Dermatology Device Market Assessment: Where Light Therapy Comes In

The dermatology industry goes far beyond purely cosmetic appeal. The increasing prevalence of skin cancer and other common skin disorders contributes significantly to the large interest in dermatology devices. 

The global dermatology device market size was valued at $11.8 billion in 2019 and is forecasted to register a CAGR of 15.1% over the next few years. And this only means one thing—dermatologists need the newest and most effective devices for their patients.  

While there’s a medical interest in dermatology, there’s also a growing interest in cosmetic procedures. Technological advancements in dermatology devices have accelerated the success of dermatological and cosmetic treatments, and in addition, the rise in disposable income is also considered to be driving the market for dermatology devices. Even so, dermatology reaches beyond skin care clinics, with dermatology devices also being used in many hospitals and dermatology clinics to treat skin disorders.

As people become more aware of skin conditions and strive to achieve today’s beauty standards, they become more interested in dermatology treatments, particularly non-invasive ones. Most people aren’t interested in going under the knife to enhance their features or treat skin conditions and this is where light therapy plays a crucial role in the global dermatology market. 

Let’s take a look at the global market and its need for light therapy devices. The rise in skin diseases is amongst the factors that are anticipated to drive the light therapy market in the Asia Pacific. Emerging markets, such as China and India, offer high growth potentials to market players. North America dominated the global light therapy market in 2018 due to the rise in the prevalence of skin disorders, including eczema and skin cancer.

Procedures associated with non-invasive cosmetic correction have witnessed a surge in demand, with the growing geriatric population, soaring healthcare expenditure, and rising disposable income of people in developing and developed countries. As much as the rise in disposable income is contributing, the high costs of dermatology devices are still preventing the full market surge.

Many technological advancements are being manufactured amongst dermatology devices, for example – laser instruments and light therapy. LED light therapy devices are being purchased more and more, as light therapy production is significantly increasing. The market of light therapy devices is predicted to witness a 5.1% CAGR from 2021 to 2027—meaning if you’re a dermatologist without a light therapy device, you’re missing out on a huge opportunity.

How does LED light therapy work? 

While it focuses on improving a person’s overall well-being, it focuses on penetrating at the cellular level, rejuvenating and healing damaged cells. Essentially, light therapy works from within. We can use light therapy for detox purposes and for other issues ranging from superficial skincare to healing inner tissue damage, thus strengthening the body and overall organism. 

Light therapy can also aid in skin concerns such as stretch marks, providing the skin with an increase in collagen production. Improved cellular turnover provides skin with increased elasticity and collagen wherever the device is used on the body, whether it be via a face mask, lamp, or panel. Stretch mark reduction is estimated to continue being the second largest application of dermatology devices in the market, estimated to reach US$ 4 billion by 2026.

As you can see, the light therapy market is bringing in non-invasive, non-pharmaceutical treatment options for the public, fulfilling both cosmetic and medical needs. It’s no wonder light therapy is expected to explode with success. 

Dermatology clinics are expected to register the highest CAGR during the forecast period. As the demand increases, dermatologists need their hands on the latest and most effective light therapy devices. Luckily, Kaiyan products are MDA-certified and FDA-approved light therapy devices designed for clinical use, and we can even private label devices for skincare professionals. They can be tailored to your clients, providing them with regulated and high-quality treatment for their medical and cosmetic needs.

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Give Mom the Gift of Beauty from Within this Mother's Day

Give Mom the Gift of Beauty from Within this Mother's Day

With Mother's day right around the corner, you're probably wondering what to get her. It's easy to stick to the traditional—gifts, flowers, jewelry, or a gift card. But do these really show your appreciation to her for everything she's done for you? In reality, most mothers' day gifts aren't really that useful. Sure, a framed fame photo or a personalized mug is nice, but why not get her something that improves her well-being and makes her feel better in her own skin? 

Have you heard of the Aduro 7-in-1 Led face mask? If this is the first time you’ve heard about red light therapy, well, you just found the perfect mother's day gift. As women get older, they want to hold onto their youthfulness and this device is how they can achieve this goal. But before we talk about how skin care light therapy works, it's important you understand how light therapy functions and its many benefits.

Light therapy uses different types of light to act as a source of energy for the cells. When light penetrates the skin, the ATP (adenosine triphosphate) is stimulated. ATP acts to fuel your body's cells. Once stimulated, the body works to repair and rejuvenate damaged and old cells. Now, the body does this naturally; however, light therapy accelerates the process; thus, light therapy users see results within days. 

Naturally, light therapy can be used on a variety of areas of the body and can help with issues ranging from joint pain, to muscle recovery, to Seasonal Affective Disorder. But the Aduro 7-in-1 LED face mask focuses on promoting skin healing and collagen production. As we age, our skin's elasticity and collagen production decrease, creating fine lines and wrinkles. However, through Aduro's 7-in-1 light therapy mask, you can literally reverse signs of aging. 

The Aduro mask is one of the most advanced at-home LED facial masks on the market, featuring 11 different light treatments for a variety of skin conditions, from acne to pigmentation to rosacea. If you're wondering, “do light therapy masks really work?” The answer is “yes!” You just need to make sure you give yourself between 15-20 minutes per day to wear the mask. That's all that needs to be done. From there, you let the mask do its job.

The hands-free device has settings for blue, green, red, amber, and purple light. You can combine them to get the desired results. For example, blue light kills bacteria, red light is anti-inflammatory, and green light fights hyperpigmentation. So, it can be adjusted depending on the needs of the individual. Our skin’s needs fluctuate over time, and this mask works perfectly for all ages and skin types. 

While most at-home treatments require you to hold the device, this face mask stays on without having to touch it. So, your mom will be able to use her phone, meditate, listen to a podcast, all while the mask does its work. 

The best part is that light therapy has been well-researched and used for decades. So, if you’ve been wondering whether light therapy face masks are safe, yes, they are. Many skin experts have weighed in and studied the safety and efficacy of light treatments. 

More importantly, Kayian's red light therapy devices are FDA-approved and MDA-certified. While many light therapy masks on the market provide weak light with limited effects on the skin, Kayian's light therapy devices are not only regulated, but they work as non-invasive at-home treatments. So, this mother's day, why not treat your mom to a gift that she'll actually benefit from? Once she sees the benefits, she'll fall in love with the Aduro 7-in-1 light therapy mask and never want to take it off!

For more information on our manufacturing and private label offering, please reach out to our team – we love working with skincare experts on building their dream devices. 

P.S. - we're currently offering a Mother's Day promo on our site! Head to our product page to learn about the free gift with purchase we're offering.

Dermatology Device Market Assessment: Where Light Therapy Comes In

Dermatology Device Market Assessment: Where Light Therapy Comes In

The dermatology industry goes far beyond purely cosmetic appeal. The increasing prevalence of skin cancer and other common skin disorders contributes significantly to the large interest in dermatology devices. 

The global dermatology device market size was valued at $11.8 billion in 2019 and is forecasted to register a CAGR of 15.1% over the next few years. And this only means one thing—dermatologists need the newest and most effective devices for their patients.  

While there’s a medical interest in dermatology, there’s also a growing interest in cosmetic procedures. Technological advancements in dermatology devices have accelerated the success of dermatological and cosmetic treatments, and in addition, the rise in disposable income is also considered to be driving the market for dermatology devices. Even so, dermatology reaches beyond skin care clinics, with dermatology devices also being used in many hospitals and dermatology clinics to treat skin disorders.

As people become more aware of skin conditions and strive to achieve today’s beauty standards, they become more interested in dermatology treatments, particularly non-invasive ones. Most people aren’t interested in going under the knife to enhance their features or treat skin conditions and this is where light therapy plays a crucial role in the global dermatology market. 

Let’s take a look at the global market and its need for light therapy devices. The rise in skin diseases is amongst the factors that are anticipated to drive the light therapy market in the Asia Pacific. Emerging markets, such as China and India, offer high growth potentials to market players. North America dominated the global light therapy market in 2018 due to the rise in the prevalence of skin disorders, including eczema and skin cancer.

Procedures associated with non-invasive cosmetic correction have witnessed a surge in demand, with the growing geriatric population, soaring healthcare expenditure, and rising disposable income of people in developing and developed countries. As much as the rise in disposable income is contributing, the high costs of dermatology devices are still preventing the full market surge.

Many technological advancements are being manufactured amongst dermatology devices, for example – laser instruments and light therapy. LED light therapy devices are being purchased more and more, as light therapy production is significantly increasing. The market of light therapy devices is predicted to witness a 5.1% CAGR from 2021 to 2027—meaning if you’re a dermatologist without a light therapy device, you’re missing out on a huge opportunity.

How does LED light therapy work? 

While it focuses on improving a person’s overall well-being, it focuses on penetrating at the cellular level, rejuvenating and healing damaged cells. Essentially, light therapy works from within. We can use light therapy for detox purposes and for other issues ranging from superficial skincare to healing inner tissue damage, thus strengthening the body and overall organism. 

Light therapy can also aid in skin concerns such as stretch marks, providing the skin with an increase in collagen production. Improved cellular turnover provides skin with increased elasticity and collagen wherever the device is used on the body, whether it be via a face mask, lamp, or panel. Stretch mark reduction is estimated to continue being the second largest application of dermatology devices in the market, estimated to reach US$ 4 billion by 2026.

As you can see, the light therapy market is bringing in non-invasive, non-pharmaceutical treatment options for the public, fulfilling both cosmetic and medical needs. It’s no wonder light therapy is expected to explode with success. 

Dermatology clinics are expected to register the highest CAGR during the forecast period. As the demand increases, dermatologists need their hands on the latest and most effective light therapy devices. Luckily, Kaiyan products are MDA-certified and FDA-approved light therapy devices designed for clinical use, and we can even private label devices for skincare professionals. They can be tailored to your clients, providing them with regulated and high-quality treatment for their medical and cosmetic needs.

Light Therapy & Acne Treatment

Light Therapy & Acne Treatment

We all know what acne is—for many, just hearing the word is traumatizing. While not everyone’s had to deal with it, many people do; and despite the fact that it’s an extremely common skin condition, it can be extremely challenging both emotionally and physically. 

You’d be surprised at how many people think “just washing your face” will help acne, or that there’s a miracle skincare product to cure. This generally not the reality, as acne occurs at an internal, cellular level in many cases. 

The types of acne vary, from acne that you don’t really notice, to acne that literally hurts. The reason to treat your acne shouldn’t be superficial, you should take into account that acne may be a sign of something going on within your body, for example, hormonal acne. But whether it is hormonal, genetic, cystic, or any of the many variants, acne is treatable, while there is no guaranteed cure. 

And, the more serious acne types are often treated medically. While many people don't want to take medication, most don't feel they have any other choice. There are dozens of different acids, creams, and antibiotics that are prescribed to treat acne. While they can work, they can also leave you with unpleasant side effects.

But what about light therapy for acne treatment? 

Not only does light therapy work on improving your acne, but it’s also focused on working from the inside out. Light therapy works at the cellular level, accelerating ATP production and cell turnover. This provides your skin with a new, healthier coat, eventually replacing old and dead skin cells. While your skin naturally dies and regenerates itself, light therapy accelerates the regeneration process with younger and stronger cells. 

Blue light therapy, for instance, is used to specifically combat skin bacteria that can lead to the development of acne. LED light therapy shows that 77% of acne cases that have been treated with blue light therapy have shown improved skin condition.Overall, people have experienced a significant decrease in the number of acne lesions, both pimples and cysts, with the at-home light therapy device. 

Light therapy is a non-harmful, non-irritating, and non-invasive skincare treatment. It’s not magic, but it has proven to be highly effective in treating acne. Studies support that it is antibacterial, anti-inflammatory, and has virtually no side effects. 

LED light therapy for hyperpigmentation also works to improve spots or discoloration post-acne, returning the skin to normal pigmentation levels. An increase in melanin is what causes our spots and hyperpigmentation, so to prevent it, light therapy could be you or your patients’ best friend. 

If you’re looking for a non-invasive, non-pharmaceutical acne treatment, a light therapy mask is what you want. Kayian's light therapy devices are for home use, MDA-certified and FDA-approved, ease-to-use, and effective for your own at-home treatment. You can take charge of your acne with light therapy, and if you’re a skincare practitioner, perhaps it’s time to consider private labeling your own device to better serve your clients by offering effective, safe products in-clinic, or even for your clients to use in the home.

Transitioning Skincare Routines from Winter to Spring

Transitioning Skincare Routines from Winter to Spring


The right skincare routine is something to be crafted meticulously. Not only is it individual––meaning that what’s best for one person might not work for another––but what’s best for a person in winter may not work for them during spring and summer. 

As we get older, naturally, so does our skin. As we age, our cells age, slowing down the cellular turnover process. With aging skin, there are certain needs to cater to that differ throughout the aging process. Ingredients that are good for mature skin could be too harsh for teenage skin, and vice-versa. 

Finding the right skincare for winter can be a challenge. The air is drier and harsher, making skin more prone to dryness and irritation. Of course, people can do things like sleeping with a humidifier in the room, eating clean, showering in warm water, and staying hydrated; and while these ideas do help to prevent flaky and dehydrated skin, they only work to a certain extent. 

While many stick to a strict winter skincare routine, following the same routine during spring and summer can actually be counterproductive in achieving the results desired. In the winter, most skincare enthusiasts use thicker and heavier products for hydration and protection; however, it’s important to just incorporate lighter products during spring time

Why can’t we use the same products all year round? Spring brings us different temperatures and climate. Humidity goes up, UV increases, and the temperature is warmer. The creams used during winter become too heavy during springtime, and the cleansers and moisturizers that helped skin in wintertime clog can sometimes pores during the spring and summer. However, there is a way to help transition skincare routines from winter to spring, and that’s with light therapy.

What is light therapy? Well, before we dive in, you may be wondering, ‘is light therapy treatment safe?’ Absolutely. It’s a non-invasive, and non-pharmaceutical treatment providing outstanding skincare results. It helps produce ATP, which provides the energy that runs our whole body. Through increased ATP, cellular turnover is improved with long-term light therapy treatments. 

Light therapy can help with the transition in the way that it prepares the skin for the change. It helps reprogram cell turnover, which provides fresher skin and balances out the natural nutrients our skin needs. This can help with getting ready for the transition of seasonal skincare products. 

Within one week, you or your client’s skin sees an improvement in ATP production, thus, reducing complexion, aging, and acne issues. By regenerating new cells, you’re likely witnessing a fresher face, and glowing skin. Naturally, the longer a person commits to light therapy, the better the results – all good things come with time. But light therapy presents a more powerful solution than simply relying on creams and serums, alone. With skincare products, the outer layer of the skin is repaired and the job gets halfway done. 

Getting used to a new skincare routine can take from 5-8 weeks, which is why it’s important to have the skin in the best possible condition in-between transitions. Light therapy helps reduce the chances of the negative effects that can easily occur in changing a skincare routine. Having the option to avoid irritation, acne, and redness comes simply by integrating light therapy into one’s facial routine.

However, irritation is sometimes inevitable, particularly in those with acne-prone or sensitive skin, and this can sometimes lead to hyperpigmentation and acne scars. But, luckily, this irritation and acne scarring can be treated at home with light therapy, as well. 

And, it’s ideal for dermatologists and aestheticians who want a non-invasive and non-pharmaceutical treatment for their clients in the treatment room. In addition, light therapy masks can be customized with multi or single light to suit your client’s needs. Kayian's light therapy devices are MDA-certified and FDA-approved, and created for clinical use. If you’re a dermatologist or aesthetician, you have the freedom of customizing your light therapy device to provide the best results for your clients. With a light therapy device in your office, you’ll give your clients the results they want, and have them coming back for more.

Frequency Modulation - Nogier & Light Therapy

Frequency Modulation - Nogier & Light Therapy

Many physiological processes depend on the light cycle. There are special photoreceptive molecules in our cells called cytochrome c oxidases, which are enzymes of mitochondria's respiratory chain. Mitochondria are cellular organelles that supply cellular energy. Cytochrome c oxidases absorb light in the phototherapeutic window (NIR and R spectrum), triggering a sequence of redox reactions on the inner mitochondrial membrane. These primary mechanisms' photobiological response is evident in the photo signal transduction to secondary mechanisms that ensure several clinical effects: wound healing, improved blood and lymph circulation, regeneration, and immunomodulation. Photobiomodulation provides the organism with substantial support in maintaining homeostasis of the body. This applies particularly to the red and the near-infrared spectrum. Light contributes to maintaining or re-establishing balance in the organism at even cellular level, where it:

  • Acts as an antioxidant contributing to the protection of cells from free radicals.
  • It affects the proteins that protect cells from degenerative processes.
  • Enhances the osmotic resistance of red blood cells, thus preventing hemolysis.
  • Affects the growth factors in the nervous system and microvessels and the muscular and connective tissue.
  • Affects cell signaling.
  • Regulates inflammations, the immune response, and circadian rhythms.
  • Supports tissue regeneration.
  • Stimulates local circulation.
  • Supports the lymphatic system.

Light affects the mechanisms of disease incidence and substantially shortens the recovery time. It thus helps reduce medical costs, as it cuts down on the use of medicinal products. A light stimulator cannot replace a healthy lifestyle and medical care required in injuries or illnesses, but complementary effects have been proven. The irradiated area shows better circulation, cellular metabolism, and energy production in cells improves, and the healing and regenerative effects on the tissue are stimulated. The light stimulator can be used as an independent or complementary therapy.

Frequency Modulation

Therapeutic light devices can be modulated at various frequencies. Modulation unites the properties of light with technically compatible frequencies that additionally stimulate the body’s regenerative abilities and enhance the effects of light therapy.

Nogier Frequencies

Seven different frequencies are used to treat different injuries and alleviate illnesses through light. These frequencies, Nogier frequencies, regulate various conditions. Dr. Paul Nogier was a French neurologist and the founder of auriculotherapy, who determined frequencies for treating individual types of tissue. The seven experimentally determined Nogier frequencies can be used in light therapy to support an affected organ's rehabilitation through acupressure points or of injured tissue. Furthermore, these frequencies help establish a healthy balance of energies through meridian and acupressure points according to acupressure and acupuncture principles. Voll frequencies can also modulate light devices. These frequencies are used for bioresonance therapy with individual electronic devices that include both frequencies for diagnosing and frequencies for treating conditions that occur due to impaired cellular activity. The 2.45 Hz Voll frequency is effective for acute, subacute, and chronic conditions. Using the light of a wavelength of 610–670 nm and 830–870 nm helps with muscular and skeletal injuries, pain, tendon and ligament injuries, and injuries to the nervous system. It affects the acupuncture points. It strengthens and relaxes the body and directly affects individual systems of the organism or individual organs. It is used for edema, sinusitis, insomnia, and vegetative disorders. Light therapy is often complemented by Nogier and Voll frequencies that simulate various tissue types and offer effective support to treating various medical conditions and injuries. The type of injury or the medical condition determines the appropriate frequency to be used.

Seven Nogier frequencies to achieving a healthy energy balance of the body that are most commonly used in light therapy:

  • Frequency A: 292 Hz
  • Frequency B: 584 Hz
  • Frequency C: 1,168 Hz
  • Frequency D: 2,336 Hz
  • Frequency E: 4,672Hz
  • Frequency F: 73 Hz
  • Frequency G: 146 Hz

It generally applies that lower frequencies are used to facilitate cell activity and for regeneration, while higher frequencies (C-E) are used for alleviation and relief of pain. The effects of these frequencies are enhanced if several frequencies are included in one therapy.

  • Analgesic effect: C, E.
  • Regenerative effect: F,G,D.
  • Relaxation: A,B,E.

Benefits & Effects

F :  Facilitates cellular activity, especially when this activity is reduced. Activates bodily functions. Stimulates acupuncture points

G :  Anti-inflammatory function stimulates the immune system. Accelerates recovery. This setting is often combined with other settings, as inflammations comprise several phases.

A : It has a stimulating effect on the tissue of ectodermal origin (the central and the peripheral nervous system, the sensory epithelia, the epidermis with hair, nails, cutaneous glands, the pituitary gland, the epiphysis). It facilitates recovery following surgical procedures, restores the skin and the mucous membrane (wounds, wrinkles, ulcers, aphthae, herpes). Helps with migraines. This frequency is used as the universal frequency for acupuncture points.

B : It has a stimulating effect on endodermal origin tissue (the liver, gall bladder, pancreas, intestinal loop, the urinary bladder). It enhances blood and lymph circulation. It also affects the conduction of nerve fibers. It prevents the development of blisters in the initial phase of herpes and facilitates wound healing in the mouth cavity.

C : It stimulates mesodermal origin tissue (connective and supportive tissue, striated and smooth muscle tissue, hematopoietic organs, the lymph, kidneys, the genitals). It supports bone healing and facilitates recovery following muscle, ligament, and joint injuries. It relaxes the muscles and improves joint mobility.
D :  Complements frequencies A and C.

E :  Relieves pain.

Modern light devices for photobiomodulation are frequency modulated and are intended for specific therapies that we wish to conduct. This means that in addition to treatment with the seven basic frequencies, they enable the use of preset programs that automatically combine various frequencies in recommended time intervals. The frequencies change automatically concerning the type of injury or the medical condition. After the therapy, the devices shut down automatically.

References

https://awalightingdesigners.com/nogier-frequencies-part-2-6-of-a-7-part-series/

Douris P, Southard V, Ferrigi R et al. EFFECT OF PHOTOTHERAPY ON DELAYED ONSET MUSCLE SORENESS (DOMS). Photomed Laser Surg. 2006; (3): 377–82.

Ramagole DA. EFFECTS OF LOW LEVEL LIGHT THERAPY IN TREATMENT OF OVER USE SPORTS INJURIES IN PROFESSIONAL ATHLETES – DESCRIPTIVE PILOT STUDY.

Department of Orthopaedics, University of Pretoria, South Africa.3. Junior EC, Lopes-Martins RA, Baroni BM et al. COMPARISON BETWEEN SINGLE-DIODE LOW LEVEL LASER THERAPY (LLLT) AND LED MULTI-DIODE (CLUSTER) THERAPY (LEDT) APPLICATIONS BEFORE HIGH-INTENSITY EXERCISE. Laboratory of Human Movement, University of Caxias do Sul, RS, Brazil.

Carroll JD. LOW LEVEL LASER/PHOTOBIOMODULATION DOSIMETRY. WHAT ARE THE TRESHOLDS AND WHAT ARE THE LIMITS? Photodiagnosis and Photodynamic Therapy. 2008, 5(1): S25(71).

Back to Nature: The Healing Power of Bird Sounds

Back to Nature: The Healing Power of Bird Sounds

What is Sound Therapy?

Sound has been used to heal and calm people for thousands of years. Himalayan singing bowls used in Asia during prayer and meditation positively affect one’s health and well-being. This is just one example of age-old instruments from all over the world being applied as healing instruments.

Sound therapy is based on the premise that we are all made up of energy frequencies, and audio frequencies can interact with our body’s energy to rebalance our systems.

Since music is basically just organized sound, it can be deconstructed to affect our physical and psychological well-being positively.

Ailments Sound Therapy can Help:
  • Anxiety
  • Depression
  • Post-traumatic stress disorder
  • Autism and learning disabilities
  • Dementia
  • Behavior and psychiatric disorders
Five Other Benefits of Sound Therapy
  • Lower stress responses
  • A decrease in mood swings
  • Pain management
  • Improves sleep
  • Lowers blood pressure

How Does Bird Music Help in Sound Therapy?

Our body’s response to noise traces back to when humans began roaming the earth. Think about loud noises  such as your alarm clock in the morning, the rattling of a jackhammer, or the din of the open office. These sounds evoke an instinctive fight-or-flight reaction in our brains, causing a release of chemicals that stimulates immediate action. This reaction has been instrumental to our survival for eons and remains so to this day. The loud honk of a car horn immediately stimulates our brain and body to respond quickly and get us out of harm’s way.

The things we see, hear, and experience moment after moment not only change our mood but impact us on a deeper physical level; it alters the way our nervous, endocrine, and immune systems function.

Listening to birdsong is a wonderful way to reconnect with nature and shift your focus away from the clutter and chaos that is often part of our daily lives.

According to Eleanor Ratcliffe from the University of Surrey, in her thesis examining the restorative perceptions and outcomes associated with listening to birds, bird sounds have the ability to transport yours to nature.

So, not only does bird music affect us positively on a fundamental level of sound frequency, but it also has the capability to make you think you’re in a natural environment, which will in and of itself reduce stress, anxiety, and depression.

Why Is Bird Music So Powerful For Relaxation And Reducing Anxiety?

In today’s fast-paced world, it is vital to make lifestyle choices that will reduce stress and ultimately prolong your life. It has been revealed that listening to slow tempo, low-pitched music with no lyrics can reduce stress and anxiety in people who are to undergo invasive surgery. It also lessens the requirement of subsequent pain medication.

Now, the above are some proven benefits of listening to ordinary music. Just think how powerful it will be to add bird sounds to the mix?

Bird songs and calls are the sorts of natural sounds that most people associate with perceived stress recovery.

During semi-structured interviews conducted with twenty adult participants, Eleanor Ratcliffe determined the following reasons why bird song helps with relaxation and reducing anxiety.

1. Invokes Positive Memories

Bird sounds associated with enjoyable or special events help combat stress and anxiety and ease depressive episodes, as it creates positive emotions linked with particular places and times.

2. Shifts the Focus

Listening to bird music during trying times moves the focus away from the problems and leads to calm.

3. Change of Stimuli

We get used to the everyday sounds of city life. When we listen to bird music, it provides a break from the emotions associated with our surroundings. This short reprieve will help reduce stress.

4. Welcome Distraction

Bird music has the ability to effortlessly take you out of your current environment without you having to move a muscle.

As a symbol of nature, a bird song transports you far from the daily hustle and bustle and removes you from day-to-day demands that may be causing anxiety.

Although science hasn’t yet caught up with bird music believers’ confidence in its healing properties, the evidence speaks for itself since most support is anecdotal.

Bird music is by no means a miracle cure and should still be used in conjunction with medicine as prescribed by your general practitioner.

How Does Bird Music Work Scientifically?

Bird music can clearly have positive effects on a person’s mood, mental health, and physical well-being.

But what real scientific proof is there of music in general’s impact on mental states?

Below you will find some studies that back up what people have been saying for years — music has healing properties.

1. Changes Brain Function

Using electroencephalographs (EEGs) — a device that measures electrical impulses in the brain — established that music with a strong beat stimulates the brain. In contrast, slow beats encourage the brain to relax by promoting a meditative state. When you listen to faster beats, it can lead to deep concentration.

According to a psychologist who was one of the participating researchers, the human brain is usually locked into a specific functioning level. But by speeding up or slowing down the brainwaves, it is easier for the brain to change its speed in reaction to external and internal stimuli.

2. It Increases Blood Flow in the Brain

Thomas Budzynski, an affiliate professor of psychology at the University of Washington, found that the mind enjoys new stimuli. Whenever the brain experiences new sights or sounds, blood flow increases, equalling a better cognitive response. Some anecdotal evidence indicates that this increase in blood flow may help in repairing damaged brain cells.

3. Stimulates the Release of Internal Opioid Peptides

In a review titled The Neurochemistry of music, it is mentioned that listening to music lowers the need for pain medication due to the euphoria often experienced when listening to specific music.

4. Increases Dopamine Levels

Dopamine is responsible for body movements but also plays a role in a person’s emotional response. For this reason, should music raise dopamine, it will be an excellent thing, especially if you’re suffering from mood swings, depression, anxiety, and other mental illnesses or associated symptoms.

Using neuroimaging technology, the central dopamine release while listening to enjoyable music was measured, and the results are positive. The right type of music does increase dopamine.

No wonder listening to music is one of life’s most pleasurable and relaxing activities.

Kaiyan Medical

We are pioneers and architects of light therapy products. Slowly, we are implementing sounds into our devices. We no longer design for our skin and muscles but also our ears.

Light Therapy and Eczema

Light Therapy and Eczema

Atopic dermatitis and atopic eczema are extremely common — many of us have gone to the doctor with one of these conditions, seeking treatment.

This dermatitis, increasingly frequent in today's reality, has a chronic course with flare-up phases that can cause serious personal discomfort and occur on various parts of the body. While most doctors will often provide topical creams for short-term relief, it doesn't do justice for the long-term implications of this condition. 

These conditions are characterized by inflammation of the skin that occurs with the sudden formation of dry, itchy, and red, blistering patches, especially on hands, feet, wrists, ankles, face, neck, chest, internal crease of the elbow, and backbend of the knees.

Eczema can be a very irritating and uncomfortable condition to deal with. The itching and redness are highly unpleasant and can significantly impact your quality of life. Common sense pushes us to lather on moisturizers and creams to heal the dryness; however, that doesn't always work

But what causes these conditions? Doctors don't actually know the reason for atopic dermatitis, but it's believed to be related to genes and is often paired with asthma and hay fever. Atopic dermatitis is not an allergy to a particular substance; however, its presence increases the likelihood of developing asthma and hay fever (what doctors call atopic triad). Luckily, atopic dermatitis is not contagious.

The skin is the largest organ in the human body and, in the same way, the most accessible from the outside. Sunlight has been used since ancient times for the treatment of some skin diseases.

Light therapy is a therapeutic method based on scientifically-backed equipment capable of artificially reproducing light and thus simulating the beneficial action of the sun.

Using light therapy in skin disease is one of the therapeutic treatments offered to patients suffering from chronic dermatitis and a high majority of patients respond positively to this type of treatment. Light therapy works by using a narrow band with non-invasive UV which is more effective in treating these specific skin conditions.

“The most common form of light therapy is narrowband UVB, which has largely replaced other forms of phototherapy such as broadband UVB and PUVA,” says Dr. Guttman-Yassky, MD, Ph.D., dermatologist and the director of the Laboratory of Inflammatory Skin Diseases at the Icahn School of Medicine at Mount Sinai in New York City. “Narrowband UVB may be best as it’s safe and effective.”

The pathologies that can be addressed and controlled with light therapy are numerous, the main ones being psoriasis, mycosis fungoides, and of course, acne. Light therapy can also help with severe chronic eczema by controlling itching and skin inflammation. Led light therapy for skincare has been used for a while now, with incredible results. 

Light therapy lamp for eczema is used specifically for aiding the issue, not in the same way it treats a regular acne-problem. Light therapy at home for eczema is best to be done after consulting a professional. Once you have the knowledge, you can use it to your power. During the dermatological visit, the specialist assesses the history of skin neoplasms, the patient's skin, the type, anatomical site, and extent of the skin in progress and prescribes the most suitable light therapy treatment. 

When it comes to your skin, treatments can vary from person to person. For most patients, light therapy best time of day is most effective if it occurs early in the morning and is contraindicated late in the evening or night, as it can cause sleep disturbances. The anti-inflammatory action of light therapy allows for good control of the disease and can be used even for severe chronic eczema (with symptoms that persist for months or even years). 

However, it does more than just treat these conditions. There’s another payoff to using light therapy. As Dr. Guttman-Yassky continues, “light therapy also smoothes the lesions, decreasing skin thickening.”

It’s clear that light therapy can provide multiple treatments to various conditions. Not everyone is dealing with only one skin condition, yet, light therapy is able to tackle them all in one go. With Kayian’s MDA-certified and FDA-approved light therapy devices, users will be able to heal themselves from the inside out and get back to feeling balanced.

Product Spotlight: Aduro Mask

Product Spotlight: Aduro Mask


When trying out new forms of non-invasive treatments such as light therapy, it’s extremely important that you find something that satisfies your own needs. Finding a product that suits you isn’t always as easy, which is why many of us conduct our own due diligence before trying something new. 

Light therapy has been around for decades, but is making a serious comeback as its effectiveness and results become more widely known. The best part is it’s not only beneficial for gaining a youthful glow, but overall health as well. So if you’re interested in incorporating a mask into your practice, it’s time you checked out the Aduro Mask (and guess what – with Kaiyan, you can create a private-labeled, premium light therapy facial mask of your own, too)! 

“Although I have only used it a few times, I can state that as LED goes, this one is amazing. I am not new to LED, so I speak from experience when I say - WOW. It is comfortable and has a nice weight. But most importantly, it leaves your skin glowing and smooth. Cannot wait to see even more results the longer I use it.” - Mary F.

Our LED face mask is a light therapy device that uses different wavelengths to create 11 different treatments for many types of skin problems. It took inspiration from NASAs light therapy devices. It has 7 different LED light options, and when the selected light color penetrates the skin, photon energy is transferred to the cells. This is the basic principle of all light therapy devices. 

When the light penetrates the skin, cells convert this energy into ATP (our energy source) – stimulating cellular activity and reproduction. The boosted cells improve their rate and stimulate the body’s natural rejuvenation. This leads to an increase in collagen production and the body’s natural rejuvenation processes – resulting in youthful skin and an overall improvement in your skin’s complexion. The Aduro LED light therapy is mainly for skin rejuvenation and improving skin conditions, depending on the type of light used during treatment.

“I was excited first off that it shipped so quickly!! Packaged great, instructions were easy to read. I love the device. So many features. I can really tell a difference in my complexion after just a few days. The texture of my face and the fine lines. Definitely worth it. This was a birthday gift to myself… Thank you for a great product!!!” - Judy R.

For example, to treat the epidermis—the outer layer of the skin—red or infrared light is used. When applied to the epidermis, it absorbs light and stimulates collagen production. The skin, therefore, has more collagen, appears smoother and fuller, which can reduce the appearance of fine lines and wrinkles. 

Whereas blue LED light therapy focuses on the sebaceous glands. These are necessary to lubricate the skin and hair, but they can also become hyperactive and lead to oily skin and acne.

The blue light under the skin also destroys the bacteria that cause acne, which can help in the treatment of severe acne, including cysts and sebaceous nodules. Blue light is often used in combination with red LED light to heal acne, reduce scars and increase anti-inflammatory effects. 

And this is just an example of the power of light therapy. Our LED facial masks offer seven different forms of light that all have their own unique healing components. 

The treatments available with our LED face mask range from anti-aging to pain blockers. The mask can:

  • Increases hydration from the inside out
  • Help to even out skin pigmentation and redness
  • Even skin tone and clear complexion
  • Reduce acne
  • Revitalize and brighten the skin
  • Reduce eczema and rosacea for sensitive skin

The treatments are calming and purifying for all skin types. With our face mask, there are also options of treatments for skin above the age of 40 and a specific treatment for cell rejuvenation. Depending on your needs, you get to customize the light you want to include in your therapy treatment.  

I’m over 40 & just moved to the Caribbean. Hoping that this will help with my aging & help with the sun exposure. Just started the 20 minute session 3 days ago & it truly feels like it’s working some magic! The mask is very comfortable & overall I can tell it’s extremely well made. Very happy with my purchase & will update with my results in a few months!  - Sarah D.

In addition to cosmetic purposes, the LED mask cycles through all light wavelengths, known as the overall wellness setting, can help with Seasonal Affective Disorder ‘SAD’. 

Kaiyan Medical manufactures MDA-certified and FDA-approved laser light therapy devices that can be customized to exactly what your customer’s needs are. However, one thing’s for sure, customers are raving about the Aduro mask and can’t get enough of it.

“I’ve been using LED masks for several years. This is the third type of mask I’ve used. The results have been excellent. Better than any mask I’ve used in the past. My only problem was that my skin was sticking to the plastic during treatments which made it slightly uncomfortable. Using a hydrating mask during the treatment helped. I love the mobility it gives me. I’ve done five full treatments before recharging the battery. You may be able to get more I didn’t try. I’ve only had the mask a couple of weeks but at present I find it amazing.” -Rhoda K.


Retinol and Light Therapy: Skincare Dream Team

Retinol and Light Therapy: Skincare Dream Team

You’ve probably heard of retinol. It’s been in the skincare industry for years and it provides amazing results for non-invasive treatment. It helps with wrinkles, aging, hyperpigmentation, and in general can produce flawless-looking skin.

A derivative of vitamin A, Retinol helps cellular turnover, making it powerful enough to significantly improve skin texture, pigmentation, and tone. Through cellular turnover, it combats sun damage and skin loosening for its collagen properties. 

Not to mention, you only need a couple of drops. Studies have shown that the use of an over-the-counter product with 0.1% retinol (referred to as regular and prolonged use) brings significant improvement with wrinkles, collagen production, blood flow, and sunspots, with results visible after one month. 

Once applied, the retinol is absorbed, broken down, and transformed into retinoic acid. This compound affects cellular structure (stimulates cell renewal and collagen production). 

The conversion process, however, does not occur immediately upon use—it’s not magic. Several applications may be required before it’s transformed into retinoic acid. But for faster and more immediate results, you can incorporate light therapy into your skincare regime. 

Though light therapy on its own is powerful, when paired with retinol, the two are a perfect combination for flawless skin.

On its own, light therapy proves to be highly effective for treating texture, scars, acne, and overall skin rejuvenation. However, light therapy also deals with more severe skin issues such as eczema and vitiligo. So, why is it so effective?

The specific wavelengths of red light create a biochemical effect in our cells that serves to increase mitochondrial function. This improves the production of ATP (adenosine triphosphate) in the body.

We care about ATP because it's the source of energy for every cell in the body. Without it, we don't work at all. Without enough, we don't perform well.

The wavelengths vary between 630-880 nm and are used to treat the skin’s surface. The red therapy light penetrates the skin approximately 8-10 millimeters. Depending on which area of ​​the body the red light is used for, it can easily affect all layers of the skin, reaching the blood vessels, lymphatics, nerves, and hair follicles.

When red light therapy and retinol are paired together, they quicken cellular turnover and replacement. Initially, retinol and LED light therapy were considered inadvisable. But scientists have now discovered that retinol products paired with light therapy are advantageous—if done properly.

How to prepare for LED light therapy

When it comes to using retinol and LED light therapy, you want to make sure you do it properly. Naturally, aside from using light therapy and retinol, you should focus on eating clean, staying hydrated, getting adequate sleep, and reduce your exposure to sunlight. Now that we have that out of the way, here’s what you need to do.

  1. Cleanse your face thoroughly and pat it dry
  2. Use LED Light therapy mask for 10-15 minutes
  3. Apply your preferred retinol product
  4. Apply SPF

As mentioned before, it’s best to do this at night, not to let sunlight interfere with the efficiency of the process. 

Though there are many ways to treat our skin, ideally, you want a treatment that’s the least invasive and the most effective. Kaiyan's red light therapy devices are designed to treat a variety of skin conditions, helping you stay youthful. Our devices are MDA-certified and FDA-approved, ensuring that your treatment will be safe for your skin while providing you the best results.

Red light Therapy and Hyperpigmentation

Red light Therapy and Hyperpigmentation

Skin conditions can majorly affect a person’s self-esteem. One of the most common issues: hyperpigmentation. We've all heard the term before, but what is it, exactly? 

Hyperpigmentation causes dark spots on the face, hands, and other visible parts of the body that have been exposed to the sun's rays. Not only can it cause insecurities, but it can be very difficult to hide as these spots form in different shapes and sizes, with colors ranging from light brown to black.

There are many types of hyperpigmentation, but the following are the most common:

Pigmentation spots are age spots that occur as a result of exposure to sunlight. This is why they mostly appear in parts of the body that are usually exposed, such as the face, hands and arms. These are usually small, darkened areas of skin.

Melasma or chloasma is often called a "pregnancy mask" because it affects 90% of pregnant women. It occurs as a consequence of hormonal influences during pregnancy and contraception. It causes dark spots of irregular shapes on the face or hands, which can be large in size.

Gradual hyperpigmentation occurs when a flat area of ​​discoloration remains after the skin injury has healed. It is a common occurrence among people who suffer from acne, and it can also be caused by cosmetic treatments such as dermabrasion, laser treatment, and chemical peels.

There are other factors that can darken parts of the skin - such as moles, scars, scars, sun or actinic keratosis, and skin cancer - but they’re not considered forms of hyperpigmentation. 

So, how does hyperpigmentation occur? It develops due to excessive production of melanin—a pigment that gives natural color to our skin, hair, and eyes—on certain parts of the skin. Many factors cause this overproduction, but the main ones can be related to sun exposure, genetic factors, age, hormonal influences, and injuries or inflammation of the skin. It can also be a symptom of certain diseases as well. 

Naturally, limiting the time you spend in the sun, wearing protective clothing, and using sunscreen with a high protection factor, both UVA and UVB, can help reduce the risk of hyperpigmentation and prevent worsening of existing dark spots.

Battling hyperpigmentation is possible in many ways, but red light therapy has proven to be the most effective form of treatment. It’s no secret that most of us lack vitamin D, at least in the Northern Hemisphere, yet light therapy has done wonders in vitamin D production. But red light therapy has shown to be helpful in even more ways than you could imagine. 

Red light therapy works by stimulating cells through red light. Mitochondria in the skin cells can absorb the light particles which emit through the red light, and this can help them produce more adenosine triphosphate (ATP), which is the energy source for all cells. By improving cellular energy, cells repair themselves quickly, returning the skin back to normal pigmentation levels. 

In turn, collagen levels increase, working to reduce other skin conditions, including rosacea. Elastin levels also increase, which helps fight against aging, giving the skin a lift and youthful glow. 

Though there are many ways to treat hyperpigmentation, ideally, you want a treatment that’s the least invasive and the most effective. Luna’s red light therapy devices are designed to treat a variety of skin conditions, including hyperpigmentation. Our devices are MDA-certified and FDA-approved, ensuring that your treatment will be safe for your skin while providing you the best results. 

Preparing your Skin for Light Therapy

Preparing your Skin for Light Therapy

Can I Use Serum With LED Mask?

It is a question that many people have asked — Can I use the serum with LED light therapy?

Our skin is exposed to harsh environmental factors such as sun, wind, cold, and dust daily. These factors tend to attack our immune system causing it to weaken over time.

When this happens, it allows harmful viruses and bacteria to attack our body, leading to acne breakouts and other skin issues such as dark spots and wrinkles. Acne creams are one way of reducing the symptoms associated with this skin condition. However, these can be irritating to your skin, resulting in unwanted side effects such as redness, irritation, and dryness.

The same can also be said for light therapy, which can have its own side effects. Side effects of LED light therapy include itching, burning, and pain. In fact, most users had reported experiencing these side effects when they first started using LED technology. If you were to use any acne medication type, whether prescribed by your doctor or over the counter, the results would depend largely on the person using the medication.

For example, it could take anything from a few days to a few weeks for acne to clear up. Another point to remember is that while certain medications do show better results for some people, they may not work for you at all.

This is because everyone has different skin types, responds differently to treatments, and requires different times to clear away acne completely.

Some people have found success in using LED therapy with a variety of skin creams. However, there is a downside to using this method. LED light therapy does not help remove excess dead skin cells, as some acne medications do. This means that the acne cream will just be left in place and continue to produce side effects for all patients. Besides, side effects can be more severe than a single acne medication dose when used over a long time when used over a long time.

Before you try to use a serum with an LED mask, you should consult with a dermatologist who can advise you on whether or not LED light therapy is right for you. LED light therapy is safe when administered by a certified medical professional. It can be used safely, even if you have sensitive skin, as long as you choose your doctors wisely. Before any treatment is begun, the medical professional will test your skin to determine what type of acne you have. Testing will determine whether your skin is allergic to any light-emitting diodes in the device used.

The last question to answer is, “How effective is Acne treatment with LED Light?” To answer this question, you will need to look at the results you get from the treatment. If you see immediate results after the treatment, it will likely react to the device's light and not the treatment itself.

However, if you don’t see good results after a month of continuous treatment, it is important to determine why the treatment is not working. It may be that you are allergic to any of the ingredients in the product, or it may be that your skin is not receptive to the treatment.

Hydrated Face For LED Mask Results

The serum is good for hydrated face for LED Mask. It can hydrate the skin by absorbing moisture, providing a slight lift to the skin, and removing any oil or makeup that you are using. The serum also contains vitamins and antioxidants that will help fight against free radicals in your body. Free radicals are harmful agents that have been linked with causing cancer.

By fighting against these harmful agents, Serum is good for hydrated face for LED Mask. People who have used Serum have claimed that the hydrated face and LED Mask work very well together. I have also used Serum on my skin, and I must say that the results were really amazing. In fact, I would go on to say that Serum is so good for hydrated face for LED Mask that I will be using it every single night before bed.

If you don’t have much experience making skin look hydrated, this is the forum for you. Let us first examine the ingredient list of Serum.

This product's main ingredients are Hyaluronic Acid, Vitamin C, Retinol A, Alpha Hydroxy Acids, Vitamin E, DMAE, Peptides, and Glycerin, Ferulic Acid, Aloe Vera.

  • AHA kills the bacteria causing acne and helps to get rid of blackheads.
  • Sodium Laureth Sulfate helps in cleaning the skin by getting rid of dead skin cells and excess oil.
  • Salicylic Acid gets rid of pimples and acne scars, and Glycolic Acid is good in treating acne scars.

All of these ingredients are perfectly good for your hydrated face for LED Mask.

  • Now let us move on to how does Serum works to get rid of the facial puffiness.
  • When you are applying Serum on your hydrated face for LED Mask, you are putting on a layer of serum to the surface of your face.
  • As the serum gets applied, it works its way down into your skin and starts working as a moisturizer.
  • This is why this particular product is top-rated as it works as a good moisturizer without over-drying the skin.
How to Prepare Your Skin For a Red Light Therapy Session?

There are different methods used to prepare your skin, but essentially they all work in the same way: removing all the oil and dirt from the skin and then cleaning it. When I talk about cleansing, I’m talking about daily skincare maintenance products. If you want to know how to prepare your skin for a red light therapy session, this is the part that you need to read.

Most people have no idea how their skin looks like, so when they go into the doctor’s office and they've asked if they’ve had a photodynamic therapy or a laser treatment, they’re not aware of what treatment they might have received.

  • The skin absorbs red light from the sun, and in return, it produces negative ions.
  • These are similar to the particles produced by an activated oxygen generator (you know those things at the gym).
  • During photodynamic therapy, the skin cells absorb the energy from the lasers' red light, which causes the release of more negative ions, which then penetrate deeper into the skin.
  • They’re working like the “batteries” on your car — they give the batteries extra power and allow the car to run much longer.
  • If you want to learn how to prepare your skin for a red light therapy session, you must remove all the grime from your face and neck before the session.
  • Cleansing is one of the most important steps to remember in preparation.
How to Prepare Your Skin for Red Light Therapy Session by Using Non-Dry Cleanser

You might need more than just a good cleanser when trying to prepare your skin for red light therapy. Your cleanser is your friend when you are trying to remove all the dirt and excess oil from your face, but what if your cleanser is too harsh on your skin? If you have dry skin, using a cleanser containing too harsh ingredients may cause dryness, making it harder for you to remove those excess oils from your face.

When you prepare your skin for red light therapy session using the non-drying cleanser, make sure that you would be using a toner with antioxidants and anti-inflammatory ingredients to increase the collagen level the skin.

This will help keep your skin healthy and younger-looking.

Caution: Lotion and Moisturizers For LED Masks Are Not Recommended

The use of moisturizers and lotions is not recommended for LED masks because it will damage your skin. There are also cases wherein people who used such products ended up suffering from adverse effects.

The ingredients in these products may be too strong for the skin to be able to absorb.

You can prevent this by using only non-comedogenic lotions and moisturizers for LED masks.

  • This way, the product is less likely to irritate your skin. In addition to that, you can also use other types of products designed for sensitive or dry skins to use on your face during the event's preparation.
  • However, there are cases wherein people who have been using such moisturizers and lotions as part of their LED facial make-up mask ended up suffering from adverse effects.
  • In these cases, the products were not properly applied to the skin, and the amount that was applied was also insufficient.
  • Because the skin did not get sufficient moisture, the cells underneath the skin's surface could not repair themselves properly.
  • This will result in damaged skin, which will cause more breakouts than before.

Aside from lotion and moisturizers, it would help if you also stayed away from mineral oil, alcohol, and preservatives. These ingredients are not good for your skin, as they can cause dryness and irritation. It would help if you also stayed away from using creams and lotions with fragrance, which can only irritate your skin even more. Instead, look for serums.

If you want to have a glowing complexion without enduring any adverse effects, use a good quality face serum.

Prepare Your Skin For Red Light Therapy by Removing Sunscreen

You probably have heard that it is unsafe to use the sun’s UV rays at home, especially if you use a tanning lotion or a self-tanning lotion. But did you know that it is also not safe to use self-tanning products like tan accelerators and sunless tanning pills to prepare your skin for red light therapy sessions?

This defeats the purpose of using red light therapy, and you must remove sunscreen so that your face and skin are completely ready to receive the red light therapy. This is because self-tanning products contain ingredients that can affect the skin in adverse ways and block the beneficial deep penetrating infrared wavelength from 650nm to 850nm.

How to Prepare Your Skin For Red Light Therapy by Removing Makeup

If you have chosen to have laser acne treatment and you are wondering how to prepare your skin for the red light therapy, you will want to take a moment to learn how red light therapy works before getting started.

Before your session begins, you will be given a short amount of time to get ready for the procedure. This is because your skin needs to be very clean and free of any makeup. Your skin needs to be completely dry before the procedure can begin.

If there is any moisturizer on your skin when you arrive for your appointment, you will have to remove it before your treatment.

Your doctor will ask you several questions about your skin during your appointment, including what type of skin you have and whether or not you have any allergies. During this time, they will also determine if you are a good candidate for the procedure. If you are cleared for the procedure, your skin will be exposed to an intense red light level. This is one of the most effective ways to get rid of acne, and it can also help prevent scars and aging from occurring on your face.

The amount of time that it takes to get your skin prepared for red light therapy varies. In most cases, it is normal to have it take from fifteen to thirty minutes to prepare your skin for the procedure. You may have to remove any makeup at this time as well.

How to Prepare Your Skin For Red Light Therapy by Exfoliating?

When a patient is getting a therapy session done, they will be required to go to the spa or beauty clinic to be given a facial.

A therapist will then start by cleaning the face thoroughly. After the initial cleaning process, the therapist will apply a chemical that will help exfoliate the skin.

This process can irritate the skin, so it is important to prepare your skin before undergoing this procedure. Some common preparations that people use include salicylic acid, alpha hydroxy acid, retinoids, glycolic acid, and other peel-type products.

The exfoliating procedure aims to help the skin cells shed off dead skin cells and replace them with new cells.

This is why it is important to remove all traces of dead skin cells from your face before undergoing the procedure.

It may seem odd at first, but if you want to get the best results from the procedure, you need to gently exfoliate your skin.

Prepare Your Skin For Red Light Therapy With Moisturizers

When you prepare your skin for red light therapy, you are basically preparing to expose the blue spectrum laser's high intensity and the eventual dry out of the epidermis. The skin must be prepared using a good cream containing Reductase or Salicylic Acid, or by exfoliating the skin using a scrub.

After the procedure, you will need to have topical products applied to your skin to prevent the skin from cracking and peeling. This will also help improve your appearance and prevent future scarring. Removing moisturizers before the therapy can be helpful. This is because the skin’s cells will still be in a dormant state when you receive the treatment; therefore, your skin is not at risk for the dryness associated with moisturizers.

This will also improve your skin's look, especially for those who have undergone this procedure many times. However, you must be youthful if e to remove moisturizers in preparation for the session, as some creams may cause excessive dryness and irritation. Once you are prepared for the session, you can expect the doctor to start the red light therapy by generating a small amount of blue light on your skin's top layer.

The light then travels through the skin, reaching the deepest layers where most of the damage occurs. When the blue light is emitted, it is believed that the cells below the surface of the skin begin to absorb the red light, helping to repair the skin. The increased circulation and nutrient absorption help to rejuvenate your skin, leaving it looking younger and healthier than ever before.


Sinus Infections & Low-level Laser Therapy

Sinus Infections & Low-level Laser Therapy

Sinus infections are inflammation based. Sinusitis is when inflammation is chronic, and the body is unable to overcome it. Sinusitis or sinus infections may be acute (coming on suddenly) or chronic (long-lasting & nothing seems to fix it.

There are sinus cavities above the eyebrows, behind the nose, and under the cheekbones. When the mucus membranes within the sinuses become inflamed, mucus is generated. Sometimes even air is trapped, which puts pressure on the walls of the sinus cavities, making our face hurt, causing difficulty in breathing thru the nose — this is called sinusitis.

Studies have shown that 37 million people per year in the US are affected with sinusitis at one time or another involving all age brackets.

Is There a Natural, Safer Treatment Option?

Some people immediately run to a doctor wanting antibiotics, which may not help since not all sinusitis is due to bacteria. Low-level laser therapy (LLLT) has been proven effective in enabling the body to overcome inflammation. Many of our patients find that when they use low light Laser Therapy to treat their sinus infections, they experience two things: First — patients notice a significant difference after 1 treatment (breathing easier and sinus drainage); Second — they are less likely to get recurring infections, as is often the case when taking antibiotics.

Irradiation of red light penetrates several millimeters into tissue; in the infrared part of the spectrum, the penetration goes up to several centimeters, usually 4–6 cm. This is a very advantageous fact for treating sinusitis, for laser irradiation can be applied externally. However, when applying a red laser, it is necessary to introduce a light guide in the sinus.

Laser therapy is a safe, painless, non-invasive, and effective therapy to reduce pain and swelling, allowing the body to restore damaged tissue. Laser therapy uses red and infrared light to relieve pain and accelerate healing and decrease inflammation. When the light source is placed against the skin, the photons penetrate several centimeters and get absorbed by the mitochondria, the cell’s energy-producing cells part. This energy fuels many positive physiological responses resulting in the restoration of normal cell function. Laser therapy offers our bodies the opportunity to heal with no side effects and no long term damage.

Long Term/Cumulative Effects of Laser Therapy:

  • Improved resistance to infections
  • The immune response is stimulated
  • Reduction in swelling
  • Lymphatic drainage is improved
  • The body’s natural healing process is enhanced

LLLT irradiation is a benefit for the treatment of acute sinusitis. External irradiation with a laser with 830 nm wavelength, enabling the beam to penetrate 4–6 cm deep, is recommended. Irradiation with red light-emitting lasers is also effective. Still, due to the need for application through a light guide inserted into the cavity, this method has been discarded from clinical practice.

Laser irradiation works through its analgesic, anti-inflammatory, and biostimulation effects on ease of pain or elimination. It also causes a quicker withdrawal of inflammation and edema of the mucosa. It thus brings restoration of drainage of sines as well as normalization of mucociliary function. Immunomodulatory effect — improvement of both specific and non-specific immunities by stimulation of T and B lymphocytes, lysozyme, and phagocytosis — is also significant. Stimulation of Langerhans cells of the mucose of sines is presumed, too.

Laser irradiation in treating sinusitis has no contraindications (except for general contraindications, i.e., malignant tumors in the irradiation area or epilepsy). As physiotherapy, it can suitably complement therapy with antibiotics, mucolytics, and antihistaminics. The use of a laser with 830 nm wavelength appears to be the most beneficiary on diagnosis sinusitis acute with liquid levels in paranasal sinuses, the treatment of which was cut down by 59 percent in average, and on a group of patients with plain catarrhal obscure and decreased transparency (the most frequent) where the duration of therapy was shortened by 39 percent.

By using red light therapy devices from Kaiyan Medical, you’re able to reduce sinus inflammation and improve your immune system by investing a few minutes using a red light device.

How to Integrate Light Therapy into your Lifestyle

How to Integrate Light Therapy into your Lifestyle

Our lives are busier than ever, and even though red light therapy sounds like something that could significantly benefit you, we know you might be thinking: “when will I have time for red light therapy?” 

Part of the beauty of red light therapy is that you don't need to change your current routine or lifestyle to enjoy its benefits: if you're someone whose day is busy in front of a desk, you can turn the device on while you work; or if you have easy-going mornings but hectic afternoons, you can enjoy your morning coffee while using our red light therapy device. Or, you can turn on the panel while you’re unwinding with a movie in the evenings –– the options are endless.  

Red light therapy treatment isn’t supposed to take over your day and cause an inconvenience. With an at-home red light therapy device, you make the rules. 

That said, you may be wondering what’s the best time of day to use our red light therapy devices. Well, there are a couple of ways you can integrate red light therapy into your lifestyle. 

There are three main parts of the day: morning, midday, and evening. Though you’re able to use red light therapy any time of the day, some parts of the day can be more effective than others, particularly given your personal health and wellness needs. 

If you’re someone who’s suffering from a sleep disorder, then you may want to focus on using red light therapy during the mornings and evenings. For sleep conditions, using red light therapy around sunrise or sunset are the best times of the day. Why is that? 

It has to do with our biological circadian rhythm, which is the natural internal process that helps regulate your sleep cycle within a 24-hour day. To optimize your circadian rhythm and improve your sleep cycle, you need to sync with your natural sleep rhythm. By doing so, you reduce sleep inertia, insomnia, and other sleep disorders. 

When regulating your circadian cycle, your body releases a hormone called melatonin. This particular hormone is the highest in the blood at night and optimal for helping you fall asleep. When using red light therapy at night, it can help you enhance your natural melatonin production

When using red light therapy in the morning, exposure to light helps stop melatonin production, giving your body a natural energy boost. So, either time of the day––morning or night––can be an incredible time to help your body reset its circadian rhythm. 

You don’t need to schedule off your morning for red light therapy treatment. While you’re eating your breakfast or going through your emails, you simply turn on your red light therapy device and enjoy 10 to 15 minutes of treatment. 

Or, in the evenings when you’re cozied up on the course, washing the dishes, or sitting in bed with a book, turn on your red light therapy panel to help regulate your sleep cycle, mood, and overall health. 

If you can’t manage to use red light therapy in the morning or evening, you can always have a treatment in the afternoon, as well. If you’re dealing with a sleep disorder or seasonal depression, we recommend morning or evening treatment. However, midday treatment will also provide you with a load of benefits, including collagen production, decreasing symptoms of depression, improving sleep disorders, and non-seasonal Bipolar depressive episodes. 

Whatever the condition may be, whether it's a sleeping disorder, skin condition, or depression, Lunas red light therapy devices promote cellular healing from the inside out. What’s important is you find the time of the day that best suits your body’s needs. Everyone is different, so it’s important to find out what works for you and your unique routine and lifestyle.

Light Therapy - An Alternative to Botox and Fillers?

Light Therapy - An Alternative to Botox and Fillers?

It’s safe to say that most people would prefer to slow down the physical signs of aging, particularly on their faces – and the proof is in the numbers. In 2018, the global anti-aging market was estimated to be worth around $50.2 billion U.S. dollars. Now that's a lot of skin cream and Botox. And those numbers are only increasing: by 2027, the anti-aging product industry is projected to be worth $83.2 billion U.S. dollars. 

Of course, a large portion of sales are going to anti-aging creams and serums; however, there's been an increase in soft-tissues cosmetic procedures like Botox and filler treatments. A report from the American Society of Plastic Surgeons from 2018 reported around 7.4 million injections of botulinum toxin (Botox) and 2.6 million dermal filler injections we used that year. 

In America alone, Botox and fillers ranked the second most popular, minimally-invasive cosmetic procedures. But why are they so popular? Due to their invasiveness, they're more effective than anti-aging creams. However, that comes at a potentially risky and painful price. 

Botox's side effects include bruising and swelling at the injection site, fever, chills, and headaches. Some side effects are specific to the area of injection and include drooping eyelids, excessive tearing, and uneven eyebrows and other facial muscles. More importantly, research on the long-term side effects of Botox and fillers is limited. There are immediate results, yes; however, there's an unclear understanding of what Botox and fillers do to the body in the long-term.

Aside from health concerns, Botox and fillers can quickly add up financially, too. The most common Botox and filler treatments cost hundreds of dollars per session. Women and men around the world are risking their health and money to look youthful, but what they don't realize is there's non-invasive alternatives to these procedures, including light therapy. 

Aside from light therapy’s plethora of benefits for the human body, it is an amazing anti-aging alternative for those looking for non-invasive and natural anti-aging results. Light therapy reduces fine lines and wrinkles, but goes beyond just skin deep. 

While Botox and fillers work to cover the symptoms of aging skin, light therapy solves the problem at a cellular level. As we age, our body’s collagen production decreases, leaving our skin less plump and full. However, through light therapy, you’re actually stimulating collagen production beneath the skin to receive natural and similar results to Botox and fillers. 

Light therapy works by delivering wavelengths of red and near-infrared light to our skin and cells. Red light enhances our cellular function, stimulating the cell's mitochondria to produce ATP (adenosine triphosphate) energy. This boost of cell energy promotes collagen and elastin production, bringing the plumpness back into your skin. 

A 2014 study found that users of red light therapy experienced significantly improved skin complexion and increased collagen. Angela Lamb, M.D. and associate professor of the Department of Dermatology at the Icahn School of Medicine at Mount Sinai Hospital in New York City, stated that "Science shows that red light therapy protects existing collagen and boosts new production. Plus, it helps with texture, tone, pore size, and wrinkles."

However, there are more benefits to red light therapy than natural collagen production. Light therapy also aids in diminishing fine lines and wrinkles, reduces scarring, fights acne, treats inflammation, and aids in muscle recovery.

The proof is in the research, and study after study has shown the same results: red light therapy works for anti-aging. Rhonda Klein, M.D., a board-certified dermatologist in Connecticut, said that “Realistically, you can expect RLT to improve your skin’s tone and texture. We know that it soothes inflammation, improves mild acne, and proactively treats fine lines and wrinkles, in addition to other benefits.”

Lunas’ red light therapy devices are both MDA and FDA-approved, assuring you receive the highest quality of red light treatments available on the market, which is essential in receiving the best, most efficacious results.

The Children of Fire - Infrared Light & Fire

The Children of Fire - Infrared Light & Fire

The control of fire by early humans was a turning point in the technological evolution of human beings. Fire provided a source of warmth, protection from predators, a way to create more advanced hunting tools, and a method for cooking food. These cultural advances allowed human geographic dispersal, cultural innovations, and changes to diet and behavior. Additionally, creating fire allowed human activity to continue into the evening's dark and colder hours.

Claims for the earliest definitive evidence of fire control by a member of Homo range from 1.7 to 2.0 million years ago. Evidence for the “microscopic traces of wood ash” as the controlled use of fire by Homo erectus, beginning some 1,000,000 years ago, has wide scholarly support. Flint blades burned in fires roughly 300,000 years ago were found near fossils of early but not entirely modern Homo sapiens in Morocco.

The fire was used regularly and systematically by early modern humans to heat treat silcrete stone to increase its flake-ability for toolmaking approximately 164,000 years ago at the South African site of Pinnacle Point.[5] Evidence of widespread control of fire by anatomically modern humans dates to approximately 125,000 years ago.They also used fire for light.

Infrared Light from Fire

The burning of wood (or other organic materials) releases energy in the form of infrared light. When you take a photo of someone with an infrared camera, what do you see? A heat “signature” that correlates (approximately) to their metabolic activity.

What is infrared light? It is a spectrum of light that we can’t see but that powerfully shapes our biology. You sense infrared light as “heat.” The heat you feel from the sun — that’s the sensation of infrared light. The feeling of heat you get when you put your hand close to an oven, toaster, or fire — that is also infrared light. The heat of another person’s body — infrared light again. Hot springs transfer heat to your body in the form of infrared light stored in the water itself. When you take a hot shower or hot bath, the same principle is at work.

Infrared light has been used for decades as a heat source for saunas. Before IR saunas, we had sweat lodges and traditional stone saunas. In traditional saunas and sweat lodges, stones absorb energy from either an electronic heating unit (in the case of a sauna) or a fire. The light is stored in the stones and gradually released during the sweat lodge or the sauna. Both methods use light to heal the human body.

And infrared light doesn’t just transfer “heat” to your body — it turns the water in your cells into batteries. This is likely why ancient cultures recognize the importance of fire, sweat lodges, and saunas, especially in winter.

It is not a coincidence that sitting down next to a fire is so comfortable. Firelight is natural and helps to manage melatonin production as well as keeping our circadian rhythms under control.

A fireplace or fire-pit isn’t just an ornamental detail of your home, and it’s a tool you can use to live a healthier life.

References

  1. James, Steven R. (February 1989). “Hominid Use of Fire in the Lower and Middle Pleistocene: A Review of the Evidence” (PDF). Current Anthropology. 30 (1): 1–26. doi:10.1086/203705. Archived from the original (PDF) on 12 December 2015. Retrieved 4 April 2012.
  2. ^ Luke, Kim. “Evidence That Human Ancestors Used Fire One Million Years Ago.” Retrieved 27 October 2013. An international team led by the University of Toronto and Hebrew University has identified the earliest known evidence of the use of fire by human ancestors. Microscopic traces of wood ash, alongside animal bones and stone tools, were found in a layer dated one million years ago.
  3. ^ Miller, Kenneth (May 2013). “Archaeologists Find Earliest Evidence of Humans Cooking With Fire”. Discover.
  4. ^ Jump up to: a b Zimmer, Carl (7 June 2017). “Oldest Fossils of Homo Sapiens Found in Morocco, Altering History of Our Species”. The New York Times. ISSN 0362–4331. Retrieved 6 July 2017.
  5. ^ Brown, Kyle S.; Marean, Curtis W.; Herries, Andy I.R.; Jacobs, Zenobia; Tribolo, Chantal; Braun, David; Roberts, David L.; Meyer, Michael C.; Bernatchez, J. (14 August 2009), “Fire as an Engineering Tool of Early Modern Humans”, Science, 325 (5942): 859–862, Bibcode:2009Sci…325..859B, doi:10.1126/science.1175028, PMID 19679810, S2CID 43916405

Melasma & Light Therapy

Melasma & Light Therapy

Light can be a powerful skincare tool, whether it’s an LED facial or light therapy for all skin. Light therapy can also seem a little mysterious if you’ve never done it before because light doesn’t interact with the skin in the same obvious way as, say, serum or moisturizer.

Here, we’re breaking down light therapy and melasma, explaining what they are, how they work, and experts’ advice for adding them to your skincare routine.

Melasma is sometimes referred to as the mask of pregnancy because it is sometimes triggered by an increase in pregnant women's hormones. But while the condition may be common among pregnant women, it isn’t limited to them.

“It’s not only associated with pregnancy but can affect women at all stages of life,”

Says Dr. Shadi Kourosh, director of the Pigmentary Disorder and Multi-Ethnic Skin Clinic at Harvard-affiliated Massachusetts General Hospital. And it may last for many years.

“Women who develop melasma in their teens or 20s or 30s may see it stay around for decades,”

Says Dr. Barbara Gilchrest, senior lecturer on dermatology at Harvard Medical School.

What is Melasma

Melasma is a common skin problem. The condition causes dark, discolored patches on your skin.

It’s also called chloasma, or the “mask of pregnancy,” when it occurs in pregnant women. The condition is much more common in women than men, though men can get it too. According to the American Academy of Dermatology, 90 percent of people who develop melasma are women.

Causes of Melasma

It isn’t obvious what causes melasma. Darker-skinned individuals are more at risk than those with fair skin. Estrogen and progesterone sensitivity are also associated with the condition. This means birth control pills, pregnancy, and hormone therapy can all trigger melasma. Stress and thyroid disease are also thought to be causes of melasma.

Additionally, sun exposure can cause melasma because ultraviolet rays affect the cells that control pigment (melanocytes).

How is Melasma Diagnosed?

A visual exam of the affected area is often enough to diagnose melasma. To rule out specific causes, your healthcare professional might also perform some tests.

One testing technique is a Wood’s lamp examination. This is a special kind of light that’s held up to your skin. It allows your healthcare professional to check for bacterial and fungal infections and determine how many skin layers the melasma affects. To check for any serious skin conditions, they might also perform a biopsy. This involves removing a small piece of the affected skin for testing.

Light Therapy Based Treatments

Light therapy for melasma treatment is best suited for patients with refractory melasma who failed with topical treatment or a series of chemical peels. Topical therapy takes at least three months or longer to see skin lightening, and those patients who are interested in a more rapid response could consider light therapy.

When a patient wishes for an accelerated pace of improvement, analogous to chemical peels, these modalities accelerate melanin pathways’ removal. Still, they do not target the melanin production itself.

One key point of patient counseling before laser- and light-based treatment is that these therapies can speed up removing melasma-related hyperpigmentation, but they are not cures for melasma.

References

Arora P, Sarkar R, Garg VK, Arya L. Lasers to treat melasma and post-inflammatory hyperpigmentation. J Cutan Aesthet Surg.

Barolet D. Light-emitting diodes (LEDs) in dermatology. Semin Cutan Med Surg. 2008;27(4):227–238.

Lee HM, Haw S, Kim JK, et al. Split-face study using a 1,927-nm thulium fiber fractional laser to treat photoaging and melasma in Asian skin. Dermatol Surg. 2013;39(6):879–888.

Kauvar AN. The evolution of melasma therapy: targeting melanosomes using low-fluence Q-switched neodymium-doped yttrium aluminum garnet lasers. Semin Cutan Med Surg.

Weiss RA, McDaniel DH, Geronemus RG, Weiss MA. A clinical trial of a novel non-thermal LED array for reversal of photoaging: clinical, histologic, and surface profilometric results. Lasers Surg Med. 2005;36(2):85–91.

Bear, Wolf, Lion or Dolphin: How Understanding your Sleep Type Will Change your Life

Bear, Wolf, Lion or Dolphin: How Understanding your Sleep Type Will Change your Life

Sleep is big business these days — one in three people are believed to experience sleep deprivation — and everyone is keen to rely on the latest fashionable theory.

For years, sleep cycles were divided into two categories. People who enjoy mornings were known as “early birds.” And those of us who prefer staying up late were labeled “night owls.”

Well, step-aside birds. Mammals are the new name of the game. That’s right; scientists now believe there are four ways to classify sleep/wake cycles. In the science world, these classifications are known as chronotypes.

Chronotypes describe the periods when your body wants to sleep and when it wants to be awake. And to make it easier, the chronotype categories are named after animals. Our natural sleep tendencies are now categorized as bear, wolf, lion, and dolphin.

It is crucial to understand your animal chronotype. Once you do, you can start to schedule your life around your body’s natural cycles. Kaiyan Medical suggests that this may help you sleep better and feel more productive at work.

Two Animals are not Enough

People have different circadian rhythms. That’s just a fact of life.

Science shows that:

“The human circadian system actively synchronizes to the 24-h day via environmental signals of light and darkness.”

Circadian? A 24-hour cycle. It’s your body clock. Sleep psychologists reckon they can determine our natural sleeping patterns. By understanding our own, we can have a happier, more productive life.

Now, Chronotype is a term that describes a person’s natural rhythm. And it doesn’t only relate to sleep. Chronotypes influence all primal instincts.

Author Michael Breus, Ph.D., recently suggested that there are 4 natural chronotypes. And he named these after 4 animals that follow similar sleep/wake patterns. So, say goodbye to night owls and early birds. Wolves, lions, bears, and dolphins are the new circadian rhythm mascots.


The Chronotypes

Check out the chronotypes below and let us know in the comment section which one sounds like you!

Wolves

Alright, night owls, this is your group. Just like these nocturnal creatures, you are most alert at night. Wolves tend to stay up later and struggle with waking up early.

Only about 15% of the population falls into this group. Wolves are more productive in the later afternoon and evening.

Sleep experts recommend that wolves set their alarm for 7 a.m. (snooze for 30 minutes) and go to sleep by midnight.

Lions

Lions are the new early birds. Like these wild cats, you are most alert in the morning. You have no trouble waking up and getting to work. But, lions tend to feel the afternoon slump. And by the evening, they feel drained.

About 15% of the population identifies as a lion. Sleep experts recommend that lions wake up around 5:30 a.m. and go to sleep by 10:30 p.m.

Bears

No, you don’t need to hibernate. But, like these diurnal (awake during the day, asleep at night) creatures, you follow the solar cycle. Bears generally feel awake during the day and need 8-hours of solid sleep at night.

About 50% of the population falls into this category. This group is productive in the morning and struggles with the mid-afternoon slump. Sleep experts recommend that bears wake up around 7 a.m. and go to sleep by 11 p.m.

Dolphins

Dolphins “only sleep with half of their brain at a time?” Sound familiar? Well, this is the insomniac (often self-diagnosed) group. You might be anxious and have trouble turning your brain off at night. Dolphins usually don’t get a complete night’s sleep.

About 10% of the population falls in this category. And even though they wake-up tired, dolphins are most productive by mid-morning.

Sleep experts recommend that dolphins get up around 6 a.m. and try to sleep around midnight.

Sleep Like an Animal

Who doesn’t want a better night’s sleep and a more productive day? Start scheduling your days based on your chronotypes! Once you know more about your chronotype, you can form sleep patterns that work with (not against!) your body’s natural rhythms.

So what are you waiting for? Here in Kaiyan, we are embracing our inner animals and start following our optimal sleep schedule.



Sources:

Fischer, Dorothee et al. "Chronotypes in the US – Influence of age and sex." PubMed, 21 Jun. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5479630/

Bellis, Rich. "How To Design Your Ideal Workday Based On Your Sleep Habits." Fast Company, 26 Nov. 2017, www.fastcompany.com/40491564/how-to-design-your-ideal-workday-based-on-your-sleep-habits

Levi, Anthea. "This Is the Best Time of Day to Do Everything, According to Your Chronotype." Health.com, 31 Oct. 2016, www.health.com/mind-body/how-to-get-more-energy-chronotype

Stretch Marks & Light Therapy

Stretch Marks & Light Therapy

Why Do We Get Stretch Marks?

A stretch mark is a type of scar called striae, meaning “thin, narrow scar”. In people who develop stretch marks, the skin has stretched faster than it can grow, such as during pregnancy, growth spurts, or rapid fat or muscle gain. The abrupt stretching causes the collagen and elastin proteins responsible for the skin’s structure and elasticity to rupture. This, in turn, causes the dermis to tear.

As the dermis tears, the body’s healing mechanisms spring into action to close the wound as quickly as possible to prevent infection and further damage.

Normally, as the skin regenerates and grows, it’s an elegantly organized latticework of collagen and elastin proteins. But when the skin tears, the body doesn’t have time to build an elegant structure to fill in the gap. Time is of the essence in any wound repair, including torn skin.

The collagen clumps together hurriedly, aiming for efficient closure of the wound before infection can set in. “Scarring is the result of a system that has learned to respond extremely quickly to a wound,” says Dr. John Newman, a cosmetic surgeon and researcher at the Laser Center of Virginia in Virginia Beach.

This haphazard process results in tough and functional but unattractive tissue — what we know as a scar. “It is kind of like nailing down a crisscross of two-by-fours over a hole in a deck,” says Newman. “It seals the hole, but it doesn’t look very nice.”

Newly formed stretch marks are darker than the surrounding skin and can be slightly raised, itchy, or painful. If they’re left untreated, they become permanent scars. Their color will lighten, and their appearance will fade below the top layer of the surrounding skin.

The bigger mystery is why stretch marks don’t disappear over time as the skin regenerates. The key lies in the information that emerging cells receive from adult cells in the area. Skin cells, whether they’re normal cells or scar cells, regenerate about once every 30 days. Growth of new skin cells begins at the bottom-most layer of the scar, and older (dying) cells are pushed to the surface where they naturally slough off.

However, Neuman explains that that that that emerging cells “learn” from their immediate neighbors and predecessors and develop the same characteristics as ir replacement their replacement cells. As a result, any emerging cell in contact with scar cells will become new scar tissue rather than normal skin tissue.

Red Light Therapy For Stretch Marks

If you have tried to get rid of stretch marks, perhaps you’ve used specialized creams that contain retinoids. These work to some extent, but only if you catch your stretch marks early and treat them while they’re still forming. Retinoids work by stimulating collagen production. However, they can irritate sensitive individuals, and doctors often recommend that pregnant women avoid anything containing retinoids.

Another common treatment, known as microdermabrasion, essentially involves “sandblasting” the skin with tiny crystals. This sloughs off dead skin

cells and stimulates the production of collagen. Microdermabrasion is a fairly harsh treatment that can lead to irritation and damage, especially to sensitive skin.

The most extreme treatment for stretch marks is plastic surgery, such as a mini tummy tuck. This may be effective, but there are risks associated with any invasive procedure and the high cost.

Is there a better option for restoring the appearance of the skin? The answer is yes, absolutely. Also known as photobiomodulation and low-level light therapy (LLLT), red light therapy improves skin appearance, reduces signs of aging, treats chronic skin conditions, reduces scarring, and promotes skin wound healing.

When red light therapy is used, visible red light and invisible near-infrared (NIR) light are applied to the skin with LED bulbs' devices. Wavelengths of light are measured in nanometers (nm), with red light ranging from 630nm to 660nm and NIR light ranging from 810nm to 850nm. Human cells respond favorably to these wavelengths, similar to how natural sunlight affects plant cells by stimulating more energy and optimization of cell function.

When the red light is shone on bare skin, it soaks into the mitochondria, colloquially referred to as the powerhouses of cells' energy factories. The mitochondria are, in turn, stimulated to produce more adenosine triphosphate (ATP), which is the primary cellular fuel. This energizes cells to perform their normal functions, from fighting off pathogens to performing repair and regeneration.

Improved Blood Flow

Proper healing relies on good circulation to the skin. Red light promotes the proliferation of endothelial cells, which make up the inner layer of capillaries (the tiny blood vessels that deliver oxygen and nutrients throughout the body). This was the focus of a 2017 study by a team of researchers from Austria, who found that red light consistently increased migration and proliferation of endothelial cells.

Without proper blood circulation, there would be no healing since endothelial cells also deliver white blood cells to the sites they need. In skin wound healing, white blood cells are necessary to protect the vulnerable area from infection while the wound closes up.

Reduced Inflammation

Acute inflammation results in the redness that’s noticeable in fresh stretch marks. This is a normal and necessary part of the tissue regeneration scar's process. Acute inflammation, which is a function of the immune system, actually sets the stage for normal tissue repair and regeneration. Inflammation is quickly followed by the production of new skin structures — which, as previously described, are hastily assembled to ensure that the torn skin doesn’t become infected.

But sometimes, the inflammatory process continues after the wound has healed, leading to chronic inflammation. It can lead to a variety of widespread problems throughout the body, including disease. “Some inflammation is good,” says Dr. Robert H. Shmerling, an associate professor of medicine at Harvard Medical School. “Too much is often bad. The goal is to recognize when inflammation is simply doing its job, and when it can potentially cause problems.”

Hundreds of studies have shown how red light therapy can significantly reduce inflammation. Many of these were conducted by Dr. Michael A. Hamblin, an associate professor of dermatology at Harvard Medical School and a noted expert on red light therapy. In the final report of a 2017 study, Hamblin refers to red light therapy’s “pronounced anti-inflammatory effects.”

Mobilize Stem Cells

During the skin-rebuilding phase, stem cells, which are unspecialized “master” cells, mobilize to the site and develop into most any type of specialized cells that are needed by the body. Ideally, they develop into normal skin cells, rather than scar tissue, to replenish damaged or destroyed cells due to skin tearing.

Red light has been shown to activate stem cells. As Barbara Gefvert, editor-in-chief of BioOptics World, explains: “Recent research shows … that noninvasive application of light can boost the natural growth of an individual’s own stem cells to enable exciting new treatments.” Stem cells can assist with the tissue regeneration process and stimulate normal and healthy behavior in existing cells. This can prevent the formation of new stretch marks and gradually reduce the appearance of existing stretch marks.



Photodynamic Therapy for Cancer

Photodynamic Therapy for Cancer

Photodynamic therapy (PDT) is a treatment that uses a drug, called a photosensitizer or photosensitizing agent, and a particular type of light. When photosensitizers are exposed to a specific wavelength of light, they produce a form of oxygen that kills nearby cells

Each photosensitizer is activated by light of a specific wavelength. This wavelength determines how far the light can travel into the body. Thus, doctors use specific photosensitizers and wavelengths of light to treat different areas of the body with PDT.

How is PDT Used to Treat Cancer?

In the first step of PDT for cancer treatment, a photosensitizing agent is injected into the bloodstream. The agent is absorbed by cells worldwide but stays in cancer cells longer than it does in normal cells. Approximately 24 to 72 hours after injection, when most of the agent has left normal cells but remains in cancer cells, the tumor is exposed to light. The photosensitizer in the tumor absorbs the light and produces an active form of oxygen that destroys nearby cancer cells.

In addition to directly killing cancer cells, PDT appears to shrink or destroy tumors in two other ways. The photosensitizer can damage blood vessels in the tumor, thereby preventing cancer from receiving necessary nutrients. PDT also may activate the immune system to attack the tumor cells.

The light used for PDT can come from a laser or other sources. Laser light can be directed through fiber optic cables (thin fibers that transmit light) to deliver light to areas inside the body. For example, a fiber optic cable can be inserted through an endoscope (a thin, lighted tube used to look at tissues inside the body) into the lungs or esophagus to treat cancer in these organs. Other light sources include light-emitting diodes (LEDs), which may be used for surface tumors, such as skin cancer.

PDT is usually performed as an outpatient procedure. PDT may also be repeated and used with other therapies, such as surgery, radiation therapy, or chemotherapy.

Extracorporeal photopheresis (ECP) is a type of PDT in which a machine is used to collect the patient’s blood cells, treat them outside the body with a photosensitizing agent, expose them to light, and then return them to the patient. The U.S. Food and Drug Administration (FDA) has approved ECP to help lessen the severity of skin symptoms of cutaneous T-cell lymphoma that has not responded to other therapies. Studies are underway to determine if ECP may have some application for other blood cancers and help reduce rejection after transplants.

What Types of Cancer are Currently Treated with PDT?

To date, the FDA has approved the photosensitizing agent called porfimer sodium, or Photofrin®, for use in PDT to treat or relieve the symptoms of esophageal cancer and non-small cell lung cancer. Porfimer sodium is approved to relieve esophageal cancer symptoms when cancer obstructs the esophagus or when cancer cannot be satisfactorily treated with laser therapy alone. Porfimer sodium is used to treat non-small cell lung cancer in patients for whom the usual treatments are not appropriate and relieve symptoms in patients with non-small cell lung cancer that obstruct the airways. In 2003, the FDA approved porfimer sodium to treat precancerous lesions in patients with Barrett esophagus, a condition that can lead to esophageal cancer.

What are the Limitations of PDT?

The light needed to activate most photosensitizers cannot pass through more than about one-third of an inch of tissue. For this reason, PDT is usually used to treat tumors on or just under the skin or on the lining of internal organs or cavities. PDT is also less effective in treating large tumors because the light cannot pass far into these tumors. PDT is a local treatment and generally cannot treat cancer that has spread.

Does PDT have any Complications or Side Effects?

Porfimer sodium makes the skin and eyes sensitive to light for approximately 6 weeks after treatment. Thus, patients are advised to avoid direct sunlight and bright indoor light for at least 6 weeks.

Photosensitizers tend to build up in tumors, and the activating light is focused on the tumor. As a result, damage to healthy tissue is minimal. However, PDT can cause burns, swelling, pain, and scarring in nearby healthy tissue. Other side effects of PDT are related to the area that is treated. They can include coughing, trouble swallowing, stomach pain, painful breathing, or shortness of breath; these side effects are usually temporary.

What Does the Future Hold for PDT?

Researchers continue to study ways to improve the effectiveness of PDT and expand it to other cancers. Clinical trials (research studies) are underway to evaluate PDT's use for cancers of the brain, skin, prostate, cervix, and peritoneal cavity (the space in the abdomen that contains the intestines, stomach, and liver). Other research is focused on the development of more powerful photosensitizers, more specifically target cancer cells, and are activated by light that can penetrate tissue and treat deep or large tumors. Researchers are also investigating ways to improve equipment and the activating light's delivery.

Red Light Therapy and Quarantine

Red Light Therapy and Quarantine

If there’s one thing most of us likely haven’t had enough of in 2020, it’s natural light. The pandemic has changed our lives in so many ways, particularly concerning the drastic increase in the amount of time spent indoors and home. Most of us are stationed at our computers all day, only to log off just in time for dinner. At that point, it’s already dark, and we’re likely ready to decompress and relax.

Throw a lockdown on top of this, and we’re lucky if we even get to see the sky that day.

Our current lifestyle, specifically in quarantine, makes natural daylight a rare sight, and this can be extremely detrimental to our mental and physical health — but why?

Without a sufficient amount of light, your circadian rhythm becomes out of sync, as does our hormone production levels. And if you’ve been experiencing poor sleep, lack of light is likely the reason why. A study from the Journal of Clinical Sleep Medicine found that employees who work near windows receive twice as much sunlight as those who don’t receive natural light — they also receive 46 more minutes of sleep on average.

So: darkness isn’t the determiner of sleep; rather, light is.

It’s clear how our daily routines have become more indoors-bound, yet there seems to be no way to reduce these light-limiting circumstances. The lack of sleep disrupted hormones, and constant uncertainty has a severe effect on our bodies, which we’re all experiencing during this time. So, how do we overcome these health concerns with limited options?

This is where red light therapy plays a crucial role in improving health. With the average American spending 90 percent of their time indoors, red light therapy allows you to receive light in your own environment. But just because we’re staying at home due to quarantine doesn’t mean we can’t supplement the natural light we need.

Red light therapy works by increasing energy production at a cellular level. The more energy our cells produce, the better our bodies feel as there’s sufficient blood flow. However, there’s more to it than just feeling good.

For people working in front of the computer all day, carpal tunnel syndrome, muscle fatigue, and arthritis are serious concerns. And since we’re working from home, our screen time has significantly increased. Red light therapy can also alleviate these issues by increasing circulation, repairing tissue, and relieving stiffness.

And while some may have received more natural light during quarantine in the summer, winter is right around the corner. During the winter months, Seasonal Affective Disorder (SAD) affects around 5% of people in general. However, with quarantine, these numbers are increasing. Thankfully, SAD symptoms can be significantly reduced, as light therapy mimics the sun’s light.

With COVID-19, it’s also incredibly difficult to manage mental and emotional health with the current circumstances. Before quarantine, if someone was stressed, they could reduce their symptoms by working out, going to yoga class, or enjoying nature with friends. But these activities have been either eliminated or significantly reduced. So, the reality is that we’re sitting at home all day, stressed, overworked, and fatigued.

Red light therapy is a game-changer for mitigating stress levels, as light cultivates calmness within the body. And since light therapy aids with cell production, it helps the body bounce back after experiencing stress or illness. In these times, red light therapy can aid with stress and help people recover from COVID-19 by reducing lung inflammation, pneumonia, and other acute respiratory disorders.

So although the quarantine presents many new challenges, we can be empowered to control our own health and wellness during these times. At Lunas, we’re passionate about helping people achieve their balance and intend to have our light panels in homes around the world, particularly during this challenging period. We hope to help everyone around the world find their light — literally!



Muse - The Brain Sensing Headband

Muse - The Brain Sensing Headband

Overview

Muse is a wearable device in the form of a headband that senses the brain's electrical rhythms (EEG). The headband is coupled with a smartphone app (Calm) that monitors the user’s brain electrical activity and gives immediate feedback to achieve a “calm” or meditative pattern. Over time, the use of this device is thought to help reduce distractibility, improve stress control, and improve mood.

Use

The headband is light and comfortable but requires a bit of experience to fit properly and to transmit reliable signals by BlueTooth to the associated smartphone app. The device will not work with older versions of many smartphones (such as the iPhone 4). The instructions for use are straightforward and easy to follow, and the program is up and running within minutes. Once one gets started, it is straightforward to adjust settings and to personalize the program.

UI

The user is asked to sit quietly with eyes closed and to focus on counting expirations. The app displays one of two pleasant visual backgrounds associated with wind or water sounds. The volume and frequency of these weather sound decrease as the EEG rhythm become the “calm” state. Therefore, one gets immediate and easy to understand feedback as to how one is doing. The sessions can be set to last from 3 minutes to 45 minutes.

Appropriateness

Immediately after finishing a session, the app provides a graphical depiction of one’s EEG rhythm, grouped into “calm,” “neutral,” or “active” bands. The app calculates the amount of time spent “calm” and awards points for “calm” time. The points are associated with certain awards and expressions of positive feedback. Besides, the app graphically displays the percentage of time spent “calm” over variations and prescribes several challenges to increase time performance. All times performance of this is lovely and easy to understand and to manipulate.

Account Management

The company’s website provides a great deal of information regarding frequently asked questions and troubleshooting. When I submitted a question to the company over the website, I received an answer within hours. The app allows one to permit for session data to be aggregated by the company for research purposes. I think it is useful to share personal data because they may ultimately determine how effective the device might be.

Scientific Basis

The Muse headband is a remarkable technological advance over earlier versions of EEG neurofeedback technologies. Neurofeedback is a technique that has been employed for mental health conditions for more than a decade and formerly required a link between traditional EEG recording devices with desktop or laptop computers. Through operant conditioning, these techniques seek to alter brain functioning by giving live feedback about EEG rhythms to the patient. Patients are rewarded if they can achieve certain EEG rhythm characteristics, such as decreased theta activity (4–7 cycles per second) or an increase in alpha activity (12–15 cycles per second). A higher proportion of alpha wave activity is thought to be associated with focused attention and a feeling of calm or well-being.

Traditional neurofeedback techniques have never been fully tested in psychiatric conditions for several reasons. First, these techniques are not protected by exclusive intellectual property, so industrial funding for large-scale trials has not been available. Similarly, devices designed to deliver neurofeedback have not been seen as unique medical devices by the FDA, which could be protected by patents. Furthermore, there is some disagreement about which pattern of EEG rhythms would be most therapeutic for particular groups of patients. I was not able to locate references to clinical trials using Muse technology specifically.
Although not formally approved for clinical use by the FDA, many clinics currently offer neurofeedback treatments. However, widespread clinical adoption of neurofeedback has not occurred due to concerns about cost relative to the uncertainties about efficacy. Most protocols recommended that individuals come to a supervised clinical setting for multiple sessions per week over several months. This is a time consuming and expensive endeavor which, due to lack of published scientific data on efficacy, is not reimbursed by insurance companies. With the Muse technology, EEG neurofeedback has entered the world of self-directed activity using a wearable device coupled with a smartphone app. Therefore, the cost is much reduced, and it becomes feasible to decide individually whether the techniques are a worthwhile investment of time.

Cost

The Muse headband costs $299, and the app is free. This appears to be a very reasonable cost, given the complexity of the technology and the amount of information obtained with its use.

Reviewed April 2015

References
  • ADHD
    Neurofeedback has been studied most extensively in Attention Deficit Hyperactivity Disorder, for which at least 5 randomized controlled trials with mixed results have been published.
    Bink M, van Nieuwenhuizen C et al: Neurocognitive effects of neurofeedback in adolescents with ADHD: A randomized controlled trial. J Clin Psychiatry 75:535–542, 2014
  • Major Depression
    Peeters F, Oehlen M, et al.: Neurofeedback as a treatment for the major depressive disorder — a pilot study. PLoS One. 2014 Mar 18;9(3):e91837. DOI: 10.1371/journal.pone.0091837. eCollection 2014
  • Performance Anxiety
    Gruzelier JH, Thompson T et al: Application of alpha/theta neurofeedback and heart rate variability training to young contemporary dancers: state anxiety and creativity. Int J Psychophysiol 93:105–111, 2014
  • Obsessive-Compulsive Disorder
    Koprivova J, Congedo M et al: Prediction of treatment response and the effect of independent component neurofeedback in obsessive-compulsive disorder: a randomized, sham-controlled, double-blind study. Neuropsychology 67:210–223, 2013
  • Reading Disabilities
    Nazari MA, Mosanezhad E et al.: The effectiveness of neurofeedback training on EEG coherence and neuropsychological functions in children with reading disability. Clin EEG Neurosci, 43:315–322, 2012
  • Autism Spectrum Disorders
    Kouijzer ME, van Schie HT et al.: Is EEG-biofeedback an effective treatment in autism spectrum disorders? A randomized controlled trial. Appl Psychophsiolo Biofeedback 38:17–28, 2013
  • Traumatic Brain Injury
    Nelson DV, Esty ML: Neurotherapy of traumatic brain injury/posttraumatic stress symptoms in OEF/OIF veterans. J Neuropsychiatry Clin Neurosci 24:237–240, 2012
  • Insomnia
    Hammer BU, Colbert AP, et al.: Neurofeedback for insomnia: a pilot study of Z-score SMR and individualized protocols. Appl Psychophysiol Biofeedback 36:251–264, 2011.
  • Several other studies have proposed benefits in cognitive performance for normal subjects or in meditators.
  • Gruzelier JH: EEG-neurofeedback for optimizing performance. I: A review of cognitive and affective outcomes in health participants. Neuroscience and Biobehavioral Reviews 44:124–141, 2014
  • Ros T, Munneke MAM, Ruge D, Gruzelier JH, and Rothwell JC: Endogenous control of waking brain rhythms induces neuroplasticity in humans. European Journal of Neuroscience, 31:770–778, 2010
  • Vidyarthi J and Riecke BE: Interactively mediating experiences of mindfulness meditation. International Journal of Human-Computer Studies 72:674–688, 2014


Parkinson's: From the Gut to the Brain

Parkinson's: From the Gut to the Brain

Margaret Jarrett was diagnosed with Parkinson’s disease eight years ago. And although she was bothered by many of the symptoms that commonly afflict people living with Parkinson’s — resting tremor, uncertain gait, and terrible nightmares — the thing that bothered her the most was the loss of her sense of smell. An avid gardener, she took great pride in her roses but being unable to inhale their perfumed scent really got her down.

“You take something like your sense of smell for granted,” Jarrett, 72, said. “You don’t realize how precious something is until it’s gone.”

Parkinson’s disease combines movement disorders, including resting tremors, muscle rigidity, impaired balance, and movement slowness. It can also cause neurological problems such as depression, insomnia, memory loss, and confusion.

Its cause is unknown, but it is associated with dopamine depletion and destruction of neurons in the brain's basal ganglia region.

The current mainstay of treatment for Parkinson’s disease involves physical therapy and medications that act to increase dopamine levels in the brain. One relatively new therapy for Parkinson’s is exposure to infrared light.

Dr. Ann Liebert, co-ordinator of photomolecular research at the Australasian Research Institute, has been exploring the idea of using infrared light to modulate the gastrointestinal tract’s microbiome in humans.

The gut’s microbiome — composing trillions of bacteria, fungi, and protozoa from hundreds of different species that normally inhabit our gastrointestinal tract — has come under increasing scientific attention over the past decade, with links being established between the microbiome and several conditions including obesity, type 2 diabetes, cardiovascular disease, and depression. Several studies have also observed that the gut microbiome is markedly altered in patients with Parkinson’s disease. Fecal microbiota transplantation can have a protective effect in animal models of Parkinson’s.

The reason for this is unknown. However, an interesting observation is that another common pathology seen in Parkinson’s disease is the accumulation of misfolded proteins, called Lewy bodies, in the brain. It has been shown that certain sensory cells of the gut contain these same proteins.

Researchers have hypothesized that abnormal forms of the protein could travel from the gut to the brain through the vagus nerve, a phenomenon observed in animal models of Parkinson’s. Further support for this theory comes from findings that people who have had a surgical vagotomy — where branches of the nerve are cut — have a lower lifetime risk of developing Parkinson’s.

“We know that infrared light can reduce Parkinson’s symptoms and offer protection to brain cells. So, we wanted to test if it could modulate the gut’s microbiome as well,” Liebert said.

Provisional results from the first half dozen Adelaide participants, including Margaret Jarrett, have been promising.

“The six patients . . . showed an increase by up to 20 percent in the favorable microbiome that is associated with obesity reduction and short-chain fatty acid production. And the bacteria associated with rheumatoid arthritis, Crohn’s disease and insulin resistance were all decreased,” said Hosen Kiat, a professor of cardiology at Macquarie University, who oversaw the trial.

“For the last three years, I haven’t been able to smell flowers,” Jarrett said. “But several weeks into the trial, I started to smell my roses, daphnes, and gardenias again, and it was wonderful.”

Another participant, Barry Weldon, 70, had a similar experience. “My sense of smell improved significantly,” he said. “One day, I walked into the house, and for the first time in a long time, I could actually smell the soup my wife was cooking.”

Ron Till, 68, had an even more dramatic improvement. “The trial gave me the ability to sleep again,” he said. “It was amazing.”

Till’s neurologist cautioned him not to get his hopes up before the trial but changed his mind when he saw the results. “He told me it was voodoo medicine and probably wouldn’t work,” Till recalled. “But after the trial, I went back for my three-monthly assessment with him, and he said to me, ‘You’re actually testing better than when you first started with me ten years ago.’”

Retired geologist Sean Kennedy, 76, also experienced an improvement in his coordination and balance. “My juggling skills have improved,” he said.

In a review published in Photobiomodulation, Photomedicine and Laser Surgery, Liebert and her co-authors acknowledge that while the exact mechanism by which light therapy alters the microbiome is unknown, there is definite potential in light therapy.

“The ability of PBM [light therapy] to influence the microbiome (if proven to apply to humans) will allow an additional therapeutic route to target multiple diseases, including cardiovascular disease and Parkinson’s disease, many of which have thus far eluded effective treatment approaches,” the paper concludes.

Kiat is excited by light therapy’s potential. “If we can create non-­invasively a metabolically healthier microbiome through this extremely cheap and easy way, then inflammatory diseases and neurodegenerative diseases should be positively influenced,” he said.

Gold Coast-based GP Mark Jeffery is a clinician who has been using lasers in his practice for more than four years. He says the research supports the use of light therapy for a wide range of diseases, including Parkinson’s, Alzheimer’s, depression, and chronic pain.

“The reality is there are no real side effects from low-level laser therapy, and it’s one of the safest treatments you can ever do,” he says.

Liebert says the promising results they have seen thus far will inform a large, double-blinded randomized control trial planned for this year. “It has the potential to apply to huge fields of medicine,” she said.

Weldon’s neurologist, Chris Kneebone, is keeping an open mind on infrared light therapy’s potential. “We all just have to wait and see what the trial results tell us,” he said.

His advice for people who wish to give it a try for their Parkinson’s? “If you want to give it a go, give it a go,” he said. “I’ve got no reason not to recommend it, but at this stage, I’ve got no reason to think it is helpful either.”

As for Jarrett, she has no doubts that infrared light therapy has helped her. She enjoys pottering around in her garden again and has more energy than she has had for a long time.

“I feel like I could take on the world again,” she said. “My garden has never looked better.”

References

https://pubmed.ncbi.nlm.nih.gov/30074108/

https://pubmed.ncbi.nlm.nih.gov/29247431/

Light Therapy can Benefit Patients with TBI (Traumatic Brain Injury)

Light Therapy can Benefit Patients with TBI (Traumatic Brain Injury)

According to a pioneering study by researchers from the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH), light therapy is safe and has measurable effects on the brain.

Senior investigators Rajiv Gupta, MD, Ph.D., director of the Ultra-High Resolution Volume CT Lab at MGH and Benjamin Vakoc, Ph.D., at the Wellman Center led the study, which was supported by a grant from the Department of Defense (DOD) and published in JAMA Network Open September 14th.

This study is one of the first, if not the first, prospective, randomized, interventional clinical trials of near-infrared, low-level light therapy (LLLT) in patients who recently suffered a moderate brain injury. If further trials support these findings, light therapy could become the first widely-accepted treatment for this type of injury.

TBI is the leading cause of traumatic injury worldwide, and an estimated 69 million people experience such an injury every year. However, there are no treatments for this condition yet, largely because the underlying biological mechanisms are not well understood. It is so challenging to do studies with actual patients in the acute stage of trauma.

"The Gulf War put TBI in the headlines because body armor had been greatly improved by then. But there were still brain injuries caused by the shock waves from high powered explosives.”

Rajiv Gupta, MD, PhD, Director, Ultra-High Resolution Volume CT Lab

For various reasons, the number of TBIs has increased around the globe since then, but effective treatments are still sorely needed. For this study, a special helmet had to be designed specifically to deliver the therapy, an undertaking that required a mix of medical, engineering, and physics expertise.

This multidisciplinary team included Gupta, a neuroradiologist, Vakoc, an applied physicist, and others specializing in developing and translating optical instrumentation to the clinic and biologic laboratories. Both Gupta and Vakoc are also associate professors at Harvard Medical School.

“For this study, we designed a practical, near-infrared treatment based on Wellman Center research and working directly with DOD on the vexing problem of TBI, a condition faced by so many,” says Rox Anderson, MD, the center’s director.

Another challenge was optimizing the wavelength of the near-infrared LLLT.

“Nobody knows how much light you need to get the optimal effect,”

explains Lynn Drake, MD, one of the study co-authors and director of business development at the Wellman Center.

“We tried to optimize the wavelength, dosing, timing of delivery, and length of exposure.”

This was done through a series of pre-clinical experiments led by Anderson. These included multiple preclinical studies led by Michael Hamblin, Ph.D. Anderson and Hamblin are both co-authors of this paper.

Near-infrared LLLT has already been considered for multiple uses, but to date, few if any studies of this technology have been tested and none in patients with TBI.

It has been studied in stroke patients, and Wellman's basic laboratory research suggests it is neuroprotective through a mechanism mediated by specialized intracellular organs called mitochondria. It took several years of research at Wellman to understand the basic mechanism before the clinical trial.

The randomized clinical trial included 68 patients with moderate traumatic brain injury who were divided into two groups. One group received LLLT via the special helmet, which delivered the light. Patients in the control group wore the helmet for the same amount of time but did not receive the treatment.

Vakoc’s team at Wellman designed the helmet. During the study, the subjects’ brains were tested for neuron activity using quantitative magnetic resonance imaging (MRI) metrics, and the subjects also underwent neurocognitive function assessment.

MRI was performed in the acute (within 72 hours of the injury), early subacute (2–3 weeks), and late subacute (approximately three months) stages of recovery. During each visit and at six months, clinical assessments were performed using the Rivermead Post-Concussion Questionnaire, with each item assessed on a five-point scale.

Twenty-eight patients completed at least one LLLT session, and none reported any adverse reactions. Also, the researchers found that they could measure the effects of transcranial LLLT on the brain.

The MRI studies showed statistically significant differences in myelin's integrity surrounding the neurons of treated patients versus the control group. Both these findings support follow-up trials, especially since there are no other treatments for these patients.

The study also showed that light does impact the cells. While it is well established that cells have light receptors, “going into this trial, we had several unanswered questions such as whether the light would go through the scalp and skull, whether the dose was sufficient, and whether it would be enough to engage the neural substrates responsible for repair after TBI,” says Gupta.

It’s important to note, and he adds that for this initial study, the researchers focused on patients with moderate traumatic brain injury. That helped ensure their study could have statistically significant findings because patients in this category are more likely to demonstrate a measurable effect.

“It would be much more difficult to see such changes in patients with mild injuries, and it is quite likely that in patients with severe brain injuries, the effect of light therapy would be confounded by other comorbidities of severe trauma,”

says Gupta.

He adds that researchers are still very early in the development of this therapy. It is unknown if it could be applied to other types of brain injury, such as chronic traumatic encephalopathy (CTE), which has received a lot of public attention over the last few years.

CTE is a progressive degenerative disease associated with a history of repetitive brain trauma such as that experienced by certain athletes, most notably football players.

This study opens up many possibilities for the broader use of photomedicine. “Transcranial LED therapy is a promising area of research, with potential to help various brain disorders where therapies are limited,” says Margaret Naeser, Ph.D., a prominent researcher in photomedicine and research professor of Neurology at Boston University School of Medicine. She was not affiliated with this particular study.

Source:

Massachusetts General Hospital

Journal reference:

Longo, M, G. F., et al. (2020) Effect of Transcranial Low-Level Light Therapy vs. Sham Therapy Among Patients With Moderate Traumatic Brain Injury. doi.org/10.1001/jamanetworkopen.2020.17337.

Light Therapy Clinical Trial Aims to Accelerate Recovery from COVID-19

Light Therapy Clinical Trial Aims to Accelerate Recovery from COVID-19

Ontario is a known leader in conducting innovative clinical trials, and the clinical trials community in Ontario has proven this strength throughout the COVID-19 pandemic. One innovative trial underway in Ontario is Vielight Inc.’s COVIDlight trial, which tests whether the recovery of COVID-19 patients may be accelerated by the use of a specialized light therapy device. This trial was made possible in part by Clinical Trials Ontario’s Trial Site Network through a connection made between Vielight Inc. and Impact Clinical Trials. CTO spoke with representatives from Vielight and Impact Clinical Trials about their trial and their experience with the Trial Site Network.

Light Therapy Device for the Treatment of COVID-19

Vielight Inc. has developed a compact and portable device named the “Vielight RX Plus,” based on the science of photobiomodulation (PBM). PBM uses certain light energy to modify cellular functions and can play a role in the management of COVID-19. This clinical trial assesses the efficacy of the Vielight RX Plus to reduce symptom duration and severity in patients suffering from COVID-19.

The Vielight RX Plus device delivers light therapy to the sternum and the nasal canal.

“This device brings a holistic approach to the treatment of COVID-19 patients,”

said Nazanin Hosseinkhah, Research Scientist and Physicist at Vielight Inc.

“The device stimulates the thymus gland, creates nitric oxide, increases natural killer cells, acts as an anti-inflammatory therapy, and increases cellular energy.”

This unique, at-home study has the potential to modulate immune cell and cytokine activity in COVID-19 patients with an easy to use the device.

“We are very hopeful that this trial will prove to help patients recover from COVID-19 at home, and result in less burden to the healthcare system,”

said Hosseinkhah.

Clinical Ttrial

This randomized controlled trial, being managed by Impact Clinical Trials, is actively recruiting 280 participants who are confirmed to have contracted COVID-19. The trial was authorized by Health Canada in early September and is recruiting participants in Ontario and the United States. Participants are allocated into a treatment or a control group, with 140 participants randomized to receive the Vielight RX Plus device and the other 140 participants receiving the current standard of care. The trial is conducted remotely with non-hospitalized participants.

Participants in the treatment group receive the device by courier within 24 hours of registering for the trial. They are asked to place the device on their chest and onto their nostril for 20 mins each day. They then track their symptoms within a daily survey over a 30-day period.

“This is a simple, at-home study for participants to be involved in,”

said Andrea Berk from Impact Clinical Trials.

“Participants in both the treatment and the control groups are completely supported throughout the trial, with a 24-hour number they can call if they have any questions.”
Connections

This trial was made possible in part by a connection made directly through CTO’s Trial Site Network.  The Trial Site Network, part of CTO’s Industry Concierge program, comprises more than 230 sites. The Network allows CTO to provide warm introductions to Ontario’s hospitals, research institutions, private research networks, and CROs.

“We have been able to guide companies such as Vielight in getting their trials up and running in Ontario,”

said Andrew Haller.

“I was introduced to Andrew Haller from CTO a few months before the COVID-19 pandemic,”

said Berk.

“Pre-COVID I was working on half a dozen connections that had been made through the Trial Site Network. When COVID-19 hit, those projects were put on hold. I reached out to Andrew to let him know Impact Clinical Trials had the consulting capacity, and that is when he introduced us to Vielight.”

Haller knew that Vielight had been searching for someone to take on the management of their clinical trial. “When Andrew introduced us to Andrea Berk from Impact Clinical Trials, we immediately connected and knew they were the right fit,” said Hosseinkhah.