healthy wavelengths of light, which can help treat hyperpigmentation.

Why is Red Light Therapy Better than Near-infrared Light Therapy in Treating Hyperpigmentation?

There’s a study that shows near-infrared light can help produce tyrosinase enzyme, which prevents melanin production. This helps patients with vitiligo stimulate melanocytes, the same compound in vitamin C that helps lighten hyperpigmentation. But the truth is, there is no clear clinical consensus among photomedicine researches about using near-infrared light for hyperpigmentation.

Red light wavelengths are considered to be safe as it does not stimulate the production of pigment. It creates healthy wavelengths of light to help the skin cells heal and rejuvenate naturally.

When can Results be Seen After Doing Light Therapy to Treat Hyperpigmentation?

Results can be seen after several treatments done per week. The level of skin improvement depends on how consistently you use red light therapy. Also, the more consistent and the more careful you are in the process, the better the results you can see. Be sure not to pick or touch the treated areas to avoid infection or irritation.

Conclusion

Light therapy, especially when combined with other treatment options, can greatly help remove hyperpigmentation. To learn more benefits of red light therapy, you may reach out to us. We offer safe and easy-to-use light therapy devices that physicians use both for aesthetic and medical purposes. Meanwhile, if you have more questions about hyperpigmentation, please reach out to your dermatologist.

More References

https://www.aocd.org/page/Hyperpigmentation#

https://www.healthline.com/health/hyperpigmentation

https://www.healthline.com/health/beauty-skin-care/hyperpigmentation-treatment

https://theskincareedit.com/red-light-therapy-benefits#:~:text=Red%20Light%20

The Benefits of Red Light Therapy in Treating Hypothyroidism

Thyroid issues are a commonplace problem that affects all ages and genders. It significantly contributes to changes in mental outlook, energy levels, skin, and weight. Hypothyroidism has drawn much attention due to many cases that are left undiagnosed, untreated, or inadequately treated. As a result, it led to more serious problems such as infertility, heart disease, neurological problems, and high cholesterol and blood pressure levels. Not to mention, treatment studies for hypothyroidism have experienced a significant backlog throughout the years.

In this article, we take a look at the basic precepts of hypothyroidism and how Red light therapy plays a role in treating the thyroid problem.

What is Hypothyroidism?

Hypothyroidism is a chronic abnormality of the thyroid gland, demonstrating an inadequacy of thyroid hormones such as triiodothyronine and thyroxine (T4). Normal levels of thyroid hormones stimulate a healthy amount of mitochondrial energy production. This means that in hypothyroid cases, the thyroid inhibits a state of low cellular energy.

As a result, people who suffer from this chronic problem often feel unusual fatigue, tiredness, weight changes, and skin problems. However, symptoms can vary from person to person and may even be subtle enough to be left undiagnosed and untreated. When left untreated, the disease causes more irreversible neurological, reproductive, and cardiovascular problems. It’s also found that Hypothyroidism is found to be five to eight times more prevalent in women than in men.

What Causes Hypothyroidism?

Hypothyroidism can be caused by a wide range of diet and lifestyle issues. Some cases can be caused by a lack of iodine intake, especially in more underdeveloped parts of the world. It can also be caused by other dietary issues such as low carb intake, excess polyunsaturated fat intake, and alcoholism. Other typical causes include stress, aging, sleep deprivation, and heredity.

What is Light Therapy?

When talking about light, we often think of it as the first thing we switch on in a dark room or the bright rays that set up the mood. We don’t usually think of it as having bioactive properties, penetrating beneath our skin, affecting the way our hormones, tissues, and cells function.

In reality, our cells actually capture photons of light, just like how plants do. Light therapy, also called photobiomodulation, essentially means light (photo) changing (modulation) your biology (bio).

How Can Red Light Therapy Help Treat Hypothyroidism?

Red and near-infrared light therapy, backed by over 5,000 studies, has grown its significance in medicinal treatments throughout the years.

Red light therapy is significantly targeted for hypothyroidism because unlike other kinds of light; they have a greater penetrability beneath our skin.

In fact, a 2010 study found that 38% of patients with Hashimoto’s hypothyroidism who were given red light therapy treatments have reduced their medication dose, while 17% have been able to stop the medication completely.

Here’s how it works:

  1. It Supplies energy

Because hypothyroidism is reflective of low cellular energy in the thyroid, red and near-infrared light helps the cells work better by supplying more energy to your body.

They have a photoreceptor called cytochrome c oxidase that works by catching photos of light. Like how our food is being processed by our body for the mitochondria to stimulate energy, the photos of light also stimulate energy production in the mitochondria. The mitochondria are responsible for the energy production of our body’s cells.

  1. It Prevents Stress

Red light is also shown to prevent stress by averting nitrous oxide poisoning. This means that aside from helping the mitochondria supply more energy, red light helps the thyroid hormone by alleviating stress-related molecules' effects.

  1. It Breaks the Cycle

Hypothyroidism is a vicious cycle of having low energy availability and decreased thyroid hormone production. By stimulating energy production in the mitochondria and preventing nitrous oxide poisoning prevention, red light can potentially break the cycle responsible for hypothyroidism.

In Kaiyan Medical, we produce a medical-grade red light therapy device that is effective and non-invasive, ideal for supplementing hypothyroidism treatments. Our device has a dual optical energy technology that combines red light and infrared light therapy as an excellent spectrum for deeper penetration and absorption. You can now rise above hypothyroidism and maximize your body’s healing properties with our Red Light therapy device.

More References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247385/

https://drruscio.com/red-light-therapy-part-ii/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822815/

https://www.health.harvard.edu/newsletter_article/treating-hypothyroidism


How Saunas and Red Light Therapy are Distinct but Complementing

Saunas and red light therapy devices are clinically-proven treatments that complement each other wonderfully, even if they depend on distinct biological mechanisms to yield various natural health and aesthetic benefits.

In this article, we’ll focus on how things work for red light therapy and the distinctions of traditional saunas, and what you can actually gain by availing of either of them.

What You Need to Know About Saunas

Saunas can make your body’s core temperature hotter by supplying sufficient heat throughout your body. It has been a part of traditional medicine for various centuries, as the old century folks realized the health benefits of sweating. Although there are multiple types of saunas, two of them are the most popular:

  1. Traditional Convection Saunas

When you think of saunas, this is the first scenario that comes to mind: hot and steamy. This type of sauna requires more energy as it delivers heat to the atmosphere, warming the air inside the sauna, and distributes heat in the body. Traditional convection saunas can maintain air temperatures between 170–200°F and are an ideal type of sauna for general use. It is important to comprehend the different temperatures required for specific health concerns since being exposed to heat more than what has required triggers a warning for unsubstantiated claims.

  1. Infrared Saunas

The latest trend in saunas is the infrared saunas. Inside, instead of warming the air, this kind of sauna heats actual objects. Such objects include those with emitting surfaces, charcoal, and carbon fiber. Infrared saunas' effectivity is directly attributed to the temperature, humidity, and length of time your body is exposed to heat, even though many saunas claim to provide “full-spectrum” infrared wavelengths.

The farther the wavelengths are in the infrared spectrum, the more they are considered efficient and effective in heat production. This will be thoroughly discussed later, but the general gist is that heat supplementation is the primary purpose of saunas, convection, and infrared.

On the other hand, near-infrared wavelengths in near-infrared saunas generate very little heat. Most of the high-quality standard saunas use more effective heats from the far-infrared spectrum or IR-C wavelengths.

What are the Health Benefits of Saunas?

Inducing thermal stress on the body is the primary function of every sauna, but what does it really mean?

One of many biological responses from sauna usage is increased heart rate as well as perspiration. The essential body processes protein metabolism and is also affected by enough heat. Heat shock proteins are a special kind of protein that responds specifically to cellular stress from heat. Heat stress induction leads to natural health benefits like those we gain doing physical activities.

One experiment had participants sat in a sauna treatment for 30 minutes at 194°F for 3 weeks, totaling 13 work sessions. The results showed that the participants improved 32% in performance tests versus those who underwent sauna treatments.

Besides improving your cardiovascular functions, using saunas can help reap benefits such as detoxication, decreased depression, and lesser chronic fatigue.

Red Light Therapy vs. Saunas

What differentiates saunas from red light therapy devices is their mechanism of action. While saunas utilize heat for biological effects, red light therapy devices supply healthy light wavelengths directly to the skin and cells. Even when producing almost no heat, red light therapy devices help with cellular function improvement and support bodily balance. Simply put, red light therapy helps energize the body with light, while saunas heat your body.

How does red light therapy work?

Mitochondria, the powerhouse of our cells, is wonderfully affected by certain wavelengths of natural light. This helps in producing energy within the cells of our body, feeding photons to our cells from natural light via red light therapy.

What about clinically-proven wavelengths?

We feel warm when exposed to sunlight and other heat sources such as fire and hot coals because most of the wavelengths, including ultraviolet (UV), are rapidly absorbed by the outer layers of the skin tissue as heat.

However, unknown to many, some wavelengths have the unique capability of boosting your cellular functions and energy. These are those few wavelengths that can penetrate human tissues more effectively, having photons power-up your “cellular batteries.”

What to Look for When Buying Red Light Therapy Devices and Saunas?

One of the first few things you need to look for in saunas is the temperature it produces. You need to consider some other factors, including the type of wood, the heating unit (Is it conventional or infrared? Is it near far or full-spectrum?), finishes and stains, price, and more.

On the other hand, some of the factors you need to consider when choosing a red light therapy device are the device’s light energy output, light color or frequency range in terms of nanometers, warranty, body or treatment coverage area, the price, and the credibility of the company provider.

Light Therapy and Saunas: Friends with Benefits

Saunas and red light therapy devices offer a wide range of natural health benefits, which surprisingly go well with each other. They both support balance and health to improve your fitness and function but do not overlap with each other’s effects because of energy supplementation in distinct forms and wavelengths. What a great combination of complementary natural therapies!

Here at Kaiyan Medical, we provide different types of red light therapy devices for various medical, wellness, and aesthetic uses. To see our list of products, click here.

References:

https://www.health.harvard.edu/staying-healthy/saunas-and-your-health

https://www.healthline.com/health/fitness-exercise/are-saunas-good-for-you

Scoon GS, Hopkins WG, Mayhew S, Cotter JD. Effect of post-exercise sauna bathing on the endurance performance of competitive male runners. Journal of Science and Medicine in Sport. 2007 Aug.

Crinnion WJ. Sauna as a valuable clinical tool for cardiovascular, autoimmune, toxicant- induced and other chronic health problems. Altern Med Rev. 2011 Sep.



Let’s Talk About Optimal Performance Recovery and Red Light Therapy

Performance and recovery go hand in hand when training or doing physical activities, regardless if you’re an athlete or not. In fact, athletes and their trainers utilize light therapy to improve their performance and muscle health and optimize recovery. To expound further, this article will tackle optimizing performance in fitness, improving the recovery process, and breaking down the significance of light therapy.

Optimizing Performance and Improving Recovery

Optimizing performance means paying attention to the body and how it functions, to live and train the body, and to find the best way to support its functions. Performance is not based on how hard or heavy are the weights you lift or the number of kilometers you’ve run; it is how effective your performance is and how you match it with your lifestyle (with the way you eat, drink and sleep).

On the other hand, recovery is about the effectiveness of the body’s healing process and the conscious effort of being in your best shape by enhancing your workout. It is also about utilizing the body’s tools and functions to effectively finish the jobs required daily.

Physical Performance and Recovery

Performance and recovery are correlated to one another. In exercising or training, if you want to improve fitness, workouts should be consistent. To get stronger, faster, and bigger, certain efforts must be made to increase performance levels. The recovery process is essential in health. It contributes to the workout; it is the downtime between training sessions or a break due to an injury or a period of healing from any exhaustion experienced.

Breaks like cool-downs, rest, and ample time of sleep give your body time to recuperate. They also allow healing for the muscles and tissues affected, strained, or damaged from workouts or training.

Performance is better when recovery time from soreness or inflammation is maximized. It also helps prevent burnout, fatigue, and possible injuries. If recovery is not made right, your physical performance may not reach its optimal state. Some athletes and trainers even make a recovery a priority over training itself. They believe that when an athlete recovers better than their competition, they will train harder in the long run.

Recovery is for Everyone

Even if you are not an athlete, you should know how to let your body rest, heal, and recover properly from any form of injury or physical activity. Everyone has their own activity levels to maintain. It may not be sports-related, but everyone demands effort from their bodies on a day-to-day basis.

When Recovery is Not Prioritized…

Regardless if you are an athlete, your body has limits. And if you push too hard, the body can break down and perform worse, especially if you didn’t observe any recovery time. Overtraining and pushing the body beyond its limits can affect performance in the short term or long term. Chances of injury are higher when you don’t allow yourself to recover, and it may also affect hormonal levels and the function of the immune system. The body needs time to process inflammation or any injury.

Inflammation and the Importance of Recovery

Inflammation happens when the body responses to danger or strain. It often takes place during a strenuous workout. When exercising, inflammation may indicate muscular damage. And when a muscle is “damaged,” it means that the tissue is growing and undergoes repair to get stronger.

Experiencing inflammation is a normal part of the growth and repair of muscle tissues. However, if you won’t set aside time for recovery, your inflammation may worsen over time and lead to greater health consequences.

4 Easy Ways to Improve the Recovery Process

Here are some ways that can help you improve your body’s recovery process:

  1. Body awareness

The body speaks when it sends signals to the brain. Sometimes, we dismiss these signals because of training goals. This may eventually lead to fatigue and injury. When you experience pain or when your muscles are sore, it is important to give your body time to recuperate. You must also be aware of your heart rate, especially at rest, as it may be saying something about the state of your health.

  1. Getting enough sleep

Besides giving your body time to recuperate, deep sleep also allows the body to digest and process fat and recover from inflammation or damaged muscle tissues. It is harder for the body to recover from pain, strain, fatigue, and injury when you’re sleeping less than 7–8 hours per night. If you’re struggling with getting enough sleep, try doing meditation or speak with a doctor so he/she can advise you about developing a sleeping routine.

  1. Eating a balanced diet.

Getting the right amount of whole foods, good carbohydrates, protein, and good fat can also boost your performance and recovery. Lowering your intake of processed foods, alcohol, and sugary drinks can also help decrease inflammation.

  1. Aiming for balanced and healthy cells

The performance and recovery of our bodies depend entirely on our cells. When our cells are creating and using energy efficiently, our bodies recover faster. ATP (adenosine triphosphate) energy is released to give us power in what we do. The process of creating ATP energy works best when our body and cells are well-balanced, reaching a state called homeostasis.

Light Therapy, Performance, Healing, and Recovery

High-quality devices are now available in the market to help athletes and trainers enhance the body’s natural healing and recovery process through light therapy.

Light therapy is a non-invasive treatment that uses LED lights to deliver red and near-infrared light to the skin and cells. It promotes efficient cellular ATP energy production and helps restore the balance of cells and tissues. Light therapy can be done before or after a workout. Some even do it both times — before and after a workout, depending on their goals.

Pre-conditioning with light therapy before working out can also help strengthen muscle performance. It can limit muscle damage and strain, lessening the chances of inflammation or soreness. When used after a workout, it promotes the speedy recovery of muscles and accelerates its adaptability to exercise. It also helps the body process acute inflammation after physical activity.

The Relationship Between Light Therapy and Muscle Cells

Muscles are composed of millions of cells that need to release ATP energy to fulfill the body's jobs, balancing exercise and stress. Light therapy helps improve cellular ATP energy, glycogen synthesis, oxidative stress reduction, and protection against muscle damage from exercising. Light therapy also helps improve blood circulation and oxygen availability, which allows better healing and recovery. It helps with the overall improvement of physical performance and faster recovery times. It also helps limit fatigue from exercising and strength training.

Recover and Improve Your Performance with Light Therapy

As discussed, light therapy promotes faster healing and recovery and soothes cells under stress when doing strenuous workouts, incurring injuries, and experiencing inflammation. When you set aside time for recovery, you give your body and cells what they need to function, thus improving your overall performance.

At Kaiyan Medical, we offer high-quality light therapy devices to help you achieve and maintain your fitness and performance goals. If you have questions about our products and the brands we offer, please don’t hesitate to contact us. We will respond to you as soon as possible.

Red Light Therapy For Hair Loss

If you’re one of the 35 million men or 21 million women in the United States who are losing their hair, you know how hard it can be to slow down getting bald. Creams, pills, and other treatments are often touted as solutions, but even if they do work, they come with side effects. Meanwhile, hair loss takes a tremendous mental toll. Among the most common effects are diminished self-esteem and confidence, as you notice others wearing hairstyles you couldn’t possibly pull off. And while some people rock the bald look, it’s not for every guy suffering from male pattern baldness and it’s rarely an option for women.

If this sounds like you, red light therapy is worth a look. Red light therapy for hair loss is backed by research, is completely natural, and can slow–or in some cases, reverse–hair loss without disruptive side effects. If you’re curious how this is possible, what the most relevant studies say, and–more importantly–if it will work, this article is for you. From cellular growth to the proper how-to steps, read on to uncover how red light can help you get your hair back.

Why Do We Lose Hair?

According to the International Society of Hair Restoration Surgery, almost half of men show noticeable hair loss by reading middle age. Surprisingly, the numbers are even higher among women: by the age of 60, nearly 80 percent of women show noticeable hair loss.

So, why do we lose hair? Briefly, losing hair helps us making room for new growth. A typical human will have up to 100,000 hairs on their head, and it’s only normal to lose 50–100 every day. After that, that causes get more complicated.

A few of the most common causes include:

Genetics

The most common cause of hair loss is hereditary hair loss or androgenetic alopecia. Male pattern baldness is characterized by M-shaped hair loss that begins at the temples and a bald spot in the back. It can begin as early as puberty or later in life. Female pattern baldness generally manifests as thinning on the head's top and crown, widening the center part but not affecting the front hairline.

Stress

Both acute and chronic stress contribute to hair loss in men and women. In acute stress, hair loss is often tied to a specific cause such as a sudden loss of a loved one, an accident, illness, or surgery; this hair loss may be temporary. Chronic stress, including job stress, relationship stress, and financial stress, also appears to accelerate hair loss.

Poor Nutrition

Specifically, inadequate protein intake affects hair follicles and contributes to hair loss. While over 40 million Americans are malnourished due to poverty, easy accessibility of junk food means that while many Americans get enough calories in their diets, they do not necessarily get the nutrition they need.

Red Light Therapy for Hair Loss


Given the side effects, cost, limited success, and ongoing hassles of these common hair restoration treatments, it makes sense to look at an alternative that is painless, non-invasive, has no side effects, and can actually enhance your health in a variety of different ways at the same time. Red light therapy is that option. Also red light therapy can help improve various other conditions, including joint pain from arthritis, sun damage, and nerve damage, to name a few. In fact, it can even treat one of the root causes of hair loss: thyroid problems.

What Is Red Light Therapy?


Red light therapy is a phototherapy that uses specific wavelengths of light to reduce inflammation, accelerate healing, and promote a healthy skin tone. Red light is part of the visible light spectrum (not to be confused with infrared light or ultraviolet light, invisible to the human eye) and is bioactive in humans. This means that our bodies respond to it beneficially in much the same way that plants respond to sunlight: by creating more energy at the cellular level.

Red light (also called low-level light therapy or LLLT) for hair loss was discovered somewhat by accident in the 1960s when mice were given chemotherapy. The chemotherapy-induced hair loss, but when the mice were irradiated with red light, the fur grew back thicker than before. Modern red light therapy works similarly, using high-power LEDs to saturate your body with wavelengths of therapeutic light. It typically uses visible light in various colors, but the red and infrared ranges are best for a wide variety of conditions, including hair loss. While sunlight provides a complete spectrum of wavelengths (including red light), it also contains harmful UVA and UVB wavelengths. Using the red light frequency alone has no side effects, such as burning or skin damage.


How Red Light Therapy Restores Hair


Red light is especially effective at treating hair loss; specifically, light in the 620nm (nanometer) to 660nm wavelengths work best. It works by increasing blood flow in the scalp; this stimulates the metabolism in hair follicles, resulting in more hair production.

You lose hair during hair loss but not the follicles–the tube-like formations that anchor hair to the skin. At the base of each follicle is the hair bulb (the whole thing looks somewhat like a tall vase). At the bulbous part of the vase are the papilla and the matrix; this is where hair begins to grow. We see as “hair” mostly a protein called keratin that makes up the hair shaft. When the hair follicles and the papilla and matrix cells are not functioning properly, they cannot support hair growth,, causing it to slow or cease altogether.

Red light penetrates the skin to the base of the hair follicles, stimulating the cells, papilla,, and matrix to produce more energy, which results in these cells replicating more successfully. This replication leads to new hair growth from these previously-dormant follicles. Red light also:

Stimulates Adenosine Triphosphate (ATP) production, a coenzyme responsible for fueling cellular structures. Increases in ATP cause individual cells within the hair follicle to increase their activity, including the rate at which they replicate. Restoring the energy of the hair follicles' cellular structures means the papilla creates more keratin, which results in hair growth.

Increases collagen production. Hair is primarily made up of a protein called keratin. While collagen — another type of protein — isn’t present in hair, it acts as an antioxidant to fight damage caused by free radicals (compounds that develop in the body during stress, environmental pollutants, poor nutrition, etc.). Free radicals damage hair follicles, which contributes to their inability to grow hair. Increased collagen means less oxidative damage, which can lead to increased hair growth.

Increases the creation of new capillaries, which improves blood flow to the scalp and brings oxygen and nutrients to hair follicles,, and removes waste that can lead to hair follicle damage. One study linked improved blood flow to the growth of thicker, healthier hair. Barbers have long encouraged men to massage their scalps to increase blood flow, but increasing blood flow using red light is generally more effective.

Cases Where Red Light Does NOT Work

It’s important to note that while red light therapy is effective for many types of hair loss (especially alopecia or temporary hair loss due to hormonal imbalances or illness), it’s not effective 100% of the time. For example, hair loss due to chemotherapy will continue until the treatment is stopped. The same applies to hair loss due to the side effects of other medications. Also, any hair follicles that have been destroyed due to injury, surgery, burns, or other permanent injuries will not grow back. And remember, please see your doctor if you experience sudden or dramatic hair loss, which can signal a serious underlying condition. Red and Near-Infrared Light: a Potent Combination

More References

https://pubmed.ncbi.nlm.nih.gov/30843235/

https://pubmed.ncbi.nlm.nih.gov/29957664/

https://pubmed.ncbi.nlm.nih.gov/29797431/

https://pubmed.ncbi.nlm.nih.gov/28328705/

https://pubmed.ncbi.nlm.nih.gov/25124964/

Blue Light Therapy for Acne: Does it Work?

Having acne-prone skin can be incredibly frustrating, especially when your oral and topical treatments don’t seem to work well enough. Skincare ingredient junkies know actives that target acne problems such as salicylic acid and benzoyl peroxide can be a few of the most irritating ingredients that you can put on your skin- especially when used in hefty amounts.

If you’ve been wallowing into these-but to no avail, you might ease your frustrations by learning about what Blue Light Therapy can do to acne problems.

What is Blue Light Therapy?

Blue Light therapy is a form of phototherapy that uses a visible light device that has been used by dermatologists for decades as a clinically proven treatment for acne.

The treatment is considered a generally safe, non-invasive, and pain-free procedure with no downtime. Besides being a popular anti-acne treatment, Blue Light therapy has also been shown to remove stubborn acne marks and sunspots. It eliminates free radicals caused by exposure to harsh environments that may oxidize and age your skin.

One significant impact of Blue light therapy is that it has been used to treat skin cancer in patients with actinic keratoses at University of Iowa Hospitals & Clinics. The American Academy of Dermatology considers Blue light therapy a promising treatment for numerous skin issues like acne.

How effective is Blue Light Therapy Work for Acne?

Blue light has been shown to have an antimicrobial effect that penetrates deep into the skin’s pores to eliminate the acne-causing bacteria, otherwise known as Propionibacterium acnes, or P. acnes. Blue Light has been proven to have an antimicrobial effect, making it an ideal treatment to effectively kill several types of bacteria in your pores and oil glands responsible for causing breakouts.

A clinical study shows that 77% of people with acne-prone skin treated with blue light therapy for five weeks have seen significant changes in their skin. Another research suggests that at-home blue light therapy has reduced acne lesions on people who have used the therapy for 28 days.

Unlike other topical treatments that address inflammation, blue light therapy targets breakout-causing bacteria in your pores and by healing the skin from within. Blue Light Therapy is a form of defensive treatment to acne by eradicating bacteria that causes redness and inflammation and a proactive solution to preexisting acne.

Who is a good candidate for Blue Light Therapy?

Experts at the American Academy of Dermatologists agree that blue light therapy works best for people who have mild to moderate acne problems. It is also a great treatment to eliminate acne scars. Blue light therapy works by addressing the acne issue from its core. It works by removing preexisting mild to moderate acne while preventing sebum build-up that causes the inflammation. Severely too deep abdominal cystic acne may benefit from other prescriptive medications that target more serious skin problems. People who incorporate Retinols in their skincare routine may also want to avoid getting Blue Light treatments as such ingredients make the skin very sensitive.

What Blue Light Devices should I use?

Although many dermatologists use current clinical studies, there are available at-home blue light therapy devices that effectively treat acne problems.

The best Blue Light Devices should be FDA- cleared, just like our Blue Lights Therapy Beauty Skin Complexion Handheld Device and Aduro Mask, that is made with medical-grade quality. FDA-cleared at-home devices have innovated into using the same technology that delivers satisfactory results for acne-related problems.

Blue Light therapy works best as a treatment for acne when used consistently. A weekly maintenance appointment to your dermatologist’s clinic for a blue light treatment may cost you $100, which makes it a much more expensive endeavor than investing in at-home devices.

Portable blue light therapy devices can be more beneficial for you as they can be used more frequently as an addition to your skincare routine at a lower price point.

The best blue light therapy devices in the market provide a safer alternative to other harsh treatments for acne that may require risks such as scarring and irritation. If you want to know more about effective light therapy treatments, check this out.

Now you can add a cool, avant-garde addition to your skincare that can be a very convenient and effective treatment for your stubborn acne problems.

References

https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/radiation/photodynamic-therapy.html
https://www.medicalnewstoday.com/articles/319254
https://uihc.org/health-topics/blue-light-therapy-warding-skin-cancer
https://www.healthline.com/health/blue-light-therapy

Putting the Light on Psoriasis

Psoriasis is an autoimmune inflammatory skin disease where the skin cells build up and form scales and itchy, dry patches over the surface. It is a misunderstood skin condition. The misbelief is that it not treatable and affects a particular gender or at a certain age. However, it can affect both men and women equally, and more than 5 million adults deal with this skin disorder — which is about 2% of the U.S. population.

Another common misconception is that it is contagious and can spread from one person to another. Well, Psoriasis is an immune system problem in which your immune system does not work as it should normally do.

Light Therapy: The Advanced Way

With some options available for Psoriasis, light therapy is one of the oldest, safest, effective, convenient, and highly preferred treatment by dermatologists. It has been widely used to treat stable psoriatic lesions, including different parts like the trunk, scalp, arms, and legs, and partial nail psoriasis. The treatment of light therapy is available in a variety of light with different mechanisms of action. Based on the bandwidths, the varied versions includes ultraviolet B (UVB), psoralen ultraviolet A (PUVA), pulsed dye laser (PDL), photodynamic therapy (PDT), intense pulsed light (IPL), light-emitting diodes (LED), etc.

How it Works

Light therapy has a very long history of dermatological benefits. Psoriasis happens when the skin cells there is an abnormal production of skin cells. Light therapy works by slowing down the excessive production of skin cells on the epidermis layer. This reduces plaque formation. It also reduces inflammation and limits the growth of skin cells by affecting the functioning of the DNA.

Many clinical studies and researches have displayed positive and effective result in the treatment of various types of Psoriasis like –

  • Small areas of stubborn, thick plaque psoriasis
  • Palmoplantar psoriasis (on hands and feet)
  • Nail psoriasis
  • Scalp psoriasis

Why do Dermatologists Prescribe Light Therapy?

Light therapy treatment can:

  • Slow down the growth of abundant skin cells
  • Repress the functioning of an overly active immune system
  • Reduce inflammation and allow the skin to heal itself
  • Reduce or eliminate the dry and itchiness

Light Therapy Mechanism

Light therapy can be delivered on any affected skin areas such as the hands or scalp, or across their whole body. But proper care and protection are given to the skin areas, such as the eyes and genitals, before treatment.

The treatment doesn’t work in on-go. Several sessions are required as the effect is gradually seen in patients. The treatment requires multiple sessions where the amount of light is gradually increased per session. The light exposure is not instant and varies for a different duration depending on the skin condition severity.

The sessions give proper time to heal the skin. Usually, the sessions go from two to three months. We need to understand the fact that every person’s skin reacts to light therapy differently. Hence, how much improvement one sees in their psoriasis symptoms and how long those benefits last depends totally on their system.

Now the time has changed, and technology has brought more convenience in getting the treatment. Kaiyan Medical provides you numerous products that you can use at your home and enjoy your daily activities without getting disturbed. Break the old and mainstream treatments and adopt effective light therapy to let your skin and life heal completely!

References:

The Effect of Green & Red Light Therapy on Hearing

Low-level laser therapy

Low-level laser therapy (LLLT) has been practiced for over 20 years in Europe and has been introduced in the United States as a treatment for pain and postsurgical tissue repair. It has been proposed that laser energy in the red and near-infrared light spectrum may aid in the repair of tissue damage. A proposed mechanism for this therapeutic effect is the stimulation of mitochondria in the cells to produce more energy through the production of adenosine triphosphate.

Studies in humans have investigated the effects of LLLT on both hearing loss and tinnitus, with equivocal results. Some studies have found an improvement in hearing thresholds and tinnitus symptoms.

The Subjects

A total of 35 adult subjects were enrolled in the study. Two subjects withdrew from the study due to loss of interest and/or scheduling difficulty. The data from three additional subjects were not included in the analysis. One subject yielded unreliable audiometric and speech understanding data, speech scores could not be obtained from one subject with a profound hearing loss, and calibration problems compromised data from the third subject. Data from the remaining 30 subjects were included in the analyses. The experimental protocol was approved by the Institutional Review Board of The University of Iowa, and written informed consent was obtained from all participants.

The Device

An Erchonia EHL laser was used to provide the laser stimulation. The device was a portable unit that consisted of a hand-held probe and a main body. The probe contained two laser diodes. One diode produced light in the green part of the visible light spectrum (532 nm wavelength), and the other diode produced light in the red part of the visible light spectrum (635 nm wavelength). Both diodes produced energy levels of 7.5 mW (class IIIb). The laser beams from both diodes were dispersed through lenses to create parallel line-generated beams, rather than spots. A second Erchonia EHL device served as the placebo. It was identical to the treatment device, except that the laser diodes were replaced with nonfunctioning standard light-emitting diodes.

The Groups

The study used three groups: treatment, placebo, and control. Subjects were pseudorandomly assigned to one of the three groups.

Initial group assignment was random with occasional adjustment to ensure that the three groups were similar in terms of number of participants, female/male ratio, mean age of participants, and mean pure-tone audiometric thresholds. The treatment group received the laser treatment protocol using the functional laser device. The placebo group also received the laser treatment protocol, but using the nonfunctioning laser device. The control group made similarly timed visits to the laboratory but received no real or feigned “treatment.” The study used a repeated-measures design, with each subject taking a battery of pretests, followed by treatment followed by a battery of posttests.

Analysis

Data were obtained from both ears of each subject. Since no obvious differences were seen between left and right ears, data from both ears were combined in the following analyses. Strictly speaking, this likely violates the statistical assumption of independent sampling, since the test results from left and right ears of a single subject are likely to be highly correlated. None of the statistical tests used in the analyses are robust to the assumption of independent sampling, and the effect of including both ears is likely to be that of artificially increasing the sample size, making it more likely that a statistically significant result will be found. All statistical tests were conducted using a significance level of .

Conclusions

No statistically significant effect of LLLT on auditory function was found, as assessed by pure-tone audiometry, speech understanding, and TEOAEs in this test. Additionally, no individual subjects showed any clinically significant change. It remains possible that other methods of LLLT could have an effect on hearing. The type of device used was not the best one for this type of study. Further research elucidating the anatomic and physiologic bases for therapeutic effects of LLLT on hearing are needed before further clinical testing is warranted.

More References

Clinical Study | Open Access. Volume 2013 |Article ID 916370 | https://doi.org/10.1155/2013/916370

ClinicalTrials.gov (NCT01820416)

T. I. Karu, “Molecular mechanism of the therapeutic effect of low-intensity laser radiation,” Lasers in the Life Sciences, vol. 2, no. 1, pp. 53–74, 1988.View at: Google Scholar

L. Wilden and R. Karthein, “Import of radiation phenomena of electrons and therapeutic low-level laser in regard to the mitochondrial energy transfer,” Journal of Clinical Laser Medicine and Surgery, vol. 16, no. 3, pp. 159–165, 1998.View at: Google Scholar

J. Kujawa, L. Zavodnik, I. Zavodnik, V. Buko, A. Lapshyna, and M. Bryszewska, “Effect of low-intensity (3.75–25 J/cm2) near-infrared (810 nm) laser radiation on red blood cell ATPase activities and membrane structure,” Journal of Clinical Laser Medicine and Surgery, vol. 22, no. 2, pp. 111–117, 2004.View at: Google Scholar

C. K. Rhee, C. W. Bahk, P. S. Chung, J. Y. Jung, M. W. Suh, and S. H. Kim, “Effect of low-level laser treatment on cochlea hair-cell recovery after acute acoustic trauma,” Journal of Biomedical Optics, vol. 17, no. 6, Article ID 068002, 2012.View at: Google Scholar

G. I. Wenzel, B. Pikkula, C. H. Choi, B. Anvari, and J. S. Oghalai, “Laser irradiation of the guinea pig basilar membrane,” Lasers in Surgery and Medicine, vol. 35, no. 3, pp. 174–180, 2004.View at: Publisher Site | Google Scholar

P. Plath and J. Olivier, “Results of combined low-power laser therapy and extracts of Ginkgo biloba in cases of sensorineural hearing loss and tinnitus,” Advances in Oto-Rhino-Laryngology, vol. 49, pp. 101–104, 1995.View at: Google Scholar

S. Tauber, W. Beyer, K. Schorn, and R. Baumgartner, “Transmeatal cochlear laser (TCL) treatment of cochlear dysfunction: a feasibility study for chronic tinnitus,” Lasers in Medical Science, vol. 18, no. 3, pp. 154–161, 2003.View at: Publisher Site | Google Scholar

A. Gungor, S. Dogru, H. Cincik, E. Erkul, and E. Poyrazoglu, “Effectiveness of transmeatal low power laser irradiation for chronic tinnitus,” Journal of Laryngology and Otology, vol. 122, no. 5, pp. 447–451, 2008.View at: Publisher Site | Google Scholar

D. Cuda and A. de Caria, “Effectiveness of combined counseling and low-level laser stimulation in the treatment of disturbing chronic tinnitus,” International Tinnitus Journal, vol. 14, no. 2, pp. 175–180, 2008.View at: Google Scholar

A. H. Salahaldin, K. Abdulhadi, N. Najjar, and A. Bener, “Low-level laser therapy in patients with complaints of tinnitus: a clinical study,” ISRN Otolaryngology, vol. 2012, Article ID 132060, 5 pages, 2012.View at: Publisher Site | Google Scholar

M. Rogowski, S. Mnich, E. Gindzieńska, and B. Lazarczyk, “Low-power laser in the treatment of tinnitus — a placebo-controlled study,” Otolaryngologia Polska, vol. 53, no. 3, pp. 315–320, 1999.View at: Google Scholar

F. Mirz, R. Zachariae, S. E. Andersen et al., “The low-power laser in the treatment of tinnitus,” Clinical Otolaryngology and Allied Sciences, vol. 24, no. 4, pp. 346–354, 1999.View at: Publisher Site | Google Scholar

T. Nakashima, H. Ueda, H. Misawa et al., “Transmeatal low-power laser irradiation for tinnitus,” Otology and Neurotology, vol. 23, no. 3, pp. 296–300, 2002.View at: Google Scholar

R. Teggi, C. Bellini, B. Fabiano, and M. Bussi, “Efficacy of low-level laser therapy in Ménière’s disease: a pilot study of 10 patients,” Photomedicine and Laser Surgery, vol. 26, no. 4, pp. 349–353, 2008.View at: Publisher Site | Google Scholar

R. Teggi, C. Bellini, L. O. Piccioni, F. Palonta, and M. Bussi, “Transmeatal low-level laser therapy for chronic tinnitus with cochlear dysfunction,” Audiology and Neurotology, vol. 14, no. 2, pp. 115–120, 2009.View at: Publisher Site | Google Scholar

C. H. Graham, “Behavior, perception and the psychophysical methods,” Psychological Review, vol. 57, no. 2, pp. 108–120, 1950.View at: Publisher Site | Google Scholar

M. Nilsson, S. D. Soli, and J. A. Sullivan, “Development of the hearing in noise test for the measurement of speech reception thresholds in quiet and in noise,” Journal of the Acoustical Society of America, vol. 95, no. 2, pp. 1085–1099, 1994.View at: Google Scholar

R. M. Cox, G. C. Alexander, and C. Gilmore, “Development of the connected speech test (CST),” Ear and Hearing, vol. 8, no. 5, supplement, pp. 119S–126S, 1987.View at: Google Scholar

R. M. Cox, G. C. Alexander, C. Gilmore, and K. M. Pusakulich, “Use of the connected speech test (CST) with hearing-impaired listeners,” Ear and Hearing, vol. 9, no. 4, pp. 198–207, 1988.View at: Google Scholar

R. Probst, B. L. Lonsbury-Martin, and G. K. Martin, “A review of otoacoustic emissions,” Journal of the Acoustical Society of America, vol. 89, no. 5, pp. 2027–2067, 1991.View at: Google Scholar

D. H. Keefe, “Double-evoked otoacoustic emissions — I: measurement theory and nonlinear coherence,” Journal of the Acoustical Society of America, vol. 103, no. 6, pp. 3489–3498, 1998.View at: Publisher Site | Google Scholar

G. A. Studebaker, “A “rationalized” arcsine transform,” Journal of Speech and Hearing Research, vol. 28, no. 3, pp. 455–462, 1985.View at: Google Scholar

R. S. Schlauch and P. Nelson, “Puretone evaluation,” in Handbook of Clinical Audiology, J. Katz, L. Medwestsky, R. Burkard, and L. Hood, Eds., pp. 30–49, Lippincott Williams & Wilkins, Baltimore, Md, USA, 2009.View at: Google Scholar

L. E. Humes, D. L. Wilson, N. N. Barlow, and C. Garner, “Changes in hearing-aid benefit following 1 or 2 years of hearing-aid use by older adults,” Journal of Speech, Language, and Hearing Research, vol. 45, no. 4, pp. 772–782, 2002.View at: Google Scholar

M. S. Robinette, M. J. Cevette, and R. Probst, “Otoacoustic emissions and audiometric outcomes across cochlear and retrocochlear pathology,” in Otoacoustic Emissions: Clinical Applications, S. Robinette and T. J. Glattke, Eds., pp. 227–272, Thieme, New York, NY, USA, 2007.View at: Google Scholar


The Brain in Our Skin

Dr. Claudia Aguirre which has a Ph.D. in neuroscience from USC and travels the world lecturing on a broad range of topics from neuroscience to skin care has been researching the power of the skin and its connection with the brain.

The skin is highly innervated and intricately connected to the brain and central nervous system, just as other sensory organs are. Dr. Claudia Aguirre is discovering that the skin has a lot of neuro potential, or neuroplasticity, that has gone unrecognized. For example, just as our eyes have receptors that transduce light photons into signals to the brain that we process as vision, we’re discovering that our skin also has light receptors. Although we don’t yet know how they work, we speculate that they might be signaling the brain to make systemic changes that affect the full nervous system. Similarly, olfactory receptors in the hair follicles, just as we do in the nose.

Examples

Another example is touch, for which our skin is the primary sense organ. Skin is also our largest organ, which gives us a clue as to how important touch is. Different receptors in the skin can tell us not only whether what we touch is hot or cold, rough or smooth. Skin can even sense the intention behind the touch. A gentle touch feels much different than an aggressive one. We can tell whether the person giving us a massage is paying attention or whether they’re distracted. Moreover, different kinds of touch elicit different biochemical and hormonal responses, which have systemic results. A hug or kiss stimulates the release of oxytocin, the bonding hormone, through the bloodstream, while a punch or shove will release adrenaline and cortisol. All of these capabilities are what we say by the hidden brain in the skin.

Nervous System

The skin is connected to the nervous system; it’s connected to the endocrine system. The skin is impacted by our emotional states and, conversely, our skin can impact how we feel about ourselves. Cultural stress and anxiety can trigger or aggravate many skin conditions—from acne to eczema to herpes, psoriasis, and rosacea. Conversely, a disfiguring skin condition can trigger stress, anxiety, depression, and even suicide. Chronic, generalized anxiety can create chronic inflammation and exacerbate inflammatory skin conditions, such as the ones mentioned previously. Chronic stress can result in chronic anxiety, hypervigilance, poor sleep, and a whole cascade of effects resulting in a constant breakdown of tissues and organs, including the skin. There’s a whole new field of medicine being developed called psychodermatology, which is the study and treatment of the psychological component of skin conditions. Better understanding of the neuropotential of skin also opens the possibility of whole new avenues of treatment with light therapy for many of our chronic conditions.

In Kaiyan Medical we have understood that neuroscience should absolutely be part of the conversation about skincare and beauty because the brain and the skin are intimately connected. Skincare is important not only for the skin, but also the brain. That's why we keep developing light therapy devices for skin and brain. In Kaiyan we always recommend to listen for all the little signs that your skin tells you that you tend to ignore. You get a rash, and you brush it off: “Maybe it’s just dry out. Maybe I need to switch creams.” But if it occurs repeatedly, you need to look more closely and ask, “What could my skin be trying to tell me?” Are you repressing emotions? Is there a relationship issue you’re avoiding? Is there some other life circumstance that’s “gotten under your skin”? The body has a wisdom we should listen to.

References

https://drhowardmurad.com/the-brain-in-our-skin-an-interview-with-dr-claudia-aguirre/

http://doctorclaudia.com/about

https://www.janinerod.com/the-hidden-brain-in-your-skin-claudia-aguirre-tedxucla/

Why Hollywood Stars Love Light Therapy

Julia Roberts Uses LED Face Mask | PEOPLE.com
Julia Roberts using LED light therapy mask

From the red carpet to the spotlight stage, Hollywood’s stars are no strangers to the powerful power of light. Their skin is glowing thanks to the latest light-based skin treatment. Stars like Julia Roberts, Kate Hudson, and Jessica Alba have been sharing their experience with LED light therapy masks that are designed to boost collagen, reduce inflammation and banish acne-related bumps and scars.

In Kaiyan Medical we can develop your own beauty light therapy mask worth of the celebrities’ skin.

Kate Hudson using LED light mask
How it Works

These amazing light masks are recommended by dermatologists and estheticians who credit the masks’ multi-colored UV-free wavelengths with improving clients’ complexions.

“Tiny particles of light are called photons, which cells absorb and transform into ATP (adenosine triphosphate), the form of energy that cells use to carry out normal functions,”

says L.A.-based celebrity facialist Shani Darden.

“ATP is then used to power the metabolic process and repair and regenerate cells.”

In short, just like LEDs have been proven to encourage plant growth (what’s a greenhouse without a good grow light?), LEDs can have a similar stimulating effect on skin cells by jump-starting the rejuvenation process.

But not all lights are created equal. Different wavelengths of light have different benefits.

“Blue-light wavelengths destroy bacteria in the skin to improve acne,”

says Toronto-based cosmetic dermatologist Dr. Martie S. Gidon. It’s worth noting that LED therapy is not effective at treating hormonal acne and is only recommended for inflammatory acne — in other words, pimples caused by bacteria — and works best when paired with topical acne medication.

Anti-aging benefits

For anti-aging results, red light therapy is for you.

“Red-light wavelengths penetrate more deeply than blue light and stimulate fibroblasts to produce collagen, resulting in tighter skin and smooth fine lines,”

says Dr. Gidon, who also praises the red light’s anti-inflammatory effect for use post-facials and peels. Another light used in combination with the other two is infrared.

“It accelerates healing and encourages greater product absorption,”

says Shani who recommends clients use a combination of both blue/red light therapy and infrared.

Home LED masks have been growing in popularity, especially with the COVID restrictions. You can opt for flexible home masks for personal use or well, the spa line which packs more lights and cover a bigger zone. With so effective results, it’s no wonder stars like Michelle Williams and Rachel Weisz are opting to lay down inside LED beds in order to treat their entire bodies to the rejuvenating powers of the lights.

If you have question on how to create your own beauty mask, don’t hesitate in contacting us. We will guide you in the whole creative process.

More References


https://ca.hellomagazine.com/health-and-beauty/02017032134254/guiding-light

https://www.womansworld.com/posts/celebrities/julia-roberts-light-therapy-mask

When it Comes to Headaches, Light (Except Green Light) Triggers Pain

One of the Most Disabling Illnesses in the World

Migraines are considered one of the most disabling illnesses in the world,  most of whom are unable to function normally during a migraine. Migraines are much worse than the common headache - bringing on excruciating pain and other symptoms like dizziness, blurred vision, or vomiting.

Green light therapy lamps have been recommended by Harvard Medical School headache specialist Rami Burstein who found that light exacerbates migraines. Photophobia (extreme sensitivity to light) is associated with more than 80% of migraine attacks - but the green light in his research is different. He found that a narrow wavelength of green light is less aggravating than other colors because it sends a smaller, less disruptive signal to the brain via the visual cortex.

Stueids have been recording of dura- and light-sensitive thalamic neurons in rats to show that green activates cone-driven retinal pathways to a lesser extent than white, blue and red; that thalamic neurons are most responsive to blue and least responsive to green; and that cortical responses to green are significantly smaller than those generated by blue, amber and red lights.

"It became apparent that we should be able to use a narrow band of green light to treat photophobia," Burstein says.

Now patients could put their kids to bed, read a book, or enjoy a hearty meal with friends - instead of being isolated in darkness. Not only did green light fail to trigger pain, his research even found that it has a soothing effect.

Can Green Light Relieve Other Pain?

Padma Gulur, who does not work with Burstein, is looking into the possibility that green light might relieve other forms of pain besides migraines. Already one year into a clinical trial - testing the effects of green, blue, or white light on people's post surgery or fibromyalgia pain experience - Gulur says the data looks promising that green light therapy could provide benefit to those in pain. Gulur, a Duke University anesthesiologist, says that finding a way to reduce pain without drugs is essential, given the addictive nature and side effects of opioids and other pain relievers. Not only did green light fail to trigger pain, his research even found that it had a soothing effect.

"We have very few options that are safe, easy to comply with, and have an impact on the pain experience. So it was a quest for non-pharmacological options that could help patients in pain that led to looking at the potential for light-based therapy," she says

Mohab Ibrahim, an anesthesiologist at the University of Arizona, found that when rats were exposed to green light, they felt less pain - or, at least, they were able to tolerate more discomfort in the form of heat or pressure. Wondering which mattered more - the light washing over the skin or contacting the eyes - Irbahim created tiny, rat-sized contact lenses. He found that when rats were wearing the contact lenses, which let only green light through, they similarly showed less discomfort.

Green light exposure has been found to significantly reduce migraine intensity and discomfort from fibromyalgia. In Kaiyan Medical we can create your green light therapy device to treat migraine and other conditions.

More References

https://www.freethink.com/articles/green-light-therapy

https://allaylamp.com/blogs/light-reading/green-light-therapy

https://www.nccih.nih.gov/health/statistics-from-the-national-health-interview-survey

https://sleep.med.harvard.edu/news/356/Green+Light+Affects+Circadian+Rhythm

Therapeutic and Aesthetic Uses of Blue & Red Light Therapy Together

Acne vulgaris remains one of the most common dermatologic disorders. Clinicians are always searching for new therapies to utilize in their therapeutic armamentarium for this common skin concern. We have many medical therapies at our disposal and these have proven useful in many cases in controlling the disease process. However, some patients need or want other therapies, and laser and light treatments for acne vulgaris have become popular over the past several years.

Regarding LED light therapy for the skin, “There is a science to support it” says Angela Lamb, director of the Westside Mount Sinai Dermatology Practice,

“but it’s important to know its limitations.”

Exposing your skin to different forms of low-level LED light does have anti-bacterial and anti-inflammatory benefits, which is why they’re commonly used for treating redness or acne. Blue light therapy in the right wavelength can be FDA-cleared.

Light Therapy with Aduro Mask

Other blue light trials have supported the efficacy of blue light. Papageorgiou described their experiences with phototherapy comparing a mixed blue and red light system (415 and 660nm) with blue light therapy alone and white light therapy. The results showed that the combination of blue and red light decreased inflammatory acne vulgaris lesions by 76 percent versus 58 percent in the blue light alone group, which were both better than white light (25%). Meffert reported experiences with a high-energy, broad-spectrum, blue light source that combined blue light and UVA with a wavelength of 410 to 420nm and noted marked improvement in patients with pustular acne vulgaris after 10 treatments.

There are a variety of at-home light treatments out there like the Aduro mask (which is patented with medical grade quality) who uses red, orange, purple, infrared, cyan, blue,green and yellow light — but typically what you’ll see on shelves are ones harnessing blue or red light . Blue light is a shorter wavelength that destroys acne-causing bacteria on the skin’s surface, while red light penetrates deeper to help with inflammation, but Hooman Khorasani, the chief of the division of Dermatologic and Cosmetic Surgery at the Icahn School of Medicine at Mount Sinai, says that both blue- and red-light therapy “may reduce the size of the sebaceous glands, so you don’t produce as much oil.”

Blue & Red Light Therapy

The good thing about light therapy is that experts say that there aren’t really downsides if you’re willing to give it a shot. Light treatments have been shown to be relatively safe, with minimal side effects. For acne, Khorasani notes that LED devices won’t take the place of acne fighters like retinoids; instead, they should be used in concert with a multipronged treatment plan — and never for severe acne. If you are combining them with retinoids, Lamb also suggests alternating the days you use either of them, to avoid photosensitivity.

When you combine the blue and red light using the aduro mask, you can get a pink/purple amazing color that will help remove the p-acne causing bacteria from the skin while purifying and cleansing it. Also, you will speed up the healing process and rejuvenate the skin cells increasing the cell regeneration.

More references

https://www.accessdata.fda.gov/cdrh_docs/pdf9/K093963.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013592

Sigurdsson V, Knulst AC, van Weelden H. Phototherapy of acne vulgaris with visible light. Dermatology. 1997;194:256–260. [PubMed] [Google Scholar]

Taub AF. Photodynamic therapy in dermatology: history and horizons. J Drugs Dermatol. 2004;3:S8–S25. [PubMed] [Google Scholar]

Gold MH, Goldman MP. 5-aminolevulinic acid photodynamic therapy: where we have been and where we are going. Dermatol Surg. 2004;30:1077–1083. discussion 1083-1084. [PubMed] [Google Scholar]

Touma DJ, Gilchrest BA. Topical photodynamic therapy: a new tool in cosmetic dermatology. Semin Cutan Med Surg. 22;2003:124–130. [PubMed] [Google Scholar]

Light Therapy & Vitiligo

Our life is full of patches!

Patches in job, career, personal life, and skin too! When we can handle the life patches and hardship with determination, then why not with skin. The skin patches disease is termed as Vitiligo. It is a medical condition where skin loses its color. Vitiligo affect not only physically but also cause a mentally & emotionally. According to VRF, this condition affects 2% of the world’s population. So, around 70 million people across the world have vitiligo. It can affect can affect people of any age, gender, or ethnicity.

How does it occur?

Well many of us are not aware of the biological reasoning behind the condition. It occurs when cells responsible for making skin pigment called melanocytes get destroyed. It can affect any part of your body like limbs, back, neck, face, etc. The body stops producing melanin — the pigment that gives your skin, hair and eyes color.

The symptoms of Vitiligo are like – Patchy, loss of skin color, which usually first appears on the hands, face, and areas around body openings. Other like premature whitening or greying of the hair on the scalp, eyelashes, eyebrows or beard. Vitiligo is an auto-immune disease, where the person’s immune system mistakenly attacks its own body (or host body). Other than that, the skin cells (melanocytes) of the affected person appears to unable to deal with the imbalance of antioxidants and harmful free radicals generated inside the body. This results in cell damage and death.

Light therapy - the hope

Today a number of treatments which are aimed for the restoring the discoloration of the skin. But the best and the convenient is Light Therapy. Especially the narrow-band ultraviolet B (NB-UVB) has come up as one of the safest and most effective therapy for this skin condition.

In this treatment, the depigmented or discolored skin is exposed under a specific wavelength of light for a specific amount of time and using a specified amount of light monitored or prescribed by the dermatologist. The duration of a session can gradually increase as one’s progress based on his/her skin’s response to the light.

Light therapy treatment often involves the usage if specific light which are used in combination with topical medications that are applied to the skin. The topical treatments can be topical steroids, topical calcineurin inhibitors or topical Vitamin D etc. Although the treatment can be used without the topical as well. Topical medications may also be used on their own, without light therapy, however, when the two treatments are used together, the results are typically seen well.

According to the studies, the light therapy session have a great response to treatment. The greatest response is shown majorly on the face and neck. Several retrospective and prospective studies have displayed superior repigmentation, color matching results.

Light therapy is a hope for people who perceive it as an incurable disease. The technology of light therapy helps people to overcome the physical as well as mental aspect of their body.

References:

https://nyulangone.org/conditions/vitiligo/treatments/phototherapy-laser-treatment-for-vitiligo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536079/

https://www.medscape.com/answers/1068962-87933/how-is-narrowband-uv-b-nb-uvb-used-to-treat-vitiligo

https://www.umassmed.edu/vitiligo/vitiligo-treatment/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607222/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817459/

Healing Muscular Pain with Light Therapy

Light Therapy Healing Muscular Pain

When it comes to pain, we could hardly avert it! Especially the muscle pain. Given that the human body has over 600 muscles, it is tough to avoid muscle pain. Evidently, one out of three Americans is affected by muscle pain annually.

Not only this, Musculoskeletal pain affects around 116 million Americans, which results in poor productivity, missed work or school, fatigue, and lost interest in work.

But doesn’t we treatments for this chronic pain? Of course, we do have several options. Currently, therapies available consist of non-steroidal anti-inflammatory drugs, steroid injections, pain medications, and surgery. Each of these has its own specific risk profiles.

What we need now is an effective solution that is less time-consuming, low risk, safe and non-invasive, and yet cost-effective. All these features are available in treatment; we call Low Laser Light Therapy (LLLT). Light therapy has been in the medical field over the past forty years. Light therapy has been demonstrated to lessen inflammation and edema, promote healing in a range of musculoskeletal pathologies. LLLT is being accepted around the globe. This is an advanced, cost-effective, non-invasive therapy for pain that could elevate the quality of life while reducing your financial strains. The causes of muscular pain are numerous. Hence, LLLT helps people from all fields like sports, fitness, medical, and even old age.


Mechanism of LLLT

In this process, light with a wavelength in the red to the near-infrared region of the spectrum (660nm–905nm) is employed on the skin surface. The reason for using these wavelengths is that they have the ability to penetrate the skin and soft/hard tissues. From various conducted clinical trials, this treatment is proven to have a good effect on pain, inflammation, and repairing of the tissues. The therapy goes from 30 to 120 seconds or more a week, depending upon the pain's severity.

Based on the tissue condition, the therapy can go on for weeks or months. LLLT has resulted in relief and reduction of inflammation, pain relief, and accelerated tissue regeneration.

But how does the light actually work?

LLLT in the Treatment of Pain

Do you know that many acute orthopedic conditions such as strains, sprains, muscular back pain, frozen shoulder, neck and back pain, etc., are amenable to Low Laser Light Therapy (LLLT)?

The Infra-Red light relieves pain in a different section of the body and increases relaxation sensation while also comforting the muscles. LLLT has been shown to enhance the multiplication of cells like fibroblasts, keratinocytes, endothelial cells, and lymphocytes. Fibroblasts and keratinocytes are two major cell types that respond to the inflammatory phase in the repair/regeneration process.

LLLT can enhance neovascularization, promote angiogenesis, and increase collagen synthesis to succor in the healing of acute and chronic wounds. The LED light sessions have shown the ability to heal skin, nerves, tendons, cartilage, and bones. Low-intensity LLLT stimulates mitochondria and also enhances the mitochondrial membrane potential.

The peripheral nerve endings of nociceptors (also known as the pain receptors), consisting of the thinly myelinated and unmyelinated, slow-conducting C fibers, lie within the epidermis. This complex network converts harmful stimuli into action potentials. Moreover, these nerve endings lie on the surface or superficial in nature, making the LLLT wavelength penetration work easy.


Hence, with the rise of chronic pain in different countries, it is imperative to validate cost-effective and safe techniques for managing painful conditions, allowing people to live active and productive lives. Light therapy is constantly evolving in relieving muscular pain. It improves the muscle's endurance, reduces muscle soreness, joint pain, and inflammation.

It’s time to let go of the pain!!

Experience the difference with light therapy from Kaiyan Medical.

More References:

https://pubmed.ncbi.nlm.nih.gov/12605431/

https://pubmed.ncbi.nlm.nih.gov/27472858/

https://arthritis-research.biomedcentral.com/track/pdf/10.1186/s13075-015-0882-0

https://www.sciencedirect.com/science/article/pii/S0004951414601276?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743666/

Treating Glaucoma with Green Light Therapy

According to the National Eye Institute, glaucoma is the third leading cause of blindness in the U.S cataracts and macular degeneration rank first and second, respectively. There are an estimated 2,218,000 patients who suffer from glaucoma (approx. 1 in 136 or 0.74%).

What is Glaucoma

Glaucoma is a disease of the optic nerve often caused by an abnormally high pressure the eye (also called IOP, intra-ocular pressure). It is one of the leading factor for blindness. It can occur at any age but is more common for people over the age of 60. The vision loss due to glaucoma can't be recovered and many forms of glaucoma have no warning signs at an early stage, so it is important that we do regular eye exam or get prevention as early as possible.  

Currently, there are 3 Keys that allow for a more accurate diagnosis of glaucoma:
An elevation of intraocular pressure
Changes in the optic nerve
• Peripheral field loss

Diagnosis

Your doctor will review your medical history and conduct a comprehensive eye examination. He or she may perform several tests, including:

  • Measuring intraocular pressure (tonometry)
  • Testing for optic nerve damage with a dilated eye examination and imaging tests
  • Checking for areas of vision loss (visual field test)
  • Measuring corneal thickness (pachymetry)
  • Inspecting the drainage angle (gonioscopy)
Medical Treatment

The damage caused by glaucoma can't be reversed. But treatment and regular checkups can help slow or prevent vision loss, especially if you catch the disease in its early stages.  Glaucoma is treated by lowering your eye pressure (intraocular pressure). Depending on your situation, your options may include prescription eyedrops, oral medications, laser treatment, surgery or a combination of any of these.

However, the method of treatment of glaucoma is mainly of medication, which can lower the intra-ocular pressure, but also many medication would also block aqueous production. It is similar to the condition that a patient with hypertension taking medications to decrease the production of blood to reduce the blood pressure. That is harmful to the eye health.

In Singapore, the mean direct cost of glaucoma treatment with glaucoma medications alone per patient over 10 years was SGD 2042.47 (± 2078.54) or US$1,592.86 (±1620.99), while the mean cost of surgery was SGD 8038.75 (± 2829.4) or US$6,269.18 (± 2206.56) and laser was SGD 1163.63 (± 532.9) or US$907.48 (± 415.59).

Green light therapy is way cheaper and can lead to great results


Green Light Treatment

One of the biggest advantage of light therapy is that there is no side-effect like medication and it can be used at an early stage for prevention.

Scientists and researchers first began to study light therapy in the treatment of glaucoma in 1948. According to R. B. Zaretskaya, MD’s research, published in American Journal of Ophthalmology, it shows that, while the red light has a pressure raising effect, the effects of green light are greater than white light even at a higher brightness. So, green light should be considered a therapy for the reduction of intra-ocular pressure in glaucoma.

The following important experiment was done by R. B. Zaretskaya, MD, also published in the American Journal of Ophthalmology, showed that eye pressure was lowed for patients wearing green spectacles, also with fluctuation of eye pressure decreasing. These patients were required to a 10 minute exposure of green light with an intensity of 1.4 lux. Pressures were then measured at every half hour until pressures returned to baseline.

The conclusion indicates that green light (mu delta) has a pressure lower affect in the majority of patients 82% and the average pressure lower affect was 5 mm Hg and this effect persisted for 4 hours after a brief 10 minute exposure.  

The second article also by R. B. Zaretskaya, MD, which was published in the American Journal of Ophthalmology 1948 31: 985-989 refers about 19 patients that were studied and pressures were determined 3 times a day. Once at 7:00 AM (still in bed), 1:00 PM and then between 7:00 and 8:00 PM. Medications were withheld for a day or two and then green spectacles were given on the second day for full time wear. The spectacles were a hue corresponding to 511 nm and a daylight transparency of 21%. In a certain number of cases, the green spectacles were combined with a greatly reduced strength of pilocarpine. One group had a combination of green glasses and adrenalin (1:1,000) which was also made to test Kravkov’s statement that the installation of adrenalin might increase the eyes sensitivity to green.

Results of this study showed that IOP showed a pronounced tendency to decrease in patients wearing green spectacles.  The fluctuation of IOP during the day was also found to decrease in patients wearing green glasses.  There was an appreciable effect when the use of green spectacles was combined with very small dosages of pilocarpine (0.5 percent).  20 out of 25 eyes had an expressed decrease in IOP as well as a decrease in fluctuations. The pressures decreased by  6.0 mm Hg in 8 cases, 10 mm Hg in 9 cases and 10 mm Hg and more in 3 cases. The results were more striking when combined with small dosages of adrenalin.

Conclusions:
Green spectacles prescribed with a total withdrawal from Pilocarpine produces a decrease in IOP
The affects are most pronounced when used with the administration of small doses of adrenalin
• Mechanism of action is proposed to be on the color receptors of the human eye
• Green light brings about a definite arrangement in the autonomic nervous system and thus affects the neurovascular system of the eye

How to Do a Green Light Therapy Treatment?

Consistency and proper use is key for effective green light therapy. For optimal results with a high-quality device like the ones in Kaiyan, follow these basics for general wellness benefits:

  • Expose your eyes for best results
  • 10-minute treatment each time
  • Daily use is ideal
  • Any time of day
The Future for Green Light and Glaucoma

As we also know that green light could also treat migraine as well as glaucoma, and both migraine and glaucoma are disease of nerve, we may want to know is there connection between these two illness, both of which would cause the pain in the front part of our brain. Hope future research would find out.

References

Conference speech presented at the International Syntonic Light Conference held in St. Pete Beach, Fl , April 28th – May 1st

https://www.healingtheeye.com/Articles/Syntonic_Light_Therapy_Glaucoma.html

https://www.healingtheeye.com/Articles/AJO_IOP_%20light.pdf

https://www.mayoclinic.org/diseases-conditions/glaucoma/diagnosis-treatment/drc-20372846#:~:text=Glaucoma%20is%20treated%20by%20lowering,combination%20of%20any%20of%20these.

https://iovs.arvojournals.org/article.aspx?articleid=2360086#:~:text=The%20mean%20direct%20cost%20of,US%24907.48%20(%C2%B1%20415.59).

R. B. Zaretskaya, MD. Intraocular Pressure of Normal and Glaucomatous Eyes as Affected by Accessory Light Stimuli. American Journal of Ophthalmology 1948 – 31-721-727.

The Key for Better Sex - Red Light Therapy

The famous fitness coach Ben Greenfield uses red light naked every morning. He flips a switch, flooding the room with a bright red glow. Then he stands naked in the red light for 20 minutes.

“It seems to like, wake you up a little bit; it kind of simulates sunrise,” Greenfield tells. “And it’s almost mildly addictive — the feel-good effect of how you feel after you use one of these.”

Greenfield, a 39-year-old fitness instructor, is an evangelist for red light therapy, a treatment that’s increasingly popular in the world of sports, beauty, and biohacking. Some converts to red-light therapy treatment soak in the ruddy glow for a very personal reason.

Red Light for Testosterone
Red Light Therapy

Light therapy has been for hundreds of years. Recently, we can trace it back to 1967 with Hungarian scientists, red light therapy, scientifically known as photobiomodulation or low-level laser (light) therapy, has made a comeback in the last two decades.

Michael Hamblin, a researcher at Massachusetts General Hospital and professor at Harvard Medical School, explains in a 2017 research paper on the topic that the treatment was confined to a “SCIENTIFIC WASTELAND,” and widely considered “SNAKE OIL.”

But recent studies suggest red-light therapy can improve skin quality, addictions, pets’ mood, sleep quality, depression, muscle recovery, and relieve pain.

Indeed, some studies suggest light therapy stimulates mitochondria, a.k.a. the “powerhouse” of a cell, and increases the production of adenosine triphosphate, the organic chemical that carries energy in the body and plays a big role in metabolism.

Bio-hacking yourself

In Kaiyan Medical, we are on a constant quest to optimize our brains and bodies. Some studies have actually demonstrated that exposing the torso or the testes to light can potentially increase testosterone. In fact, studies on the effects of light on the testes go way back to 1939, when researchers exposed various parts of men’s bodies to UV light. They found that men’s testosterone levels went up by 120% when the participants’ chests were exposed to UV light, and they went up by 200% with UV exposure to the genital area.

Sunlight exposure directly to the testes reportedly has an even more profound effect, boosting production in Leydig cells (the cells that produce testosterone) by an average of 200%

The theory is this: while sunlight has many beneficial effects, such as vitamin D production and improved mood, it is not without its downsides. Too much exposure to sunlight, particularly to sensitive areas like the skin around your precious ball sac, can create sunburn, excess radiation, inflammation and damage. And let’s face it: you don’t want a shrunken, shriveled, dehydrated dick, no matter how impressive the tan.

Red light, however, is different than sunlight. Red light is comprised of light wavelengths in the range of 600–950 nanometers (nm). According to red light therapy proponents, red light works to stimulate ATP production, increase energy available to the cell and in particular, increase the activity of the Leydig cells in your testes, which are the cells responsible for testosterone production.

Optimizing Sex

In the last five years, light therapy researchers and red-light therapy companies set their sights on men like Greenfield — the guy who gets naked every morning in his home office.  “The impact of [low-light therapy] on sexual health is an emerging field, but I see its potential to improve sexual function and libido with recent studies,” Hamblin says. “It has been shown to improve sperm function and may have applications in increasing fertility in both men and women.”  Research on sexual health applications of red-light therapy is relatively minimal in men, and basically nonexistent for women. A few studies in animals suggest red light therapy might influence LEYDIG CELLS — the body’s sperm producers, which live in the testicles. Another study in humans suggests red light therapy can increase testosterone levels and sexual satisfaction.

Don't let the fear defeat you

Sexual health issues — from “low T” to erectile dysfunction — can be challenging to treat because of the social stigma, Goldstein explains. There’s a “fear,” the urologist says. Many men are ashamed and avoid seeing a doctor.  “If they can get something over the counter that's purported to help them, millions of men will be willing to try it and maybe they would never buy it again,” Goldstein tells.  “Good advertising and good marketing will create a market for a product, whether it's proven to be of value or not.”  

Reduce Infertility

One of the biggest concerns for those who suffer from Low-T is infertility. Several studies show that red light therapy helps increase sperm motility, which is essential for successful impregnation. In 2017, researchers from the University of California, San Diego, found that sperm exposed to 630nm red light increased sperm swimming speed and force.

A similar study by researchers from Iran found an after exposing sperm to an 830nm NIR light device. Sperm motility is associated with cellular energy; more energized sperm will swim with greater vigor. This is a vital component of male reproductive health, and success in improving sperm motility points to the use of red light therapy as a way to treat male infertility.

Red Light for Testosterone
Feeling like a super hero

On top of using red light, both Greenfield and Wiles eat healthy, work out regularly, and practice stress-management techniques. Which habit, or a combination of each, helps them “optimize” their sex life or their physical health isn’t clear.

Even though the research doesn’t match their claims — yet— Greenfield and Wiles have no intention of slowing down.  “Before I go and give a presentation or if I'm giving a lecture or even if I'm just seeing a patient in clinic, I'll go ahead and throw that thing on and I will feel like a million bucks," Wiles says. "I’ve noticed increased overall sexual health, sexual satisfaction, and stamina."  Recently, Greenfield has been shining the light for one very specific reason: He and his wife are trying for a baby.  “Sometimes if I know I've got like a date night with my wife or we're going to have sex that night, I'll wait until the evening to do the treatment because the immediate effects are even better, especially the blood flow," Greenfield says.  "Erectile quality is just better right after you use it.”

More References

https://platinumtherapylights.com/blogs/news/red-light-therapy-for-boosting-testosterone

https://www.inverse.com/mind-body/red-light-therapy#:~:text=A%20few%20studies%20in%20animals,testosterone%20levels%20and%20sexual%20satisfaction.

Light Therapy - Color Meaning

Introduction to Color Light Therapy

Color Light therapy is based on the idea of restoring balance by applying color to the body. Its history is rooted as far back as the Mayan culture.

In India, Ayurveda, an ancient form of medicine practiced for thousands of years, is based on the idea that every individual contains five elements of the universe that are present in specific proportions unique to each individual, including their personality type and constitution. When these elements are out of balance, Ayurveda works with the energies inherent in the colors of the spectrum to restore this balance.

In ancient Egypt the art of healing with color was founded in the Hermetic tradition, the Ancient Egyptians and Greeks used colored minerals, stones, crystals, salves, and dyes as remedies, and painted treatment sanctuaries in various shades of color.

In China, traditional Chinese medicine incorporates color to be associated with each organ and elemental system. This healing method looks at the idea that every individual is a balance. The first color wheel was invented by Sir Isaac Newton. He split white sunlight into red, orange, yellow, green, cyan, and blue. He then joined the two ends of the color spectrum together to show the natural progression of colors.

Light Therapy has been valued throughout history as a remarkable source of healing. Today, the therapeutic applications of light and color are being investigated in major hospitals and research centers worldwide. Results indicate that full-spectrum, ultraviolet, colored, and laser light can have therapeutic value for a range of conditions from chronic pain and depression to immune disorders.

Wellness Benefits

Light Therapy has been reported, as part of a healthy lifestyle, to temporarily reduce swelling, relieve pain, decrease inflammation, accelerate open wound healing and greatly reduce overall recovery after medical/surgical procedures. Patients have demonstrated an increased range of motion, decreased muscle tension and spasm, and improved circulation.

Rejuvenating LED light therapy can be used for temporary pain management such as joint and back pain, sore or torn muscles, sprains, arthritis, post-surgical scars, burns, wounds, and more. When used with infrared technology, light therapy (phototherapy) is one of the most effective and non-invasive ways to improve overall wellness.

Light therapy is also used to temporarily relieve Seasonal Affective Disorder (SAD). SAD affects individuals when the lack of sunlight results in seasonal depression. Phototherapy helps with SAD by resetting the internal biological clock (Circadian rhythms), helping individuals sleep better, and regulate their mood. Even companies, such as GE and Philips, have created phototherapeutic products to improve and regulate mood.

Cosmetic Benefits

Light therapy is also a growing treatment for anti-aging. Many individuals have seen a temporary reduction in the appearance of fine lines, wrinkles, crow’s feet, and age spots.

Light therapy is “effective at improving the appearance of the face, neck, and chest by reducing the signs of aging, wrinkles and age spots”, says Web M.D. Combined with infrared therapy, LED phototherapy can be a great way to revitalize skin.

Healing With Color

Color is light split into different wavelengths vibrating at different speeds and at different frequencies. Objects that ABSORB all wavelengths and DO NOT reflect are black in nature. Objects that REFLECT all wavelengths and DO reflect are white in nature. Between black and white lies COLOR. Colors are wavelengths of energy that, to us, appear as color because of the potential and capabilities of the object to either absorb or reflect the energy.

Red Light

In the early 1990s, RLT was used by scientists to help grow plants in space. The scientists found that the intense light from red light-emitting diodes (LEDs) helped promote the growth and photosynthesis of plant cells.

The red light was then studied for its potential application in medicine, more specifically to find out if RLT could increase energy inside human cells. The researchers hoped that RLT could be an effective way to treat the muscle atrophy, slow wound healing, and bone density issues caused by weightlessness during space travel.

You may have heard of red light therapy (RLT) by its other names, which include:

  • photobiomodulation (PBM)
  • low-level light therapy (LLLT)
  • soft laser therapy
  • cold laser therapy
  • biostimulation
  • photonic stimulation
  • low-power laser therapy (LPLT)

Red is called “The Great Healer”. So far is the most popular light therapy. To wind down before bed, use red light. “The color signals that it’s night, which may encourage the body to produce melatonin,” says Michael Breus, Ph.D., an advisory board member for SleepScore Labs.

Red light can also improve your workout. Just one to five minutes of exposure to red and infrared light right before exercise boosted strength and prevented soreness, says Ernesto Leal-Junior, Ph.D., the head of the Laboratory of Phototherapy in Sports and Exercise at Nove de Julho University in Brazil. “Certain wavelengths of red and infrared light-660 to 905 nanometers-reach skeletal muscle tissue, stimulating the mitochondria to produce more ATP, a substance that cells use as fuel,” he says.

Green Light

Green is the universal healing color. Originally, the color of love. Green is midway in the color spectrum; therefore, it contains both a physical nature and a spiritual nature, in equal balance and in equal harmony.

Gazing at green light can reduce chronic pain (caused by fibromyalgia or migraines, for example) by up to 60 percent, according to a study in the journal Pain, and animal studies have shown that the beneficial effects can last up to nine days. “Looking at green light seems to lead to an increase in the body’s production of enkephalins, pain-killing opioid-like chemicals. And it reduces inflammation, which plays a role in many chronic pain conditions,” says researcher Mohab Ibrahim, M.D., Ph.D.

More studies are needed before doctors can make recommendations on how and how often to use green light to treat migraines and other pain, and Dr. Ibrahim says you should see a physician before trying to treat yourself at home. But at this point research indicates that exposing yourself to an hour or two every night-either by using a green light bulb in a lamp or by wearing glasses fitted with tinted optical filters-may decrease migraines and other types of chronic pain

Helps to treat and prevent hyper-pigmentation by inhibiting the production of excess melanin which then prevents it from traveling to the surface. It will help break up the melanin clusters that are already on the surface.

Yellow Light

Yellow helps awaken mental inspiration arousing a higher mentality. Thus, it is an excellent color for nervous or nerve-related conditions or ailments; fueling the solar plexus. Yellow has a very enriching effect upon the intellect. Yellow can be used for conditions of the stomach, liver, and intestines. It can help the pores of the skin by repairing scarred tissue. These rays have an alkalizing effect which strengthens the nerves. Awakening, inspiring, and vitally stimulating the higher mind promoting self-control. Typical diseases treated by yellow are constipation, gas, liver troubles, diabetes, eczema, and nervous exhaustion. Providing clarity of thought, increasing awareness, stimulating interest, and curiosity yellow energy is related to the ability to perceive or understand.

The yellow is used for treating redness, flushing, irritation, and Rosacea. It may also reduce the appearance of the tiny blood vessels on the nose and face.

Blue Light

Blue light therapy technology is an additional option for the treatment of acne. Research has shown in-office and at-home systems produce positive results.

“Blue light therapy effectively helps alleviate this common skin condition affecting 50 million Americans and 94 percent of all females, according to Judith Hellman, MD, a board-certified dermatologist, in practice in New York City. Dr. Hellman, who practices medical dermatology and specializes in dermatological surgery, laser surgery, and anti-aging skin treatments, explains how the blue light treatment system works for acne, its uses, and her clinical experience with the technology.

Cyan Light

It is used as a gentle acne treatment to control oil production in the skin as well as reduce inflammation. It also promotes the synthesis of protein and collagen.

Orange Light

Orange has a freeing action upon the mind, relieving repression. Because orange is a blend of red and yellow, it combines physical energy with mental wisdom, inducing a transformation between lower physical reaction and higher mental response. Thus, it is often referred to as “The Wisdom Ray.” Orange is warm, cheering, and non-constricting.

Through orange, we are able to heal the physical body (red) and, at the same time, induce within the mind (yellow) greater understanding. Orange helps assimilate new ideas. Orange is the best emotional stimulant, helping to remove inhibitions paving independent social behavior. Bring joy to your workday and strengthen your appetite for life. Orange aids in repairing inflammation of the kidneys, gallstones, menstrual cramps, epilepsy, wet cough, and all sinus conditions.

Purple Light

Violet is the last color we can see before light passes on to ultra-violet. Violet purifies our thoughts and feelings giving us inspiration in all undertakings. The violet energy connects us to our spiritual self bringing guidance, wisdom, and inner strength and enhances artistic talent and creativity. Leonardo da Vinci proclaimed that you can increase the power of meditation ten-fold by meditating under the gentle rays of Violet, as found in church windows.

Light therapy uses colors for their proposed wellness abilities in treating emotional and physical disturbances. Light therapy is based on the premise that different colors evoke different responses in people. For example, some colors are considered to be stimulating, whereas others may be soothing. Color therapy has been suggested for many uses, based on tradition or on scientific theories. Consult with a health care provider before using color therapy for any use.

Infrared Light

Infrared light penetrates to the inner layers of the skin at about 2 to 7 centimeters deep. Hence, it reaches the muscles, nerves, and even the bones. Many studies have shown that a frequency of infrared light, with wavelengths from 700 to 1,000 nanometers, is best used for healing inflammatory conditions.

The use of electricity for healing purposes began in 2,750 BC when people used electric eels to give electric shocks. Electricity and magnetism were used in people with just little success. However, in 1975, transcutaneous electrical stimulation (TENS) was developed to treat chronic pain. It was not until recently that infrared therapy was developed to improve wound healing, reduce the pain caused by arthritis, boost endorphin levels, and bioactivate neuromodulators.

Infrared therapy technology allows people to harness the benefits of the sun, without being exposed to harmful ultraviolet rays. Also, infrared therapy is safe and effective, without adverse side effects. As a matter of fact, infrared light is safe and is used even for infants in neonatal intensive care.

Infrared light is absorbed by the photoreceptors in cells. Once absorbed, the light energy kickstarts a series of metabolic events, triggering several natural processes of the body on a cellular level.

Kaiyan Medical

In Kaiyan, we are in love with light therapy. We believe in the natural balance in our bodies. We develop devices such as the Aduro mask which will provide you with the full range of color light therapies.

References

https://www.estyspot.com/blogs/esthetician-tips/an-estheticians-view-of-led-therapy-benefits-for-all-7-colors

https://www.the-dermatologist.com/content/acne-treatment-blue-light-therapy-benefits-0#:~:text=A%3A%20Blue%20light%20kills%20the,oil%20glands%20in%20the%20skin.

https://www.healthline.com/health/red-light-therapy#summary

https://www.estyspot.com/blogs/esthetician-tips/an-estheticians-view-of-led-therapy-benefits-for-all-7-colors

Deppe A. Ocular light therapy: a case study. Aust J Holist Nurs 2000;7(1):41.

Geldschlager S. Osteopathic versus orthopedic treatments for chronic epicondylopathia humeri radialis: a randomized controlled trial. Forsch Komplementarmed Klass Naturheilkd 2004;Apr, 11(2):93-97.

Maher CG. Effective physical treatment of chronic low back pain. Orthop Clin North Am 2004;Jan, 35(1):57-64.

Natural Standard Research Collaboration, Chief Editors: Ulbricht C, Basch E, Natural Standard Herb and Supplement Reference: Evidence-Based Clinical Reviews, USA. Elsevier/Mosby, 2005.

Ohara M, Kawashima Y, Kitajima s, et al. Inhibition Of lung metastasis of B16 melanoma cells exposed to blue light in mice. Int J Molecular Medicine 2002;10(6):701-705.

Wileman SM, Eagles JM, Andrew JE, et al. Light therapy for seasonal affective disorder in primary care: randomised controlled trial. Br J Psych 2001;178:311-316.

Wohlfarth H, Schultz A. The effect of colour psychodynamic environment modification on sound levels in elementary schools. Int J Biosocial Res 2002;(5):12-19.

Zifkin BG, Inoue Y. Visual reflex seizures induced by complex stimuli. Epilepsia 2004;45(Suppl 1):27-29.

Fighting Breast Cancer with Light Therapy

Researcher fighting breast cancer with light therapy
"Metastatic breast cancer can be a devastating diagnosis with high rates of relapse and death, and there are currently no effective therapies,"

Nalinikanth Kotagiri, MD, Ph.D. says.

"Despite newer treatments, many patients still succumb to the disease. Major limitations include acquired resistance to therapies and serious side effects from treatment. Due to the widespread location of breast cancer cells, particularly in the bone marrow, which harbors the tumor cells as well as vital stem cells, the risk of toxicity is even higher with conventional therapies. Therefore, new therapeutic strategies that selectively destroy tumor cells, increase treatment efficacy, prevent relapse and reduce side effects by sparing the healthy stem cells are necessary."


This is why Nalinikanth Kotagiri, MD, Ph.D., assistant professor in the James L. Winkle College of Pharmacy and a cluster hire for the Cincinnati Cancer Center, is hoping to study ways ultraviolet light can activate light-sensitive drugs to treat this invasive breast cancer and provide that light at the end of the tunnel patients yearn for.

Kotagiri has been awarded the Department of Defense Breast Cancer Breakthrough Award—over $600,000 for three years—to try to do just that. His project will focus on light-mediated therapies, which could activate light-sensitive drugs to target only the cancerous cells.

"Therapies such as photodynamic therapy (PDT), involving light and a photosensitizing chemical substance, which used in conjunction with molecular oxygen can cause cell death, offer a high degree of control that is effectively used to manage cancer in early to advanced stages," he says. "It operates on a simple principle where a light-sensitive drug, which is otherwise nontoxic, introduced into certain tissues can cause cell death when activated by light. Despite the promise of PDT, it can't penetrate tissue deeply so its use is limited. Also, current light-sensitive drugs require oxygen to be effective, but many tumors, including breast tumors, have pockets of low oxygen or grow in regions where oxygen is either low or absent, which could prevent effective application of PDT in cancer treatment."

However, Kotagiri says recent work in the lab has led his team to a "two-pronged approach" in addressing these issues.

"We've been using ultraviolet (UV) light from radionuclides (radioactive nuclide or atom), which are already used to image tumors and tissues, and tried to solve oxygen dependence by using metal-based light-sensitive drugs for depth- and oxygen-independent PDT," he says. "By replacing the external light source, such as lasers and lamps, with light from radionuclides as an 'internal' light source, we've been able to better control therapy in the body.
"This could mean more effective therapies with minimal toxicity to vital organs and tissues. Since radionuclides are used in imaging and locating tumors, we can now simultaneously image and treat breast cancer metastasis using the same radionuclide."

Using animal models, researchers in Kotagiri's lab will test whether radionuclide light activation of tumor targeting, light-sensitive drugs will destroy metastatic cancer cells—including those that are resistant to traditional therapies.

"Since how we're killing the cells is not dependent on a certain molecular pathway, the technology could be applicable to treat a wide variety of breast cancers," he adds. "This has the potential to be a common image-guided treatment strategy to treat patients in early as well as advanced stages of the disease, and because of the safety of this treatment strategy, it could be effectively used alongside other treatments, like chemotherapy and immunotherapy, without the risk of additional side effects.
"This could tremendously benefit patients, as it could potentially improve therapeutic outcomes in addition to setting a precedent to tailor other FDA-approved light-sensitive drugs as radionuclide activated therapies, expanding the scope and range of the diseases these drugs currently treat. If proven beneficial, this treatment could be ready for a patient population in 5 to 10 years, since all the materials involved have already been used in humans—this could be an exciting breakthrough."
Clinical Trial - The Effects of Light Therapy to Treat Cancer-related Side Effects

ClinicalTrials.gov Identifier: NCT04418856

Besides what Kotagiri said, severe fatigue, depression, sleep problems and cognitive impairment are the most commonly reported side effects of cancer treatment. These aversive side effects are hypothesized to be related to the disruption of circadian rhythms associated with cancer and its treatment. Exposure to Bright White Light (BWL) has been found to synchronize the circadian activity rhythms but research with cancer patients has been scarce. Therefore, the proposed randomized control trial (RCT) will test if systematic light exposure (sLE) will minimize overall levels of cancer-related fatigue (CRF), depression, sleep problems and cognitive impairment among breast cancer patients undergoing breast cancer treatment (i.e., surgery, chemotherapy). SLE incorporates the delivery of harmless UV-protected BWL or Dim White Light (DWL - standard comparison in light studies) delivered to patients by using special glasses for 30 minutes each morning, during their treatment.

Learn more about the how to improve your circadian rhythm and light therapy & breast feeding

References

https://medicalxpress.com/news/2018-10-breast-cancer-therapy.html

https://www.mayoclinic.org/tests-procedures/photodynamic-therapy/about/pac-20385027#:~:text=Photodynamic%20therapy%20(PDT)%20is%20a,energy%2C%20usually%20from%20a%20laser.

https://clinicaltrials.gov/ct2/show/NCT04418856

The Sleeping Beauty Secret: The Red Light Therapy

Lack of sleep is a villain in America and Europe. Light intake is a big part of the problem. Over 65% of adults say they don’t get enough good sleep every week. Most people also don’t get nearly enough natural light for optimal health: the average American spends over 90% of their time indoors.

In addition to not getting enough natural light, people today are surrounded by artificial blue light from screens and overhead lighting. An overload of artificial blue light can cause headaches and make it harder to get to sleep and stay asleep. When we take in all that bright blue light from laptops, TVs, and phones, especially before we go to bed, our bodies get the signal that it's time to be awake, even if we're tired.

Melatonin is the naturally-occurring hormone that regulates sleep and wakefulness. Emerging research is showing that red light therapy treatments can help people produce more of their own, natural melatonin than exposure to other light sources like blue light. Red light therapy is natural light. It’s much less bright than blue light, with a lower color temperature than daytime sun, as the image above shows. Research has shown that red light doesn’t upset your sleep cycle like bright blue light. Red light therapy is showing great clinical results for people with insomnia and sleep disorders.

The light therapy is a simple, non-invasive treatment that delivers concentrated natural light to your skin and cells. Clinical research is showing that red light therapy can improve sleep quality and duration, and help people produce more of their own melatonin.

Light plays a major role in your sleep cycle. The body’s circadian clock interprets light as a sign of when to sleep and when to be awake. Artificial blue light from phones, computers, and other screens is extremely bright and can knock your circadian rhythm out of whack. Red light has the opposite effect: it’s ideal for evenings because it has a low color temperature—far lower than blue light and much closer to the natural sunset.

Red light therapy treatments are quick and simple: you just sit or stand in natural light for 5 to 15 minutes, ideally every day. This stimulates your mitochondria and gives your cells the natural light they need to make energy.

How Does Red Light Therapy Help You Sleep?

Natural light is a key ingredient for a healthy circadian rhythm and restful sleep. If you struggle to sleep, your light intake could be a big factor. Red light therapy delivers natural light like you’d get from the sun, but without UV rays, excess heat, or the need for sunny weather.

Red light therapy treatments supercharge your cells with the natural light they need to make more core ATP (adenosine triphosphate) energy. This helps your body run more efficiently, heal faster, and has shown great results for producing more natural melatonin and improving sleep disorders like insomnia.

Red light therapy treatments have shown great sleep results in a range of peer-reviewed clinical studies. One study on the sleep of pro basketball players showed that a 2-week course of red light therapy in the evening improved players’ sleep quality in the short term. Based on the results, the researchers suggested red light therapy would be a good non-invasive, drug-free solution to sleep struggles.

Overcoming Sleep Disorders with Red Light Therapy

Kaiyan's light therapy products are registered with the FDA as class II medical devices for the treatment of pain, strain, and inflammation. While the existing clinical research has been very positive for red light therapy and sleep, keep in mind that Kaiyan's devices are not cleared with the FDA for the treatment of various sleep disorders or melatonin.

Recent research on sleep disorders among people with migraine headaches has shown that red light therapy both decreased headache frequency, and was the only treatment that improved patients’ sleep disorders.

A 2014 study on cognitive function and traumatic brain injury (TBI) recorded that participants had significantly decreased episodes of post-traumatic stress disorder (PTSD), and improved sleep.

Analyzing patients’ electrical brain activity, a 2013 sleep study concluded that red light therapy was especially effective at helping people with sleep disorders fall asleep.


When I’m indoors training under the buzz of artificial lights, my body doesn’t get the natural light it needs. Add computers, cell phones, televisions, etc. and it’s easy to overload yourself with blue light. I used to have trouble sleeping after long training days, but since adding more natural light to my routine with red light therapy, I’ve been falling asleep as soon as I lie down, and I’ve been staying asleep all night.*

Sanne Wevers

Gold-Medal Winning Dutch Gymnast

Red Light Therapy, Sleep, Depression, and Seasonal Affective Disorder (SAD)

Research is showing how closely mood and sleep disorders are interconnected. Parts of the brain that regulate sleep have also been found to closely affect mood. A 2013 review concluded that “nearly all people suffering from mood disorders have significant disruptions in circadian rhythms and the sleep/wake cycle.”

This Greatist post on natural light and serotonin gives good background on the connections between natural light intake, mental health, and sleep. It also mentions using Kaiyan's red light therapy devices to get more natural light, even when you can’t get more sunlight.

Trouble sleeping is one of the most common symptoms of seasonal affective disorder, a type of depression most common in the darker winter months. Some physicians treating patients with mental health disorders have said red light therapy both improves mood, and helps people with depression get better sleep.

Sources and References:

Morita T., Tokura H. “ Effects of lights of different color temperature on the nocturnal changes in core temperature and melatonin in humans” Journal of Physiological Anthropology. 1996, September

Lirong Z., Phyllis Z. “Circadian Rhythm Sleep Disorders” Neurologic Clinics. 2012, November.

Color Temperature

The State of Sleep Health in America.

Klepeis N., Nelson W., et al. “The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants”. Journal of Exposure Analysis and Environmental Epidemiology 2001.

Sheppard A and Wolffsohn J. “Digital eye strain: prevalence, measurement and amelioration.” BMJ Open Ophthalmology. 2018 April.

Gooley, J., Chamberlain, K., Smith, K., Khalsa, S., et al. “Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans” J Clin Endocrinol Metab. 2011 Mar.

Hamblin M. “Mechanisms and applications of the anti-inflammatory effects of photobiomodulation”. AIMS Biophys. 2017.

Zhao J., Tian Y., Nie J., Xu J., Liu D. “Red light and the sleep quality and endurance performance of Chinese female basketball players” Journal of Athletic Training. 2012, November-December.

Loeb LM, Amorim RP, et al. “Botulinum toxin A (BT-A) versus low-level laser therapy (LLLT) in chronic migraine treatment: a comparison.” Arquivos de neuro-psiquiatria. 2018 Oct;76(10):663-667.

Naeser MA, Zafonte R, et al. “Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study.” Journal of Neurotrauma. 2014 Jun 1;31(11):1008-17.

Wu JH, Chang YC. Effect of low-level laser stimulation on EEG power in normal subjects with closed eyes. Evidence Based Complementary and Alternative Medicine. 2013; 2013:476565.

Vadnie C, and McClung C. Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus. Neural Plasticity. 2017 November.

McClung C. How might circadian rhythms control mood? Let me count the ways. Biological Psychiatry. 2013 April.

Nutt D, Wilson S, et al. Sleep disorders as core symptoms of depression. Dialogues in Clinical Neuroscience. 2008 September.

Avci P, Gupta A, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Seminars in Cutaneous Medicine and Surgery. Mar 2013.

Can LED Light Give me The Perfect Skin?

Following the article from the New York Times.

One day, shining light on your face may be the most important part of your skin care routine. We take a look at the newest devices.

The MMSphere, a ring of LED lights, casts a red glow over my face. It sits adjacent to my laptop so that as I write, research and procrastinate, I can simultaneously calm a fiery constellation of acne on my left cheek.

Red light’s anti-inflammatory and collagen-building effects on the skin are well documented. But this hands-free device, designed by Ellen Marmur, a dermatologist in New York, has settings for blue, green, amber and purple light too.

“It has just enough variety that people stay excited to use it,” Dr. Marmur said.

I, too, begin cocktailing. I bathe my face in blue light to kill acne bacteria while watching reruns, and immediately follow up with a FaceTime call to my mother, my face lit up in a bright green light to fight hyperpigmentation.

Skin care efficacy lives and dies by patient compliance. Most at-home LED skin care devices are small and hand-held, requiring time set aside to treat the entire face. People eventually stop using them.

Even with persistent acne as a motivator, I’ve always had trouble following LED protocols. The MMSphere ($495) is a big deal for me because it harnesses a powerful fix-everything-while-doing-nothing ease that makes it almost addictive. You actually want to use it.

“It makes people feel good, like they’re taking care of themselves,” Dr. Marmur said. “You can treat your skin while doing other things, so it’s easier to form the habit of doing it every day.”

Because, really, if we’re just sitting around — talking, eating, working — shouldn’t we be fixing our skin, too?

So How Does LED Work?

First, LED therapy is not the same as a laser treatment, which creates controlled damage to the skin to promote healing. The easiest way to understand the light-as-skin-care concept is to think of skin-friendly visible light as ultraviolet light’s benevolent counterpart.

In a process called photobiomodulation, light alters biological material; for example, UV rays from the sun change our skin in ways that can catalyze cancer and aging.

But some wavelengths of visible light alter our skin for the better, and light-emitting diodes (LED) are a source that delivers that energy.

Jared Jagdeo is an associate professor of dermatology and director of the Center for Phototherapy, SUNY Downstate Health Science University, where he studies LED therapy.

“You can alter the skin through photo-damaging with lasers, or photobiomodulation, which is a much more gentle way of changing the way the skin functions,” Dr. Jagdeo said. Red and blue light are the heavy hitters. He explained why red light in particular works so well.

“There’s a specific receptor in the mitochondria of the skin cells that red light specifically acts upon,” he said. “And that’s why red light is an ideal wavelength for changing the way the skin functions.”

Red light penetrates the skin deeper than other visible light and stimulates the mitochondria, which has an anti-inflammatory and rejuvenating effect. Collagen is built in the dermis, the skin is calmed, and wrinkles eventually fade.

Blue light doesn’t penetrate the skin as deeply but zaps acne-causing bacteria on the surface. The science on green light isn’t as solid, but in theory, it targets melanocytes, discouraging excess melanin production.

Rigorous independent studies have yet to be conducted, but Dr. Marmur did a very small clinical trial on green light for the MMSphere in which subjects self-reported a 32 percent decrease in “brown spots” after a week of green light treatment.

Is All of This Light Ok for my Eyes?

Eye safety is a valid concern, particularly because earlier this year Neutrogena recalled its LED mask over fears that it could cause eye injuries.

Brian S. Biesman, an assistant clinical professor of ophthalmology, dermatology and ENT at Vanderbilt University Medical Center in Nashville, said that most home devices aren’t powerful enough damage the eyes. The MMSphere comes with opaque goggles, but, Dr. Biesman said, the device is low energy, so it should be safe to use without them.

“Just normal blinking and eye movements should be sufficient to protect the eyes,” he said. “But never stare at a bright light source.”

More Thoughts

“As far as the F.D.A. is concerned, if I use CO2 laser resurfacing, it better work because of the amount of risk involved,” said Suzanne Kilmer, a clinical professor of dermatology at the UC Davis School of Medicine in Sacramento and director of the Laser and Skin Surgery Medical Group.

“Compare that to a home device,” Dr. Kilmer said. If it doesn’t kill you, blind you or make things much worse, it’s probably going to get approved. So it’s actually more incumbent upon the people selling home devices to show efficacy. You have to trust the people who are selling them.”

“LED is real, but it’s probably not optimized yet,” Dr. Kilmer said.

Many factors determine the amount of light your skin needs and receives: the strength of the light, the distance from source to skin, how long the light is used, and your skin color.

“Some of these lights on the market are very weak, and they may not have enough energy output to actually have a biological effect,” Dr. Jagdeo said. “Imagine a glow stick. It produces a color. But you could shine it on your face all day, and it’s not going to change the way your skin works.”

Furthermore, the medical community has yet to establish standard doses for treating conditions like hyperpigmentation and acne at home. Dr. Marmur based her MMSphere dosing on Blu-U, an in-office blue light that is commonly used as an alternative therapy for precancerous lesions.

“Consistent Sphere treatment for seven weeks will equal the energy given in the office with the Blu-U,” she said.

Another device, the Dr. Dennis Gross DRx SpectraLite FaceWare Pro, $435, emits red and blue light in a mask format, and each session is only three minutes. The mask’s LEDs are in contact with the skin, which may be a more effective treatment. Dr. Jagdeo said that you lose some energy on the way from device to skin, a potential downside of the MMSphere design.

“This is a tremendously undertapped area in medicine,” he said. “But LED light therapy is going to revolutionize the way home medical treatment is delivered for skin care over the next 10 to 15 years.”

Kaiyan Medical

In Kaiyan Medical you can create your own LED facial mask. We have developed Aduro mask who is one of the top facial masks in the beauty industry. Julia Roberts is a big fan of Aduro Mask. For more information visit https://www.aduroled.com/

Sculpting your Body with Green Light

Wouldn’t it be great if we could each reduce a couple of inches off our waist without having to diet or exercise for so long? Losing weight and fat is one of the most common health goals, both for medical and cosmetic reasons. For years, millions of people have tried different pills, injections, “natural” herbs, and many products that are supposed to help us reduce weight. Unfortunately, these usually don’t work

Clinical trial

Many people trying to lose weight just want to look better in the mirror, or at the beach. A wide variety of therapies to target fat and improve appearance are called “body contouring” or “body sculpting”, some surgical, others noninvasive. But many of them don’t work, or produce troublesome side effects. Green light therapy is completely natural & noninvasive and has proven to be an effective option for changing the way your body looks.

In the clinical trial NCT03647748 a double-blind, placebo-controlled randomized evaluation of the effect of Cellulize, a green light low-level laser system for aesthetic use for the non-invasive reduction in fat layer for body contouring and reduction of cellulite.

Device Description

The Cellulize is a non-invasive green light system with a power output of 105mW/cm2, consisting of 150 light-emitting diodes (LEDs) that emit visible light at a nominal wavelength of 532nm ± 3nm (visible green light spectrum) and a spectral bandwidth of 10nm. Cellulize® is indicated for uses non-invasive dermatological aesthetic treatment for the reduction of circumference of hips, waist, and thighs. The Massager component is indicated for the temporary reduction in the appearance of cellulite.

Clinical Testing

Cumulative circumferences of waist, hip, left and right thighs for each patient was calculated before and after treatment. Three main points were concluded as a result of the study:

1. Cellulize causes immediate inch loss in subjects after a regimen of six treatments of 32 minutes (8 minutes on each of four positions) compared to individuals subjected to a placebo device for equivalent treatment. In a typical regimen, patients lost an average cumulative of 2.67 inches of circumference compared to the placebo average of 0.5 inches. This meets the anticipated primary outcome measure “Average Change in Inches of Total Circumference Measurements for the effect of Cellulize, a LED 532nm green light low-level laser system for aesthetic use for the non-invasive reduction in fat layer for body contouring from baseline measurements, and after treatment. ”

Figure 1, below, shows the graphical summary of inch loss for patients in the Cellulize active group and the Placebo control group respectively. Table 1 gives the mean values for both groups as well as the standard deviation for the “after” measurements, as well as 7-day and 14-day follow-ups relative to the “before” measurements for each patient:

Figure 1

2. While the durability of effect is also impacted by extrinsic factors after treatments such as diet, it was demonstrated that subjects were more likely to show continued inch loss upon following up with each subject at 7 days and again at 14 days. In general, patients undergoing active Cellulize 532nm green light continued losing some inch with an average continued loss of an additional 1.20 inches for a total average inch loss of 3.87 inches where average placebo measurements after 14 days yielded a net gain (not a loss) of 0.875 inches. This implies that the green light treatment meets the expected primary outcome of demonstrated durability of effect after a short -term follows up of 2 weeks.

3 Finally, the effect of Cellulize LED 532nm green light without any other intervention was measured for its effect on cellulite as part of the study. The Nurnberger-Muller Scale (NMS), a four-stage scale used as an industry standard to classify stage or degree of cellulite and to determine the change in stage or degree of cellulite following treatment intervention, was used to ensure consistent evaluation standards. Results from the active device as well as placebo both showed that cellulite, in general, did not decrease on the back of thigh/buttocks for subjects after a single treatment of 532nm green light. This result failed to meet the anticipated primary outcome measure of decreasing the appearance of cellulite as a measure of the Nurnberger-Muller Scale (NMS) from baseline to completion of treatment for the thigh/buttock area.

Fat Reducing Low-Level Laser — OLI

The FDA product classification code, OLI, has a guidance document which is the special control for this product, Guidance for Industry and FDA Staff — Class II Special Controls Guidance Document: Low-Level Laser System for Aesthetic Use. According to the guidance document, FDA believes that special controls, when combined with the general controls, will be sufficient to provide reasonable assurance of the safety and effectiveness of the low-level laser system for aesthetic use. Cellulize complies with all of the standards outlined in the special controls consensus standards.

To learn more about OLI products, you can visit https://fda.report/Product-Code/OLI

Kaiyan Medical

Here in Kaiyan Medical, we are pioneers and innovators with light therapy. We keep developing technologies with green light and trying to reach more markets.

kaiyanmedical.com


References

Effects of Green Light Therapy on Body Contouring and Cellulite - Full Text View …
Primary Outcome Measures : Average Change in Inches of Total Circumference Measurements [ Time Frame: 2 weeks ] Average…clinicaltrials.gov

Duarte FO, et al. Can low-level laser therapy (LLLT) associated with an aerobic plus resistance training change the cardiometabolic risk in obese women? A placebo-controlled clinical trial. J Photochem Photobiol B. 2015 Dec;153:103–10.

da Silveira Campos RM, Dâmaso AR, et al. The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women. Lasers in Medical Science. 2018 Aug;33(6):1245–1254.

The 5 Best LED Pain Relievers

What is Holistic Medicine?

Holistic medicine is a whole-body approach to healthcare. It aims to improve health and wellness through the body, mind, and soul.

Principles of Holistic Medicine

Holistic medicine is based on several core values:

  • Good health is a combination of physical, emotional, mental, spiritual, and social wellness.
  • Prevention first, treatment second.
  • The disease is caused by a problem with the whole body, rather than a single event or body part.
  • The goal of treatment is to fix the underlying cause of disease, instead of just improving the symptoms.
LED Light Therapy: What is it, and Does it Work?

LED stands for light-emitting diode. These lights have been in use since the 1960s, but people have only recently begun to use them as a skin treatment.

NASA originally developed LED lights for plant growth experiments in space.

However, since then, LEDs have shown promising results in wound healing and human tissue growth.

Different wavelengths of light in LED lights, including blue and red, penetrate the skin at different depths. This penetration may trigger biological processes that help the skin rejuvenate and heal.

LED light therapy is a popular non-invasive skin treatment for acne, sun damage, wounds, and other skin problems.

If you prefer to avoid the pharmaceutical way to manage issues with joints or muscles, you might want to try one of these LED pain relievers instead. Using a combination of wavelengths from the visible and infrared light spectrum, you can help to relieve many conditions, including arthritis, without the risk of potentially harmful side effects.

Here the Top 5 Pain Relief Devices


5) Double Side FDA Cleared Red/Infrared Lights Therapy Glove

People suffering from arthritis or a repetitive strain injury to their fingers or wrists can appreciate the design of the Red Light Therapy Double Side. It surrounds your hand for complete coverage.


4)The Multifunction Pen LED

For a portable solution, the multifunction pen LED is about the size of a small flashlight. It uses a special wavelength that’s supposed to offer antiinflammatory effects in localized areas of application.

3) Handheld Device with LED Red Light

The handheld device boasts an ergonomic handle that has comfortable rests for your fingers to provide you with a firm grip as you use it. Its compact design makes it a good option for travel.



2)Light Therapy Infrared Light Panel for Whole Body

With a bigger number of diodes, this panel is designed for deeper penetration than many of its competitors. It claims to be able to help reduce inflammation, stimulate cell growth, and increase circulation.

1. FDA Cleared Red/Infrared Led Light Therapy Pad

The sheer size of the therapy pad makes it suitable for treating a wide number of areas on the body, most notably the lower back. With only 15minutes of therapy needed, is the best balance between convenience and LED power.

To order or discuss your LED light medical device don’t hesitate to contact us at info@kaiyanmedical.com


Which is the Vitamin that is not Normally Found in any Vegetarian Food? — Vitamin D

What would happen if you don’t get enough sun?

Which is the vitamin that is not normally found in any vegetarian food? Vitamin D.

Scientists have defined vitamins as organic (carbon-containing) chemicals that must be obtained from dietary sources because they are not produced by our bodies. Vitamins play a crucial role in our body’s metabolism, but only tiny amounts are needed to fill that role.

The discovery of Vitamin D was the culmination of a long search for a way to cure rickets in the 1920s, a painful childhood bone disease. Within a decade, the fortification of foods with vitamin D was on the way, and rickets became rare in the United States. However, research results suggest that vitamin D may have a role in other aspects of human health.

Vitamin Dit’s absent from all-natural foods except for fish and egg yolks, and even when it’s obtained from foods, it must be transformed by the body before it can do any good. That’s why the energy of the Sun is so important.

The sun’s energy turns a chemical in your skin into vitamin D3, which is carried to your liver and then your kidneys to transform it into active vitamin D.

The main cause of vitamin D deficiency is a lack of direct sunlight.
The main cause of vitamin D deficiency is a lack of direct sunlight

Humans, day by day, spend less time outdoors. Most people work indoors now, and many of our leisure pursuits occur in an indoor setting as well. What’s more, when we are outside, many people avoid the sun as much as possible. The result is the body not absorbing enough UVB rays to create the amount of vitamin D it requires. Often, symptoms of vitamin D deficiency are quite mild. When noticed, they mainly consist of:

  • Bone pain.
  • Chronic fatigue.
  • Frequent bone fractures.
  • Muddled thought processes.
  • Muscle weakness.
  • Soft or deformed bones.

Though you may not notice any symptoms, that doesn’t mean that vitamin D deficiency doesn’t present serious health risks. These include:

  • Children may develop severe asthma.
  • Immune system problems, raising your risk of infection.
  • Insulin resistance, impacting your body’s ability to process sugar and increasing your risk of diabetes, multiple sclerosis, and glucose intolerance.
  • Osteoporosis, a condition that includes brittle bones that are more likely to fracture.
  • Reduced cognitive function.
  • Rickets, a bone disease that causes soft bones and skeletal deformities.
Other conditions that would happen without enough sunlight

Less chance of having a baby

Without sunlight, there will be more melatonin in a woman’s body. This is a hormone that suppresses fertility, thereby reducing her chances of conceiving a baby. Moreover, women who get less sunlight reach their menopause earlier than those who are exposed to the Sun. Men can also suffer from a lack of sunlight; it directly influences testosterone levels.

Less chance of having a baby

Raw nerves

It’s believed that if children don’t get enough sunlight, they’ll be more at risk of developing multiple sclerosis, a disease of the central nervous system when they become adults.

All those aches and pains

Without sunlight, be prepared to get more pains all over your body. Sunlight helps to warm the body’s muscles and reduce the pain caused by inflammatory conditions such as arthritis.

No sunny emotions

Image for post

Without sunlight, we would be forever stuck with the seasonal affective disorder (SAD), commonly known as the winter blues. It’s a form of depression that is specifically caused by a lack of sunlight. Artificial light cannot fully replace natural sunlight.

Recent evidence suggests that vitamin D may help prevent many disorders, such as diabetes, multiple sclerosis, rheumatoid arthritis, chronic obstructive pulmonary disease, asthma, bronchitis, premenstrual syndrome, increased blood pressure, strokes and heart attacks, and even cancer. Low serum vitamin D levels are also associated with being overweight, abdominal obesity, metabolic syndrome, stroke, and diabetes. In addition, having lower blood vitamin D levels for a long period is associated with increased heart attacks and all-cause mortality.

In Kaiyan medical, we believe in the benefits of light. We believe in healing without chemicals. With our lights, we want you to have the best version of yourself. More at kaiyanmedical.com

References:

Holick MF (March 2006). “High prevalence of vitamin D inadequacy and implications for health”. Mayo Clinic Proceedings. 81 (3): 353–73. doi:10.4065/81.3.353. PMID 16529140.

Holick MF (December 2004). “Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease”. The American Journal of Clinical Nutrition. 80 (6 Suppl): 1678S–88S. doi:10.1093/ajcn/80.6.1678S. PMID 15585788.

Weick MT (November 1967). “A history of rickets in the United States”. The American Journal of Clinical Nutrition. 20 (11): 1234–41. doi:10.1093/ajcn/20.11.1234. PMID 4862158.

Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC, O’Beirne M, Rabi DM (March 2013). “Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies”. BMJ. 346: f1169. doi:10.1136/bmj.f1169. PMID 23533188.

Palacios C, De-Regil LM, Lombardo LK, Peña-Rosas JP (November 2016). “Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes”. The Journal of Steroid Biochemistry and Molecular Biology. 164: 148–155. doi:10.1016/j.jsbmb.2016.02.008. PMC 5357731. PMID 26877200.

Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E (November 2017). “Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials”. BMJ. 359: j5237. doi:10.1136/bmj.j5237. PMC 5706533. PMID 29187358.

The Beauty and the Beam: the Magic of the Red Light Therapy.

Skeptical

While I was initially skeptical at the 8-minute treatment, after I started to calm my mind, I fell in love with it. From age spots, to dry skin and acne, it cures whatever ails you. Could sound like a magic potion from a princess but is just light therapy. Before you go with the “What the…?” face, it’s only a matter of time before it shows up in most of the celebrities’ social media.

Most of our users describe it as

“warm and relaxing, and allows you to go into a meditative state of mind.”

LED light therapy has an established history of skin uses. The U.S. Navy SEALs began using it in the 1990s to help heal wounds quickly and to help regenerate damaged muscle tissues.

Since then, the treatment has been researched for different situations in aesthetics. It’s mainly noted for increasing collagen and tissues.

There are different frequencies, or wavelengths, used with LED light treatment. These include red and blue light frequencies, which don’t contain ultraviolet rays and are readily absorbed into the skin.

Light therapy

Different than Daylight

Unlike ultraviolet rays from the sun which damage the DNA of skin cells, “light emitted in this spectrum is perfectly safe,” said Dr. Susan Bard, a board-certified dermatologist based in New York City.

That means there’s no tanning or burning when you’re exposed to red light. Its effects happen deep inside at the cellular level. All living things need to make ATP cellular energy to function and survive, and nearly all living things rely on natural light to power this process in our cells every day. Red and near-infrared wavelengths of natural light stimulate the mitochondria in your cells, the powerhouses responsible for taking light, oxygen, and the food we eat — and turning it into usable energy for our bodies through the process of cellular respiration.

Light therapy

Uses of Red Light

Red light therapy has been used to treat or improve the following:

  • pain
  • inflammation
  • healing
  • tissue regeneration
  • autoimmune diseases
  • brain disorders
  • athletic performance
  • eyesight
  • heating
  • cancer therapy side effects

“The number of conditions red light can treat is ‘continuously expanding”

said Michael R. Hamblin, PhD, a principal investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital and associate professor of dermatology at Harvard Medical School.

The Short Version

Light therapy delivers safe, concentrated wavelengths of natural light to your skin and cells, with no chemicals, UV rays, or excess heat. These red and near-infrared wavelengths of light stimulate the mitochondria in your cells similar to natural sunlight, reducing oxidative stress, and increasing circulation, so your body is able to make more core energy to power itself.

In Kaiyan medical, we believe in the benefits of light. We believe in healing without chemicals. With our lights, we want you to have the best version of yourself.